휘발성 유기용매의 In vitro 대사속도 측정 장치의 개발

황인영,이윤,Hwang, In-Young,Lee, Yoon 환경독성보건학회 1997 환경독성보건학회지 Vol.12 No.3

Species, doses and routes extrapolation can be sucessfully carried out by using a physiologically-based pharmacokinetic (PBPK) approach. And PBPK approach to assess risk of hazardous chemicals is reasonable whatever the exposure scenarios are happened. Both partitioning coefficients of chemical between tissue and blood and enzymatic metabolic rate constants are key parameters to build up the PBPK model. In this study, we tried to estimate in vitro metabolic rate constants using a special apparatus instead to measure the in vivo constants which are used to PBPK simulation since the in vitro tests are less expensive and more convenient than in vivo tests. For the purpose, we designed and tested the new system to measure continuously the headspace concentration of VOC. The newly designed system is composed with a diffusion chamber which generates gaseous substrate, a reaction vessel with a recirculating pump to establish a closed system, an autbmatic sampler from a gas phase, a gas chromatography to analyze the headspace. In addition, a cold water condenser is attached between the reaction vessel and pump to reduce the content of gaseous moisture which interferes with chemical analysis. To validate the newly developed methodology, in vitro metabolic rate constants of trichloroethylene (TCE) as a prototype VOC were estimated by simulating observed results with an ACSL program. The simulated results are consistent to those estimated by the other research groups. This finding suggests that our newly designed closed system may be a useful apparatus to estimate in vitro metabolic rate constants for VOC.

살균제 Tricyclazole에 대한 안전성 평가 (I)

황인영,최의주,노정구,Hwang, In-Young,Choi, Eui-Ju,Roh, Jung-Koo 한국환경농학회 1985 한국환경농학회지 Vol.4 No.1

Tricyclazole을 수확전 $90{\sim}40$일에 $2{\sim}3$회 처리한 작물과 토양중에서의 수확시 잔류되는 tricyclazole의 양은 각각 현미가 $0.37{\sim}0.46ppm$, 백미가 $0.29{\sim}0.39ppm$, 볏짚이 $0.14{\sim}0.30ppm$ 및 토양이 $0.15{\sim}0.19ppm$이었다. 담수조건하에서의 tricyclazole의 분해 양상은 처리후 $2{\sim}3$주까지 비교적 빠른 속도로 분해가 진행되다가 그 이후로는 안전한 속도로 분해되었으며 그 때의 반감기는 $140{\sim}180$일이었다. 또한 토양 미생물의 생균수에 미치는 영향은 거의 없었으며 Salmonella, Saccharomyces 등을 이용한 돌연변이성 유무 실험에서는 대조구와 별차이가 없었다. Fate of tricyclazole in rice paddy system was studied. The effect on soil microorganism as well as the mutagenicity of the compound was also examined. The residues of tricyclazole in crops and soil with two times application before harvest were 0.37 in unpolished rice, 0.29 in polished rice, 0.14 in rice straw, and 0.15 ppm in paddy soil. With three times of application the residues were increased to 0.46, 0.39, and 0.19 ppm, respectively. Until $2{\sim}3$ weeks after treatment of pesticide the degradation of tricyclazole was progressed comparatively but very slowly afterward and the half life of that was about $140{\sim}180$ days. There was no effect for viable count of soil microorganisms and for mutagenic test by Salmonella and Saccharomyces systems.

포스터 발표 : 수질환경 분야 ; In-situ biomonitoring기법에 의한 도시 인근 하천의 수질 평가 연구 (초)

안지영 ( Ji Young An ),황인영 ( In Young Hwang ) 한국환경농학회 2009 한국환경농학회 학술대회집 Vol.2009 No.2

Peroxidase와 Lipoxygenase에 대한 농약의 저해작용

황인영,장병선,박관화,노정구,Hwang, In-Young,Chang, Byeong-Seon,Park, Kwan-Hwa,Roh, Jung-Koo 한국환경농학회 1984 한국환경농학회지 Vol.3 No.2

