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RISS 인기검색어
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- 저자 : 황호근(Ho Geun Hwang) (검색결과 15 건)
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당뇨병성 경화부종 - 임상 - 병리조직학적 연구 및 문헌고찰 -
황호근(Ho Geun Hwang),이승하(Seoung Ha Lee),형근영(Keun Young Hyoung),신봉주(Bong Joo Shin),김경년(Kyoung Nyeon Kim),조정구(Chung Gu Cho),김주섭(Ju Seob Kim),차승훈(Seung Hoon Cha),박석돈(Seok Don Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: We studied clinical feature, underlying disease and histo-pathologic finding of scleredema diabeticorum that was observed as non-pitting indurated edematous skin of the nape, occiput in non-insulin dependent diabetes mellitus. Methods: We performed clinico-histopathologic study in 5 cases of scleredema diabeticorum which were diagnosed at our hospital and reviewed 6 cases in Korean literatures. Results: 1) The male to female ratio was 4:1, The overweight or obese middle-aged (mean:54.6) males were prone to develop these cutaneous changes. There was no relationship between the development of diabetic scleredema and the duration, the severity of diabetes. Hypertension and hyperlipidemia were frequent associated finding among the patients. 2) The increased level of fasting C-peptide implicated that the ability of insulin secretion was preserved. 3) Non-pitting hardening of the skin on the nape, head and surrounding parts of the body was common skin change in all patients. No evidence of systemic involvements was found. 4) Typical histopathologic findings, consisted of the thickening of dermis, the degeneration of collagen bundles in mid- to deep dermis, and the deposition of acid mucopoleysaccharides, hyaluronic acid, were noted in 4 cases of our study. 5) The therapeutic responses of cutaneous changes were generally poor. Conclusion: These results implies that scleredema diabeticorum is not a rare cutaneous manifestation among the diabetic dermadromes, and special histopathologic stainings with skin tissue sections are necessary for diagnosis. Although the exact mechanisms of this disease are not known, and no effective therapy is available, it needs to be studied exactly that the facts of hyperlipidemia, overweight, hypertension and well-preservation of fasting C-peptide observed in our cases, may be related to syndrome-X.
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황호근(Ho Geun Hwang),김제형(Je Hyung Kim),양세훈(Sei Hoon Yang),안선호(Seon Ho Ahn),서검석(Geom Seog Seo),최석채(Suck Chei Choi),김학철(Haak Chul Kim),나용호(Yong Ho Nah) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
Hepatic granuloma is an uncommon entity, occurring in various conditions; infectious disease, sarcoidosis, primary biliary cirrhosis, drug reactions, and unknown etiology. It represents the hosts immunologic response. Granulomas are most frequent near the portal tracts, are sharply defined and do not disturb the normal pattern of the liver. The histopathologic findings consist of pale-staining, epithelioid cells with surrounding lymphocytes, giant cells, and central caseation nec.rosis. Older lesions may be surrounded by a fibrous capsule, and hyaline change. We experienced hepatic granuloma of unknown etiology diagnosed by its clinical features, laboratory findings and liver biopsy and this case underwent surgical excision of the mass, subsidence of his symptoms. We report this case with review of the related literature. (Korean J Gastroenterol 1997;29:683-686)
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김연하(Yeun-Ha Kim),김성중(Sung-Jung Kim),황호근(Ho-Geun Hwang),최석채(Suk-Chei Choi),김유림(Yu-Rim Kim),김경숙(Kyung-Suk Kim),김철(Chul Kim),최덕화(Deok-Hwa Choi),오정택(Jung-Taek Oh),김강득(Gang-Deuk Kim),김혜원(Hye-Won Kim),전창덕(C 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.2
