고속도로 분류부 교통사고모형 개발

황경주(Hwang Kyung Joo),박재범(Park Jae Beom),이승준(Lee Seung Jun),강정규(Kang Jeong Gyu) 대한토목학회 2006 대한토목학회 학술대회 Vol.2006 No.10

다낭성 난소 증후군 환자에서 체중과 임신이 내분비 양상 및 당 대사에 미치는 영향

황경주(Kyung Joo Hwang),오기석(Kie Suk Oh),김세광(Sei Kwang Kim),권혁찬(Hyuck Chan Kwon),박영한(Young Han Park),양정인(Jung In Yang),유희석(Hee Suk Rhyu) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3

N/A Objective: The purpose of this study attempts to determine the endocrinologic characteristics and changes in glucose metabolism before/during pregnancy according to different body weights in women with Polycystic ovarian syndrome (PCOS). Methods: 94 women dia with PCOS were evaluated through measuring serum hormone levels and oral glucose tolerance tests preconceptionally and gestationally. Results: In patients who were of normal weight showed significantly increased serum LH levels compared to those who were overweight (12.8+-0.9 Vs. 7.1+-0.8 mIU/ml, p= 0.000), and the serum levels of insulin was increased significantly in the overweight group (7.1+-0.7 Vs. 15.2+-2.8 ulU/ml, p= 0.000). the IGFBP-I (32.8+-10.6 Vs. 8.3+-2.5 ng/ml, p=0.034) and SHBG (55.8+-4.2 Vs. 37.1+-3.1 nmol/ml, p= 0.001) were significantly lower in the ovnweight group. The oral glucose tolerance test before/after pregnancy showed increased frequency of abnormal glucose metabolism, in both of the non-obese group (38.8%, 26,9%) and the obese group (64.2%, 53.9%) compared with normal population. Conclusion: It is thought that in the normal weight group with polycystic ovarian syndrome androgen production is stimulated in the theca cells by abnormally high LH secretion, while in the overweight group the hyperinsulinemia state which decreases the SHBG and IGFBP-I, lead to increase biologically active hee androgens and IGF-I and increase insulin binding to its receptor. And during/before pregnancy, women with PCOS showed that incidence of abnormal glucose metabolism was significantly increased in both of non-obese and obese groups.

임신 제 3 분기까지 진행된 비교통성 흔적자궁각 임신 1 예

황경주(Kyung Joo Hwang),양정인(Jeong In Yang),오기석(Kie Suk Oh),김행수(Haeng Soo Kim),안은주(Eun Joo Ahn),양성천(Seong Cheon Yang),이은주(Eun Ju Lee),주희재(Hee Jae Joo) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1

The uterus with rudimentary horn occurs as a result of a lack of development during fetal life of the middle and lower parts of one of the Miillerian ducts, in which there is a failure of fusion of the two ducts, The incidence of this uterine anomaly is rare. Many cases of rudimentary uterine horn are not discovered since they do not become involved in a pregnancy, and thus remain symptomless and uncomplicated, and the diagnosis usually being made only with pregnancy with rupture. In this presentation, we describe a case of diagnosis and management of unruptured non-communicating rudimentary uterine horn pregnancy at the third trimester. The patient diagnosed by ultrasonography and MRI, was hospitalized for further evaluation and delivery under the impression of unruptured non-communicating rudimentary horn pregnancy. A living male infant weighing 1,930 gm was delivered by cesarean section at 33+l weeks due to impending preterm labor. Some articles concerned this subject were reviewed briefly to discuss relevant method of diagnosis, treatment, and clinical characteristics.

Recent Advances in Reproductive Endocrinology : Assisted reproductive technology ; Implantation from the bench to the clinic

황경주 ( Kyung Joo Hwang ) 대한산부인과학회 2004 서울심포지움 Vol.10 No.-

GFRP을 이용한 구조디자인

박돈우,황경주,Park, Don-Woo,Hwang, Kyung-Joo 한국공간구조학회 2005 한국공간구조학회지 Vol.5 No.1

기존의 고정관념의 틀을 깨고 새로운 것을 추구하는 인류의 행태는 보다 뛰어난 기술을 잉태하는 모체가 되어왔다. 그럼에도 불구하고 많은 건축 재료들 가운데서 플라스틱을 이용한 건축재료는 풍부한 가능성과 장점에도 불구하고 기존재료에 대한 고정관념에 사로잡혀 다른 분야에 비해 그 발전 속도가 현격하게 떨어지고 있는 것이 사실이다. 다시 말해 우리 주변의 실제 구조물에 훌륭히 적용할 수 있는 가능성을 쉽게 놓쳤다고 말할 수 있는 것이다. 따라서 본 슈트트가르트대학교 건축학과 구조디자인 연구실에서는 유리강화플라스틱 (GFRP)를 이용해서 본 재료가 갖고 있는 장점을 최대한 살려 실제 구조물에 적용할 수 있는 가능성을 찾고 연구하고자 한다. 이를 위해 총 2회에 걸쳐 기존의 연구동향과 적용 가능성을 검토하고 본 연구실에서 이루어지고 있는 Prototyp을 소개하고자 한다.

