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아급성 육아종성 갑상샘염의 세침흡인 세포소견 -아급성 육아종성 갑상샘염 10예의 임상-세포소견 및 면역세포염색 소견 분석-
김도경,표주연,박종필,김연화,정우희,손은주,홍순원,Kim, Do-Kyung,Pyo, Ju-Yeon,Park, Jong-Pil,Jin, Lian-Hua,Jeong, Woo-Hee,Son, Eun-Ju,Hong, Soon-Won The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.1
Although subacute granulomatous thyroiditis(SGT) is usually diagnosed clinically, papillary carcinoma or other thyroid conditions must be considered in the differential diagnosis. We retrospectively reviewed the clinical and fine-needle aspiration(FNA) cytologic findings seen in 10 SGT cases to decide what are the most reliable cytologic findings and the most helpful molecular tools for reaching a confident cytologic diagnosis. The most representative smear slides were retrieved to perform immunocytochemistry for cytokeratin 19(CK19) and Ret protein. Five papillary carcinomas(PTCs) were included as controls. The constant and typical cytologic findings of SGT were multinucleated giant cells(MGCs) (100%), epithelioid granulomas(90%), an inflammatory dirty background(90%) and plump transformed follicular cells(80%) without fire-flare cells, oncocytic cells or transformed lymphocytes. The immunoreactivities for CK19(37.5%) and Ret(10%) of the follicular cells of SGT were less than those(CK19 and Ret:100%) of PTC. CK19 immunoreactivity of the MGCs was seen in only one case of PTC. There was no significant difference between CK19 and Ret immunocytochemical staining for the MGCs of both SGT and PTC. The results of this study demonstrate that the cytological diagnosis of SGT can be improved by employing a combination of the typical and constant diagnostic cytological features and immunocytochemical results.
소변검사의 재검 시 세포원심분리법과 액상세포검사 $ThinPrep^{(R)}$의 효율성에 관한 비교
김현경,표주연,이윤희,정우희,김세훈,홍순원,Kim, Hyun-Kyung,Pyo, Ju-Yeon,Lee, Yoon-Hee,Jung, Woo-Hee,Kim, Se-Hoon,Hong, Soon-Won 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1
Once diagnosed as "cell paucity"or "atypia" by the cytospin (CS) preparation, this CS preparation does not secure a precise diagnosis by repeated testing alone. Although the ThinPrep (TP) preparation is acknowledged to show increased cellularity, performing the screening tests for the cases that have enough cellularity, according to CS, raises issues for the cost-effectiveness. To obtain a more precise diagnosis through increasing the cellularity by performing TP, we selected the cases that were diagnosed as "cell paucity" or "atypia" by CS, but they required a more precise diagnosis, and the samples were processed via both CS and TP to compare the results. 11 patients diagnosed as "cell paucity" and 22 patients diagnosed as "atypia" by CS participated in this study. When the detection rate of atypical cells in both preparations with repeated urine cytology was compared, the overall detection rate of TP (16cases, 48.5%) was superior than that of CS (11cases, 33.3%), with statistical significance. The cellularity of both preparations was compared on repeated urine cytology; the general cellularity of TP (29cases, 87.9%) was higher than that of CS (20cases, 60.6%), but there was no statistical significance. Particularly, we repeated the TP for the 1 case that was diagnosed as "atypia" and we performed polyoma virus immunohistochemical staining, which confirmed polyoma virus. In conclusion, we can avoid obtaining negative diagnosis from cases with uncertain "atypia" or "cell paucity" by performing repeated TP testing.