화학물질(化學物質)에 의(依)한 서양고추냉이와 사과의 peroxidase 및 정제된 대두(大豆) lipoxygenase 역가저해(力價沮害)를 조사(調査)하였다. 서양고추냉이와 사과의 peroxidase 역가(力價)에 저해효과(沮害效果)를 주는 농약중(農藥中) maneb가 zineb의 효과(效果)보다 컸으며 10,20,30ppm의 처리농도(處理濃度)에서 maneb는 12.5,23.0,34.5%, zineb는 9.5, 17.5,27.5%의 역가저해(力價沮害)를 보였다. Maneb와 zineb의 혼합체(混合體)인 mancozeb 를 500 ppm의 농도(濃度)로 사과나무에 철포(撤布)했을때 사과의 peroxidase 역가변화(力價變化)는 무처리구(無處理區)와 별 차이(差異)가 없었다. 대두(大豆)의 lipoxygenase 역가(力價)에 미치는 영향(影響)은 zineb의 경우 가장 저해도(沮害度)가 컸으며 phosphamidon과 carbofuran 이 또한 저해효과(沮害效果)가 있었다. 그러나 maneb는 저해효과(沮害效果)가 없었다. 10, 20, 30 ppm의 처리농도하(處理濃度下)에서의 lipoxygenase 역가저해도(力價沮害度)는 zineb가 14.0, 27.0, 40.0%, carbofuran이 6.5, 12.5, 20.0% 그리고 phosphamidon이 4.5, 9.0, 13.0%였다. 또한 이들 세농약(農藥)은 $100{\sim}200\;ppm$에서 100% lipoxygenase 역가저해(力價沮害)를 보였다. The effect on the activities of peroxidase and lipoxygenase by chemicals was determined. Peroxidase activities of horseradish and apple were inhibited strongly by maneb and comparativelyby mancozeb, zineb. The inhibitory rate of enzyme activity was ranged in $12.5{\sim}34.5%$ by maneb, $11.0{\sim}30.5%$ by mancozeb, and $9.7{\sim}27.5%$ by zineb in the level of $10{\sim}30\;ppm$ at the final concentration. No signification was in the peroxidase activity of apple during ripening between control and plot, treated with 500 ppm mancozeb. On the activity of purified soybean lipoygenase, zineb inhibited it more strongly than carbofuran or phosphamidon, but maneb did not have inhibitory effect on that. The inhibition ranges of $14.0{\sim}40.0%$ by zineb, $6.5{\sim}20.0%$ by carbofuran and $4.5{\sim}13.0%$ by phosphamidon were shown in the final pesticide concentration of $10{\sim}30$ ppm. But in $100{\sim}200$ ppm, lipoxygenase activity was almost inhibited by carbofuran and phosphamidon.

In-situ biomonitoring기법에 의한 도시 인근 하천의 수질 평가 연구

안지영 ( Ji Young An ),황인영 ( In Young Hwang ) 한국환경농학회 2009 한국환경농학회 학술대회집 Vol.2009 No.1

초등 음악수업에 있어서 교사의 교수행동 분석

황인영(In Young Hwang) 한국음악교육학회 2004 음악교육연구 Vol.26 No.-

The purpose of this study is to investigate teaching behavior in elementary school music class by analyzing teachers` verbal and non-verbal teaching behavior and to present an aim of desirable teaching behavior. The study was analyzed each music class with class analysis table based by Hyun kyungsil`s Korean Category System for Music(KCSM) based by Flander`s verbal interaction analysis and Choi Eunsik`s A Measure of Non-verbal Music Teaching Behaviors(AMNMTB) for the analysis of teaching behavior with high quality music classes of Incheon(1997~2002). The conclusions were as follows : First, all six classes focused more time in verbal teaching behavior than non-verbal teaching behavior. Second, much more directional utterance than non-directional utterance within the aspect of verbal teaching behavior was charged by considerably high ratio. Regardless of class types, lecture of directional utterance showed the highest rate in most classes. Third, one of verbal teaching behavior aspects, comment which could give negative reinforcement to students, was charged in very little time. verbal modifying action was little, too. Fourth, the type of the presentation of musical modeling was changed by each class type in the aspect of non-verbal teaching behavior. However, there were much presentation of singing modeling in the singing class and in listening class, the presentation of modeling charged much time. On the other hand, there was not or little presentation time of teachers` demonstration in creating class. Fifth, in six classes all the students` actual music activity time was charged much in whole class. So music class came into not a class for listening but a class for experiencing music directly. In particular, playing instruments is an activity which is being used actively in all the classes regardless of the type of class. Sixth, the periods of blank space, silence, noise by the preparation or presentation of material showed in any classes. These pause periods were much longer in that case of using instruments in turn on account of absence of personal instruments. Seventh, most of teachers` questions took up proposal to progress class, knowledge, and understanding level. So teachers should have an interest in their speaking to consider music class for developing students` musical thinking. Eighth, development for music program which helps students to experience doing music during the music class is requested very much.

