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抗癌化學療法劑가 白鼠唾液腺組織에 미치는 影響에 關한 實驗的 硏究
Eui Wung Lee(李義雄) 대한구강악안면외과학회 1982 대한구강악안면외과학회지 Vol.8 No.1
This study was undertaken to observe the salivary gland of white rat when administrated to single dose of antineoplastic agents: 5-Fluorouracil, Cyclophosphamide, and Methotrexate. Eighty eight Sprague Dawley strain white rats, weighing about 180 grams were used and devided into control and three experimental groups. Sixteen rats were injected 0.5cc of normal saline solution intravenously as placebo in control group. In experimental groups, each twenty four rats in group I, II and Ill were injected intravenously 200mg. 5-Fluorouracil, 32mg. Cyclophosphamide, and 2.5mg. Methotrexate per kilogram body weight with single dose respectively. Rats were serially sacrificed on 1st, 3rd, 5th, 7th, 10th, 14th, 21st, 28th day after injection of placebo and antineoplastic agents. At sacrifice, the parotid, submandibular, and sublingual gland were dissected out in toto, and stained with 1) Hematoxylin and Eosin: 2) Periodic Acid Shiff. After examination and comparision of all specimen, the results of this study were obtained as follow. 1. The severity of tissue damage after injection of antineoplastic agents showed duct and acinar, whereas serous and mucous gland in order. 2. Parotid gland showed rather high cytotoxic effect while submandibular and sublingual gland showed varied cytotoxic deffect which is thought due to a mixed gland. 3. The cytotoxic effects showed Cyclophosphamide, 5-Fluorouracil, and methotrexate in order. 4. The most destructive salivary gland was on 3rd day after injection of antineoplastic agent and began to repair after 7th day. 5. In PAS reaction, severe change was observed especially in serous gland while irregularity of reaction revealed.
Eui Wung Lee(李義雄),Houng Gon Kim(金亨坤),Jung Ho Yoon(尹仲鎬),Hyoung Sik Park(朴亨植),Jung Kyun Kim(金正均),Gi Ho Kim(金知浩) 대한구강악안면외과학회 1981 대한구강악안면외과학회지 Vol.7 No.1
This is a case report of the bilateral bony ankylosis of temporomandibular joint associated with micrognathia, which was corrected by arthroplasty with silicone rubber implant in left side, condylectomy and coronoidotomy in right side. We suspected this deformity to be arised from unknown high fever in childhood. Ankylosis occured before mixed dentition period was main etiological factor of facial deformity. So, the earlier correction is the better result. It is to prevent recurrence of ankylosis and improve the prognosis that adequate bone resection, proper selection of interposing material and post-operative continuous forceful mandibular movement.
下顎 右側 骨體部 및 隅角部에 發生한 琺瑯芽 細胞齒牙腫의 骨 切除術에 依한 治驗例
Eui Wung Lee(李義雄),Dong Kyun Park(朴東均),Jung Ho Yoon(尹仲鎬),Hyung Sik Park(朴亨植) 대한구강악안면외과학회 1977 대한구강악안면외과학회지 Vol.3 No.1
This is a case report of an ameloblastic odontoma occured in the right mandibular body and angle region of 46-year-old male In reviewing this case, the following points should have been understood 1. In this case, this tumor occured at 46-yea-old male, and it was rarely seen in this age 2. It is important early detection of ameloblastic odontoma is of value in preventing the bone destruction, malocclusion and facial disfigurment. 3. mandibular ostectomy on the right mandibular body and angle region, and reconstruction with the acrylic resin plate resulted in satisfactory cosmetic and functional improvement and removal of potential recurrence.
