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소아 복막투석환자에서 혈관내피성장인자 유전자 다형성이 복막의 용질이동성에 미치는 영향
최현진,백경훈,조희연,강희경,정해일,최용,하일수,Choi, Hyun-Jin,Paik, Kyung-Hoon,Cho, Hee-Yeon,Kang, Hee-Kyung,Cheong, Hae-Il,Choi, Yong,Ha, Il-Soo 대한소아신장학회 2010 Childhood kidney diseases Vol.14 No.2
목 적 : 복막투석환자에서 복막의 용질이동성에 영향을 미치는 요인으로 유전적 요인과 임상적 요인이 있다. 복막평형검사는 복막투석환자의 복막 용질이동속도를 평가하는 데에 유용한 검사로, 본 연구에서는 소아 복막투석 환자에서 복막평형검사 결과를 이용하여 혈관내피성장인자(VEGF)의 유전자 다형성과 복막 용질이동성의 상관관계를 연구하였다. 방 법 : 서울대학교 어린이병원과 삼성서울병원의 소아 복막투석환자 중에서 복막염의 병력이 없고 복막투석 시작한 지 1년 이내에 복막평형검사가 시행된 환자를 대상으로 하였다. VEGF 유전자 -2578 C/A, -14978T/C, -1154G/A, -634G/C, +936 C/T의 단일 유전자다형성분석을 시행하였고 VEGF 유전자 다형성의 분포와 복막평형검사 결과간의 상관관계를 분석하였다. 결 과 : 복막평형검사를 분석한 결과, 4시간 크레아티닌의 투석액/혈장비(D/P creatinine)는 $0.56{\pm}0.13$였고 4시간 투석액/0시간투석액포도당비(D/$D_0$ glucose)는 $0.43{\pm}0.11$였다. 배수체 CTGGC의 이형접합체 또는 동형접합체인 경우가 배수체 CTGGC를 가지지 않은 경우에 비해 높은 4시간 D/P creatinine ($0.67{\pm}0.12$ vs $0.50{\pm}0.09$, P=0.007)과 은 4시간 D/$D_0$ glucose ($0.35{\pm}0.12$ vs $0.47{\pm}0.08$, P=0.037)를 보였다. 결 론 : VEGF 유전자 다형성은 복막 용질이동성에 영향을 미칠 수 있다. Purpose : Genetic and clinical factors can influence the permeability of the peritoneal membrane. The peritoneal equilibration test (PET) is helpful in measuring peritoneal permeability in peritoneal dialysis (PD). We investigated the influence of genetic polymorphism of vascular endothelial growth factor (VEGF) on the PET parameters. Methods : Pediatric patients who underwent PET within 12 months of initiating PD at Seoul National University Children's Hospital and Samsung Medical Center were selected. The patients with positive history of peritonitis before PET were excluded. The VEGF -2578C/A, -14978T/C, -1154G/A, -634G/C, and +936C/T single-nucleotide polymorphisms were genotyped. Results : The mean 4-hour dialysate-to-plasma ratio for creatinine (D/P creatinine) and the mean 4-hour dialysate glucose to baseline dialysate glucose ratio (D/$D_0$ glucose) were $0.56{\pm}0.13$ and $0.43{\pm}0.11$, respectively. The patients with haplotype CTGGC showed higher 4-hour D/P creatinine ($0.67{\pm}0.12$ vs $0.50{\pm}0.09$, P=0.007) and lower 4-hour D/$D_0$ glucose ($0.35{\pm}0.12$ vs $0.47{\pm}0.08$, P=0.037) than those without haplotype CTGGC. Conclusion : The VEGF genetic polymorphism may influence the peritoneal solute transport.
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최현진,송윤경,여장옥,허세형,진성민,Choi, Hyun-Jin,Song, Yun-Kyung,Yeo, Jang-Ok,Huh, Se-Hyung,Jin, Sung-Min 대한후두음성언어의학회 2008 대한후두음성언어의학회지 Vol.19 No.2
Background and Objectives: The voice changes can occur in peritonsillar abscess and the labeling of this changes as a "muffled voice". The aim of this study was to investigate the changes in acoustic feature of voice before and after treatment in patients with peritonsillar abscess. Materials and Method: 12 patients with peritonsillar abscess were enrolled in the study. Acoustic analysis on sustained Korean vowels /a/, /i/ and /u/ were performed before and after treatment. Results: In patients with peritonsillar abscess, the first formant frequency (F1) and second formant frequency (F2) of /a/ were decreased. There was tendency of articulation of back-low vowel /a/ as back-high vowel /u/. F1 of /i/ and /u/ were increased, while F2 were decreased. There was tendency of articulation of front-high vowel /i/ as back-low vowel /a/. The third, forth, fifth formant frequency (F3, F4, F5) of /a/, /i/ and /u/ were decreased although statistically not significant. Conclusion: The anatomical and functional changes of oropharynx by peritonsillar abscess can cause changes in resonance and speech quality. We suggest that these changes could be the cause of 'muffled voice' in patients of peritonsillar abscess.
