골다공증의 분자생물학적 기전

한기옥 ( Ki Ok Han ) 대한폐경학회 2005 대한폐경학회지 Vol.11 No.3

한국 폐경 후 여성에서 유전자 다형성과 골밀도의 연관성 유전자 상호 작용

한기옥(Ki Ok Han),한인권(In Kwon Han) 대한내과학회 2001 대한내과학회지 Vol.60 No.5

N/A

개 피부병 유래의 Microsporum canis의 생물학적 성상

한기옥,최원필,Han, Ki-ok,Choi, Won-pil 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.2

1999년 3월부터 12월에 걸쳐 대구지방에서 피부사상균증에 이완된 개 110두에서 57주(51.8%)의 Microsporum canis를 분리하여 표준균주 1주와 함께 육안적, 현미경적 및 생물학적 성상을 조사하고 고찰하였다. M canis 57주는 집락의 성상 및 현미경적 소견에 따라 4가지(A~D)형으로 나눌 수 있었다. A형(white-yellow type)은 73%(42주)이며 표준주(ATCC 18615)의 전형적인 집락과 동일한 형이며, B형(fluffy type)은 21.1%(12주)이고, C형(flat type)은 3.5%(2주)이며, D형(radial groove type)은 1.7%(1주)이었으며, 이들 형은 전형적인 대분생자의 수적 차이가 인정되었다. 한편 계대가 진행됨에 따라 3가지 변이형(E~G)이 출현하였다. E형은 B형 12균주 중 25%(3주)가 변이한 균주로 갈색색소를 산생하고 비전형적인 대분생자가 관찰되며, G형은 B형의 변이주로 색소 및 대분생자가 소실된 형으로 25%(3주) 이었고, F형은 A형 42균주 중 7.1%(3주)가 변이한 균주로 섬유다발 모양의 성상과 뒷면의 색소 소실 및 비전형의 대분생자, 아령 모양의 균사가 관찰되었다. M canis 58주(표준주 포함)의 urease test, rice medium test, 모발천공시험에서 정도의 차이는 있었지만 전 균주가 양성이었다. The present study was conducted to examine morphological and biological characteristics of 57 strains of Microsporum canis isolated from 110 dogs with dermatophytosis in Taegu, 1999. Isolated strains of M canis were classified into 4 types(A: white-yellow type, B: fluffy type, C: flat type, D: radial groove type) according to their pigmentation and morphology of colonies with typical conidia and hyphae. Some strains of A and B type happened variation by subculture for 6~8 months. The variation strains were classified into 3 types(E, F, G), E type had aberrant macroconidia with typical macroconidia, F type had aberrant hyphae(like dumb-bell) and macroconidia, and G type had no conidia and racket hyphae. All strains showed positive urease test, rice medium growth test and hair perforation test.

개 피부병 유래의 Microsporum canis의 항진균제 감수성

한기옥,최원필,Han, Ki-ok,Choi, Won-pil 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.2

개 피부병 유래 Microsporum canis 57주와 표준균주 1주 등 58주를 broth microdilution test로 계통이 다른 7가지 항진균제에 대한 감수성을 조사하고 고찰하였다. M canis의 항진균주에 대한 MIC(기하평균) 측정에서 terbinafine은 $MIC{\leq}0.004{\sim}0.031(0.007){\mu}g/ml$, itraconazole은 $MIC{\leq}0.004{\sim}0.125(0.029){\mu}g/ml$, ketoconazole은 MIC $0.015{\sim}0.5(0.097){\mu}g/ml$, tolnaftage은 MIC $0.031{\sim}1(0.155){\mu}g/ml$순으로 감수성이 높았고, griseofulvine은 MIC $0.063{\sim}2(0.285){\mu}g/ml$, amphotericin B는 MIC $0.125{\sim}2(0.540){\mu}g/ml$, flucytosine(5-Fe)은 MIC $4{\sim}64(26.430){\mu}g/ml$으로 감수성이 낮았다. The present study was conducted to examine the drug susceptibility of 57 strains of Microsporum canis isolated from dogs with dermatitis in Taegu, 1999. Antifungal susceptibility test was performed by the microdilution method, using 7 antifungal drugs as follows: itraconazole(I), terbinafine(T), ketoconazole(K), griseofulvin(G), amphotericin B(A), flucytosine(5-Fc)(F), tolnaftate(To). All tester strains of M canis were highly susceptible to T, I, K and To(geometric mean $MICs{\leq}0.007{\sim}0.155{\mu}g/ml$), while those were lowly susceptible to G, A and F(geometric mean MICs $0.285{\sim}26.430{\mu}g/ml$).

