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규칙적인 걷기운동이 하지정맥류 환자의 혈류 역학 요인에 미치는 영향
이정훈(Lee Jung-Hun),김병로(Kim Byung-Roh),김병균(Kim Byung-Kyun),김창수(Kim Chang-Su) 한국체육과학회 2005 한국체육과학회지 Vol.14 No.1
The purpose of this study was analysed the effect of walking exercise on the hematocele dynamic factors in patients with venous disease. The subjects of this study were composed of 7 adult patients with venous disease. Exercise intensity was 40-70% of HRmax. Measurement variables were the velocity for back flow in veins, the diameter of veins, the time for recharge in the veins etc. The results were as follows: First, there were significant difference between pre and post walking exercise in the velocity for back flow in veins. Second, there were no significant difference between pre and post walking exercise in the diameter of veins. Third, there were no significant difference between pre and post walking exercise in the time for recharge in the veins.
주요 우울장애에서 Cytotoxic T Lynphocyte Antigen(CTLA-4) 유전자의 다형성
전태연,배치운,김병균,채정호,박원명,김광수,유태열,한훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5
연구목적 : 세포의 면역 기능 조절에 관여하는 CTLA-4의 유전자 다형성을 분석하여 주요 우울장애와의 면역 유전학적 관련성을 알아보고자 하였다. 방 법 : DSM-Ⅳ진단 기준에 따라 주요 우울장애로 진단된 환자 77명을 선정하였으며 가톨릭대학교 의과대학 조혈모세포은행에서 보유하고 있는 149명의 정상 한국인 자료를 대조군으로 사용하였다. 전혈에서 DNA를 추출하였으며 중합효소반응으로 CTLA-4유전자 exon 1 부위를 증폭한 후 SSCP방법으로 유전?? 형별 분석하였다. 결 과 : 대조군과 주요 우울장애 환자군 사이의 CTLA-4 유전자형과 대립유전자의 발현 빈도를 비교시 유의한 차이가 없었다. 결 론 : 본 연구 결과 exon 1 CTLA-4 유전자형 및 대립유전자의 발현빈도는 주요 우울장애 환자군과 정상 대조군 사이에 차이가 없어, exon 1 영역은 후보 유전자로서의 가능성이 없었다. 향후 연구에서는 다양한 변인들에 따라 대상군을 임상적으로 동질성을 지닌 집단으로 세분하여 조사대상 유전자와의 관련성에 대한 연구가 이루어져야 하겠다. Objectives : This study was carried out to explore the relationship between major depressive disorder and CTLA-4 which is related to the immunologic function such as T cell regulation. Methods : Among the korean patients diagnosed as major depressive disorder according to DSM-Ⅳ, 77 patients without neurological illness, hormonal disorder, or comorbid mental illness were selected. The stored data of 149 normal Koreans from the Catholic Hemopoietic Stem Cell Bank of Korea, were used as a normal control group. The data of Korean control group were compared with those of the studies of different ethnics. DNA was extracted from whole blood and the exon I region of CTLA-4 gene was amplified by polymerase chain reaction. Gene typing was performed by using SSCP and then, the results were assessed. Results : There were no significant differences in genotype frquencies of CTLA-4*G/G, CTLA-4*G/A, and CTLA-4*A/A between the patients with major depressive disorder and the control group in Korean population(48.1% vs 46.3%, 41.6% vs 39.6%, 10.3% vs 14.1%, respectively).There were no significant differences in allelic frequencies of CTLA-4*G and CTLA-4*A between the patients with major depressive disorder and the control group in Korean population(68.8% vs 66.1%, 31.2% vs 33.9%, respectively). Conclusion : Considering negative result for the association of the exon I polymorphism of CTLA-4 gene with major depressive disorder in this study, the exon I polymorphism does not appear to be possible candidate gene for major depressive disorder. Moreover, further systematic researches including diverse clinical variables would required.
흉부 둔상에 의한 기관 파열의 지연성 진단 : 1 례 보고 Report of one case
김성호,최준영,이정은,이상호,장인석,김병균 대한외상학회 2000 大韓外傷學會誌 Vol.13 No.1
A 52-year-old man visited our hospital for multiple rib fractures caused by blunt chest trauma. He was diagnosed as having a flail chest, for which he needed ventilator therapy with endotracheal intubation for 13 days. On the 37th hospital day, he complained of dyspnea, and stridor was heard at the cervical region. A cervical tracheal obstruction was diagnosed by using laryngeal computerized tomography. An emergency operation was performed. His trachea was found to be ruptured circumferentially, and the surrounding soft tissues were pressing the tracheal lumen. We resected the trachea and anastomosed it directly. The patient was discharged on the 18th postoperative day without complication. The patient was followed up for 15 months and had no symptoms.