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제1형 당뇨병 환자에서 병발한 막증식성 사구체신염 1례
최현진,조희연,강주형,양세원,정해일,최용,문경철,하일수,Choi Hyun-Jin,Cho, Hee-Yeon,Kang Ju-Hyeong,Yang Sei-Won,Cheong Hae-Il,Choi Yong,Moon Kyung-Chul,Ha Il-Soo 대한소아신장학회 2005 Childhood kidney diseases Vol.9 No.1
저자들은 당뇨병성 신병증의 자연경과에 맞지 않는 요검사상 이상 소견을 보인 제 1형 당뇨병을 가진 소아에서 신생검을 시행하여 막증식성 사구체 신염을 진단하였기에 보고하는 바이다. Renal diseases other than diabetic nephropathy can occur In diabetic patients. Urinary abnormalities or clinical courses inconsistent with the natural progression of diabetic nephropathy are suggestive of non-diabetic renal diseases and should lead to more extensive investigations. Presence of non-diabetic renal diseases in diabetic patients can alter the treatment plan and the prognosis. We report a 9-year-old girl who had type 1 membranoproliferatiye glomerulonephritis as well as type 1 diabetes mellitus.
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소아 Henoch-$Sch{\ddot{o}}nlein$ 신염의 예후 인자
최현진,조희연,김어진,이병섭,강희경,하일수,정해일,최용,Choi Hyun Jin,Cho Hee Yeon,Kim Eo Jin,Lee Byong Sop,Kang Hee Gyung,Ha Il Soo,Cheong Hae Il,Choi Yong 대한소아신장학회 2005 Childhood kidney diseases Vol.9 No.2
목 적 : 소아 HSPN의 임상 경과와 이에 영향을 미치는 예후 인자를 조사하였다. 방 법 : 소아 HSPN 환자 75명(남아 44명, 여아 31명)을 대상으로 하였으며 발병연령은 $8.0{\pm}3.1$세(2.3-l5.3세)였고 추적관찰 기간은 $4.3{\pm}3.6$년(1.0-17.1년)이었다. 신생검은 24명(32$\%$)에서 시행되었다. 발병시 임상 양상과 검사 결과를 조사하였으며, 대상 환자들의 RAS 유전자의 다형성(ACE 유전자의 I/D 다형성, AGT 유전자의 M235T 다형성, AGTR 유전자의 A1166C 다형성)에 대해 검사하였다. 발병시와 마지막 추적관찰시 임상 상태는 다음과 같이 4군으로 분류하였다: A, 정상; B, 정도의 소변이상; C, 활동성 신질환(신증후군 범위의 단백뇨) 또는 고혈압 소견을 보이면서 혈청 크레아티닌 1.5 mg/dL 이하; D, 신부전. 결 과 : 발병시 환자들의 임상 상태는 26명(35$\%$)이 B, 45명(51$\%$)이 C였고 D가 3명(4$\%$)이었다. RAS 유전자 다형성의 분포는 100명의 건강한 대조군과 다르지 않았다. 마지막 추적관찰시 환자들의 임상 상태는 A가 23명(31$\%$), B가 38명(50$\%$), C가 9명(12$\%$), D가 5명(7$\%$)이었다. Multiple logistic regression 결과 발병 연령과 발병시 단백뇨의 양이 유의한 예후 인자로 확인되었다. RAS 유전자는 HSPN의 예후 인자로 통계학적 유의성이 없었다. 결 론 : 본 연구에서는 발병 연령이 높을수록, 발병시 단백뇨의 양이 많을수록 소아 HSPN의 예후가 나쁜 것으로 나타났고 RAS 유전자는 HSPN의 예후와 상관 관계가 없었다. 더 정확한 연구를 위해서는 더 많은 수의 환자를 대상으로 전향적인 연구가 필요하리라 생각한다. Purpose : The long term disease course and prognostic factors were evaluated in childhood Henoch-$Sch{\ddot{o}}nlein$ puruura nephritis(HSPN). Methods : A total of 75 children(44 boys and 31 girls) with HSPN were included in this study. The onset age was $8.0{\pm}3.1$ years(2.3-l5.3 years), and the follow-up period was $4.3{\pm}3.6$ years(1.0-17.1 years). Kidney biopsy was done in 24 children(32$\%$). Initial clinical and laboratory findings were evaluated. In addition, polymorphisms of the renin angiotensin system(RAS) genes(insertion/deletion in intron 16 of ACE gene, M235T in AGT gene, and A1166C in AGTR gene) were analysed. The initial and last clinical states were classified into 4 groups as follows A, normal; B, minor urinary abnormalities; C, active renal disease (nephrotic-range proteinuria and/or hypertension with serum creatinine $\leq$1.5 mg/dL); D, renal insufficiency. Results : At the onset, the clinical states of the patients were B in 26(35$\%$), C in 46(61$\%$), and D, in 3(4$\%$). The distribution of the RAS gene polymorphism of HSPN were not different from that of 100 healthy control subjects. At the last follow-up, the clinical states of the patients were A in 23(31$\%$), B in 38(50$\%$), C in 9(12$\%$), and D in 5(7$\%$). A multiple logistic regression identified age at the onset and initial urine protein excretion as significant prognostic factors. Analysis of genotypes of the 3 RAS genes as prognostic values revealed no statistical significance. Conclusion : Older age at onset and severe proteinuria were identified as poor prognostic factors of childhood HSPN. Implication of the RAS gene polymorphism In HSPN could not be validated in this small-scale retrospective study. (J Korean Soc Pediatr Nephrol 2005;9:183-192)
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최현진,남기원,Choi, Hyun-Jin,Nam, Ki-Won 대한물리치료학회 2014 대한물리치료학회지 Vol.26 No.4