Actual Use of that-clauses in EFL Writing

Huh Myung-Hye(허명혜),Hwang In-Young(황인영) 새한영어영문학회 2011 새한영어영문학 Vol.53 No.1

In this study, we focus on that-clauses in an attempt to compare the kinds of grammatical information presented in the Longman Grammar of Spoken and Written English with the actual use in EFL student essays. First, we analyze the overall patterns of use for that-clause types in the student essays. Next, we work on native/EFL student similarities and differences in the lexical associations of that-clauses. In addition, we take a closer look at two structural variants for that-clauses, considering the extent to which that is deleted and the grammatical factors influencing deletion in the student essays. A corpus of academic writing was compiled from the essays of students attending a Korean university. The corpus consisted of 311 essays written by 38 students, totaling 104,727 words. The overall extent of the use of that-clause in the student essays is notably different from those of native academic prose. In particular, the patterns of use in the student essays are strikingly different from those found in native academic prose. The single most common verb controlling that-clauses is think in the student essays while show, suggest, and say are most frequent verbs controlling that-clauses in native academic prose. Furthermore, both native academic prose and the student essays also showed different patterns for the factors influencing that omission. A very large percentage (58%) of the that-omissions occur in the student essays, which clearly brings out the EFL learners’ tendency to opt for the more informal structural variants for that-clauses.

자궁경부종양에 있어서 증상군과 무증상 검진군간의 병기 비교

임현우,이원철,황인영,권용일,박종섭,김훈교,Yim, Hyeon-Woo,Lee, Won-Chul,Hwang, In-Young,Kwon, Yong-Il,Park, Jong-Sup,Kim, Hoon-Kyo 대한예방의학회 1998 예방의학회지 Vol.31 No.4

Screening is for the early detection and treatment of diseases in prior to development of symptoms, so that more favourable prognosis could be obtained. To evaluate efficiency of screening test for cervical neoplasms, we compared the histopathologic stages of asymptomatic cervical neoplasm patients diagnosed by screening test, with those of symptomatic patients confirmed by pathology. Total 1,120 cases of cervical neoplasm patient, diagnosed at Kang-nam St. Mary's hospital from Jan. 1990 to Dec. 1996, were reviewed by chart, and classified as asymptomatic and symptomatic group based on the presence of subjective symptoms on their hospital visit. Their histopathologic stages were analysed. The results were as follows, 1. From the total of 1,120 patient, asymptomatic group comprised 264 cases (25.5%). Asymptomatic proportion increased 15.3% in 1991 to 34.7% in 1996. 2. Mean age for the occurrence of cervical neoplasm was $44.3{\pm}10.4$ years for the asymptomatic group, and $49.3{\pm}13.2$ years for the symptomatic group, showing statistically significant differences (p=0.001). 3. Among the study subjects, 465 cases(45.0%) had preinvasive lesions and 569 cases(55.0%) had invasive cancers. 4. Percentage of cervical neoplasm patient diagnosed at asymptomatic stages were 45.8% in twenties, 32.0% in thirties, 27.7% in forties, 21.7% in fifties, 18.7% in sixties and 1.8% in above seventies, showing statistically significant differences according to age group(p=0.001). 5. In thirties, 87.2% of the asymptomatic patients were diagnosed as preinvasive lesion and 45.0% of symptomatic patient were diagnosed as preinvasive lesion. With increment of ages, preinvasive lesion proportion were markedly decreased. 6. 76.9% of asymptomatic patients were diagnosed as preinvasive lesion, and 34.0% of symptomatic patients were diagnosed as preinvasive lesion, suggesting screening test at asymptomatic stage can increase preinvasive lesion proportion. 7. preinvasive lesion proportion of asymptomatic patient was highest in thirties(40.4%) and 2nd highest in forties(34.0%). Screening test for cervical neoplasm should be actively carried out from the thirties.

