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홍용우,고광욱,김기환,Hong, Yong-Woo,Ko, Kwang-Wook,Kim, Ki-Whan 대한생리학회 1987 대한생리학회지 Vol.21 No.2
The activation mechanism of the sustained contractions induced by norepinephrine and K-depolarization was studied in renal vascular muscle. Helical strips of arterial muscle were prepared from rabbit renal arteries. All experiments were performed in Tris-buffered Tyrode solution which was aerated with 100% $O_2$ and kept at $35^{\circ}C$. Renal arterial muscles developed a contracture rapidly when exposed to a 40 mM K-Tyrode solution. In the absence of external $Ca^{2+}$, however, no K-contracture appeared. The contracture induced by K-depolarization was abolished by the treatment with $Ca^{2+}-antagonist\;(verapamil)$ or lanthanum $(La^{3+})$. From these results, it is obvious that K-contracture of renal arterial strip required $Ca^{2+}$ in the medium and this contracture was developed by the increased $Ca^{2+}-influx$ due to K-depolarization. Noradrenaline (5 mg/l) induced also a similar sustained contraction rapidly in all strips. Even on the K-contracture and in $Ca^{2+}-free$ Tyrode solution and also in the Tyrode solution pretreated with verapamil or $La^{3+}$, noradrenaline produced a contraction. However, the contraction in $Ca^{2+}-free$ Tyrode solution was not sustained and decreased gradually. The amplitude of noradrenaline-induced contracture was dependent on external $Ca^{2+}$; The contracture increased dose-dependently, but over 3 mM $Ca^{2+}$, decreased. The results of this experiment suggest that K-contracture was developed by an increased $Ca^{2+}-influx$ due to membrane depolarization, while noradrenaline-induced contracture was developed by both transmembrane $Ca^{2+}-influx$ and the mobilizaiton of cellular $Ca^{2+}$
증례보고 : 수술 로봇을 이용한 심방중격결손 수술의 마취
최용선 ( Yong Seon Choi ),곽영란 ( Young Lan Kwak ),전동혁 ( Dong Hyuk Jeon ),홍용우 ( Yong Woo Hong ),박한기 ( Han Ki Park ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.3
Minimally invasive cardiac surgery including robotic technique has become increasingly popular over the last decade. The advantages of such technique include improved cosmesis and healing, and reduced stress response, hospital and intensive care unit stay, and transfusion requirements. Robot-assisted cardiac surgery requires prolonged one-lung ventilation to optimize exposure. Remote-access perfusion requires appropriate positioning of multiple catheters to establish cardiopulmonary bypass. Carbon dioxide insufflation into the thorax can cause hemodynamic instability and carbon dioxide embolism. Limited exposure of the heart may pose difficulties with management of arrhythmia, hemostasis, myocardial protection and de-airing at the end of surgery. Limited access due to robot manipulator would make rapid intervention for cardiopulmonary resuscitation difficult or impossible. This case report describes robot-asssisted atrial septal defect repair and discusses the anesthetic issues associated with minimally invasive cardiac surgery including robotic cardiac surgery. (Korean J Anesthesiol 2007; 52: 371~5)
박성용 ( Sung Yong Park ),주은진 ( Un Jin Ju ),김진수 ( Jin Soo Kim ),민상기 ( Sang Ki Min ),홍용우 ( Yong Woo Hong ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.3
Bullet embolism is a rare complication of non-penetrating gunshot trauma. There are two types of bullet embolisms: arterial and venous. Accurate preoperative localization of the bullet is important for selecting the proper surgical and anesthetic techniques. We report here on a rare case of venous bullet embolus to the right ventricle from the right iliac vein, as was demonstrated by transesophageal echocardiography. (Korean J Anesthesiol 2009; 56: 345∼8)
조직판막을 이용한 승모판막대치술 후 경식도심초음파 검사에서 발견된 판막 내 역류 -증례보고-
