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病態動物에서 Acetylsalicylic acid의 生物藥劑學的 硏究
李珍煥,崔俊植 조선대학교 약학연구소 1978 藥學硏究誌 Vol.1 No.1
The purpose of this paper was to investigate the bioavailability of acetylsalicylic acid in phathological rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows ; *Blood level of the absorbed acetylsalicylic acid as increased in rabbits damaged liver and kidney as compared with that of normal rabbits. Especially, blood level of acetylsalicylic acid in rabbits damaged kidney was more increased than that of rabbits damaged liver. *Urinary excretion of acetylsalicylic acid in rabbits damaged kidney was more inhibited than that of rabbits damaged kidney. *As the results, it could be considered that increase of blood level of acetylsalicylic acid was due to inhibition of urinary excretion by interaction with carbon tetrachloride and mercuric chloride.