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- 저자 : 허기영 ( Gi Yeong Huh ) (검색결과 16 건)
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노미숙,서지영,허기영,최필조,홍숙희,정진숙,Roh, Mee-Sook,Seo, Ji-Young,Huh, Gi-Yeong,Choi, Pill-Jo,Hong, Sook-Hee,Jeong, Jin-Sook 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1
Pleuropulmonary blastoma (PPB) is an unusual intrathoracic blastoma presenting in childhood and charac-terized by a biphasic neoplastic population of undifferentiated, small round blastemal cells and larger spindle-shaped sarcomatous cells with entrapped benign epithelial-lined structures. We experienced the cytologic features of PPB in imprint smear from the pleural-based huge mass of the middle lobe of the right lung in a 4-year-old boy. The smears showed high cellularity composed of small ovoid blastemal elements and scattered spindle mesenchymal tumor cells. Lobectomy and pathologic investigation confirmed the diagnosis. PPB seems to be a tumor in which accurate diagnosis may be achieved by cytoiogy if appro-priate clinical information were given. Timely and accurate diagnosis of PPB by cytology paves the way for attempting preoperative treatment in future cases.
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안용우,전희선,허기영,태일호,고명연,Ahn, Yong-Woo,Jeon, Hee-Sun,Huh, Gi-Yeong,Tae, Il-Ho,Ko, Myung-Yun 대한안면통증구강내과학회 2008 Journal of Oral Medicine and Pain Vol.33 No.2
Forensic odontology can be defined in many ways. One of definitions is simply that forensic odontology represents the overlap between the dental and the legal professions. The most important function of forensic odontology to determine of human identity from dental character. We had found 7 unidentified human bodies in Busan metro politan city, 2007 and we have identified 5 bodies among them.
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K562 세포주에서 Genistein에 의해 억제되는 Radiation-induced Apoptosis의 조절 유전자
정수진,진영희,유여진,도창호,정민호,허기영,배혜란,양광모,문창우,오신근,허원주,이형식,Jeong, Soo-Jin,Jin, Young-Hee,Yoo, Yeo-Jin,Do, Chang-Ho,Jeong, Min-Ho,Huh, Gi-Yeong,Bae, Hye-Ran,Yang, Kwang-Mo,Moon, Chang-Woo,Oh, Sin-Geun,Hur, Won-Jo 대한방사선종양학회 2001 Radiation Oncology Journal Vol.19 No.3
목적 : K562 세포를 대상으로 PTK inhibitor (herbimycinA와 genistein)에 의한 방사선 유도 apoptosis의 변화에 따른 관련 유전자를 탐색하고자 하였다. 대상 및 방법 : K562 세포는 $2\times10^5\;cells/mL$의 비율로 준비하여 대수증식기로 성장한 세포를 각각의 실험조건에 따라 처리하여 사용하였다. 방사선 조사는 6-MV X-Ray 10 Gy (Clinac 1800C, Varian, USA)를 $200\~300\;cGy/min$의 선량율로 상온에서 일정하게 조사하였다. Herbimycin A (HMA, Calbiochem, UK)와 genistein (Calbiochem, UK)은 dimethylsulfoxide (DMSO, Sigma, UK)에 녹여서 각각 1 mM과 10 mM의 농축용액으로 조제한 각각 250 nM과 $25\;{\mu}M$의 최종농도로 처리하였다. 내성 변화의 조절에 관여하는 유전자를 찾고자 PCR-select cDNA subtractive hybridization을 실시하여 128개의 차별 발현되는 clones을 재선별하였다. DNA sequencing을 통하여 염기서열을 분석하였으며, GenBank database를 이용하여 이미 밝혀진 유전자들과의 상동성을 비교하였다. 상동성을 갖는 clone을 확인하여 이를 probe로 사용하여 방사선 단독조사한 실험군과 방사선과 HMA 또는 genistein을 동시 처리한 실험군들간의 mRNA 발현의 차이를 Northern hybridization을 통하여 확인하였다. 결과 : homo sapiens Smad6 유전자와 $95\%$의 상동성을 갖는 clone을 확인하였다. 이를 probe로 사용하여 방사선 단독 조사한 실험군과 방사선과 HMA 또는 genistein을 동시 처리한 실험군들간의 mRNA 발현의 차이를 비교 분석한 결과, 방사선과 genistein을 동시 처리한 실험군의 mRNA 발현이 방사선 단독 조사한 실험군과 방사선과 HMA를 처리한 실험군들에 비하여 현저히 높았다. 결론 : Smad6와 방사선에 의해 유도되는 apoptosis의 억제에 관한 연관성을 보고한 문헌은 없으나, Smad6가 일부세포에서 apoptosis를 억제한다는 보고들과, 본 연구에서 관찰한 genistein에 의한 방사선에 의해 유도되는 apoptosis의 억제에서 그 발현이 두드러지게 증가한 점 등을 미루어 보아 방사선에 의하여 유도된 apoptosis의 억제 및 방사선 내성의 조절에도 관여할 것으로 생각된다. Prupose : The genes involved on the suppression or radiation-induced apoptosis by genistein in K562 leukemia cell line was investigated. Materials and methods : K562 cells in exponential growth phase were irradiated with a linear accelerator at room temperature. For X-ray irradiation and drug treatment, cultures were prepared at $2\times10^5\;cells/mL$. The cells were irradiated with 10 Gy (Clinac 