[학생기자단 기사] 가을 건축 답사 여행을 떠나요~♬

박용주(Park, Yong-Ju),최찬일(Choi, Chan-Il),심애리(Sim, Ae-Ri) 대한건축학회 2014 建築 Vol.58 No.10

브라우저 확장 기반 웹 문서 수집기

최찬(Chan Choi),정근성(Junggeung Sung),한성재(Sungjae Han),이강태(Kangtae Lee),차재혁(Jaehyuk Cha) 한국정보과학회 2017 한국정보과학회 학술발표논문집 Vol.2017 No.06

토끼 후두내 삽입한 풍선도관에 대한 단기 조직 반응

유영삼,최찬,김동원,Yoo, Young-Sam,Choi, Chan,Kim, Dong-Won 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.1

Objectives : This study was aimed to investigate soft tissue reaction such as inflammation, immune reaction of rabbit larynx to implanted foley catheter. Methods : After 8 rabbits were anesthetized, their thyroid cartilage and trachea were exposed through a skin incision and a 6 French foley catheter was inserted into the thyroid cartilage via cricothyroid membrane and ballooned with normal saline (0.1 mL). The other end of catheters were ligated and cut. The wound was closed keeping catheter under the skin. Two rabbits were used as normal control Larynges were removed for pathologic examination at 4weeks and 8 weeks of the study respectively, Results : Ten rabbits were euthanized for gross and pathologic examination (5 rabbits after 4 weeks and 5 rabbits after 8 weeks). All rabbits survived the study periods and inflammations or foreign body reactions were minimally found on pathologic examinations. Conclusions : Foley catheter could be useful and safe material for vocal fold medialization in rabbit models.

풍선도관을 이용한 새로운 갑상성형술의 제안

유영삼,최찬,김희주,Yoo, Young-Sam,Choi, Chan,Kim, Heui-Ju 대한후두음성언어의학회 2007 대한후두음성언어의학회지 Vol.18 No.2

Background and Objectives: Silicone, Gore- Tex, Gelfoam, Collagen and autologous fat are used for thyroplasty in case of vocal fold paralysis or paresis. These implants have many advantages, such as biocompatibility, low price and easy handling and accessibility. But additional voice modification is impossible using these materials. So, we design new thyroplasty technique, called balloon thyroplasty using Foley catheter. Materal and Methods: The fresh human larynx was dissected in midline posteriorly. Minithyrotomy hole was created using 5mm cutting burr in the midline of thyroid cartilage. Subperichondrial dissection was done using Duckbill elevator up to vocal process. Balloon catheter(1.5cm balloon size) was inserted through the subperichondrial tunnel. The balloon was inflated to medialize the vocal cord. Results: After ballooning, the true vocal cord medialized mimicking thyroplasty. Conclusion: The authors found that Balloon thyroplasty could be a good candidate for vocal fold medialization technique. The technical refinement and in vivo safety are reserved for the ongoing study.

Claudin-7 is Highly Expressed in Chromophobe Renal Cell Carcinoma and Renal Oncocytoma

Yoo Duk Choi,정상우,최찬,Ki Seung Kim,Sunhyo Ryu,박영규,조남훈,나서희,장자준,Jae Y Ro 대한의학회 2007 Journal of Korean medical science Vol.22 No.2

Claudin-7 has recently been suggested to be a distal nephron marker. We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron. We examined the immunohistochemical expression of claudin-7 and parvalbumin in 239 renal tumors, including 179 clear cell renal cell carcinoma (RCC)s, 29 papillary RCCs, 20 chromophobe RCCs, and 11 renal oncocytomas. In addition, the methylation specific-PCR (MSP) of claudin-7 was performed. Claudin-7 and parvalbumin immunostains were positive in 3.4%, 7.8% of clear cell RCCs, 34.5%, 31.0% of papillary RCCs, 95.0%, 80.0% of chromophobe RCCs, and 72.7%, 81.8% of renal oncocytomas, respectively. The sensitivity and specificity of claudin-7 in diagnosing chromophobe RCC among subtypes of RCC were 95.0% and 92.3%. Those of parvalbumin were 80.0% and 88.9%. The expression pattern of claudin-7 was mostly diffuse in chromophobe RCC and was either focal or diffuse in oncocytoma. All of the cases examined in the MSP revealed the presence of unmethylated promoter of claudin-7 without regard to claudin-7 immunoreactivity. Hypermethylation of the promoter might not be the underlying mechanism for loss of its expression in RCC. Claudin-7 can be used as a useful diagnostic marker in diagnosing chromophobe RCC and oncocytoma.