다발성 골 침습과 병적 골절을 동반한 단일조직 랑게르한스 세포 조직구증: 증례 보고
허재승,김홍식,박용욱,표주연,이영호,박예수,Hur, Jae-Seung,Kim, Hong-Sik,Park, Yong-Wook,Pyo, Ju-Yeon,Lee, Young-Ho,Park, Ye-Soo 대한근골격종양학회 2013 대한골관절종양학회지 Vol.19 No.2
랑게르한스 세포 조직구증(Langerhans' cell histiocytosis)은 단핵구계에 속하는 정상 조직구들이 과도하게 증식하여 다양한 임상 경과와 치료결과를 보이는 질환 군으로 알려져 있다. 특히, 척추에 침범하는 경우에는 단발 혹은 다발성의 골 용해를 특징으로 한다. 병변의 침범 부위, 진행 정도 및 동반 증상에 따라 단순 경과 관찰에서부터 방사선 치료, 화학요법 및 수술적 치료에 이르기까지 다양한 치료법들이 적용되어 왔으나, 아직까지 확립된 치료법은 없는 것으로 알려져 있다. 저자들은 경추와 요추를 동시에 침범하면서 척추 내 골수 파괴 소견과 병적 골절을 동반한 단일조직 랑게르한스 세포 조직구증 환자에 대해 수술적 치료 및 전신화학요법을 시행한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Langerhans cell histiocytosis is known as one of the diseases related to excessive proliferation of normal monocytes and has the variety of clinical courses and treatment. Especially, in cases with the spine, it shows a feature of single or multiple osteolysis. According to the location, disease progression and concomitant symptom, variety of treatments (observation, radiotherapy, chemotherapy, surgery, etc.) have been attempted, however, appropriate treatment has not been established yet. The authors introduce the case of single system Langerhans cell histiocytosis which involves cervical and lumbar vertebrae simultaneously with bone marrow destruction and pathologic fracture.
강귀언 ( Gui Eon Kang ),진성아 ( Sung Ah Jin ),부혜연 ( Hye Yeon Boo ),표주연 ( Ju Yeon Pyo ),오영하 ( Young Ha Oh ),김승룡 ( Seung Ryong Kim ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.11
Primary malignant lymphomas in the female genital tract are rare, but when it occurs, the cervix or the ovary are more common site than the uterine corpus. Most common symptoms are abnormal vaginal bleeding but sometimes it is symptom free. Due to rarity of primary malignant lymphoma, the standard treatments are not yet established, but rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy after the surgery is general executed. We present a case of primary malignant lymphoma originating from endometrium with spine involvement.
김재훈 ( Jae Hoon Kim ),전용철 ( Yong Cheol Jeon ),이길우 ( Gil Woo Lee ),윤지영 ( Ji Young Yoon ),표주연 ( Ju Yeon Pyo ),오영하 ( Young Ha Oh ),한동수 ( Dong Soo Han ),손주현 ( Joo Hyun Sohn ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.2
A gastric carcinoma with the endoscopic features resembling a submucosal tumor (SMT) is rare, and reportedly accounting for 0.1% to 0.63% of all resected gastric carcinomas in Japan. A diagnosis of a SMT-like gastric carcinoma is often difficult as the tumors are almost entirely covered with normal mucosa. Furthermore mucinous gastric adenocarcinoma is uncommon histologic subtype of gastric cancer. These tumors are detected mostly in an advanced stage and rarely in an early stage. Early mucinous gastric adenocarcinoma is characterized as an elevated lesion resembling SMT due to abundant mucin pools in the submucosa. Here we report one case of SMT-like mucinous gastric adenocarcinoma, diagnosed by the usual endoscopic biopsy and treated with surgery. (Korean J Gastroenterol 2011;57:120-124)
췌장외 점액누출을 동반한 췌관내 유두상 점액종양에 의한 복막 가성점액종 1예
김해수 ( Hae Su Kim ),원영웅 ( Young Woong Won ),최정혜 ( Jung Hye Choi ),유교상 ( Kyo Sang Yoo ),여유미 ( Yoo Mi Yeo ),이지영 ( Ji Young Yhi ),표주연 ( Ju Yeon Pyo ),박훤겸 ( Hwon Kyum Park ) 대한췌담도학회 2013 대한췌담도학회지 Vol.18 No.4
복막 가성점액종은 원발병소에 관계없이 복막표면과 대망 등에 점액성 물질이 침착되면서 점액성 복수가 복강 내에 축적되는 상태를 말하는 임상적 질환이다. 원인질환으로 매우 드물지만 췌관내 유두상 점액종양이 보고되고 있으며, 시술과 관련된 점액의 누출, IPMN 파열 및 샛길 형성에 의한 복강내 점액누출 등이 유발기전으로 제시되고있다. 저자들은 췌장의 악성 IPMN 점액누출에 의해 발생한 복막 가성점액종 1예를 경험하였기에 문헌고찰과 함께보고하는 바이다. Pseudomyxoma peritonei (PMP) is a rare clinical entity characterized by gelatinous tumor implants within the peritoneal cavity and a large amount of mucinous ascites. Although most PMP cases originate in the appendix, few are associated with pancreatic intraductal papillary mucinous neoplasm (IPMN). IPMNs secrete thick mucin; therefore, they usually present with pancreatic duct dilatation. The presence of IPMN with extra-pancreatic mucin could be a marker of the eventual seeding of tumor outside the primary site. PMP associated with mucin leakage from pancreatic IPMN has been rarely reported. Here, we report the case of a patient with PMP that originated from pancreatic IPMN.