囊腫 摘出術과 齒根端 切除術로 治驗한 上顎 前齒部 過剩埋伏齒의 含齒性 囊腫 3例
Eui Wung Lee(李義雄),Houng Gon Kim(金亨坤),Jung Ho Yoon(尹仲鎬) 대한구강악안면외과학회 1980 대한구강악안면외과학회지 Vol.6 No.1
This is a report of three cases of dentigerous cyst treated by enucleation with apicoectomy. With X-Ray findings these cases of dentigerous were located upper anterior portionp originated from the supernumerary teeth. The result were as follows. 1. Early finding & treatment of dentigerous cyst which is associated with impacted supernumerary teeth is very important. 2. Enucleation with apicoectomy was performed and obtained good func tional & ethetic results. 3. Until now, post follow up examination of all patients revealed good result without complication & recurrence.
Eui Wung Lee(李義雄),Myung Rae Kim(金命來),Jung Ho Yoon(尹仲鎬),Nyoun Jong Lee(李年鍾),Jong Ho Shin(申宗浩) 대한구강악안면외과학회 1975 대한구강악안면외과학회지 Vol.1 No.1
This is to report a case of extreme mandibular prognathism corrected by bilateral ostectomy in the body of the mandible. After the precise clinical, cephalometric and model analysis, the 27-year-old female patient was treated by removal of a section of bone from both mandibular second molar region. The results are as follows; 1. The postoperative cephalometric analysis reveals remarkable reduction of mandibular body length, ratio of mandibular body to anterior cranial base, SNB, ANB, SNPo, anterior face height. The surgical correction resulted in satisfactory cosmetic and functional improvement without any noticeable complications. 2. To control the axial inclination of upper and lower anterior teeth, minor teeth irregularities and to eliminate the premature contact, fixed type orthodontic appliances with occlusal equilibration have been performed for about one year. The prosthodontic restoration was also required for the edentulous lower posterior region to obtain better oral rehabilitation.
Eui Wung Lee(李義雄),Il Kyu Kim(金一圭),Jung Ho Yoon(尹仲鎬) 대한구강악안면외과학회 1980 대한구강악안면외과학회지 Vol.6 No.1
This is a case report of the sialolithiasis on the left wharton s duct of the submandibular gland corrected by sialithotomy. The results are as follows. 1. The obstruction of the duct by salivary calculi is the major cause of the acute or chronic sialadenitis. 2. The surgical intervention is the choice of the treatment in the patient with sialolithiasis. 3. When sialithotomy, it is desirable to maintain the pholy ethylene tube passing through the salivary duct more than 2 weeks to avoid the fistula formation on the mucosa! incised wound. 4. When the blunt dissection through the loose connective tissue of the mouth floor, it might elicit the anesthesia or paresthesia owing to the cutting of the lingual nerve or other injuries.
악하선에서의 Na⁺, k⁺- activated adenosine triphosphatase의 특성에 관한 실험적 연구
In kyo Jeong(鄭仁敎),Eui Wung Lee(李義雄) 대한구강악안면외과학회 1983 대한구강악안면외과학회지 Vol.9 No.1
The Na-K-ATPase was isolated from cat submaxillary gland by a deoxyclolate-treated procedure. In order to determine the characteristics of Na-K-ATPase of submaxillary gland, effects of incubation time, medium composition, temperature and various drugs were investigated. The results were summarized as fellows: 1. The specific activities of Na-K-ATPase and Mg-ATPase were 0.58±0.04 and 0.42±0.03μmol Pi/㎎ protein/min, respectively, in twice deoxycholate-treated microsome. 2. The initial velocity of the Na-K-ATPase reaction was directly proportional to the incubation time and to the enzyme concentration in the medium. 3. The rate of the reaction was dependent on the concentrations of ATP, Mg, Na, K and H ions in the medium, showing maximal activity at 2mM ATP, 3mM Mg, 100mM Na and 10mM K. 4. The maximal activity of Na-K-ATPase was observed in pH 7.5 but Mg-ATPase activity increased by increasing of medium pH. 5. The Na-K-ATPase activity was inhibited by ouabain and ethacrynic acid, but not affected by NaN₃, acetylcholine and mitomycin-C. 6. The Arrhenius plot showed biphasic pattern and the higher activation energy at lower range(10-25℃) than higher temperature range(25-37℃). These results indicate that the Na-K-ATPase of submaxillary gland of cat is similar to that of the other tissue in its physiological and biochemical properties.