염증성 장 질환의 병리기전에는 tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) 및 intracellular adhesion molecule-1 (ICAM-1)의 발현 등 수많은 염증반응의 매개 물질들이 관여하고 있다. Rebamipide는 위염과 위궤양 치료제로 개발된 약제로 아직까지 염증성 장 질환의 치료효과를 검증한 연구는 거의 없다. 따라서 본 연구에서는 Rebamipide의 염증성 장 질환에 대한 치료효과를 검증하고 그 기전을 분석하고자 Rebamipide의 TNF-α와 IL-1β, 그리고 세포의 부착에 중요한 역할을 하는 ICAM-1의 발현의 조절에 대한 효과를 조사하였다. 5%의 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)를 실험 첫째날과 7일째에 직장 내로 넣어줌으로써 염증성 장질환의 동물모델을 제작하였고 2mM의 Rebamipide를 실험 0일, 3일, 6일째에 역시 직장 내로 투여하여 염증 억제 효과를 분석하였다. Rebamipide는 TNBS에 의하여 유도되는 체중감소를 현저히 억제하였으며 대장의 충혈과 부종역시 억제하였다. 조직소견에서도 Rebamipide 는 TNBS에 의해 유도되는 염증세포의 침착을 현저히 억제하였다. 또한 Rebamipide에 의해 TNF-α, IL-1β 및 ICAM-1의 발현 역시 현저히 억제되는 것을 면역 조직 화학 염색법을 통하여 확인하였다. 결론적으로 Rebamipide는 TNF-α, IL-1β와, ICAM-1의 발현을 조절함으로써 TNBS에 의해 유도되는 대장의 손상을 억제하리라고 생각되며 염증성 장 질환의 치료에도 좋은 효과가 있을 것으로 생각한다. During inflammation of the colon, cells of the gut mucosa produce or express numerous inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and intercellular adhesion molecule 1 (ICAM-1). These mediators have been implicated as contributory factors to the inflammatory process, which results in colitis during inflammatory bowel disease (IBD). Rebamipide is an anti-gastric ulcer drug with anti-inflammatory properties in vivo and in vitro. The effects of Rebamipide on IBD have not been largely evaluated. Therefore, this study investigated the potential of Rebamipide to regulate the production of inflammatory mediators such as TNF-α, IL-1β, and ICAM-1. Mice with trinitrobenzene sulfonic acid (TNBS)-induced colitis (IBD animal model), were treated intrarectally with 2 mM Rebamipide. Body weight, macro- and micro-histological scores, and activity were evaluated. As an index of tissue edema, the thickness of the colonic wall was measured between the serosal surface and the luminal surface of the mucosa. TNF-α, IL-1β, and ICAM-1 were detected by immunohistochemical staining. Rebamipide treatment of mice exhibiting TNBS-induced colitis dramatically improved the clinical and histopathological findings of inflammation. In addition, Rebamipide suppressed TNF-α, IL-1β, and ICAM-1 expression in TNBS-treated animals. Taken together, these findings suggest that Rebamipide is a potential therapeutic agent for treating patients with IBD.
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방사성동위원소를 이용한 대장분절 통과시간의 정량적 연구
최석채(Suck Chei Choi),김제형(Jae Hyung Kim),황호근(Ho Geun Hwang),양세훈(Sei Hoon Yang),김진아(Jin Ah Kim),나용호(Yong Ho Nah),이춘호(Choon Ho Lee),김창근(Chang Guhn Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.1
N/A Background/Aims: Measurements of regional transit are highly relevant to an understanding of normal colonic function and of any derangements associated with disease. Currently available clinical tests of colonic transit, such as the radiopaque marker method, are useful in detecting delayed transit but may be less sensitive for rapid transit. Our aim was to develop a method whereby the transit of solid residue measvred unprepared human colon. Methods: We used a noninvasive method to label the solid phase of contents in the unprepared human colon. 'Indium-labeled Amberlite IR-120 beads(Siga Chemica] Co.) were placed in a gelIatin capsule which was then coated with methacrylate. When ingested by healthy controls, capsules released radiolabeled beads in the dista] ileum or proximal colon in 22 of 22 controls. Transit of 'Indium-pellets through the unprepared colon could be quantitated radioscintigraphically. Results: Emptying of the ascending colon was characterized by an initial lag period(112.50' 80.75 min, mean + S.D). Mean colonic transit times were measured using both the radiopaque markers and radioscintigraphy. The mean colonic transit times were 1212.50<413.98min (rnean < S.D) in radioscintigraphy, and 1014.40+631.67min(mean < S.D) in radiopaque marker. So there was a good correlation(r=0.7) between radioisotope method and radiopaque marker method. Radioactivity counts were distributed equally between ascending colon, transverse colon, descending colon, and rectosigmoid colon at the 12th hour. Geometric center analysis showed an initial progression of activity in the proximal colon and a linear progression distally. Conclusions: Colonic scintigraphy is a safe and quantitative method for evaluating the colonic transit of fecal material and may provide a usefu] tool for evaluating large intestinal physiology. In healtby adults, normal orol-cecal transit time is about 5 hours and normal colonic transit time is about 24 hours when using radioscintigraphic method.(Korean J Gastroenterol 1997; 29:1-8)