자궁내막증 여성에서 증가된 자궁내막용종의 빈도; 질환의 중증도와의 관련성

장혜진,황경주,김미란,안상태,변재광,이은희,박진영,Chang, Hye Jin,Hwang, Kyung Joo,Kim, Mi Ran,Ahn, Sang Tae,Byun, Jae Guang,Lee, Eun Hee,Park, Jin Young 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.3

목 적: 자궁내막증에서 발견되는 자궁내막용종의 발생빈도와 자궁내막증 질환의 중증도와의 연관성에 대해 알아보고자 한다. 연구방법: 불임, 심한 월경통, 난소종양 등을 주소로 복강경 수술이 필요했던 여성 631명을 대상으로 하였다. 복강경 수술로 확인된 자궁내막증을 가진 434명과 자궁내막증이 없었던 197명의 여성에서 자궁내시경을 이용한 조직학적인 검사를 통해 자궁내막용종의 발생 빈도를 비교하였다. 또한 자궁내막증 질환의 중증도는 American Fertility Society classification 에 따라 나누었고, 그에 따른 자궁내막용종의 빈도를 비교하였다. 결 과: 자궁내막증을 가진 군 (434명)과 정상 대조군 (197명) 간에 나이, 불임기간, 호르몬 수치 등의 임상적인 차이는 보이지 않았고, 자궁내막용종은 자궁내막증을 가진 여성에서는 274명 (63%)에서 관찰되었고, 자궁내막증이 없는 대조군에서는 58명 (29.8%)에서 관찰되었다(p=0.001). 자궁내막증 1기와 2기에서는 자궁내막용종이 동반된 경우가 각각 54.2%와 64.4% 이었으나, 자궁내막증 3기와 4기에서는 67.6%와 70.2%로 통계적으로 유의하게 정상 대조군에 비해 자궁내막용종의 동반 확률이 높았고, 자궁내막증 중증도에 따라 자궁내막용종의 빈도가 유의하게 증가하는 양상을 보였다(p=0.008). 결 론: 자궁내막증을 가진 여성에서 자궁내막용종을 동반할 확률이 정상인에 비해 높았고, 중증 자궁내막증일수록 동반되는 자궁내막용종의 빈도가 증가하였다. Objective: The aim of this study was to evaluate the correlation between severity of endometriosis and the incidence of endometrial polyp. Methods: The study population consisted of six hundred thirty-one women who had undergone laparoscopic operation due to infertility, severe dysmenorrhea or ovarian tumors. We divided two groups: 434 women with endometriosis (study group) and 197 women without the disease (control group). The presence of endometriosis was documented by diagnostic or therapeutic laparoscopic operation and the disease severity was scored according to revised The American Fertility Society classification. We confirmed the endometrial polyps by pathologic examination after hysteroscopic polypectomy, and compared endometrial polyp incidence according to severity of endometriosis. Results: There was no significant difference between groups with regard to age, mean duration of infertility. Endometrial polyps were found in 274 women (63.0%) with endometriosis and in 58 controls (29.8%, p=0.0000). The incidence of endometrial polyps differed significantly according to stage of endometriosis. The incidence of endometrial polyps were 77/142 (54.2%), 58/90 (64.4%), 73/108 (67.6%, p<0.05), 66/94 (70.2%, p<0.05) in endometriosis stage I, II, III, and IV. There was a linear correlation between stage of endometriosis and endometrial polyps incidence (p=0.008). Conclusion: Endometriosis is accompanied by endometrial polyps. This results showed positive correlation between severity of the endometriosis and incidence of endometrial polyps. It is the possible mechanism for low pregnancy rate in the severe endometriosis.

시뮬레이터를 이용한 장대터널 내에서의 운전자 특성 연구

박형진,황경주,신현주,Park, Hyung-Jin,Hwang, Kyung-Joo,Shin, Hyun-Joo 대한인간공학회 2007 大韓人間工學會誌 Vol.26 No.2

Generally, it is well known that driving in tunnel imposes large burden to driver because of spatial constraint, limited visual field and so on. And such a burden of driver result in high accident occurrence. In this reason, studies dealing with features of driving and traffic flow in tunnel have been performed. However, information about characteristics of drivers and traffic in a very long tunnel is not accumulated yet. The purpose of this study is to identify the relations between tunnel length and burden of driver, driving patterns, traffic flow characteristics using the tunnel simulator that realizing various tunnel situations. For this, the tunnel simulation program was developed along 11km-length section. And biological data of 10 subjects gained from driving condition in simulation program was analyzed and compared with the result of real driving condition.