만성 C형간염 환자에서 페그인터페론 알파 2a에 의해 반복적으로 발생한 지방층염
송준석 ( June Seok Song ),손주현 ( Joo Hyun Sohn ),정재윤 ( Jae Yoon Jeong ),민지희 ( Ji Hee Min ),최원석 ( Won Seok Choi ),김원중 ( One Zoong Kim ),표주연 ( Ju Yeon Pyo ) 대한소화기학회 2016 대한소화기학회지 Vol.67 No.5
Pegylated interferon alpha (PEG-IFN-α) is widely used to treat chronic hepatitis C in combination with ribavirin. Many adverse effects of PEG-IFN-α, such as hematologic, psychologic, dermatologic, immunologic, and other abnormalities, have been reported, and some serious adverse events lead to PEG-IFN-α treatment discontinuation. For very rare adverse events such as panniculitis, there are no established guidelines on whether to continue PEG-IFN-α treatment. Published reports on panniculitis induced by PEG-IFN-α 2a are sparse. Herein we report a case of repeated occurrences of panniculitis in a patient with chronic hepatitis C, leading to treatment cessation. (Korean J Gastroenterol 2016;67:272-276)
옥트레오타이드를 이용한 유육종증과 동반된 유미흉의 보존적 치료
정경수 ( Kyung Soo Jung ),문지애 ( Ji Ae Moon ),윤설희 ( Sul Hee Yoon ),변민광 ( Min Kwang Byun ),정우영 ( Woo Young Jung ),정재희 ( Jae Hee Jung ),최상봉 ( Sang Bong Choi ),김대준 ( Dae Joon Kim ),표주연 ( Ju Yeon Pyo ),김영삼 ( 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.2
Sarcoidosis is a multi-system granulomatous disorder of an unknown etiology and affects individuals worldwide. It is characterized pathologically by the presence of non-caseating granulomas in more than one involved organ. However, pleural involvement of sarcoidosis is rare and there are no reported cases in Korea. Traditionally, sarcoidosis has often been treated with systemic corticosteroids or cytotoxic agents. In particular, chylothorax with sarcoidosis is usually treated with corticosteroid for approximately 3~6 months, followed by repeated therapeutic thoracentesis, talc pleurodesis, dietary treatment, or thoracic duct ligation where needed. We encountered a 46 years old female patient presenting with cough, dyspnea and both hilar lymphadenopathy (stage I) on chest radiograph. The patient was diagnosed with a non-caseating granuloma, sarcoidosis by a mediastinoscopic biopsy. For one month, she had suffered from dyspnea due to right side pleural effusion, which was clearly identified as a chylothorax on thoracentesis. Corticosteroid therapy with dietary adjustment was ineffective. She was treated successfully with a subcutaneous injection of octreotide for 3 weeks and oral corticosteroid. We report a case of successful and rapid treatment of chylothorax associated with sarcoidosis using octreotide and oral corticosteroid. (Tuberc Respir Dis 2007; 62: 119-124)