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반복적인 천음과 호흡곤란을 보인 영아에서 진단된 선천성 심, 폐기형 3례
남효경 ( Hyo Kyoung Nam ),라경숙 ( Kyong Suk La ),변정혜 ( Jung Hye Byeon ),최익선 ( Ic Sun Choi ),장기영 ( Gi Young Jang ),유영 ( Young Yoo ),정지태 ( Ji Tae Choung ),손창성 ( Chang Sung Son ),함수연 ( Soo Youn Ham ) 대한소아알레르기호흡기학회 2009 소아알레르기 및 호흡기학회지 Vol.19 No.2
Although laryngomalacia is the most common cause of congenital stridor in infancy, it is a benign, self-limited disease which usually resolves by the age of 18 months with no long-term sequelae. Nevertheless, infants who suffered from recurrent stridor and respiratory distress should be evaluated for other causes of stridor such as cardiopulmonary anomalies. We report 3 cases of infants who had recurrent stridor and respiratory distress from their early infancy. Case 1 had a double aortic arch and a tracheomalacia, case 2 had a hypoplasia of the right lung, and case 3 had a horseshoe lung as well as scimitar syndrome. Physicians should be alert for the possibility of the congenital cardiopulmonary abnormalities in infants with recurrent stridor and/or respiratory distress. [Pediatr Allergy Respir Dis(Korea) 2009; 19:183-190]
방사성동위원소 표지 단일클론항 GGT 항체를 이용한 간 질환에 대한 연구
함수연,최재걸,이민재,정규병,김명곤,류총근 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.3
This study was designed to investigate whether radioisotope labeled tissue-specific monoclonal anti-γ Glutamyltransferase (GGT) antibodies can be used for the scintigraphic localization of abnormal hepatic tissue of rat. Three monoclonal anti-GGT antibodies (GGT MAb-1, 5, 6) were biochemically purified from the ascites of BALB/c mice which were injected hybridomas secreting monoclonal antibody to a 7.17 mg of immunoglobulin per ml of protein and the mean immunoglobulin amount was 4.98 mg. Then I-131 was incorporated to GGT MAbs by lodogen method with an average labeling efficiency of 77.4% (GGT MAb), and 86.8% (GGT PAb) and in case of Tc-99m by sodium dodesylsulfate, they were 57.7% (GGT MAb), and 77.6% (GGT PAb) respectively. In vitro assay revealed that there was a significant correlation between the result of immunohistochemistry and that of tissue autoradiography according to the type of tissue and monoclonal antibodies in normal heaptic tissue, preneoplastic liver and normal kidney. Modified GGT MAb-1 was specific for the hepatic tissue of preneoplastic liver, GGT MAb-5 for the normal liver, and GGT MAb-6 for the normal kidney. In vivo assay revealed selective localization of radioactivity over tissue specific GGT distributed organs of Wister rat by immunoscintigraphy and tissue γ-counting. In conclusion, radioisotope labeled anti-GGT antibodies might be used for both in vitro and in vivo assays and could be used for the localization of musine hepatic disorders by immunoscintigraphy.