미세절편으로 얻은 위암 조직세포에서 p53 유전자의 돌연변이와 종양단백 발현에 관한 연구

김철,주재균,최찬,김영진,Kim Chul,Joo Jai Kyun,Choi Chan,Kim Young Jin 대한위암학회 2003 대한위암학회지 Vol.3 No.3

Purpose: The p53 tumor suppressor gene is believed to play a pivotal role in preventing the uncontrolled cellular growth characteristic of cancer. Mutation of the p53 gene represent one of the most common genetic alterations in human cancers, and the acquisition of such defects is strongly associated with tumor progression and metastasis. The aim of this study was to evaluate the relation between p53 immunoreactivity and the mutation of p53 gene in gastric adenocarcinoma obtained by laser capture microscope. Materials and Methods: Formalin fixed paraffin embedded tissue specimens were obtained from 20 patients who underwent surgery for gastric cancer. According to UICC TNM system, 3 of the cases were Ia, 2 cases II, 4 cases IIIa, 5 cases IIIb, and 6 cases IV. Results: Immunohistochemical staining revealed eight cases as negative (less than $10\%$), twelve cases as postive (more than $10\%$). The locations of mutations were as follows; 7 cases had point mutation at exon 4, and 3 cases point mutation at exon 8. There was no mutation at exon 5, 6, 7 and 9. The mutation was observed in 1 case out of 8 p53 oncoprotein negative cases, and 7 cases out of 12 p53 positive cases. The mutation was more common in p53 positive cases (P<0.05), However, there was no significant correlation between p53 mutation observed by DNA sequencing after laser capture microdissection and expression of p53 oncoprotein. Conclusion: These result suggest that he expression of p53 oncoprotein not to be related to the mutation of p53 gene at exons 4 through 9 in gastric cancer.

Thanatophoric Dwarfism 1 예

김흥곤 ( HG Kim ),최찬 ( C CHoi ),박현미 ( HM Park ),최영득 ( YD Choi ) 대한산부인과학회 1991 Obstetrics & Gynecology Science Vol.34 No.9

저자들은 본원 산부인과에서 25세 초산부에서 출산된 재태기간 37주 남아의 부검결과로 판명된thanatophoric dwarfism 1예를 경험하였기에 문헌적 고찰과 함께 보고하는 바이다. Thanatophoric dwarfism is a lethal from of bone dysplasia described by Morteaus, Lamy and Robert in 1967. We experienced a case of thanatophoric dwarfism with relatively large head, narrow thorax and short limbs. It has been confused with achondroplastic and another congenital short limb dwarf condition. The diagnosis was confirmed by clinical features, radiographic and autopy findings. We reported one case of thanatophoric dwarfism with a review of literatures.

오프라인 커뮤니케이션 유무에 따른 네트워크 별 정보전달 방법 비교 분석

박원국(Won Kuk Park),최찬(Chan Choi),문현실(Hyun Sil Moon),최일영(Il Young Choi),김재경(Jae Kyeong Kim) 한국지능정보시스템학회 2011 지능정보연구 Vol.17 No.4