Purpose: The purpose of this study is to examine the effects of using a horseback riding simulation on static balance in children with cerebral palsy. Methods: This study was conducted with 30 children with cerebral palsy at levels I~IV in the Gross Motor Function Classification System (GMFCS), who were randomly divided into a control group and a hippotherapy group. Both the control group and the experimental group received NDT for 30 minutes per session, four times per week, for ten weeks, while the experimental group also received hippotherapy, 15 minutes per session, four times per week, for ten weeks, after the neurodevelopmental treatment (NDT). The horseback riding simulators JOBA (JEU7805, Panasonic, 일본) used in this study simulated actual horse movements; static balance was measured in each group before the exercise and five weeks and ten weeks after the beginning of the exercise using a pedoscan system (Diers Pedo, Germany). Results: The intergroup effects on static balance were tested, and the results showed no significant differences (p<0.05). Conclusion: The horseback riding simulation exercise was shown to be effective for the static balance of children with cerebral palsy. Therefore, additional studies should be conducted with more children with CP divided according to type.
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최현진,오영근,전기찬,이승춘,이경환 ( Hyun Jin Choi,Young Kun Oh,Ghi Chan Jun,Sung Chun Lee,Gyung Whan Lee ) 한국주조공학회 1997 한국주조공학회지 Vol.17 No.6
N/A Coating materials for Evaporative Pattern Casting (EPC) process have been developed to investigate the effect of refractories on coating material properties. Three types of developed and one foreign coating materials were used. The former designated as A, B, C and the latter named S.K. The refractory of coating material A is spherical shape of zirconia, and the ones of B, C and S.K. is flake shape of mica. Strength, permeability at room and elevated temperature, anti-sand attachability and carbon residuary were evaluated at each coating materials. Permeability measurement device for elevated temperature was also designed. The zirconia type of coating material had excellent permeability, on the other hand the mica type had good strength and anti-sand attachability. It was found that the refractories were not broken during casting, so permeability indicated same trend at both room and elevated temperature. Based on results, coating material contained small size of mica which is designated as B has the best combination for cast iron. (Received September 29, 1997)
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트레드밀 훈련이 경직성 양하지 마비 아동의 대동작 운동 기능에 미치는 영향
최현진,김윤환,Choi, Hyun Jin,Kim, Yoon Hwan 대한물리치료과학회 2012 대한물리치료과학회지 Vol.19 No.3
The purpose of this study was to apply treadmill training through motor learning to cerebral palsy children and examine its effects on their Gross Motor Functions. The subjects of this study were 13 spastic diplegia children who had difficulty in independent gait, and GMFCS level III, IV. We performed treadmill gait training using the principle of weight bearing, based on 4times a week for 30 minutes before and after each session physical therapy we gave weight bearing treadmill training 5 to 10 minutes, during 7 weeks(April 9, 2012~May 26, 2012) fittingly for the children's gait characteristics. In order to test how the weight bearing treadmill training affects spastic diplegia children's gross motor functions, we measured body mobility with Gross Motor Function Measure (GMFM). These data were collected before and after the experiment and analyzed through comparison. Data collected from the 13 spastic diplegia children the results were as follows. For evaluating with regard to change in body mobility, significant difference was observed between before and after the experiment in measured gross motor functions, which were crawling, kneeling, standing, walking, jumping and running(p<0.05). According to the results of this study, when gait training through motor learning was applied to spastic cerebral palsy children, it made significant changes in their body mobility. Accordingly, for the effective application of gait training through motor learning to cerebral palsy children, it is considered necessary to make research from different angle on how such training affects children's mobility, activity of muscles in the lower limbs, and gait characteristics.
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