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제2형 당뇨병 환자에서의 당뇨병성 망막증과 대혈관 합병증과의 관계
홍상모 ( Sang Mo Hong ),박정환 ( Jung hwan Park ),임영효 ( Young Hyo Lim ),박용수 ( Yong Soo Park ),김동선 ( Dong Sun Kim ),최웅환 ( Woong Hwan Choi ),안유헌 ( You Hern Ahn ) 대한내과학회 2011 대한내과학회지 Vol.81 No.3
Background/Aims: Type 2 diabetes with microvascular complications is often accompanied by macrovascular complications. However, the relationship between the two complications is unclear. In this study, we determined the relationship between diabetic retinopathy and morphological changes of the carotid artery. Methods: We analyzed the presence of plaque and mean carotid intima-media thickness (CIMT) in patients with type 2 diabetes (n = 133) using high-resolution ultrasound. The presence and severity of retinopathy were graded according to fundus photographs. Results: The mean CIMT of the diabetic retinopathy (DR) group (0.111 ± 0.048 cm) was significantly greater than that of the nondiabetic retinopathy (No DR) group (0.074 ± 0.039 cm, p = 0.007). An abnormal mean CIMT (> 0.08 cm) was more frequently observed in the DR group (76%) than that in the No DR group (23.1%; odds ratio, 10.609; 95% confidence interval, 3.072-36.639; adjusted by age, body mass index, hypertension, and diabetes duration). Although the mean CIMT in patients with plaque was significantly greater than that of patients without plaque, no significant difference was observed between the DR (36%, 17 patients) and NoDR (18.5%, 20 patients) groups in the presence of plaque. Conclusions: Diabetic retinopathy was associated with an increased CIMT but not with atherosclerotic plaques. However, the increases in IMT were associated with the presence of plaques, which predispose patients to cardiovascular disease. These results imply that the microvascular complications of diabetes have indirect relationships with the cardiovascular complications of diabetes. (Korean J Med 2011;81:351-358)
이식신 생검을 시행 받은 환자에서 신이식 후 단백뇨와 이식신 기능소실의 연관성
홍상모 ( Sang Mo Hong ),최낙원 ( Nak Won Choi ),윤재훈 ( Jai Hoon Yoon ),이창화 ( Chang Hwa Lee ),김근호 ( Gheun Ho Kim ),박문향 ( Moon Hyang Park ),강종명 ( Chong Myung Kang ) 대한내과학회 2004 대한내과학회지 Vol.67 No.6
목적 : 신장 이식 후 발생하는 지속적인 단백뇨는 이식신 기능소실의 중요한 표지자이지만, 단백뇨가 이식신 기능부전의 단순한 결과인지 혹은 이식신 기능부전을 유발하는 원인적 인자인지는 아직 분명하지 않다. 저자들은 신장 이식 후 단백뇨와 이식신 기능소실의 연관성을 분석함으로써 이식신 기능소실에 있어서 이식 후 단백뇨가 미치는 병인적 효과를 평가하고자 하였다. 방법 : 신장 이식 수술을 받고 1년 이상 경과 후 단백뇨 혹은 고질소혈증이 발생하여 이식신 생검 Background : Previous studies reported a poor prognosis in patients with persistent proteinuria later in the posttransplantation course, suggesting that posttransplantation proteinuria is a marker for graft failure. This study was undertaken to elucidate
홍상모 ( Sang Mo Hong ),최웅환 ( Woong Hwan Choi ) 대한내과학회 2012 대한내과학회지 Vol.83 No.4
Sarcopenia is defined the loss of muscle mass and strength with aging. Although the etiology and the pathogenesis, the diagnosis of sarcopenia are obscure, the sequel of sarcopenia, i.e. morbidity and mortality, metabolic complications, are a major public health problem. Particularly, aged people in Korea are increasing rapidly more than expected; therefore the interest of sarcopenia is also increasing rapidly. This article provides an overview of the pathogenesis, and diagnosis, epidemiology, clinical results. (Korean J Med 2012;83:444-454)
복분자, 헛개나무열매 추출물 식이가 전신경락마사지 시 피로저감화에 미치는 영향
홍경지 ( Kyeong-ji Hong ),강상모 ( Sang-mo Kang ) 한국미용학회 2017 한국미용학회지 Vol.23 No.1
