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Fetal Loss Rate after Mid-trimester Amniocentesis
Han, You-Jung,Kim, Yun-Young,Lee, Si-Won,Kim, Min-Hyoung,Chung, Jin-Hoon,Ahn, Hyun-Kyong,Han, Jung-Yeol,Kim, Moon-Young,Yang, Jae-Hyug,Choi, Kyu-Hong,Park, So-Yeon,Ryu, Hyun-Mee Korean Society of Medical Genetics and Genomics 2012 대한의학유전학회지 Vol.9 No.1
Purpose: The aim of this study was to asses the fetal loss rate after mid-trimester amniocentesis. Materials and Methods: This was a retrospective cohort study including singleton pregnant women who underwent mid-trimester amniocentesis at Cheil General Hospital from January 2008 through December 2010. The procedure-related fetal loss was defined as miscarriage within 2 weeks after amniocentesis. We evaluated the fetal loss rate within 2 weeks after amniocentesis and fetal loss rate before 24 gestational weeks. Results: During the study period, a total of 4,356 singleton pregnant women underwent mid-trimester amniocentesis. A total of Five hundred ninety six women were excluded owing to follow up loss and termination of pregnancy due to abnormal karyotype or major anomaly. At our institute, the fetal loss rate within 2 weeks was 0.1% and before 24 gestational weeks was 0.3% after amniocentesis. Conclusion: The fetal loss rate after mid-trimester amniocentesis in our study is lower than previously reported rate. We suggest that amniocentesis is a safe procedure.
Fetal Loss Rate after Mid-trimester Amniocentesis
You Jung Han,Yun Young Kim,Si Won Lee,Min Hyoung Kim,Jin Hoon Chung,Hyun Kyong Ahn,Jung Yeol Han,Moon Young Kim,Jae Hyug Yang,Kyu Hong Choi,So Yeon Park,Hyun Mee Ryu 대한의학유전학회 2012 대한의학유전학회지 Vol.9 No.1
Purpose: The aim of this study was to asses the fetal loss rate after mid-trimester amniocentesis. Materials and Methods: This was a retrospective cohort study including singleton pregnant women who underwent midtrimester amniocen tesis at Cheil General Hospital from January 2008 through December 2010. The procedure-related fetal loss was defined as miscarriage within 2 weeks after amniocentesis. We evaluated the fetal loss rate within 2 weeks after amniocentesis and fetal loss rate before 24 gestational weeks. Results: During the study period, a total of 4,356 singleton pregnant women underwent mid-trimester amniocentesis. A total of Five hundred ninety six women were excluded owing to follow up loss and termination of pregnancy due to abnormal karyotype or major anomaly. At our institute, the fetal loss rate within 2 weeks was 0.1% and before 24 gestational weeks was 0.3% after amniocentesis. Conclusion: The fetal loss rate after mid-trimester amniocentesis in our study is lower than previously reported rate. We suggest that amniocentesis is a safe procedure.
임신초기 약물노출 후 임신결과; 10년간의 경험 -생식 발생 독성 정보 활용화 방안 연구-
최준식 ( June Seek Choi ),한정열 ( Jung Yeol Han ),안현경 ( Hyun Kyong Ahn ),이시원 ( Si Won Lee ),김민형 ( Min Hyoung Kim ),정진훈 ( Jin Hoon Chung ),류현미 ( Hyun Mee Ryu ),김문영 ( Moon Young Kim ),양재혁 ( Jae Hyug Yang ),최 대한주산의학회 2010 Perinatology Vol.21 No.1
Purpose: In Korea, pregnancy termination is frequently reported among women who took medications for an acute or chronic disease during pregnancy, for fear of teratogenic risk. We have previously shown that a service providing evidence-based information is helpful for women who week counseling to make a rational decision regarding their pregnancies. This study aimed to evaluate whether termination of pregnancy based on such perceptions, is justified using the `DRug Exposure and risk Assessment in Moms` (DREAM) registry. Methods: The study included 5,032 consenting pregnant women from the clinic and call center at the Korean Motherisk Program, from November 1999 to October 2008. The DREAM registry recorded the pregnancy outcomes (preterm birth, low birth weight, intrauterine fetal death, and congenital anomaly) of 3,328 women. Results: Among women exposed to medications, time of exposure ranged from 3.5-4.6 weeks of gestation. There were 1,308 different drugs prescribed to these women. The drug most frequently prescribed was acetaminophen followed by chlorpheniramine maleate, and pseudoephedrine. There were 4.7% (n=156/3,328) women who underwent a voluntary abortion for fear of birth defects. We compared frequency of birth defects between exposed women and unexposed pregnant women in our institution during gestation. The frequency of major congenital malformations was 2.5% (n=74/2,977) in exposed group and 2.9% (n=75/2,573) in unexposed group (P=0.32). There was no statistically significant difference between exposed and control group in the rate of preterm births, intrauterine fetal death and low-birth weight babies. Conclusion: We did not observe increased risk of congenital malformations and adverse pregnancy outcomes in a population of pregnant women exposed to a variety of medications. Therefore these medications are not considered teratogen.
