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Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Thermal Degradation Kinetics of Antimicrobial Agent, Poly(hexamethylene guanidine) Phosphate
Lee, Sang-Mook,Jin, Byung-Suk,Lee, Jae-Wook The Polymer Society of Korea 2006 Macromolecular Research Vol.14 No.5
The thermal degradation of poly(hexamethylene guanidine) phosphate (PHMG) was studied by dynamic thermogravimetric analysis (TGA) and pyrolysis-GC/MS (p-GC). Thermal degradation of PHMG occurs in three different processes, such as dephosphorylation, sublimation/vaporization of amine compounds and decomposition/ recombination of hydrocarbon residues. The kinetic parameters of each stage were calculated from the Kissinger, Friedman and Flynn-Wall-Ozawa methods. The Chang method was also used for comparison study. To investigate the degradation mechanisms of the three different stages, the Coats-Redfern and the Phadnis-Deshpande methods were employed. The probable degradation mechanism for the first stage was a nucleation and growth mechanism, $A_n$ type. However, a power law and a diffusion mechanism, $D_n$ type, were operated for the second degradation stage, whereas a nucleation and growth mechanism, $A_n$ type, were operated again for the third degradation stage of PHMG. The theoretical weight loss against temperature curves, calculated by the estimated kinetic parameters, well fit the experimental data, thereby confirming the validity of the analysis method used in this work. The life-time predicted from the kinetic equation is a valuable guide for the thermal processing of PHMG.
Lee, Eun-Sil,Kim, Hwan-Mook,Lee, Sung-Dong,Lee, Kwang-Seung,Park, Song-Kyu,Lee, Chang-Woo,Lee, Ki-Ho,Lee, Ki-Hoon,Lee, Jun-Soo,Hwang, Woo-Ik,In, Man-Jin,Kim, Dong-Chung The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.3
A lipid-soluble ginseng extract possesses an anticancer activity against advanced human lung tumors in an established murine xenograft model without any sign of toxicity. The extract also shows a potent anti-proliferative activity against human cancer cell lines, leading to expansion of its preclinical applications to specific human tumor types.
Lee, Byoung-Min,Jung, Jin-Mook,Hwang, In-Tae,Shin, Junhwa,Hong, Sung-Kwon,Jung, Chan-Hee,Jeong, Young Gyu,Choi, Jae-Hak Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.456 No.-
<P><B>Abstract</B></P> <P>In this study, the development of electrically-heatable carbon thin films (CTFs) from water-soluble poly(vinyl alcohol) (PVA) is described. CTFs are easily obtained by room-temperature and solid-state proton irradiation-induced stabilization of PVA thin films followed by carbonization at a high temperature. The results of the chemical, optical, and structural analyses reveal that polyene-network structures, enabling high-temperature dimensional stability, are effectively created in the PVA thin films by combined reactions of crosslinking and dehydration during proton irradiation; these structures are further converted to pseudo-graphitic CTFs by carbonization. The prepared CTFs exhibit the fluence and thickness-dependent electrical conductivity ranging from 0.8 × 10<SUP>2</SUP> to 2.63 × 10<SUP>2</SUP> S cm<SUP>−1</SUP>, and a very low surface roughness of below 0.41 nm. Moreover, the prepared CTFs show excellent electric-heating characteristics and the performance is clearly dependent on the thickness and fluence. The CTFs prepared in this study have good potential for application in the fabrication of automobiles, smart windows, and medical devices for deicing, defrosting, and warming.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Carbon thin films (CTFs) were prepared by proton irradiation and carbonization. </LI> <LI> The CTFs showed a high electrical conductivity and a very low surface roguhness. </LI> <LI> The CTFs exhibited an excellent electric heating performance. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>This study describes the preparation of poly(vinyl alcohol)-derived carbon thin films by via simple dry and ambient proton irradiation-induced stabilization and carbonization.</P> <P>[DISPLAY OMISSION]</P>
Lee, Pan-Mook,Jun, Bong-Huan,Park, Jin-Yeong,Shim, Hyung-Won,Kim, Jae-Soo,Jung, Hun-Sang,Yoon, Ji-Young Korean Society of Ocean Engineers 2011 International journal of ocean system engineering Vol.1 No.2
This paper presents an in-situ correction method to compensate for the position error of an autonomous underwater vehicle (AUV) near the sea floor. AUVs generally have an inertial navigation system assisted with auxiliary navigational sensors. Since the inertial navigation system shows drift in position without the bottom reflection of a Doppler velocity log, external acoustic positioning systems, such as an ultra short baseline (USBL), are needed to set the position without surfacing the AUV. The main concept of the correction method is as follows: when the AUV arrives near the sea floor, the vehicle moves around horizontally in a circular mode, while the USBL transceiver installed on a surface vessel measures the AUV's position. After acquiring one data set, a least-square curve fitting method is adopted to find the center of the AUV's circular motion, which is transferred to the AUV via an acoustic telemetry modem (ATM). The proposed method is robust for the outlier of USBL, and it is independent of the time delay for the data transfer of the USBL position with the ATM. The proposed method also reduces the intrinsic position error of the USBL, and is applicable to the in-situ calibration as well as the initialization of the AUVs' position. Monte Carlo simulation was conducted to verify the effectiveness of the method.
Evaluation of Immunotoxicity of Shizukaol B Isolated from Chloranthus japonicus
( Sang Bae Han ),( Jin Tae Hong ),( Jee Youn Kim ),( Young Soo Kim ),( Hwan Mook Kim ),( Young Kook Kim ),( Jong Soon Kang ),( Soon Woo Kwon ),( Hwa Sun Ryu ),( Hong Kyung Lee ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.1
Dimeric sesquiterpenoid shizukaol B (SKB) was isolated from Chloranthus japonicus Sieb. Except that SKB inhibited adhesion molecule expression in monocytes and endothelial cells, no more biological and pharmacological activity of SKB had been reported until now. In this study, we examined immunosuppressive activity of SKB. SKB strongly inhibited lipopolysaccharide (LPS) induced B cell proliferation with IC50 of 137 ng/ml, but slightly or not concanavalin A-induced T cell proliferation, LPS-induced macrophage NO production, and LPS-induced dendritic cell maturation. As a mechanism, SKB strongly induced apoptotic death of B cells, but not other cell types. These results suggested that SKB induced toxicity-mediated immunosuppression against B cells.
Monotherapy in patients with type 2 diabetes mellitus
( Sang Youl Rhee ),( Hyun Jin Kim ),( Seung-hyun Ko ),( Kyu Yeon Hur ),( Nan-hee Kim ),( Min Kyong Moon ),( Seok-o Park ),( Byung-wan Lee ),( Kyung Mook Choi ),( Jin Hwa Kim ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.6
In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type <sub>2</sub> diabetes mellitus (T<sub>2</sub>DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.