PageRank 알고리즘을 활용한 RBF 인공신경망 기반 결함 위치 식별 기법

장정수(Jeong-Su Jang),김정호(Jeong-Ho Kim),이은석(Eun-Seok Lee) 한국정보과학회 2018 한국정보과학회 학술발표논문집 Vol.2018 No.6

자연기흉의 임상적 고찰

김종진,장정수,Kim, Jong-Jin,Jang, Jeong-Su 대한흉부심장혈관외과학회 1987 Journal of Chest Surgery (J Chest Surg) Vol.20 No.2

In this study, 186 cases of spontaneous pneumothorax experienced at the Dept. of thoracic and Cardiovascular surgery, chosun University Hospital during from Jan. 1978 to Mar. 1987 were analysed retrospectically. The results were as follows: 1. The sex ratio of the stadied patient was 2.5:! in male prominence and the incidence and the incidence was highest in the adolescence between 20-29 year of age. 2. The clinical symptoms were frequently Dyspnea (52.2%) and Chest pain (38.7%). The etiologic factors were as follows, Tuberculous origin in 55.9%, Unknown origin in 17.2%, Bullae in 11.8%. 3. In the method of treatment, closed thoracotomy was the most effective procedure in achieving the expansion of collapsed lung in 87.1%. Other methods were bed rest with high oxygen inhalation, thoracentesis and open thoracotomy. 4. The incidences of complication were developed in 12.4% and recurrent rates were seen in 9.7%.

개심술시 장시간 대동맥 차단 [200 분]: 3례 보고

최영호,장정수,이종국,Choe, Yeong-Ho,Jang, Jeong-Su,Lee, Jong-Guk 대한흉부심장혈관외과학회 1983 Journal of Chest Surgery (J Chest Surg) Vol.16 No.3

Three cases of multiple cardiac valve replacement were done in March 1983 at the department of thoracic and cardiovascular surgery, Chosun University College of Medicine. The patients were moderately symptomatic in all cases, and belonged to the class II and III of the NYHA functional criteria. The diseased valved were replaced with Bjork--Shiley, Ionescu-shiley valve prosthesis under cardiopulmonary bypass using hemodilution technique. The kind of cardioplegic solution used in our institute were Young and GIKs solution with core surface cooling. The average cardiopulmonary bypass time was 251.6 minutes and the average aortic cross clamping time was 223 minutes for aortic and mitral valve replacement. There was no operative morality.

성인에 발생한 Bochdalek 허니아 2례 보

유시원,최형호,장정수,Yu, Si-Won,Choe, Hyeong-Ho,Jang, Jeong-Su 대한흉부심장혈관외과학회 1984 Journal of Chest Surgery (J Chest Surg) Vol.17 No.4

Congenital diaphragmatic hernia through of Bochdalek foramen, posterolateral diaphragmatic hernia, is the result of a congenital malformation of the posterolateral region of the diaphragm. Bochdalek hernia is not a rare anomaly and is the most common type of congenital diaphragmatic hernia. The defect is more frequently on left [about 5 times]. The purpose of this paper to present the Authors recent experience with two cases of the congenital posterolateral diaphragmatic hernia adult women which was treated surgically in the Dept, Thoracic Surgery, Chosun University Hospital. The postoperative course was uneventful and both of them were discharged without any other complications. Our study and surgical experience was discussed and the literature reviewed.

흉부손상의 임상적 고찰: 311례 보고

임진수,최형호,장정수,Im, Jin-Su,Choe, Hyeong-Ho,Jang, Jeong-Su 대한흉부심장혈관외과학회 1985 Journal of Chest Surgery (J Chest Surg) Vol.18 No.1

A clinical analysis was performed on 312 cases of the chest trauma experienced at department of thoracic surgery, Chosun University Hospital during the past 6 years 10 months period from January 1978 to October 1984. 1. The ratio of male to female patient of the chest trauma was 3.1:1 in male predominance and age from 20 to 50 occupied 71.2% of the total cases. 2. The most common cause of the chest trauma was traffic accidents [45.5%] in this series. 244 cases [78.2%]were injured due to non-penetrating injuries and the remainders [68 cases, 21.8%] were injured due to penetrating injuries. 3. The frequently injured site of the chest trauma was left side of the chest [56.4%], the right side was 33% and the both side was 10.6%. 4. The most common symptoms were chest pain and dyspnea, and common signs were diminished breathing sound and subcutaneous emphysema. 5. The Hemothorax, Pneumothorax, Hemopneumothorax, and Hemopericardium were observed in 190 cases [60.9%] of the total cases, and etiologic distribution revealed 76.5% due to penetrating injuries and 56.6% due to non-penetrating injuries. 6. The rib fractures were observed in 210 cases [67.3%] of the total cases and the most common site of the rib fracture was 6th rib 140 cases [19.2%]. The common site of the rib fracture was from 4th rib to 7th rib [63.8%]. 7. The lung injuries were observed in 150 cases [48.1%] and the other organ injuries were observed in 260 cases [83.3%]. 8. Conservative treatment including thoracentesis were performed in 153 cases [49.1%], Closed thoracotomy with water seal drainage were performed in 112 cases [35.9%], and open thoracotomy were performed in 45 cases [14.4%]. 9. The complications of the chest trauma were developed in 63 cases [20.2%] and the common complications were atelectasis, wound infection and pneumonitis etc. 10. Overall mortality was 0.96% [3 cases] and the cause of death was bacteremia, hypovolemic shock, heart failure and pulmonary edema.

