급성 전염성 단핵구증 환아에서 Epstein-Barr 바이러스의 감염형과 사람 백혈구 항원형 연구

한승훈,신완식,한훈,강진한,Hahn, Seung-Hoon,Shin, Wan-Shik,Han, Hoon,Kang, Jin-Han 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

목 적 : EBV는 전 세계적으로 다양한 질환을 일으키고, EBV는 지역과 EBV에 노출된 사람의 면역 또는 병적 상태에 따라 감염형이 달라 EBV 감염형에 관한 연구는 EBV의 역학연구와 EBV 관련 질환의 병인연구에 제일 기본적이다. EBV의 잠복감염 유전인자들에 의한 세포독성 T 림프구 면역상태는 EBV에 의한 다양한 질환의 병인적 역할이 있으며 HLA에 의하여 유발되어지는 것으로 알려져 있다. 과거에 시행한 많은 연구에서 EBV 감염과 HLA형과의 연관성은 객관적으로 입증되지 않았으나, HLA II형에 속한 항원이 EBV의 인체 내 침투에 관여한다는 사실이 최근에 보고됨으로써 이에 대한 관심이 재조명되고 있다. 이에 저자들은 EBV 감염에 의한 국내 급성 전염성 단핵구증 환아에서 주된 EBV 감염형의 분포를 확인하고, 급성 전염성 단핵구증의 발생이 HLA형과 연관성이 있는 지를 분자생물학적 분류법으로 알아보고자 이 연구를 실시하였다. 방 법 : 연구 대상은 6세에서 13세 사이의 급성 전염성 단핵구증으로 확진된 24명의 환아 이었다. 감염형의 비교 대조군은 건강한 정상 소아 중 면역혈청학적 검사로 EBV 노출이 확인된 동일한 연령의 58명이었고, HLA형 분류의 비교 대조군은 연구대상 환아와 동일한 연령의 정상 소아 200명을 대상으로 실시하였다. EBV에 의한 급성 전염성단핵구증 환아에서 중합 효소 연쇄반응법으로 EBV 감염형을 분류하여 주된 감염형을 확인하고, ARMs PCR법으로 HLA-A, B, C 항원형을, PCR-SSOP법으로 HLA-DRB 항원형을 분류하여 다음과 같은 결과를 얻었다. 결 과 : 1) EBV 감염형 결과 : 연구 대상 환아 24명에서 EBV A형이 20명(83.3%)이었고, B형은 4명(16.7%)이었다. 비교 대조군의 경우에는 58명 중 14명(24.1%)이 EBV가 검출되고 이들 중 A형은 11명(78.6%)이었고, B형이 3명(21.%)이었다. 2) HLA 형 분류 결과 : HLA I형 결과는 HLA-A24형에서 비교 대조군 200명 소아 중 69명이 양성이었고, 연구 대상 환아 24명 중 14명이 양성을 보여 RR치가 3.5724, chi-square치가 5.26, P<0.05으로 통계적 유의성을 보였다. 그러나 HLA-B, C항원형에서는 통계적으로 유의한 결과가 없었다. HLA II형 결과는 HLA-DRB1*07형에서 비교 대조군 200명 소아 중 18명이 양성이었고, 연구 대상 환아 24명 중 8명이 양성을 보여 RR치가 5.6173, chi-square치가 9.73, P<0.01로 통계적 유의성을 보였다. 결 론 : 위의 연구 결과를 통하여 국내 급성 전염성 단핵구증 환아의 EBV 감염형은 정상 비교 대조군의 소아에서 주된 감염형인 A형과 동일한 감염형임을 확인하였다. 그리고 HLA형 연구에서 HLA-A24형과 HLA-DRB1*07형이 정상 대조군과 비교하여 통계적 유의성을 보여 EBV에 의한 급성 전염성단핵구증 발생이 HLA형과 연관성이 있음을 추정하였다. Purpose : The Epstein-Barr virus(EBV), gamma herpesvirus, is an important pathogen that is widespread around the world. The EBV causes various diseases depending on the geographic location, and on the immunity or the premorbid condition of the person exposed to EBV. To evaluate EBV typing may be the most important step to figure out the pathogenesis of EBV associated diseases, and we need to re-evaluate the pathologic role of human leukocyte antigen(HLA) in developing Epstein- Barr virus associated acute infectious mononucleosis by using newly developed methods. Methods : This study included 24 children(age range : 6 to 13 years), serologically confirmed with acute infectious mononucleosis. The control group for the HLA type consisted of 200 age-matched healthy children. To classify HLA I, modified ARMs-PCR was used, while modified PCR-SSOP was utilized in typing of HLA II. Also, we performed EBV typing in study patients by using a one-step PCR. Results : The results of HLA types : In HLA class I, HLA-A24 was positive in 69 of 200 healthy children and positive in 14 of 24 patients in the study group(relative risk : 3.5724, chi-square; 5.26, P<0.05). In HLA class II, HLA-DRB1*07 was detected in 18 of 200 healthy children, and eight of 24 patients in the study group(relative risk; 506173, chi-square; 9.73, P<0.01). The results of EBV types : In the research group, 20(83.8%) of 24 patients were shedding type A virus, while 4(16.7%) were type B. Conclusion : We conclude that development of infectious mononucleosis may be associated with HLA types, and these results suggest that acute infectious mononucleosis could have hereditary traits. And we confirm that type A EBV is highly prevalent in patients with acute infectious mononucleosis in Korea. Also, our results suggest that further large scale studies, including adult groups, regarding the association between pathogenesis of EBV with HLA-DP or HLA-DQ will be warranted.