보조생식술에 있어서 황체기 보강요법

김미란,황경주,Kim, Mi-Ran,Hwang, Kyung-Joo 대한생식의학회 2007 Clinical and Experimental Reproductive Medicine Vol.34 No.1

인간 체외수정 및 배아이식에 있어서 과배란 유도 과정에 사용한 GnRH Agonist가 배란 전 난포내 과립 세포의 세포자연사에 미치는 영향

양현원,권혁찬,황경주,박종민,오기석,윤용달,Yang, Hyun-Won,Kwon, Hyuck-Chan,Hwang, Kyung-Joo,Park, Jong-Min,Oh, Kie-Suk,Yoon, Yong-Dal 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.1

There have been many reports to date regarding the role of GnRH as a local regulatory factor of ovarian function as studies of human and rat ovaries revealed GnRH and its receptor. In recent studies it has been shown that GnRH directly causes apoptosis in the granulosa cells of the rat ovary, and such results leads to the suggestion that the use of GnRH agonist for more stable long term ovarian hyperstimulation in human IVF-ET programs causes granulosa cell apoptosis which may lead to follicular atresia. Therefore this study attempts to determine if granulosa-luteal cell apoptosis occurs in patients during IVF-ET programs in which GnRH agonist is employed for ovarian hyperstimulation. The quality of oocyte-cumulus complexes obtained during ovum pickup procedures were assessed morphologically and then the fertilization rate and developmental rate was determined. Apoptotic cells among the granulosa-luteal cells obtained during the same procedure were observed after staining with Hematoxylin-eosin. The fragmentation degree of DNA extracted from granulosa-luteal cells was determined and comparatively analyzed. There was no difference in the average age of the patients, the number of oocytes retrieved, and fertilization and developmental rates between the FSH/hMG group and GnRH-long group. There was also no difference in the apoptosis rate and pyknosis rate in the granulosa-luteal cells between the two groups. However, when the oocyte-cumulus complexes were morphoogically divided into the healthy group and atretic group without regard for the method of hyperstimulation, the results showed that the number of oocytes obtained averaged $11.09{\pm}8.75\;and\;10.33{\pm}4.53$ per cycle, respectively, showing no significant difference, but the fertilization rate (77.05%, 56.99%, respectively, p<0.01) and developmental rate (65.96%, 41.51%, respectively, p<0.01) was significantly increased in the healthy group when compared to the atretic group. The degree of apoptosis in the granulosa-luteal cells showed that in the healthy group it was 2.25% which was not significantly different from the atretic group (2.77%), but the pyknosis rate in the atretic group (27.81%) was significantly higher compared to the healthy group (11.35%, p<0.01). The quantity of DNA fragmentation in the FSH/hMG group was 32.22%, while in the GnRH-long group it was 34.27%, showing no significant difference. On the other hand the degree of DNA fragmentation was 39.05% and 11.83% in the healthy group and atretic group, respectively, showing significantly higher increase in the atretic group (p<0.01). The above results suggest that death of granulosa-luteal cells according to the state of the oocyte-cumulus complex is more related to pyknosis rather than apoptosis. Also, the GnRH agonist used in ovarian hyperstimulation does not seem to directly affect the apoptosis of retrieved oocytes and granulosa-luteal cells, and which is thought to be due to the suppression of the apoptogenic effect of GnRH agonist as a result of the high doses of FSH administered.

인간 난소의 과립 세포 배양 중 Leptin이 스테로이드 생성에 미치는 영향

김세광,김명신,황경주,권혁찬,조동제,Kim, Sei-Kwang,Kim, Myong-Shin,Hwang, Kyung-Joo,Kwon, Hyuck-Chan,Cho, Dong-Jae 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.1

Objective: To elucidate the location of leptin and receptors of ovary specimens obtained from patients undergoing hysterectomy by immunohistochemical staining and to determine the effect of leptin on the steroidogenesis of cultured granulosa cells. Method: In the culturing process of the granulosa cells, FSH (1 IU/ml)and leptin (50 ng/ml), IGF-I (50 ng/ml) was administered to each study group (Group I: FSH; Group II: FSH, leptin; Group III: FSH, IGF-I; Group IV: FSH, IGF-I, leptin), and the levels of estradiol, progesterone, androstenedione in the culture media was measured by radioimmunoassay. Statistical analysis was conducted by one-way ANOVA with Scheffe test. Results: The results showed that leptin and leptin receptors were both found to be strongly stained in granulosa and theca cells, and also in some interstitial cells. Leptin receptors were also observed in cultured granulosa cells. While there was no statistically significant difference in the androstnedione concentrations between the groups, estradiol concentrations was significantly decreased in Group IV ($2202.0{\pm}151.14$ pg/ml) compared to Group III ($2859.0{\pm}122.6$ pg/ml), and progesterone concentrations were also significantly decreased in Group II($4696.3{\pm}190.6$ ng/ml) and Group IV ($4517{\pm}206.78$ ng/ml) compared to Group III($5546.0{\pm}179.5$ ng/ml). Conclustion: The study result of this study suggest that leptin is directly involved in the regulation of ovarian functions, in particular steroidogenesis.