http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
L-1,3-Dioxolane 및 L-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
홍준희(Joon Hee Hong),박정하(Jeong Ha Park),송지연(Ji Yeon Song),최보길(Bo Gil Choi),정병호(Byung Ho Chung),김중협(Joong Hyup Kim),이종교(Chong Kyo Lee),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1994 약학회지 Vol.38 No.6
(+/-)Dioxolane-T and(+/-)BCH-189 are know to possess anti-HIV activities, and less to xicities compared to other dideoxynucleoside AIDS drugs. We have synthesized 34 different enantiomerically pure nucleosides by glycosylation of L-1,3-dioxolanyl acetate and L-1,3-oxathiolanyl acetate sugar moieties with uracil or 6-azauracil with alkyl chains(C1-C3) on 5 or 6 position.
D-1,3-Dioxolane 및 D-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
홍준희(Joon Hee Hong),차마리(Ma Rie Cha),신성은(Seong Eun Shin),최보길(Bo Gil Choi),정병호(Byung Ho Chung),김중협(Joong Huyup Kim),이종교(Chong Kyo Lee),정원근(Won Keun Chung),천문우(Moon Woo Chun) 대한약학회 1994 약학회지 Vol.38 No.6
We synthesized D-1,3-dioxolanyl acetate from D-mannose using Frazer-Reide reaction and D-1,3-oxathiolanyl acetate from either D-mannose or D-galactose in good yields. These acetates were conjugated with various disilylated pyrimidine base using trimethylsilyl trifluoromethane sulfonate as a Lewis acid catalyst to obtain 32 different D-nucleosides.
시청각 화자식별에서 신뢰성 기반 정보 통합 방법의 성능 향상
김진영,홍준희,Kim, Jin-Young,Hong, Joon-Hee 대한음성학회 2007 말소리 Vol.62 No.-
In this paper we proposed a modified reliability function for improving bimodal speaker identification(BSI) performance. The convectional reliability function, used by N. Fox[1], is extended by introducing an optimization factor. We evaluated the proposed method in BSI domain. A BSI system was implemented based on GMM and it was tested using VidTIMIT database. Through speaker identification experiments we verified the usefulness of our proposed method. The experiments showed the improved performance, i.e., the reduction of error rate by 39%.
제주지역 전력계통에 설치되는 에너지 저장장치의 경제성 분석
최준영(Joon-Young Choi),이종현(Jong-Hyun Lee),안종욱(Jong-Wook Ahn),고원석(Won-Suk Ko),홍준희(Jun-Hee Hong) 한국조명·전기설비학회 2009 조명·전기설비학회논문지 Vol.23 No.8
본 논문에서는, 제주지역 전력계통에 설치되는 에너지 저장장치의 경제성을 분석하였다. 본 논문에서 검토한 내용은, 현재 운영 중인 제주지역 내 발전소의 고정비와 변동비를 기준으로 에너지 저장장치의 고정비와 변동비를 비교한 것이다. 비교분석결과를 통해 에너지저장장치가 경제성 측면에서 이점이 있다는 것을 보여주었다. 에너지저장 장치는 유리한 경제성과 함께 신뢰도 측면에서도 좋은 역할을 할 것으로 기대된다. In this paper, economic analysis of Energy Storage System for power system is performed. Economic analysis is performed to show the benefits of Energy Storage System. Results illustrate the advantages of Energy Storage System not only acting as an alternative generation resource but also giving a better reliability and stability in power system.
