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김명주(Myeong Joo Kim),진수빈(Subin Jin),황영미(Young Mi Whang),장인호(In Ho Chang) 대한비뇨기종양학회 2017 대한비뇨기종양학회지 Vol.15 No.1
There exists a need to develop strategies that promote neovascularization in virtually all tissue engineering and regenerative medicine efforts. While research typically focuses on understanding and exploiting the role of angiogenic factors and vascular cells on new blood vessel formation, the activity of the immune system is being recognized to impact vascular formation and adaptation. This review will provide both an overview of the relationship of angiogenesis and the immune system, and how biomaterials may be designed to promote favorable angiogenesis by interaction between these 2 systems to promote effective vascularization.
김명주(Myeong Joo Kim),지병훈(Byung Hoon Chi),조민지(Min Ji Cho),황영미(Young Mi Whang),장인호(In Ho Chang) 대한비뇨기종양학회 2017 대한비뇨기종양학회지 Vol.15 No.2
Tissue engineering is limited by our inability to adequately vascularize tissues post implantation because all tissue-engineered substitutes (with the exception of cornea and cartilage) require a vascular network to provide the nutrient and oxygen supply needed for their survival. This review gives a brief overview of the processes and factors involved in the vascularization and angiogenesis and summarizes the different strategies to overcome the issue of slow vascularization and angiogenesis in a range of tissue-engineered substitutes. Moreover, we will announce some potential future plans.
흰쥐 중추신경계내 난소로 투사하는 미주신경로에 관한 연구
김명주(Myeong-Joo Kim),장명세(Myeong-Se Chang),고미희(Mi-Hee Ko),노해숙(Hae-Sook Noh),조해영(He-Young Cho),오문유(Moon-You Oh),이봉희(Bong-Hee Lee) 대한체질인류학회 2000 해부·생물인류학 (Anat Biol Anthropol) Vol.13 No.1
본 실험은 부교감신경의 하나인 미주신경이 난소를 지배하는 신경으로 관여하고 있는지를 pseudora. bies 바이러스를 이용하여 난소신경로와 난소주사후 미주신경정단을 통하여 조사한 연구 보고이다. 이를 위하여 Sprague Dawley계 암흰쥐를 대상으로 pseudorabies 바이러스를 난소에 주사한 무리와 난소 주사후 미주신경을 정단한 우리에서 뇌를 적출하여 pseudorabies 바이러스에 대한 연역조직화학 염색을 시행하여 비교하였다. 본 실험결과 미주신경 중추신경로내의 상위신경핵들이 pseudorabies 바이러스에 대하여 양성반응이 줄어들었거나 관창되지 않는 차이를 보였다 즉 적색핵, 종말판혈관기판, 줄무늬체, 침상핵과 이마엽겉질은 부분적으호 난소의 미주신경로에 관여하고 있으며 미주신경동쭉핵, 고립로핵, 최후영역, 청색반정, 팔옆핵, 코리케퓨즈핵 , 흑색질 및 시각교차위핵은 양성반응이 관찰되지 않아 미주신경으로 투사하는 부교감신경핵으로 조사되었다.