In this study, effects of Rubus coreanus Miquel and Hovenia dulcis thunb Extract Intake on the concentration of fatigue substances and antioxidant enzymes in the blood as well as the degree of fatigue after merdian massage. It was a prospective randomized controlled trial study that was conducted on 24 women, between 20 to 50 years old and they were divided into three groups Cont(control)=8, ExpA(Rubus coreanus Miquel extract)=8, ExpB(Hovenia dulcis thunb extract). After each subject were received 2hours of meridian massage, they were analyzed by blood. it was showed that fatigue. Lactic acid was shown a significant decrease of 32.5% in ExpA, 28.6% in ExpB(only experimental group). Cortisol level showed a significant decrease of 32.5% ExpA, 28.6% in ExpB. BAP showed a significant increase in Cont of 11.5%, ExpA of 20.8% and ExpB of 23.1%. d-ROMs showed a significant decrease in Cont of 5.27%, ExpA of 9.9%, ExpB of 10.6%. The experimental groups showed reduction in the degree of fatigue than compared to that of the control group. Also a significant reduction of lactic acid fatigue substance and antistress hormone cortisol occurred. Antioxidant-related factors BAP increased significantly while d-ROMs decreased significantly. From this, Rubus coreanus Miquel, Hovenia dulcis thunb extract seems to have positive effect on reducing the fatigue level after getting Meridian massage.
복분자, 헛개나무열매 추출물 식이를 병행한 전신경락마사지의 산화스트레스 변화 -ECS 검사를 중심으로-
홍경지 ( Kyeong-ji Hong ),강상모 ( Sang-mo Kang ) 한국미용학회 2017 한국미용학회지 Vol.23 No.1
The purpose of this study was to determine the effects of meridian massage after Rubus coreanus Miquel, Hovenia dulcis thunb extract on oxidative stress by ECS(electro chemical screening). It was a prospective randomized controlled trial study that was conducted on 24 women, between the age of 20 to 50 years old. They were divided into group C(control), A(Rubus coreanus Miquel extract), B(Hovenia dulcis thunb extract). After 2hours of a whole body merdian massage was performed on each subject, subjects were analyzed by urine and saliva for levels of oxidative stress. When comparing the results before and after the massage, it was showed that gorup A and B group showed a significantly decreased concentration of CON, pH, ST & SG of urine and saliva, urine P/U compared to that of group C. But rH2 of urine and saliva showed an excess of ATP production status, while urine Brix showed no significant difference between all three groups. As a result, we found that Rubus coreanus Miquel, Hovenia dulcis thunb extract intake after a whole body merdian massage had a role to form an antioxidant defense system that protects the body against the effects of reactive ROS, which is interpreted as showing a positive effect on the reduction of oxidative stress. This study is significant in that it was first to utilize ECS as abjective and systematic diagnostic tool in analyzing levels of oxidative stress.
HDTMA-, BDTDA- 및 CP-스멕타이트의 물리-화학적 특성
고상모 ( Go Sang Mo ),홍석정 ( Hong Seog Jeong ),송민섭 ( Song Min Seob ) 한국광물학회 2003 광물과 암석 (J.Miner.Soc.Korea) Vol.16 No.4
This study aims to provide the physicochemical properties of three kinds of organosmectites which can be diversely used in industries. Some properties of them were compared with Na-smectite. Three kinds of organo-smectites such as Hexadecyltrimethylammonium(HDTMA), Benzyldimethyltetradecylammonium(BDTDA), and Cetylpyridinium(CP) exchanged smectites were manufactured for this study. Three types of organo-smectites showed the alkaline character(pH 9), very low swelling property and viscosity, and a fast flocculation behavior because of strong hydrophobic property in contrast to hydrophilic Na-smectite. Three organo-smectites showed the strong interlayer expansion with basal spacing from 19 A to 23 A compared with the Na-smectite of about 12 A. Organic cations such as HDTMA, BDTDA, and CP exchanged into smectite were completely decomposed in the temperature range from 250℃ to 400℃. Generally, three organo-smectites showed the similar mineralogical, physicochemical and thermal properties. But their properties are quite different from Na-smectite. Considering economically, CP exchanged smectite would be used for the diverse utilization field in the future time.