1800C, Varian, USA), Stock solutions of herbimycin A (HMA, Calbiochem, UK) and genistein (Calbiochem, UK) were prepared in dimethylsulfoxide (DMSO, Sigma, UK). After incubation at $37^{\circ}C$ for 24 h, PCR-select cDNA subtractive hybridization, dot hybridization, DNA sequencing and Northern hybridization were examined. Results : Smad6 gene was identified from the differentially expressed genes in K562 cells incubated with genistein which had been selected by PCR-select cDNA subtractive hybridization. The mRNA expression of Smad6 in K562 cells incubated with genistein was also higher than control group by Northern hybridization analysis. Conclusion : We have shown that Smad6 involved on the suppression of radiation-induced apoptosis by genistein in K562 leukemia cell line. It is plausible that the relationship between Smad6 and the suppression of radiation-induced apoptosis is essential for treatment development based on molecular targeting designed to modify radiation-induced apoptosis.
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증례 : 감염 ; 부검을 통해 확진된 비브리오 불니피쿠스(Vibrio vulnificus) 패혈증 1예
이수진 ( Su Jin Lee ),조갑래 ( Gam Rae Jo ),허기영 ( Gi Yeong Huh ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5
Vibrio vulnificus에 의한 패혈증은 약 30%에서 저혈압성의 쇼크를 보이며 이 중 90% 정도의 사망을 보이는 치명적인 질환으로, 이 균에 의한 감염은 알려진 간질환자나 면역저하자의 경우가 대부분인데 반해 저자들은 기저 질환을 알지 못하던 환자가 내원 후 빠르게 저 혈압성 쇼크, 괴사성 근막염의 소견을 보이면서 6시간 만에 사망하였고, 이후 부검소견, 조직배양 및 혈액배양을 통해 V. vulnificus의 감염을 확진한 드문 예를 경험하였다. Vibrio vulnificus에 의한 원발성 패혈증 환자에서 병리 조직 소견의 국내 보고는 없어 임상양상과 부검을 통한 감염의 병리 소견을 포함하여 저자들이 경험한 1예를 보고하고자 한다. Vibrio vulnificus primary septicemia is a serious illness associated with high mortality rates and is caused by the ingestion of raw or undercooked shellfish. Most patients admitted with V. vulnificus infection are immunocompromised or have an underlying disease, such as liver cirrhosis or hemochromatosis. In contrast, the authors experienced an uncommon case in which a patient with no known underlying disease rapidly progressed to sepsis with hypotensive shock, followed by death within a few hours. Based on a postmortem examination, tissue cultures, and blood cultures, it was determined that the patient had been infected with V. vulnificus and had chronic liver disease. There are no reports in Korea on the clinicopathological findings of V. vulnificus infection. Here, we present the case of a patient with V. vulnificus septicemia and describe the associated clinical symptoms and clinicopathological findings discovered upon autopsy. (Korean J Med 77:649-653, 2009)
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천상진(Sang-Jin Cheon),김영호(Young-Ho Kim),이동호(Dong-Ho Lee),허기영(Gi Yeong Huh),김휘택(Hui-Taek Kim),유총일(Chong-Il Yoo) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.6
목적: 만성 압박성 신경병증의 병리조직학적 소견 및 말초 신경 주행상에 존재하는 정상적인 해부학적 협소부위를 재현할 수 있는 동물 모델을 개발하고자 본 연구를 수행하였다. 대상 및 방법: 흰 쥐 좌골 신경의 직경보다 압박대의 내경이 0.2 ㎜ 더 작게(Ⅰ군), 같게(Ⅱ군), 그리고 직경보다 0.2 ㎜ (Ⅲ군), 0.4 ㎜ (Ⅳ군), 0.6 ㎜ 더 큰 (Ⅴ군) 5 ㎜ 길이의 압박대가 되도록, 자가 슬개건으로 압박대를 제작하여 신경 주위에 감은 후 1, 2, 3, 4, 6개월이 경과된 뒤 신경 전기생리검사, 병리조직학적 검사와 형태 계측학적 신경섬유 분석을 시행하였다. 결과: Ⅲ군과 Ⅳ군의 경우, 각각 3개월과 4개월째부터 신경 압박의 조직학적 변화를 보였으며, 6개월째에는 두 군에서 신경속 변연부와 중심부의 신경섬유 측정치들이 대조군에 비해 통계학적으로 의미 있는 압박 변화를 보였다(p<0.05). V군의 경우, 6개월 및 10개월 후의 조직 소견은 대조군과 유사한 양상이었다. 신경 전기생리학적 검사상 Ⅲ군과 Ⅳ군에서는 6개월째 의미 있는 압박성 신경병증의 소견을 보였고(p<0.05), Ⅴ군에서는 검사 결과치가 정상 대조군과 차이가 없었다. 결론: Ⅲ군과 Ⅳ군은 이물 반응의 가능성을 배제하면서 만성 압박성 신경병증의 병리조직학적 소견을 재현할 수 있는 동물 모델이라고 사료된다. 