초등영재아동의 행복 척도 개발 및 타당화

전병옥(Byung-Ok Jun),한기순(Ki-Soon Han) 한국영재교육학회 2022 영재와 영재교육 Vol.21 No.1

본 연구는 초등영재아동의 행복을 파악하는데 유용한 척도를 개발하여 구성개념을 파악하고 타당도와 신뢰도를 검증하는데 목적이 있다. 이를 위해 초등영재아동의 행복 개념도 연구를 통해 추출된 문항들과 이론적 고찰을 통하여 84개의 예비문항을 추출하고, 수도권 소재의 영재교육기관에서 영재교육을 받고 있는 초등영재아동 250명을 대상으로 문항분석과 탐색적 요인분석을 실시하여 8개 요인 총 31문항을 도출하였다. 이후 수도권 소재의 영재교육기관에서 영재교육을 받고 있는 초등영재아동 505명을 대상으로 확인적 요인분석 결과, 모형 적합도는 =902.65(df=406, p=.00), TLI=.91, CFI=.92 , RMSEA=.05로 나타나 적합도 지수는 양호한 값을 보이는 것으로 나타났다. 각 하위요인의 내적합치도인 Cronbach의α 역시 인정욕구의 충족 .83, 친구의 공감과 지지 .79, 창의적 탐구의 즐거움 .76, 학업과 휴식의 균형 .75, 자기에 대한 만족 .82, 가족의 지지 .79, 몰입의 희열 .73, 미래에 대한 긍정적 지각 .81로 나타나 개발된 척도가 초등영재들의 행복을 측정하고 진단하는 도구로서 타당하고 신뢰로운 검사도구임을 알 수 있었다. 본 연구결과는 영재 개인의 자아실현과 행복 추구라는 관점에서 영재교육의 목적에 대한 당위성의 기초 자료를 제공하고, 영재아동의 부적응을 예방하고 영재성을 꽃피우는 데 도움이 될 것으로 기대한다. The purpose of this study is to develop a useful scale to understand the happiness of gifted children in elementary school, to understand the construct, and to verify the validity and reliability. To this end, 84 preliminary questions were extracted through theoretical considerations and questions extracted through a study on the concept of happiness for gifted children in elementary school, and items were analyzed for 250 gifted children in elementary school who are receiving gifted education at gifted education institutions located in the metropolitan area. and exploratory factor analysis were conducted to derive a total of 31 items of 8 factors. Afterwards, as a result of confirmatory factor analysis of 505 gifted children in elementary school receiving gifted education at gifted education institutions located in the metropolitan area, the model fit was =902.65(df=406, p=.00), TLI=.91, CFI=.92 , RMSEA=.05, indicating good fit index. Cronbach s α, which is the internal fit of each sub-factor, also satisfies the need for recognition .83, sympathy and support from friends .79, enjoyment of creative inquiry .76, balance between study and rest .75, self-satisfaction .82, family satisfaction. Support .79, joy of immersion .73, and positive perception of the future .81, indicating that the developed scale is a valid and reliable test tool as a tool for measuring and diagnosing the happiness of gifted children in elementary school. The results of this study are expected to provide basic data on the justification for the purpose of gifted education from the viewpoint of self-realization and pursuit of happiness of gifted individuals, prevent maladaptation of gifted children, and help to blossom giftedness.

폐경 전 여성에서 골밀도와 비만과의 관계

오한진(Han Jin Oh),임창훈(Chang Hoon Lim),정호연(Ho Yeon Chung),한기옥(Ki Ok Han),장학철(Hak Chul Jang),윤현구(HyunKoo Yoon),한인권(In Kwon Han) 대한여성건강학회 2000 여성건강 Vol.1 No.1

갱년기 골다공증 환자의 HRT와 Alendronate 1년 병합치료 효과

오한진(Han Jin Oh),임창훈(Chang Hun Lim),정호연(Ho Yeon Chung),한기옥(Ki Ok Han),장학철(Hak Chul Jang),윤현규(Hyun Koo Yoon),한인권(In Kwon Han) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.1

N/A Background; Rate of bone loss should be increased after menopause and then formation coupled with resoprtion also be increased. Alendronate (Fosamax ;MSD, Rahway, NJ, USA), an antiresorptive drug known to be helpful to prevent bone loss. Alendronate is one of antiresorptive drug for treatment of osteoporosis and resulted in a decrease of bone turnover, There are no available data about Korean people, So, we wanted to determine the effects of alendronate in Korean postmenopausal osteoporosis patients after 1- year treatment Subjects and Methods; We studied 42 women with postmenopausal osteoporosis (bone mineral density[BMD] T score<2.5) who visited osteoporosis clinic in Samsung Cheil Hospital from Jan. 1999 to Apr. 2000, Subjects were stratified in 2 groups. Group 1 treated with alendronate 10mg/day and estrogen, and Group 2 treated with estrogen alone. BMD at the lumbar spine were measured at baseline and 1-year after treatment. We also measured serum marker of bone formation (total alkaline phosphatase[Alk]), and marker of bone resorption (deoxypyridinoline [DPYD]) from urine at baseline, 3months and I-year after treatment. Results; The mean differences in changes of markers after 3 months and 1 year of treatment were remarked significantly (3-Month; delta Alk:-28,7±3.6%, delta DPYD:-31.0±5,4% vs 1-Year; delta Alk:-32.2±3.1%, delta DPYD:-23.0±3.5%). Markers of bone metabolism showed no significant responses between two groups at 3 months and 1year after treatment, Also, Bone mineral density at lumbar spine was significantly increased in Group treated with alendronatc and estrogen than estrogen only group (9.6±0,7% vs 5.3±0.6%, P<0,001). Conclusion; Our data showed that using alendronate with estrogen to the patients of Korean women with osteoporosis increase bone mineral density more, So, we concluded that alendronate therapy with estrogen was helpful to manage postmenopausal osteoporosis patients.