고 기능성 수질 정화 여과재로서의 장석질 모래 활용연구
고상모 ( Go Sang Mo ),송민섭 ( Song Min Seob ),홍석정 ( Hong Seog Jeong ) 한국광물학회 2003 광물과 암석 (J.Miner.Soc.Korea) Vol.16 No.4
Domestic water treatment plants operate the rapid and slow filtering system using the filtering sands. Most of them are composed of beach sands, which have less sorption capacity of heavy metals as well as organic contaminants. Therefore, the development of fortified functional filtering materials with high removal capacity of organic and inorganic contaminants is needed to prevent the unexpected load of contaminated source water. This study aims to test the hydrochemical change and the removing capacity of heavy metals such as Cd, Cu, and Pb on the Jumunjin sand, feldspathic sand(weathering product of Jecheon granite), feldspathic mixing sand Ⅰ(fe1dspathic sand mixed with 10 wt% zeolite), and feldspathic mixing sand Ⅱ (feldspathic sand mixed with 20 wt% zeolite). Feldspathic mixing sand Ⅰ and Ⅱ showed the eruption of higher amounts of cations and anions compared with the Jumunjin sand and feldspathic sand. They also showed higher eruption of Si, Ca, so4 ions than that of Al, N0₃, Fe, K, Mg, and P. Feldspathic mixing sand Ⅱ caused higher eruption of some cations of Na, Ca, Al than feldspathic mixing sand Ⅰ, which is the result controlled by the dissolution of zeolite. Jumunjin sand and feldspathic sand showed very weak sorption of Cd, Cu and Pb. In contrast to this, feldspathic mixing sand Ⅰ and Ⅱ showed the high sorption and removal capacity of the increasing order of Cd, Cu and Pb. Feldspathic mixing sand Ⅱ including 20% zeolite showed a fortified removal capacity of some heavy metals. Therefore, feldspathic mixing sand mixed with some contents of zeolite could be used as the fortified filtering materials for the water filtering and purification in the domestic water treatment plants.
비비만 환자와 비만 환자에서 루와이 위우회술 후 체중과 혈청 지질 농도의 변화 비교
박정환 ( Jung Hwan Park ),홍상모 ( Sang Mo Hong ),이창범 ( Chang Bum Lee ),안유헌 ( You Hern Ahn ),김동선 ( Dong Sun Kim ) 대한비만학회 2014 The Korean journal of obesity Vol.23 No.3
Background: This study was aimed to investigate the effects of bariatric surgery in non-obese patients through the comparison of the changes in body weight (BW) and serum lipid profile between non-obese and obese patients after Roux-en-Y gastric bypass. Methods: In this study, 116 patients who received laparoscopic Roux-en-Y gastric bypass due to early gastric cancer were included. Patients were divided into two groups, non-obese group (N=76), defined as body mass index <25 kg/m2, and obese group (N=40), body mass index ≥25 kg/m2. BW and serum lipid profile before surgery and at 3, 6, 9, and 12 months after surgery were examined. Results: In all groups, BW and triglyceride (TG) showed significant (P<0.05) decrease after surgery, while high-density lipoprotein cholesterol (HDL-C) showed a significant increase during the first 3 months after surgery, in obese group. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) decreased. However, the effect was significant for only a limited time period after surgery. Mean percentages of BW loss and TG decrease were greater in the obese group after surgery, however, the change was significant for only a limited time period after surgery. Mean percentage of HDL-C increase in non-obese group was greater but was not statistically significant. There were no differences in mean percentages of total cholesterol and LDL-C decrease between the two groups. Conclusion: At 12 months after surgery, all groups showed significant improvement in BW and serum lipid profile. However, mean percentages in BW loss, TG decrease, and HDL-C increase between the two groups were different.