또한 Ⅴ군은 말초 신경 주행상에 존재하는 정상적인 해부학적 협소 부위를 재현하는 동물 모델로서 이용이 가능하리라 사료된다. Purpose: The aim of this study was to develop a model for chronic nerve compression in a rat and a model reproducing a normal anatomical narrow portion that lies in the course of the peripheral nerve. Materials and Methods: Male Sprague-Dawley rats were used. A 5 ㎜ tendinous band was made from the patellar tendon harvested from each rat and placed around the sciatic nerve. In order to determine the degree of compression, a series of internal diameters of the band (0.2 ㎜ smaller than (group Ⅰ), same as (group Ⅱ), and 0.2 ㎜ (group Ⅲ), 0.4 ㎜ (group Ⅳ) and 0.6 ㎜ greater (group Ⅴ) than the diameter of sciatic nerve) were used. The rats were evaluated at 1, 2, 3, 4, and 6 months after banding using an electroneurophysiologic study, a pathohistologic study, and the morphometric nerve fiber analysis. Results: In groups Ⅲ and Ⅳ the morphometric findings showed statistically significant compressive changes in the periphery after 3 and 4 months, respectively and revealed significant changes in both the periphery and central portion at 6 months (p<0.05). In group Ⅴ, the measurements and histologic findings were almost identical to the control group at 6 and 10 months. The nerve electrophysiologic study showed significant compressive changes at 6 months in groups Ⅲ and Ⅳ (p<0.05). In the group Ⅴ, the measurements were similar to those of the normal control. Conclusion: Groups Ⅲ and Ⅳ appear to be a reliably reproducible chronic nerve compression model while excluding the possibility of foreign body reactions. In addition, group Ⅴ appears to be a reliable model of a normal anatomical narrow portion that lies in the course of the peripheral nerve.
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홍숙희(Sook Hee Hong),최석렬(Seok Reyol Choi),김두형(Du Hyeong Kim),한상영(Sang Young Han),노명환(Myung Hwan Roh),허기영(Gi Yeong Huh),신우원(Woo Won Shin),김종성(Jong Seong Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
N/A Background/Aims: This study is aimed to observe the expression of GST-z in colorectal adenomas and adenocarcinomas according to the risk and prognostic factors, and investigate the role during carcinogenesis and the possibility of clinical application as a tumor marker of colorectal neoplasm, in cornparision with the expression of p53 protein and CEA. Methods: Immuno- histochemical stain was performed in 15 cases of normal colon, 31 adenomas and 63 adenocarci- nomas. Results: The incidence of GST- expression was higher in adenocarcinoma (95.2%) than normal colon(40%), adenoma(87.1%) and adjacent norrnal mucosa to adenocarcinoma(63.5%) and the degree of the expression was also significantly different among them. In adenomas, the higher the degree of dysplasia, the higher the expression of GST-z. In adenocarcinomas, the expression was significantly decreased in relation with progression to lower histologic grade. The incidence of p53 expression was higher in adenocarcinomas(54.0%) than normal colon(0%), adenoma(25.8%) and adjacent normal mucosa to adenocarcinoma(0%) and the degree of the expression was also significantly different among them. In adenomas, the higher the degree of dysplasia, the higher the expression of p53. In adenocarcinoma, there was no sifnificant difference in relation with the histologic grade and stage. The incidence of CEA expression was higher in adenocarcinoma (96.8%) than normal colon(33.3%), adenoma(64.5%) and adjacent normal mucosa to adenocarci- norna(95.2%) and the degree of the expression was also significantly different among them. In adenomas, there was no significant difference in relation with size, amount of villous component and degree of dysplasia. In adenocarcinomas, the expression was increased in relation with progression to higher stage. The incidence of intense co-expression of GST-z and p53 in adenocarcinoma showed a tendency to be increasing in relation with progression to higher stage. But there was no statistically significant. Conclusions: It has been found from the above results that the expression of GST-z is progressively increased during colorectal carcinogenesiser. (Korean J Gastroenterol 1997;29:632-644)
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