추간원판 절제술후 발생한 동-정맥루 수술치험 1

유시원,최형호,장정수,Yu, Si-Won,Choe, Hyeong-Ho,Jang, Jeong-Su 대한흉부심장혈관외과학회 1984 Journal of Chest Surgery (J Chest Surg) Vol.17 No.2

A vascular complication caused by lumbar disc surgery is not infrequent till recently after the report by Linton and White in 1945. Thereafter, many reports about the accidental injuries to the great vessels anterior to the lumbar area had been reported. In June, 1982, we experienced one case of arteriovenous fistula between right common lilac artery and inferior vena cava which was corrected surgically. The arteriovenous fistula caused by lumbar disc surgery and its review of the literature and presented.

Bacillus insolitus ATCC 23299 로부터 유래된 Promoter 의 클로닝과 발현

박정현,박승국,장정수,이상화,변시명 ( Jung Hyen Park,Seung Kook Park,Jeong Su Jang,Sang Hwa Lee,Si Myung Byun ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.5

In order to investigate potential promoter activites originated from psychrophilic Bacilli, we tried promoter cloning in Bacillus subtilis DB104 by using our characteristic promoter probe shuttle vector, pZC101 which was constructed by ligation of promoterless chloramphenicol acetyltransferase-86 (cat-86) gene and plasmid pZ124. Four already-known promoters (lac, tac, aprE and spoII) have been subcloned into the promoter cloning sites of pZC101 for the purpose of using standards to compare promoter strength on cloned promoters. We cloned 55 DNA fragments with promoter activities in B. subtilis DB104 from two kinds of Bacillus chromosomal DNA source, Bacillus insolitus ATCC23299 (psychrophile) and Bacillus subtilis JU70 (mesophile). Judging from specific activity on CAT, pZC11 promoter derived from B. insolitus ATCC23299, has the highest transcription promoting activity in this study where pZC11 promoter expressed about 13 U of CAT which was 3 fold higher CAT specific activity than spoII promoter in B. subtilis DB104.

Takayasu 동맥염의 수술치험 1례 보

임진수,최형호,장정수,Im, Jin-Su,Choe, Hyeong-Ho,Jang, Jeong-Su 대한흉부심장혈관외과학회 1984 Journal of Chest Surgery (J Chest Surg) Vol.17 No.4

The Takayasus arteritis is the obstructive disease in the principal branches arising from the aortic arch, and it can cause circulatory disturbances in the head or arms. We have experienced a case of complete obstruction of the left subclavian artery, the patient was undergone surgical repair with Knitted-Dacron patch graft between the left common carotid artery and the left subclavian artery. After operation, there were no symptoms except hypertension, and also no postoperative complications were seen. In the postoperative aortogram, the patency of the graft was good. The postoperative course was eventful and he has been in good conditions up to now so far.

Inhibitory Effect of Taraxacum mongolicums (蒲公英) on NO Production in LPS-stimulated Macrophages

하현희,박순영,고우신,장정수,김영희,Ha, Hyeon-Hee,Park, Sun-Young,Ko, Woo-Shin,Jang, Jeong-Su,Kim, Young-Hee The Society of Korean Medicine Ophthalmology 2007 한방안이비인후피부과학회지 Vol.20 No.3

포공영(蒲公英)은 예로부터 청열해독약(淸熱解毒藥)으로 사용되어 왔으며 NO가 염증의 한 요인이기 때문에 포공영의 항염증 작용기작을 밝히기 위하여 LPS로 자극된 대식세포주 RAW264.7 세포에서 포공영 열수 추출물 (AETM)의 NO 생성에 미치는 효과를 조사하였다. 포공영은 NO 생성 및 iNOS 단백질 발현, iNOS mRNA 발현을 저해하였으며, 전사인자인 $NF-kB$의 핵으로의 이동을 억제하였다. 또한 LPS에 의해서 활성화되는 ERK/MAPK 효소의 활성을 현저히 억제하였다. 이 결과들로 보아 포공영의 항염증 작용이 ERK/MAPK 활성 저해 및 $NF-kB$ 활성 저해로 인한 iNOS 발현의 억제 때문인 것으로 사료된다.