언어학적 오해(misunderstandings)와 불통(miscommunications)에 대한 융합적 접근

한승훈(Han, Seung-Hoon) 한국언어학회 2014 언어 Vol.39 No.3

The purpose of this study is to reconsider linguistic miscommunications and misunderstandings, which occur in marital conversations and conversations between parent and children in korea, in terms of intentional or non-intentional case. There have been two major problems in accounting for them in many previous studies: one is that two concepts have been randomly used without any criteria; the other most of studies have focused on non-intentional cases involved in mistakes, noise, cross-cultural value and etc. As an alternative for improving them, a special focus is laid on Han’s(2014) integrated framework built by the combination of action theory and pragma-linguistic approach. On the basis of Han’s framework, an attention is paid to analyzing a set of real data involved in family discourse. The results of this analysis are discussed in terms of six types of verbal-actions. Such an attempt will be helpful to understand how intentional language usage is employed in dynamic discourse context as well as anatomize why an agent commits intentional miscommunications in his/her family context.

도서관과 학생수련시설에 대한 교육시설 안전인증 요소의 확대적용 방안 연구

한승훈,김재향,Seung-Hoon Han,Jae-Hyang Kim 한국토지주택공사 토지주택연구원 2023 LHI journal of land, housing, and urban affairs Vol.14 No.3

In order to create a safe and comfortable educational environment and improve the quality of education, the 'Act on the Safety and Maintenance of Educational Facilities' was enacted in 2021. Accordingly, 'Educational Facility Safety Certification Operation Regulations' was established. Safety certification targets are classified into 'kindergarten', 'elementary/middle/high school and special schools', and 'university and other educational facilities'. Other educational facilities include libraries and student training facilities. However, student training facilities and libraries are different from schools as facilities for special activities such as training and reading. Therefore, the unique characteristics of the facility must be reflected in the 'Educational Facility Safety Certification Operation Regulations'. This study analyzed how the 'Educational Facility Safety Certification Operation Regulation' reflects the special characteristics of student training facilities and libraries that are 'other educational facilities'. The previous certification system and guidelines were compared and analyzed, and the on-site survey method was used. Finally, it was confirmed that each of the library and the student training facility needed 9 detailed criteria reviews.