외국인 유학생들의 학교생활 적응 수준에 따른 빗속의 사람 그림(PITR)검사 반응 특성 연구

한주연(Han Joo-yeon),심효률(Sim, Hyo-Ryul),우한석(Woo, Han Seuk),안연빈(An Yeon Bin),황인영(Hwang In Young),이모영(Lee Mo-young) 한국융합예술치료교육학회 2019 예술과 인간 Vol.5 No.-

본 연구는 외국인 유학생들의 학교생활 적응 수준에 따른 빗속의 사람 그림검사의 반응특성을 분석하는 것이다. 이를 통해 외국인 유학생의 학교생활적응의 정도를 그림 검사로 진단 가능한지, 그 타당성을 검증해 보고자 하였다. 연구대상은 지방에 위치한 어느 한 4년제 대학에 재학 중인 외국인 유학생 149명과 한국인 학생 157명으로 임의표집하여 선정되었다. 외국인 유학생의 학교생활적응 수준에 따른 그림검사 반응 특성을 분석하기 위해 학교생활 적응행동 척도와 빗속의 사람 그림검사가 사용되었다. 연구결과는 다음과 같다: 첫째로, 외국인 유학생들이 한국인 유학생들에 비하여 통계적으로 유의하게 적응상의 어려움을 겪는 것으로 나타났다. 특히 사회적 적응에서 더 많은 어려움을 겪는 것으로 나타났고, 정의적 적응에서는 통계적으로 유의한 차이가 나타나지 않았다. 둘째로, 외국인 유학생들의 적응 수준에 따라 빗속의 사람 그림 검사의 스트레스 척도에서는 차이가 없는 것으로 나타났지만, 대처자원점수에 통계적으로 유의한 차이가 있는 것으로 나타났다. 셋째로 외국인 유학생의 학교생활적응 수준은 스트레스 척도 세부 항목 반응 특성과 관련이 있기 보다는 대처자원 척도 세부 항목 반응 특성과 더 많이 관련이 있는 것으로 나타났다. 이와 같은 연구 결과는 외국인 학생들의 학교생활적응의 정도를 그림검사를 통해 평가할 수 있다는 것을 부분적으로 지지하는 결과로써 외국인 유학생들의 학교생활적응에 시사하는 바가 크다. This study intended to analyze the responsive characteristics shown in the Draw a Person In the Rain (PITR) test according to the degree of foreign students’ adaptation to school life and verify the possibility and feasibility of using picture test in diagnosing the degree of foreign students’ adaptation to school life. For the study, 149 foreign students and 157 Korean students, who are enrolled in a university located outside Seoul, were randomly selected and analyzed. To analyze the responsive characteristics shown in a picture test according to the degree of foreign students’ adaptation to school life, the school life adaptive behavior scale and the PITR test were used. The result is as follows; First, it appeared that foreign students have difficulties in adapting to school life compared with Korean students from other regions with statistical significance. In particular, they appeared to have more difficulties with social adaptation while there was no difference with statistical significance in affective adaptation. Second, there was a statistically significant difference in the coping resource score while there was no significant difference in the stress criterion of the PITR test depending on the degree of foreign students’ adaptation to school life. Third, the degree of foreign students’ adaptation to school life appeared to be more related with the detailed responsive characteristics of the coping resource criterion than the detailed responsive characteristics of the stress criterion. Such results partially support the possibility of using a picture test in evaluating the degree of foreign students’ adaptation to school life and therefore have great implications for foreign students’ adaptation to school life.

원지, 애기풀 및 소초의 염산·에탄올로 유발된 흰쥐 위염에 대한 억제 효과

황인영(In Young Hwang),이선이(Sun Yi Lee),서유경(Suh Yoo Kyung),정춘식(Choon Sik Jeong) 대한약학회 2017 약학회지 Vol.61 No.1

Alcohol, coffee, salty and spicy foods, excessive acid secretion, and NSAIDs increase risk of having a gastritis. Helicobacter pylori (H. pylori), in particular, is known to be a pathogen that is capable of causing gastritis and gastric cancer. Reactive oxygen species and oxidative stress may also play a role as a major factor in gastric injury. In this study, we studied extracts of Polygala tenuifolia Willd. (root), Polygala japonica and Polygala tenuifolia (sprout) for their inhibitory effects on HCl·ethanol-induced gastritis in rats. As a result, extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, reducing power, inhibitory effect on H. pylori colonization and acid-neutralizingcapacity. Especially, the extracts of Polygala tenuifolia Willd. and Polygala japonica significantly inhibited HCl·ethanol-induced gastritis in rat. The results obtained indicate that these extracts might be useful for preventing gastritis.