아토피피부염 교육 프로그램을 통한 질병인지도 변화

염혜영 ( Hye Yung Yum ),한기옥 ( Ki Ok Han ),박지애 ( Ji Ae Park ),강미연 ( Mi Youn Kang ),장석일 ( Suk Il Chang ),조상헌 ( Sang Heon Cho ),편복양 ( Bok Yang Pyun ),나영호 ( Yeong Ho Rha ),김규한 ( Kyu Han Kim ),윤호주 ( Ho Joo Yo 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.1

Background: Education programs are essential in improving disease management and quality of life in patients with atopic dermatitis and their families by promoting disease knowledge. In these perspectives, the Seoul Atopy Asthma Education and Information Center has been established under the project ``Atopy-free Seoul`` by Seoul City since 2008. Our goal is an improvement in public health through development of education programs and counseling activities based on scientifically proven medicine. However, implementation and evaluation of effectiveness of education programs are needed to redeem configuration. The aim of this study was to determine the necessity of an education program of atopic dermatitis for optimal disease management. Methods: An education program for citizens was designed by the advisory organization of Korean Asthma Allergy Foundation. To evaluate the efficacy of the education program, 9 questionnaires about disease knowledge were developed. Participants were asked to answer the questionnaires and differences in the percentage of correct answers were compared before and after the program education. Results: In 5 sessions, 359 participants responded to the survey on disease knowledge before and after the education program. There was significant increase in the percentage of correct answers to 5 out of the 9 questions. This result proved that the education program was effective in improving the disease knowledge of atopic dermatitis. Conclusion: Significant improvement in disease knowledge after education of atopic dermatitis supports the need and feasibility of education programs for citizens. (Korean J Asthma Allergy Clin Immunol 2012;32:21-25)

양성 갑상선결절에서 부피의 변화

임창훈(Chang Hoon Yim),최현아(Hyun Ah Choi),정호연(Ho Yeon Chung),한기옥(Ki Ok Han),장학철(Hak Chul Jang),윤현구(Hyun Ky Yoon),한인권(In Kwon Han),김희숙(Hy Sook Kim),이영호(Young Ho Lee) 대한여성건강학회 2001 여성건강 Vol.2 No.2

정상 및 임신성 당뇨병 임신부의 임신 중 체중 증가량와 신생아 체중

김문영(Moon Young Kim),양재혁(Jae Hyug Yang),장학철(Hak Chul Jang),박정은(Jung Eun Park),임창훈(Chang Hoon Yim),정호연(Ho Yeun Chung),한기옥(Ki Ok Han),윤현구(Hyun Koo Yoon),한인권(In Kwon Han),김미정(Mi Jeong Kim),한혜경(Hye Kyung H 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Objective : The purpose of this study was to determine the independent factors that predict neonatal birthweight and find the relationship between maternal weight gain and neonatal birthweight in women with normal glucose tolerance (NGT) and gestational diabetes mellitus (GDM). Methods : Forty-six women with GDM and one hundred fifty women with NGT were included in the study. All subjects had singleton pregnancies and no medical diseases that may affect the fetal growth and were certain of gestational age by early ultrasonography. Maternal weight at each prenatal visit was recorded and neonatal anthropometic measurement was done within 2 days of birth. Results : The average rate of weight gain (kg/week) in NGT was lowest during the first trimester (0.09±0.10), peaked during the second trimester (0.52±0.14), and slowed after 34 gestational weeks (0.46±0.26). In women with GDM, the average rate of weight gain was also lowest during the first trimester (0.18±0.23), but it was twofold higher compared with women with NGT. There was a significant decrease of the rate of weight gain after 28 gestational weeks in women with GDM. Total weight gain during pregnancy was 3.4 kg less in women with GDM. Neonatal birthweight was correlated with maternal weight gain and the rate of weight gain during 14-27 and 28-33 weeks in NGT. However, birthweight was correlated with maternal weight gain and the rate of weight gain during the first trimester and 14-27 weeks in GDM. Conclusion : This result suggests that the women with GDM who have greater weight gain during the first and the second trimester have a increased risk of excessive fetal growth. Thus strict glycemic control during pregnancy is needed especially in these women.