장기간 기관절개공을 유지한 소아 환자들에서의 기도 세균집락에 관한 연구: 균동정 부위와 시차 간의 차이 비교

한승훈,김영석,권성근,Han, Seung Hoon,Kim, Young Seok,Kwon, Seong Keun 대한후두음성언어의학회 2021 대한후두음성언어의학회지 Vol.32 No.1

Background and Objectives Tracheostomy lead to persistent bacterial colonization of the respiratory tract. Surgical site infection and restenosis by the pathogenic bacteria is the most fatal complication after open airway surgery. The aim of this study is to describe the culture results of larynx and tracheostoma in patients with tracheostomy and the preoperative, intraoperative culture results in patients underwent open airway surgery. Materials and Method A retrospective review was performed on 18 patients who underwent culture between 2017 and 2019. Results Pseudomonas or antibiotic resistance bacteria were identified in 11 patients out of 18 patients (61.1%); Ceftriaxone-resistant Streptococcus (38.9%), Pseudomonas (33.3%), Methicillin-resistant Staphylococcus aureus (16.7%), extended-spectrum β-lactamases (ESBL) producing Klebsiella pneumoniae (11.1%). Among 18 patients, 6 patients showed the different culture result between larynx and tracheostoma. In 4 out of 10 patients who underwent open airway surgery, the bacteria were not identified before surgery, but the bacteria were isolated in the intraoperative culture. In one patient, the bacteria detected intraoperatively were different from those detected before surgery. Conclusion Preoperative respiratory tract culture and usage of perioperative antibiotics according to the culture are necessary. It is crucial to verify the bacterial culture in both tracheostoma and larynx. And it should be performed immediately before open airway surgery.

한옥의 통합 쾌적성능 평가체계 구축에 관한 연구

한승훈,천득염,이미향,임옥균,Han, Seung-Hoon,Cheon, Deuk-Youm,Lee, Mi-Hyang,Im, Ok-Kyun 한국주거학회 2013 한국주거학회 논문집 Vol.24 No.3

The purpose of this study is to develop an evaluation system for integrative comfort values of Hanok residence. For this study, a mock-up located in Yongin, Gyeonggi province built by an ongoing governmental research project has been chosen. Then, SSN (Smart Sensor Network) has been utilized for monitoring quantitative factors in the environment and detailed face-to-face surveys have been performed for analyzing qualitative comfort indexes from residents in the experimental settings. Then, this study employs a combined evaluation system using AHP (Analytic Hierarchy Process) established for estimating overall DIC (Degree of Integrative Comfort) of the Hanok residence. As a result, the evaluation system could verify the total comfort indexes of Hanok residence and suggest converged methodologies for establishing value assessment system for traditional residential facilities. The method of DIC suggested in this paper would be examined with current residents in a built mock-up to see its applicability as a comprehensive evaluation model, and it is expected that collected year-round comfort data from the facility would provide more practical information towards future strategies for the Hanok residence.

RBI기법을 이용한 CNG 버스의 Risk 분석에 관한 연구

한승훈(Seung Hoon Han),고병석(Byung Seok Ko),유병태(Byung Tae Yoo),고재욱(Jae Wook Ko) 한국가스학회 2014 한국가스학회 학술대회논문집 Vol.2014 No.11

조선후기 변란에서의 점복

한승훈(Han, Seung-hoon) 한국역사민속학회 2021 역사민속학 Vol.- No.61

유형별 청자의 명절 갈등 표현 해석 양상 연구: 취업준비생을 중심으로

한승훈 ( Han¸ Seung-hoon ) 대한영어영문학회 2021 영어영문학연구 Vol.47 No.4

The goal of this study is to investigate language usages of job seekers who participate in conflict family discourses during Korean holiday with respect to hearers’ types. Hearers are classified into three types on the basis of three self-construal types; independent, interdependent, and ambivalent self-consrtual type (Markus & Kitayama, 1991; Ting-Toomey, et al., 2001). Online self-report questionnaire is used to identify demographic data of subjects (N=100), their self-construal types, and linguistic responses to conflict expressions. The focus of analysis is laid on linearly examining a meaning-interpretation and a relation-decision process in order to understand their interpretation patterns through the conversation-developing analysis and the face-negotiation theory. As for conflict expressions, each self-construal type shows unique linguistic results; (a) independent hearers (N=44) predominantly make rebuttals, refusals, or ignorance; (b) interdependent hearers (N=11) make partial refusals, acceptances, or acknowledgments; (c) ambivalent hearers (N=45) make rebuttals, acceptances, or avoidance, especially depending on the given context and their conversational goal. (Sogang University)