협력적 거버넌스가 경제활성화에 미치는 영향에 대한 이해관계자 인식 분석
김명주(Kim, Myeong joo),안경섭(Ahn, Kyung sup) 서울행정학회 2018 한국사회와 행정연구 Vol.29 No.1
본 연구는 핵심 이해관계자를 대상으로 협력적 거버넌스의 세부 구성요소들이 민간투자활성화를 매개하여 경제활성화에 미치는 영향을 실증적으로 규명하였다. 주요 분석결과, 일부 협력적 거버넌스의 구성요소는 민자활성화나 경제활성화에 유의한 영향을 미치는 것으로 나타나 제한적이기는 하지만 협력적 거버넌스는 효과가 있다고 볼 수 있다. 자율성과 생산성은 민자활성화에 정(+)의 유의한 영향을 미치는 것으로 나타났으며, 생산성은 민자활성화를 매개하여 경제활성화에도 유의한 정(+)의 영향을 미치는 것으로 나타났다. 이러한 분석결과를 바탕으로 이론적, 정책적 시사점과 더불어, 후속연구의 필요성에 대해서 논의하였다. This study empirically investigated the Stakeholder Perception of effect of collaborative governance on economic revitalization through mediation of PPPs. As a result of the main analysis, some elements of collaborative governance have a significant effect on the activation of the PPPs and revitalization of the economy, even though its overall effect is limited. Collaborative elements such as autonomy and productivity have a positive effect on PPP activation, and other elements such as openness and productivity have a positive effect on economic revitalization. The mediating effect analysis shows that element of collaborative governance like productivity has a positive (+) effect on economic revitalization through mediation of PPPs. Based on these results, we discussed the theoretical and politic implications and the necessity of follow - up research.
창상치유목적의 골수기질세포 동종이식을 위한 고분자막의 조건
이은상,김명주,한승규,홍성택,김우경,Lee, Eun-Sang,Kim, Myeong-Joo,Han, Seung-Kyu,Hong, Sung-Taek,Kim, Woo-Kyung 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.5
Purpose: Major drawbacks of conventional bone marrow stromal cells (BSCs) transplantation method are mainly caused by direct transplanted cell to host cell interactions. We hypothesized that separation of the transplanted cells by a microporous membrane might inhibit most of the potential adverse effects and induce superior effect. The purpose of the study is to determine the optimal condition of the microporous membrane. Methods: First, BSCs were placed in polyethylene terephthalate (PET) transwell inserts with 3, 8, or $12{\mu}m$ pore size, and cultured in 24 well culture plates. After 5 days, bottoms of the plates were observed for presence of attached BSCs in monolayer and cell numbers were evaluated. Second, BSCs were placed PET, polycarbonate (PCT), and mixed cellulose esters (MCE) transwell inserts with 3 and $8{\mu}m$ pore size, and cultured in 24 well culture plates. After 3 days, the supernatants of the media left in culture plate were analyzed for collagen, vascular endothelial growth factor (VEGF), platelet derived growth factor BB (PDGF-BB), and basic fibroblast growth factor (bFGF). Third, BSCs were placed in 15% and 70% of the PET membrane with $3{\mu}m$ pore size. All the experimental conditions and methods were same as the second study. Results: The optimal pore sizes to prevent BSC leakage were $3{\mu}m$ and $8{\mu}m$. The amounts of type I collagen and three growth factors tested did not show significant differences among PET, PCT, and MCE groups. However, the collagen, VEGF, and bFGF levels were much higher in the high (70%) density group than in the low (15%) density group. Conclusion: This study revealed that the optimal pore size of membrane to prevent direct BSC to recipient cell contact is in between $3{\mu}m$ and $8{\mu}m$. Membrane materials and pore sizes do not influence the collagen and growth factor passage through the membrane. The most striking factor for collagen and growth factor transport is pore density of the membrane.
조민지(Min Ji Cho),지병훈(Byung Hoon Chi),김명주(Myeong Joo Kim),황영미(Young Mi Whang),장인호(In Ho Chang) 대한비뇨기종양학회 2018 대한비뇨기종양학회지 Vol.16 No.2
Three-dimensional (3D) printing is an additive manufacturing process by which precursor materials are deposited layer by layer to form complex 3D geometries from computer-aided designs, and bioprinting offers the ability to create 3D architecture living cells. Bioprinting methods have been developed rapidly pattern living cells, biological macromolecules, and biomaterials, and an advantage of the 3D microenviroment over traditional 2-dimensional cell culture is the ability to obtain more accurate and reliable data from model about tumor formation, progression, and response to anticancer therapies. This review focuses on recent advances in the use of biopriniting technologies for cancer research, bioprinting physiologically relevant testing platforms for anticancer drug development, and computational modeling for improvement bioprinting technique.