초음파상 자궁경부가 짧은 무증상 임신부에서 조산예방을 위한 자궁경부 원형결찰의 효용성
김민형 ( Min Hyoung Kim ),정진훈 ( Jin Hoon Chung ),최준식 ( June Seek Choi ),안현경 ( Hyun Kyung Ahn ),한정열 ( Jeong Yeol Han ),류현미 ( Hyun Mee Ryu ),김문영 ( Moon Young Kim ),양재혁 ( Jae Hyug Yang ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.11
목적: 임신 중기 초음파상 자궁경부 길이는 짧지만 조기진통의 증상이 없는 임신부에서 시행한 자궁경부 원형결찰이 조산 예방에 대한 효과가 있는지 알아보고자 하였다. 방법: 1996년 1월부터 2005년 12월까지 제일병원에서 산전 진찰을 받은 단태아 임신부들의 의무 기록을 조사하여 임신 중기 초음파에서 자궁경부 길이가 25 mm 이하로 기록된 산모를 대상으로 하였다. 초음파 당시 조기 진통의 증상이 있어 입원한 산모는 제외하였다. 조기진통의 증상이 없이 초음파상 자궁경부 길이 단축이 진단된 후 1주일 이내에 바로 자궁경부 원형결찰을 시행받은 산모를 원형결찰군에 포함시켰으며, 수술을 시행하지 않고 관찰한 경우를 기대요법군에 포함시켰다. 연구의 1차 결과로는 34주 미만의 조산의 빈도를 비교하였으며, 2차 결과로는 25 mm 이하의 짧은 자궁경부 길이를 보이는 임신부에서 조산과 가장 연관있는 요인을 분석하였다. 결과: 총 111명의 임신부가 연구대상에 포함되었으며, 평균 임신 주수는 21.6주였다. 자궁경부 원형결찰을 받은 군은 26명, 기대요법군은 85명이었다. 두 군 사이의 34주 이전에 조산한 산모의 빈도 [10예 (38.5%) vs 17예 (20.0%), P=0.069]는 차이는 없었다. 자궁경부 길이가 25 mm 이하인 경우, 조산과 연관성이 있는 요인으로는 단변량 분석에서는 15 mm 이하의 매우 짧은 경부길이와 깔때기화가 연관 있는 요인이었으나, 다변량 분석에서는 이 중 15 mm 이하의 경부 길이만이 수정 승산비가 3.67 (95% CI 1.2~10.56)로 34주 이전의 조산과 가장 연관성이 있었다. 결론: 임신 중기 초음파상 자궁경부 길이가 25 mm 이하로 짧은 임신부에서 바로 시행하는 자궁경부 원형결찰은 조산에 대한 예방효과가 기대요법과 차이가 없으며, 15 mm 이하의 자궁경부 길이를 보인 임신부는 조산에 대한 집중 관리가 필요하다. Objective: To investigate the clinical efficiency of the cervical cerclage for preventing preterm birth in asymptomatic women who showed a shortened cervix at the second trimester ultrasound Methods: From January 1996 to December 2005, we retrospectively reviewed the medical records of pregnant women who received routine second trimester ultrasound (16~24 gestational weeks) without abdominal pain or bleeding at Cheil general hospital. Women with a short cervical length ≤25 mm were classified into cerclage and expectant group. Women who received cervical cerclage within 1 week after detection of cervical shortening without any change of cervical length and shape were included in cerclage group. Primary outcome was the frequency of delivery before 34 weeks` gestation. Secondary outcome was the most important risk factor for preterm delivery in pregnant women with short cervix. Chi-square test, t-test, and multiple logistic regression analysis were used for statistical analysis. P<0.05 was considered statistically significant. Results: The mean gestational age at ultrasound was 21.6 weeks` gestation. A total of 111 women had short cervix, including 26 that were treated by cerclage and 85 managed expectantly. The proportion of preterm delivery before 34 weeks` gestation was higher in the cerclage group [38% (10 of 26)] than that of the expectant group [20% (17 of 85)], but there was no significant difference (P=0.069). In the univariate analysis, funneling (38% vs 16%, P=0.012) and cervical length ≤15 mm (47% vs 15%, P=0.069) were associated with preterm delivery before 34 weeks` gestation. In the multiple logistic regression analysis, a cervical length ≤15 mm had an adjusted odd ratio of 3.7 (95% CI 1.3~10.6) for preterm delivery before 34 weeks`s gestation. Conclusions: These data suggest that cerclage in asymptomatic woman with a short cervix in the second trimester ultrasound does not prevent preterm delivery before 34 weeks of gestation. Woman with extremely shortened cervical length ≤15 mm needs intensive management for prevention of preterm delivery.
Risk factors associated with fetal Losses after midtrimester amniocentesis
정진훈 ( Jin Hoon Chung ),( Jae Hyug Yang ),( Myoung Jin Moon ),( Ha Jung Lim ),( June Seek Choi ),( Joo Oh Kim ),( Joong Sik Shin ),( Hyun Kyong Ahn ),( Jung Yul Han ),( Moon Young Kim ),( Hyun Mee Ryu 대한산부인과학회 2003 대한산부인과학회 학술대회 Vol.89 No.-
Pregnancy Outcomes after Exposure to Phendimetrazine in First Trimester of Pregnancy
( Min Young Lee ),( Jung Yeol Han ),( Hyun Kyeong Ahn ),( Jae Hyug Yang ),( Moon Young Kim ),( Hyun Mee Ryu ),( Min Hyoung Kim ),( Jin Hoon Chung ),( Kyu Hong Choi ),( Si Won Lee ),( You Jung Han ),( 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-