일제강점기 학동팔거리 갱생지구의 공간 구성에 관한 연구

한승훈(Han Seung-Hoon),천득염(Cheon Deuk-Youm) 대한건축학회 2010 대한건축학회논문집 Vol.26 No.2

The Hak-Dong Eight-way Crossing is located at the zone of 830 Hak-Dong, Dong-Gu, Gwangju. It was constructed as a rehabilitation district for the purpose of prevention against floods over Gwangju river in 1936, during the period of Japanese occupation. The Hak-Dong Eight-way Crossing as a rehabilitation district had not only special characteristics in aspects of urban spatial planning, but also an important meaning for periodical situation that Japanese government had to pursue a management policy towards Korean low-income citizens. For those reasons, the examined area can be evaluated as a historically valuable relic showing lifestyles of Korean inferior habitants under Japanese occupation in detail. The purpose of this study is to find out the characteristics of the Hak-Dong Eight-way Crossing, especially focused on urban street planning, housing properties and habitants' lifestyles from its construction to the removal. In addition, an attempt to reveal spatial theories for a double phenomenon in terms of Relief and Surveillance has been proposed.

양궁경기방식에 따른 남자 실업선수의 긴장상황 및 대처전략 분석

한승훈(Han, Seung Hoon),박성현(Park, Sung Hyun) 한국체육교육학회 2021 한국체육교육학회지 Vol.26 No.4

목적: 양궁 남자 실업선수가 예선 싱글라운드와 본선 올림픽피타라운드 경기방식에 따라 느끼는 시합 전, 중의 생각을 심도 깊게 비교분석하여 각 경기방식에 따른 긴장상황 및 대처전략의 차이를 분석하고자 하였다. 방법: 이를 위해 제 20회 한국실업연맹회장기 양궁대회에서 각 경기방식별 상위에 랭크된 선수 14명을 대상으로 반구조화 질문지를 적용하고 심층인터뷰를 실시한 뒤 귀납적 분류분석을 통해 비교하였다. 결과: 분석 결과, 첫째, 싱글라운드 방식에서는 ‘첫 발을 슈팅 할 때’와 ‘마지막 엔드를 남기고 메달획득 기대감이 들 때’ 긴장 및 불안이 유발되며, ‘자신 있게 슈팅하기’와 ‘연습 시 잘 될 때를 생각하기’의 대처전략을 활용하였다. 둘째, 올림픽피타라운드 방식에서는 ‘점수차가 많이 나지 않을 때’ 긴장 및 불안이 유발되며, ‘자신 있게 슈팅하기’와 ‘내 것만 신경쓰기’의 대처전략을 활용하였다. 셋째, 두 가지 경기방식에 따른 긴장상황에는 다소 차이가 있었으나 공통적으로 자신감을 가지고 생각과 자세를 일정하게 유지하는 것을 대처전략으로 활용하였다. 결론: 경기방식별 다양한 긴장상황에 대한 차이를 분명히 인식 및 분석하고 효과적인 대처전략을 선수 스스로 선택 및 활용할 수 있도록 해야 할 것이다. 이는 양궁경기력 유지 및 극대화시키는데 필요한 훈련 자료로 활용될 수 있을 것으로 사료된다. Purpose: The purpose of this study was to analyze the differences in tension and coping strategies according to each method of competition by comparing the thoughts of archery male athletes according to the method of competition. Methods: A semi-structured questionnaire was applied to 14 athletes, conducted in-depth interviews, and compared. Results: First, In the single-round approach, tension and anxiety were triggered at the ‘first shot’ and ‘last end’. and uses coping strategies such as ‘shoot confidently’ and ‘think when things go well’. Second, In the Olympic FITA round, tension and anxiety were triggered ‘When the scores are similar’ and It uses coping strategies such as ‘shoot confidently’ and ‘care only about myself’. Third, There was a difference in the tension between the two ways of playing. However, they used in common coping strategies that have confidence and maintain constant thinking and posture. Conclusion: It should be able to recognize the differences in tension according to the way the competition is played and choose effective coping strategies. This could be used as data to maximize archery performance.