김대희 ( Dae Hee Kim ),박성용 ( Sung Yong Park ),김계숙 ( Kye Sook Kim ),최정웅 ( Jeong Woong Choi ),김진수 ( Jin Soo Kim ),홍유선 ( You Sun Hong ),홍용우 ( Yong Woo Hong ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.6
Intraoperative transesophageal echocardiography (IOTEE) is an invaluable diagnostic method for management of cardiac surgical patients, including patients undergoing valve replacement surgery. We report a patient who underwent reoperation for mitral valve replacement due to intravalvular regurgitation following mitral valve replacement with a bioprosthetic valve. The condition was detected by IOTEE and caused by suture entrapment. (Korean J Anesthesiol 2009; 56: 709~12)
증례보고 : 전신마취 유도 후 후두경 조작과 기관내삽관 시에 나타난 심장 무수축
김대희 ( Dae Hee Kim ),박성용 ( Sung Yong Park ),경규동 ( Kyu Dong Kyoung ),김진수 ( Jin Soo Kim ),홍유선 ( You Sun Hong ),홍용우 ( Yong Woo Hong ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
Vagal reflex during laryngosopy and tracheal intubation may result in cardiac arrhythmia such as bradyarrhythmia and asystole. A 66-year-old woman, scheduled for coronary artery bypass surgery, received intravenous bolus of midazolam 2 mg, sufentanil 50 μg, and vecuronium 10 mg for induction of general anesthesia. After two minutes of manual ventilation, tracheal intubation was attempted and the patient became asystolic during laryngoscopic manipulation. The laryngoscope was immediately withdrawn, and the patient returned to normal sinus rhythm. Ten minutes later, more experienced practitioner performed the second laryngoscopic intubation, but it eventually induced asystole again. External cardiac massage was commenced and normal sinus rhythm retuned at a rate of 60 beats/min after 1-2 minute later. (Korean J Anesthesiol 2009;57:503∼6)
임상연구 : 우심실기능평가에 있어서 경식도심초음파와 열희석법의 비교
나성원 ( Sung Won Na ),권태동 ( Tae Dong Kweon ),오영준 ( Young Jun Oh ),홍용우 ( Yong Woo Hong ),김지호 ( Ji Ho Kim ),곽영란 ( Young Lan Kwak ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.1
Background: It is important to evaluate the right ventricular (RV) function intraoperatively for optimal management of patients undergoing cardiac surgery. The clinical relevance of thermodilution method to tranesophageal echocardiography (TEE) for the measurements of RV function during off-pump coronary artery bypass surgery (OPCAB) was evaluated in this study. Methods: Fifty patients undergoing OPCAB were included. RV function was assessed with both thermodilution method and TEE after anesthesia induction (T1), 10 min after leg elevation (T2), 10 min after returning to the supine position (T3), 10 min after Y-graft formation started (T4), 10 min after sternum closure (T5) and 10 min after applying 5 cmH2O of positive end expiratory pressure (T6). Fractional area change (FAC) and tricuspid annular plane systolic excursion ratio (TAPSE) were measured by TEE and compared to RV ejection fraction (RVEF) measured by thermodilution technique. RV end diastolic area (EDA) derived from TEE was compared to RV end diastolic volume index (EDVI) derived from thermodilution technique. Results: There was no significant correlation between echocardiographic data and thermodilution data by linear regression analysis. However, only in patients with right coronary artery stenosis less than 90%, TAPSE and FAC were significantly correlated with RVEF (P = 0.008 and 0.01, respectively) and EDA was significantly correlated with EDVI (P = 0.013) only at T4. Conclusions: RV performance measured by thermodilution technique did not correlate well with TEE finding in severe coronary artery disease patients. The correlation was significant during hemodynamically stable period (during Y-graft formation) in patients without severe right coronary artery disease. (Korean J Anesthesiol 2006; 51: 58~64)