갈파래 분획, LPS, 효소활성의 상관성과 수층분획의 가치평가

남천석,강금석,하종명,이상현,이재화,이동근,장정수,강환열,하배진,Nam, Chun-Suk,Kang, Kum-Suk,Ha, Jong-Myung,Lee, Sang-Hyeon,Lee, Jae-Hwa,Lee, Dong-Geun,Jang, Jeong-Su,Kang, Hwan-Yul,Ha, Bae-Jin 한국생명과학회 2006 생명과학회지 Vol.16 No.6

갈파래는 해양성 조류 중 녹조류의 일종으로 현재 식용으로 이용되지 않고 방치되어 갈파래에 함유되어 있는 유용물질의 효용성을 과학적으로 증명하여 활용가치를 창출하고 해양자원의 이용범위를 확대하는 것은 중요하고도 절실하다. LPS는 그람 음성균의 세포벽을 만드는 물질의 일종으로 NO를 생성시키고 $Ca^{2+}$를 증가시키며 free radicals를 형성하여 간 조직의 막을 파괴하고 간의 지방을 축적시키고 노화를 촉진하는 역할을 한다. 갈파래를 에틸에테르, 에틸아세테이트, 수층으로 분획하고 그 분획을 선 투여하고 LPS를 후 투여한 경우에 항산화효소에서 분획 별 LPS에 대한 예방효과를 관찰하고 효소활성화 최적 분획을 검색하고자 하였다. 흰쥐를 사용하여 갈파래 분획을 14일간 매일 1회 복강 내로 선 투여하고 15일 째 되는 날에 LPS를 투여하였다. SOD의 활성도는 대조군에서는 정상군에 비해 1.93배 정도로 낮았으며 LPS를 투여함으로써 활성도를 낮춘 것으로 나타났다. 갈파래 분획별로 활성도를 보면 대조군에 비해 ULE군은 45.04% ULA군은 46.86%, ULW군은 47.46% 상승하였으며 갈파래 분획의 선 투여가 LPS의 후 투여로 인한 효소 불활성을 예방하여 활성을 높이는 역할을 한 것으로 나타났다. CAT의 활성도는 대조군에서는 정상군에 비해 1.29배 정도로 낮았으며 LPS를 투여함으로써 활성도를 낮춘 것으로 나타났다. 갈파래 분획별로 활성도를 보면 대조군에 비해 ULE군은 66.96% ULA군은 46.51%, ULW군은 42.94% 상승하였으며 갈파래 분획의 선 투여가 LPS의 후 투여로 인한 효소 불활성을 예방하여 활성을 높이는 역할을 한 것으로 나타났다. GPx의 활성도는 대조군에서는 정상군에 비해 3.72배 정도로 낮았으며 LPS를 투여함으로써 활성도를 낮춘 것으로 나타났다, 갈파래 분획별로 활성도를 보면 대조군에 비해 ULE군은 34.06% ULA군은 11.52%, ULW군은 24.9% 상승하였으며 갈파래 분획의 선 투여가 LPS의 후 투여로 인한 효소 불활성을 예방하여 활성을 높이는 역할을 한 것으로 나타났다. 전반적으로 3가지 항산화효소 SOD, CAT, GPx 전부에서 LPS를 투여하면 높던 효소활성이 낮아지고 갈파래분획을 선 투여하면 LPS를 투여하더라도 효소활성이 낮아지지 않고 상승된 높은 효소활성을 나타냄으로서 고-저-고 패턴의 상관성을 보여 주었고 갈파래 분획의 선투여가 LPS에 대한 예방적 보호효과에 중요한 역할을 한 것으로 관찰되었다. 갈파래 분획 중에서 에틸에테르 분획이 실험적으로는 가장 높은 예방적 보호효과틀 나타냈으나 용매의 제거비용 및 해독 면에서 불 때 수층 분획이 실용적으로는 활용가치가 더 높을 것으로 사료되었다. Lipopolysaccharide(LPS) was posttreated after the 14 day-pretreatment of Ulva lactuca fractions(ULF), and their correlativity to enzymatic activity alteration was investigated in the liver of rats. ULF was intraperitoneally administered into rats at dose of $1m{\ell}/kg$ of 100 mg/kg concentration for 14 days. On the day 15, $1m{\ell}/kg$ of LPS was injected. The corelativity was examined by measuring the changed values of superoxide dismutase(SOD) in mitochondrial fraction and catalase(CAT), glutathione peroxidase(GPx) in liver homogenate. The results showed that LPS treatment decreased the high values of SOD, CAT, GPx to the low values, but ULF pretreatment increased the low values of SOD, CAT, GPx to the high values. It was suggested that ULF, LPS and antioxidative enzymes like SOD, CAT, GPx had the corelativity of the high-low-high pattern and that the ULF pretreatment played the proper preventive role in the protection against the LPS treatment-induced enzymatic inactivity in the water fraction.