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손영제,왕규창,최기영,지제근,조병규,Son, Young-Je,Wang, Kyu-Chang,Choe, Gheeyoung,Chi, Je Keun,Cho, Byung-Kyu 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.6
Lymphocytic infundibuloneurohypophysitis is a rare inflammatory disorder, which may be caused by autoimmune response, affecting the infundibulum and the posterior lobe of the pituitary gland. The authors present a 15-year-old man with central diabetes insipidus, whose sellar magnetic resonance imaging (MRI) showed a focal thickening of the infundibulum and loss of high signal of the normal neurohypophysis on T1-weighted images. The histopathological diagnosis was lymphocytic infundibuloneurohypophysitis. When a patient presents with central diabetes insipidus and infundibular thickening on brain MRI, this entity should be included in the differential diagnosis though it is very rare. The significance of this entity in treatment is that it is basically not a surgical one, and surgery is needed only for tissue diagnosis. Symptomatic treatment and observation make it regress spontaneously.
중추신경계 생식세포종양 : 13예의 임상 병리학적 분석 Clinicopathological analysis of 13 cases
최기영,공경엽,이정교,황충진,유은실,이인철 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1
To elucidate the clinicopathological characteristics of the intracranial germ cell tumors, retrospectively examined were 13 cases that were histologically confirmed in Asan Medical Center between January 1990 and August 1992. Germ cell tumors of the central nervous system consisted of 10 cases of germinomas, one cases of endodermal sinus tumor, one embryonal carcinoma, and one mixed germ cell tumor(immature teratoma + choriocarcinoma + embryonal carcinoma). All the germinomas presented during the first three decades of life, and they were most common in the second decade with median age of 12 and were equally divided between the sexes. Germinomas were located almost exclusively in midline structures, particularly suprasellar area and/or pineal region. Occasionally, germinomas occured away from the midline in such sites as the thalamus or basal ganglia. in the suprasellar location the triad of diabetes insipidus, visual defect and hypopituitarism was typically produced. Cytological examinations of CSF or intraoperative aspiration were much useful in the diagnosis of germinomas. Histological features of the germ cell tumors were generally agreed with serum or CSF levels of tumor markers such as HCG, AFP and CEA. However, two of ten germinomas disclosed discrepency between them. Therefore, stressed was the importance of collective consideration for both tissue diagnosis and tumor marker studies. Most germ cell tumors responded to radiation therapy with or without adjuvant chemotherapy following initial surgical biopsy, at least for the short-term follow-up periods.
Fine Needle Aspiration Cytology of Hematolymphoid Malignancy
Gong, Gyeongyeob,Chung, Jaegul,Choe, Gheeyoung,Yu, Eunsil,Lee, Inchul 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1
과거 수 십년간 세침흡인 세포검사는 상피성 종양을 진단하는데 유용한 방법으로 이용되어 왔으나, 혈림프계 악성종양에 있어서는 그 유용성에 대한 의문이 제기되어 왔다. 그러나 최근 수년간, 세포학적 검색뿐만 아니라 면역세포학적 염색을 통해 혈림프계 악성종양을 진단하고 세분화하는 것이 가능하다는 보고들이 늘고 있다. 국내에서는 세침흡인 세포검사를 통해 혈림프계 악성종양을 진단하는 보고가 활발하지 않고, 면역세포학적 실제 진단에 이용하고 있는 기관은 아직 없는 것 같다. 저자들은 1992년 5유 부터 10월까지 6개월간 본원 해부병리과에 의뢰된 환자에서 행한 세침흡인 세포검사중 9예의 림프증식성 질환을 경험하였는데 그 중 6예가 비Hodgkin 림프종양, 1예가 Hodgkin 림프종양, 1예가 다발성 골수종 그리고 1예는 급성 림프모구성 백혈병이었다. 악성림프종양중 2예는 세포면역학적 염색을 통해 세포형에 대한 분류까지 가능하였다. 따라서 혈림프계 악성종양에서도 세침흡인 검사물로 세포학적 진단이 가능할 뿐 아나라, 면역세포화학 염색을 이용하면 이들 혈림프계 악성종양의 진단이 더욱 정확해 질 뿐 아니라 진단의 세분류가 가능하다고 사료된다.
타액선 종양의 세침흡인 세포학적 소견:조직학적 진단과의 비교
유은실,추광절,김상윤,최기영,공경엽,이인철 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.1
We reviewed twenty fine needle aspiration biopsies of salivary gland lesions performed between April 1992 and March 1993, which were confirmed by surgical excision. Sixteen cases were benign lesions:10 pleomorphic adenomas, 3 Warthin's tumors, 1 monomorphic adenoma, 1 benign lymphoepithelial lesion and 1 lymphoepithelial cyst. Malignant lesions were four cases:3 mucoepidermoid carcinomas, and 1 malignant mixed tumor. Preoperative fine needle aspiration cytologic findings were compaired with pathologic diagnosis of the surgically resected specimen in all cases. Overall accuracy was 80%. False negativity and positivity were 5% (1 case) and 0%, respectively. Fine needle aspiration biopsy for diagnosis of salivary gland lesion appears to be a simple, safe, and cost saving diagnistic method with relatively high accuracy.