최근 페이스북, 트위터 등 다양한 소셜 네트워크 서비스(SNS)가 등장하였으며, 많은 사용자들이 SNS를 이용하고 있다. 이러한 사용자의 증가로 인해 많은 조직들은 SNS에 관심을 가지게 되었다. 조직에서 SNS의 사용은 다양한 이점을 지니고 있다. SNS를 통해 조직들은 사용자들의 행위에 신속하고 지속적으로 반응할 수 있고, 다양한 특성을 지닌 사용자에게 쉽게 접근할 수 있으며, 타 매체에 비하여 사용자 특성이 반영된 차별화된 전략을 세울 수 있다. 또한 기업들은 SNS를 통해 상대적으로 저렴한 비용으로 활용이 가능하며, 사용자들과 양방향 소통이 가능하여 친근성과 신뢰성이 있는 관계 구축이 용이하다. 그러나 네트워크의 특성에 따라 SNS의 정보전달의 효과가 다르게 나타남에도 불구하고 조직들은 네트워크의 특성을 고려하지 않고 획일화된 방법으로 SNS를 활용하여 사용자들과 커뮤니케이션하고 있다. 따라서 본 연구에서는 네트워크에 따른 SNS의 정보전달의 효과 차이를 분석하였다. 즉 오프라인에서의 커뮤니케이션 기반으로 형성된 네트워크와 무작위로 형성된 네트워크를 생성하여, 각각의 네트워크들의 특징 차이를 분석하기 위하여 소셜 네트워크 분석을 하였다. 또한, 각각의 네트워크에서 SNS를 이용한 정보 전달 효과의 차이가 있는지 실증적으로 검증하였다. 실증 분석후 네트워크의 특성에 따라 네트워크 내 사용자들은 SNS를 받아들이는 반응이 달랐다. 따라서 조직이 효과적인 마케팅 수단으로 소셜 네트워크를 활용하기 위해서는 그 목적에 따라 네트워크의 특성을 고려하여 적절한 네트워크 형태를 구성해야 함을 도출하였다.

유방에 발견한 원발신 악성 림프종의 세침흡인 세포학적 소견 - 1예 보고 -

김현중,이경화,김조헌,심민근,최찬,이지신,Kim, Hyun-Joong,Lee, Kyung-Hwa,Kim, Jo-Heon,Shim, Min-Keun,Choi, Chan,Lee, Ji-Shin 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.2

Lymphoproliferative disorders, manifesting either as a primary lesion or as part of a generalized process, rarely involve the breast. The primary malignant lymphoma of the breast is rare. The cytologic features of this neoplasm have not been reported in Korea thus far. We described a case of primary malignant lymphoma of the breast, as diagnosed by fine needle aspiration cytology (FNAC) in an 84-year-old female. FNAC smears showed high cellularity. The main cytologic feature observed was a carpeting of monotonous, atypical, enlarged lymphoid cells. These lymphocytes showed relatively round elliptical nuclei with some indentation. One or more prominent nucleoli were seen. Biopy from the breast mass revealed diagnostic features of non-Hodgkin's lymphoma, diffuse large B-cell type.

위선암에서 안지오포이에틴 1 , 2 의 발현 및 병기와 림프절 전이와의 관계

이완식(Wan Sik Lee),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),김세종(Sei Jong Kim),김영진(Young Jin Kim),박창수(Chang Soo Park),고규영(Gou Young Koh),최찬(Chan Choi) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5

Background/Aims: In the process of tumor invasion, angiogenesis is prerequisite for tumor growth. Many studies have shown that angiogenesis plays an important role in the growth, progression, and metastasis of solid tumors. Recently, several angiogenic factors, angiopoietin 1 (Ang-1) and its naturally occurring antagonist angiopoietin 2 (Ang-2), have been identified. They are novel ligands that bind to the Tie-2 receptor on endothelial cells. Ang-1 activates Tie-2 receptor on endothelial cells to promote recruitment and interaction with support cells such as pericytes and smooth muscle cells. In contrast, Ang-2 reduces matrix contacts and interactions of support cells with endothelial cells, which are necessary for the neovascularization process to occur. Methods: In order to investigate the role of Ang-1 and Ang-2 in invasion and metastasis of the adenocarcinoma of the stomach, 108 cases of gastric adenocarcinomas were selected. These cases include 53 early gastric carcinoma (EGC) and 55 advanced gastric carcinoma (AGC). The specimens were stained with the Ang-1 and Ang-2 antibodies by immunohistochemical staining method. Results: The expression level of the Ang-1 and -2 is statistically correlated with the depth of invasion (T factor) and the lymph node metastasis (N factor) (P<0.001). Both Ang-1 and Ang-2 were more strongly and extensively expressed in AGC than in EGC (P<0.001). Carcinoma cells that metastasized to lymph nodes showed a stronger and more extensive staining pattern than their primary counter part of adenocarcinoma (P<0.001). Conclusions: These results indicate that both Ang-1 and Ang-2 are important in invasion and metastasis of gastric adenocarcinoma.