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RISS 인기검색어
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- 저자 : Dae Kyoung Choi(최대경) (검색결과 4 건)
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최대경 ( Dae Kyoung Choi ),이경문 ( Kyung Moon Lee ),김대훈 ( Dae Hun Kim ),이영 ( Young Lee ),손경철 ( Kyung Cheol Sohn ),김창덕 ( Chang Deok Kim ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.5
Background: Calcium plays a role in the proliferation and differentiation of keratinocytes. In a normal situation, the calcium concentration forms a gradient across the epidermal layers. Calcium is sparse in the basal layer and spinous layer. Skin organ culture is a useful model for conducting research on various aspects of skin biology. Skin organ culture systems are used for defining factors that affect homeostasis when elucidating the modulatory effects of biologic response modifiers, drugs and physical agents on the skin and also when studying complex aspects of cutaneous biology in normal and diseased skin. Objective: In this study, we investigated the effects of extracellular calcium on the epidermis in a skin organ culture. Methods: We compared the skin organ culture patterns under various culture conditions (calcium 0.1, 0.7, 1.4 and 2.0 mM). Results: H&E staining showed different phenotypes according to the calcium concentration and IHC also showed different phenotyes compared to that of keratin 10, involucrin, filaggrin, loricrin and PCNA. Conclusion: As a result, we concluded that the calcium gradient is also an important factor in skin organ culture to maintain the vivo-like environment and the appropriate calcium concentration is 1.4 mM. (Korean J Dermatol 2010;48(5):373~379)
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여신단(如神丹) 첩부가 만출력 이상에 의한난산을 해소한 임상증례보고
김성준 ( Seong Jun Kim ),최대경 ( Dae Kyoung Choi ),류사현 ( Sa Hyun Yoo ),김양식 ( Yang Sik Kim ),손영주 ( Yeong Joo Sohn ),손낙원 ( Nak Won Sohn ) 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.4
Objective: This clinical study investigated the effect of Yeosindan on dystocia caused by abnormal expulsive forces. Methods: Yeosindan was applied on the umbilicus of a primipara who had gone through latent phase for 15hrs and was almost expected to undergo C-sec by dystocia. It was sealed with an plaster. Yeosindan was removed immediately after the delivery. Results: 1. 90 minutes after Yeosindan had been applied on the umbilicus of the primipara, the active phase dilatation of uterus was started normally. 2. After 190 minutes from the Yeosindan application, the 2nd stage of labor was finished. 3. In this case, the delivery time, of which average is 344 minutes from the active phase to the second stage of labor, was reduced by 244 minutes. 4. So far, no abnormal condition has been detected in both the neonates and the primiparas.
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Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors
Young Lee(이영),Dong Kyun Hong(홍동균),Dae Kyoung Choi(최대경),Seul Ki Lim(임슬기),Kyung Cheol Sohn(손경철),Myung Im(임명),Young Joon Seo(서영준),Young Ho Lee(이영호),Jeung Hoon Lee(이증훈),Chang Deok Kim(김창덕) 대한체질인류학회 2014 해부·생물인류학 (Anat Biol Anthropol) Vol.27 No.2
단백질 전사 후 변형 (posttranslational modification)은 단백질 기능을 조절하는 기전의 하나로, 당화(gycosylation), 아세틸화 (acetylation), 메틸화 (methylation) 등을 포함한다. O-linked β-N-acetylglucosamine (OGlcNAc)에 의한 단백질 전사 후 변형은 많은 세포 반응에 관여하는 조절 기전으로 최근 연구가 많이 진행되고 있다. 특히, O-GlcNAc에 의한 단백질 전사 후 변형(O-GlcNAcylation)은 유방암, 폐암 및 대장암 등과 같은 암질환의 발병에 관여함이 보고되었다. 그러나 이러한 O-GlcNAcylation이 피부종양에 어떠한 영향을 미치는지 잘 밝혀져 있지 않다. 본 연구에서는 다양한 피부종양을 대상으로 하여 O-GlcNAcylation이 어떻게 일어나는지 면역조직화학을 통해 살펴보았다. 그 결과, 양성종양에 비해 암전구증 및 악성종양에서 전체적으로 O-GlcNAcylation이 증가해 있었다. 또한 O-GlcNAcylation을 담당하는 효소인 O-GlcNAc transferase (OGT) 및 O-GlcNAc을 제거하는 효소인 O-GlcNAcase (OGA) 발현 또한 양성종양에 비해 암전구증 및 악성종양에서 증가해 있었다. 이러한 연구 결과는 O-GlcNAcylation이 여러 피부종양의 발병에 관여함을 시사한다. O-linked β-N-acetylglucosamine modification is an important post-translational modification, emerging as a novel regulatory mechanism in various cellular events. Recently, several studies have shown that O-GlcNAcylation plays an essential role in human breast, lung, and colon cancers. With regard to skin cancers, the role of O-GlcNAcylation has yet to be elucidated. To investigate whether O-GlcNAcylation is linked to human skin tumor development, immunohistochemical analysis was performed to investigate the presence of OGlcNAcylation in various skin tumors. We evaluated the levels of O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in 29 benign tumors, 12 premalignant tumors, and 26 malignant tumors in skin. Compared to the benign tumors, premalignant and malignant tumors had increased patterns of O-GlcNAcylation. In addition, the O-GlcNAc transferase and O-GlcNAcase levels were higher in premalignant and malignant tumors than in benign tumors. Interestingly, O-GlcNAcase levels were significantly increased in premalignant tumors compared to benign and malignant tumors. These results suggest that O-GlcNAcylation of proteins may play an important role in the development of human skin tumors.
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황철 ( Chul Hwang ),백승주 ( Seung Ju Back ),최대경 ( Dae Kyoung Choi ),서영준 ( Young June Seo ),박장규 ( Jang Kyu Park ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
We report a case of thermal keratosis with erythema ab igne which occurred on the dorsal side of a patient`s left hand due to chronic exposure to infrared rays. A 62-year-old male presented with reticular hyperpigmentation on the dorsal side of his left hand and left knee along with multiple hyperkeratotic nodules on the dorsal side of his left hand without any symptoms. He had a hobby of playing internet games with a heater on his left side. A skin biopsy of the hyperkeratotic lesion showed hyperkeratosis and acanthosis in the epidermis. The dermis revealed many elastic fibers and superficial perivascular monocytic infiltration. The patient was diagnosed with thermal keratosis and erythema ab igne due to his history of chronic infrared exposure, distinctive clinical characteristics and the biopsy results. The application of topical steroid with the recommendation to cease exposure to heaters resulted in the almost disappearance of the papules and a little restoration of the skin color. (Korean J Dermatol 2007;45(9):926∼929)
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