토양 균주 발효 추출물 Nargenicin 및 그 유도체의 항생제 대체 효과능 평가
조승식,홍준희,채정일,심정현,나종삼,유진철,Cho, Seung-Sik,Hong, Joon-Hee,Chae, Jung-Il,Shim, Jung-Hyun,Na, Chong-Sam,Yoo, Jin-Cheol 한국유기농업학회 2014 韓國有機農業學會誌 Vol.22 No.3
본 연구진은 신규 미생물인 Nocardia sp. CS682 균주에서 항균물질인 nargenicin을 확보하고, 그 유도체 5종을 확보하여 그람양성, 음성 및 다약제 내성균에 대한 항균 효능 및 LPS로 자극된 대식세포에서의 nitric oxide 생성 억제능을 확인하였다. Nargenicin 유도체들은 nargenicin 및 vancomycin에 비교하여 우수한 항균 활성을 보여주었으며, compound 4 및 5는 광범위한 항균 효능 외에 nitric oxide 생성 억제능을 보여 항균-항염효과를 가지는 dual effector로써 감염, 면역 질환에 응용 가능성을 시사하였다. Nargenicin 유도체들은 향후 염증반응에서의 면역 조절 기작에 대한 추가 연구가 필요할 것으로 사료된다. IIn vitro antimicrobial and anti-inflammatory activities of nargenicin and its derivatives were investigated. Nargenicin, an unusual macrolide antibiotic with potent anti-MRSA (methicilin-resistant Staphylococcus aureus) activity, was purified from the culture broth of Nocardia sp. CS682. And variety of novel nargenicin derivatives was synthesized from nargenicin. Two compounds (4 and 5) exhibit a broad spectrum of antimicrobial activities against infectious bacteria. The antimicrobial activity of derivatives against fifteen organisms was assessed using the minimum inhibitory concentration (MIC). The MIC values were in the ranges of $0.15{\sim}80{\mu}g/mL$ (w/v) for compound 1 and 2, $5{\sim}80{\mu}g/mL$ (w/v) for compound 3, $1.25{\sim}40{\mu}g/mL$ (w/v) for compound 4, and $1.25{\sim}80{\mu}g/mL$ (w/v) for compound 5, depending on the pathogens studied. In vitro, we investigated cytotoxicity and inhibition of nitric oxide (NO) production of synthesized compounds 1-5 in Raw 264.7 cells. LPS-induced nitric oxide releases were significantly blocked by compound 3, 4 and 5 in a dose-dependent manner. At high concentrations ($5{\mu}g/mL$) compound 5 inhibited the NO production by 95%. Compound 4 inhibited the release of NO in LPS-activated Raw 264.7 cells by 75% at the concentration of $10{\mu}g/mL$. Compound 3 inhibited the release of NO in LPS-activated Raw 264.7 cells by 65% at the concentration of $100{\mu}g/mL$. On the other hand, nargenicin, compound 1 and 2 did not inhibit NO production. These results demonstrated that compound 4 and 5 displayed antimicrobial activity and blocked LPS-induced pro-inflammatory mediators such as NO in macrophages, which might be responsible for its therapeutic application.
1,4-위치에 측쇄를 가진 신규 뉴크레오사이드의 합성 및 항바이러스 약효검색
김애홍,고옥현,홍준희,Kim, Ai-Hong,Ko, Ok-Hyun,Hong, Joon-Hee 대한약학회 2007 약학회지 Vol.51 No.2
In these study novel 1,4-disubstituted carbocyclic nucleoside analogues were synthesized as potential antiviral agents. The coupling reaction of the alcohol 8${\alpha}$ with natural bases using Mitsunobu reaction afforded the target nucleosides 13, 14. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2 and HCMV. Cytosine derivative 13 exhibited moderate antiviral activity against HIV-1 (EC$_{50}$=16.4 ${\mu}$M).
신규 피리미딘 티오에피오 뉴크레오사이드의 합성 및 항바이러스 약효검색
이내상(Rae Sang Lee),홍준희(Joon Hee Hong),고옥현(Ok Hyun Ko) 대한약학회 2006 약학회지 Vol.50 No.2
Novel 4'-hydroxymethyl blanched thioapiosyl nucleosides were synthesized in this study. The introduction of hydroxymethyl group in the 4'-position was accomplished by a 〔3,3〕-sigmatropic rearrangement. Thisoapiosyl sugar moiety was comstructed by sequential ozonolysis, reduction and cyclization. The pyrimidine nucleosidic bases (uracil, 5-fluorouracil, 5-iodouracil, 5-cchlorouracil, 5-bromouracil) were efficiently coupled by Vorbruggen glycosyl condensation procedure (per- silyated base and TMSOTf). The antiviral activities of the synthesized compounds were evaluated against the HIV-1, HSV-1, HSV-2 and EMCV. 5-lodouracil 18 showed weak antiviral activity against HSZ-1 (EC50=30.7 ㎛).