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- 저자 : Manseop Kim(김만섭) (검색결과 2 건)
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김만섭(Manseop Kim),고길주(Kilju Ko),김정헌(Jeongheon Kim) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
The automotive wheel is an active area of automotive component design and development. The wheel must be durable enough to tolerate significant loads and harsh environmental effects. So this paper describes the fatigue life prediction on wheels by simulating the experimental procedure using finite-element analysis. Based on a high frequency fatigue property, calculations of the stresses in wheels were conducted by simulating the rotating bending fatigue test. Wheels made of an aluminum alloy ,A356.2, were tested using bending fatigue tester. Results from bending fatigue test showed a linear correlation between bending moment and stress amplitude. Consequently<br/> finite-element calculations were performed by a linear analysis. In order to find stress-cycles curves. spoke parts of wheel were tested using rotary bending fatigue tester. Also highly accurate finite-element analysis requires regression lines and confidence intervals from these results. In conclusion, if the fatigue data related to the material and manufacturing procedure are reliable, the prediction on fatigue life in wheels can be carried out with high accuracy.
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Evaluation for Biocompatibility of Gentamicin-collagen Sponge on the Experimental Animal Wound Model
윤성호,박지희,박정규,김만섭,김달원,송문용,강규일,황원구,구세광,장광호,권영삼,Yun, Sung-Ho,Park, Jihee,Park, Jeongkyu,Kim, Manseop,Kim, Dalwon,Song, Moon-Yong,Kang, Gyoo-Il,Hwang, Won-Koo,Ku, Sae-Kwang,Jang, Kwang-Ho,Kwon, Young-Sam The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
The objective of this study was to compare the biocompatibility for local irritation and bioavailability of $Gentacol^{TM}$ and $Collatamp^{TM}$, after single intramuscular loading in rats. Sixty-six male Sprague-Dawley rats were divided into 4 groups; (1) any test materials were not applied into the quadriceps muscles (control group, N = 6), (2) Gentamicin was injected into the quadriceps muscles (Gentamicin group, N = 6), (3) Collatamp was applied into the quadriceps muscles (Collatamp group, N = 27), and (4) Gentacol was applied into the quadriceps muscles (Gentacol group, N = 27). The concentration of gentamicin in muscles was gradually decreased with time after loaded in the both $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded regions. No detectable gentamicin was observed in the plasma of $Gentacol^{TM}$ and $Collatamp^{TM}$ loaded rats. Histologically, moderate to severe inflammatory cell infiltrations including PMN, lymphoid cells and macrophages were observed with slight to moderate edematous changes of muscle fibers after intramuscular injection of gentamicin. However, these histopathological changes of gentamicin injection induced local irritations were dramatically decreases after intramuscular loading of $Collatamp^{TM}$ and $Gentacol^{TM}$. These results suggest $Gentacol^{TM}$ may show favorable local bioavailability and induce only slight local irritations as comparable as $Collatamp^{TM}$ without systemic exposures in the condition of this experiment. 본 연구의 목적은 겐타마이신 함유 스폰지인 겐타콜과 콜라템프를 랫드 근육내 이식 후 생체적합성을 비교하는 것이다. SD 랫드 66 마리를 네 그룹으로 나누었다; (1) 대퇴사두근에 무처치한 군 (대조군, 6 마리), (2) 대퇴사두근에 겐타마이신 액을 주사한 군 (겐타마이신 군, 6 마리), (3) 대퇴사두근에 콜라템프를 이식한 군 (콜라템프 군, 27마리), (4) 대퇴사두근에 겐타콜을 이식한 군 (겐타콜 군, 27 마리). 겐타콜과 콜라템프 이식 한근육 내 겐타마이신 농도는 시간이 지남에 따라 점차 감소하였다. 혈액 내에 겐타마이신 농도는 측정되지 않았다. 조직학적으로 겐타마이신액을 주사 후 근육 내에 다형핵백혈구, 림프구, 대식세포를 포함하는 염증세포가 중등도에서 심하게 침윤되었고, 경도에서 중등도의 근육내 부종이 관찰되었다. 그러나, 이러한 국소 자극의 조직학적 변화는 콜라템프와 겐타콜 군에서는 현저히 감소하였다. 이상의 결과, 겐타콜은 콜라템프와 비교하였을 때에 전신적인 영향을 미치지 않으며 국소자극의 정도가 유사하였고, 생체이용성이 유사하여 좋은 생체적합성을 가지는 것으로 생각된다.
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