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김제형,황호근,최두환,유광현,류준형,최석채,김학철 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.1
Biloma has been defined as an extraductular collection of bile within a defined capsular space. Development of an intraabdominal bile collection usually occurs secondary to traumatic or iatrogenic injury including abdominal surgery, percutaneous catheter drainage and transhepatic cholangiogram. Spontaneous bile leakage associated with other primary causes, including sickle cell anemia, gall bladder cancer and hepatocellular carcinoma, has been reported rarely. We present a case of biloma secondary to traumatic injury with liver biopsy, who had right upper guadrant pain, jaundice and yellowish skin discoloration in a patient with cholangiocellular carcinoma. Huge biloma was confirmed by percutaneous transhepatic biliary drainage and drained with pig tail catheter successfully. A case of huge biloma secondary to liver biopsy is presented with brief review of the literatures.
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김제형,황호근,김학철 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2
Background Tumors of the ampulla of Vater are usually reported in the group of periampullary tumors, as they have similar clinical symptoms and therapeutic managements due to their neighboring region. And there is no review of it as an isolated literature in Korea and only a few in the world. So we review the tumors of the ampulla of Vater Subject and Method The specimens from 20 carcinoma (surgery:18, endoscopy:2) and 3 adenoma (surgery:2, endoscopy:l) patients of the ampulla are selected from 106 cases of periampullary tumor provided by Wonkwang University Hospital during the period of 1984 to 1995. The subjects are reviewed and analysed by various factors with SPSS analytic program. Results 1) Of their distribution, it is usually distributed over the 5th decade and most frequently in the 7th decade, and their mean age is 64 year old. Sex ratio of male to female is 1.6:1. 2) Their frequency are in the order of fever & chillness, jaundice, right upper quadrant pain, weight loss and pruritus in clinical manifestations and hyperbilirubinemia. elevation of transaminase and alkaline phosphatase in laboratory examination. 3) In diagnostic procedures of ampullary tumors, the abdominal sonogram and computer tomogram have indirect abnormal findings of them with high freqency(82.6%) and the direct finding of them with moderate frequency(56.2%). But all cases have had abnormal findings on the ampullary region by duodenoscopy. 4) When they are first detected as tumors, the maximal size of benign tumor(4.66±0.47㎝) is significantly larger than malignant tumor(1.43±0.66㎝). 5) Among 20 malignancies, their staging distribution are like this: stage Ⅰ: 8(34.8%), stage Ⅱ: 3(13.0%), stage Ⅲ 9(39.1%). When resection were performed in 18 cases(stage Ⅰ: 8, Ⅱ: 3, Ⅲ: 7), their mean survival time of stage Ⅰ, Ⅱ and Ⅲ are accordingly 87, 16 and 13 months. And stage Ⅰ has significantly longer survival time than others. Conclusions As the above results, it is concluded that clinical manifestations are important at least in ampullary tumor, tumor size is larger in benign than malignant tumors when they are detected and better prognosis in early stages of malignant ampullary tumor. These finding suggest early detection of malignant ampullary tumor might be related to the relationship between the characteristics of invasiveness in malignancy and the characteristic anatomy that is narrow luminal capacity in ampulla of Vater.
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