한국인 성인 하악공의 전후 위치적계측 및 방사선 계측학적 연구
Hyoung Gon Kim(金亨坤),Eui Wung Lee(李義雄),Jung Ho Yoon(尹仲鎬) 대한구강악안면외과학회 1982 대한구강악안면외과학회지 Vol.8 No.1
It is extreamly important to understand the correct anatomical position of mandibular foramen in surgery of maxillofacial anomalities. The study has been conducted on 66 dried mandibles of Korean adults to determine the anteroposterior relation ship of the mandibular foramen and the location of the inferior alveolar canal. The following results were obtained. 1. The mandibular foramen was found to be located in the third quderent anteposteriorly. 2. The mean dimension from the anterior herder of the mandible to the anterior position of foramen was 16.80㎜, and from the posterior border of mandible to the posterior position of foramen was 8.90㎜. 3. The mean width of the mandibular foramen was 8.50㎜ with the range from 14.30㎜ to 3.30㎜. 4. The mean anterior demension from the midpoint of foramen was 20.66㎜ with the range from 9.20㎜ to 30.20㎜, and the mean posterior demension was 13.43㎜ with the range from 8.10㎜ to 25.10㎜. 5. The midpoint of mandibular foramen was located in posterior to the index line with mean demension of 1.01㎜. In 132 cases, 88 oases(66.6%) were located posteriorly, and only 44 cases(33.33%) were located anteriorly to the index line. 6. The inferior alveolar canal runs nearly midpoint of the buccolingual demension at predetermined index line. The mean distance from the inferior alveolar canal to the medical surface of mandible was 7.26㎜, and to the lateral surface of mandible was 7.67㎜.
두경부 암환자의 방사선요법시 구강내 캔디다속에 대한 연구
Shin Jung Cha(車信正),Eui Wung Lee(李義雄),Jung Ho Yoon(尹仲鎬) 대한구강악안면외과학회 1980 대한구강악안면외과학회지 Vol.6 No.1
80 cases of head and neck cancer were subjected to oral culture for Candida species during radiotherapy in Yonsei Cancer Institute and Korea atomic Hospital. And 40 cases of healthy People were cultured as a control group. Irradiation was carried out using Co 60 TeleTherapy Units in all patients. Classification of Candida Genus was done using API 20 Candide Kits. The results were as follows, 1. Control group was revealed with 22.5 % positive culture of Candida. 2. Positive culture of Candida species on patients irradiated under 3000R was 30.8%. 3. Positive culture of Candida species on patients irradiated over 3000R was 50.0%. 4. 35 Candida species of eighty irradiated patients were consisted of 28 of C.albicans, 4 of C. tropicalis, each 1 of C.krusei, C. zeylanoids, and undetermined Candide sp. 5. Nine Candida species of forty control group were consisted of 5 of Candida albicans, 2 of C. guilliermondii, each 1 of C. zeylanoids and C. parapsilisis.
Sung Ik Yang(梁誠益),Eui Wung Lee(李義雄),Jong Ho Yoon(尹仲鎬) 대한구강악안면외과학회 1983 대한구강악안면외과학회지 Vol.9 No.1
The authors have treated and observed a case of sialolithiasis in the orifice of the Wharton s duct of Rt. submandibular gland. 1. This is a case of sialolithiasis in the orifice of the Wharton s duct of Rt. submandibular gland in a 71 year old male patient. 2. The salivary stone was about 3.3×1.8×1.0 cm in size, yellowish brown in color, and its sur-face was irregular and rough and its internal structure was laminated. 3. Removal of salivary stone was performed under local anesthesia via intraoral approach and follow-up results reveal the normal salivation without any complications.