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발육제한 태아에서 placental ratio 와 신생아 이환률과의 관계
이준희(Jun Hee Lee),정인배(In Bai Chung),이영심(Young Sim Lee),최중호(Jung Ho Choi),이정렬(Jeong Yel Lee),한혁동(Hyuck Dong Han),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A An increased placental ratio has known to be associated with the occurrence of cardiovascular complications in adulthood among the intrauterine fetal growth restriction. A retrospective study on 202 singleton growth-restricted infants without major congenital anomalies born from Jan. 1995 to Feb. 2001 was performed to determine the relationship between placental ratio and neonatal morbidity. The cases were categorized into three groups according to the placental ratio (<1SD below the mean, within 1SD of the mean, >1SD above the mean). There were no differences in the maternal characteristics and antenatal complications except pregnancy induced hypertension between high placental ratio group and the other groups. It presented the trend that was toward the increase of placental weight and the decrease of birth weight in high placental ratio group. The infants with a high placental ratio had increasing tendencies of meconium stained amnionic fluid, hypocalcemia, phototherapy, asphyxia.
체외수정 및 배아이식술후 임신과 자연 임신된 임신부에서 임신중기 삼중표지물질 검사결과의 비교분석
이정렬(Jeong Lyol Lee),이영심(Young Sim Lee),이상학(Sang Hag Lee),최중호(Jung Ho Choi),정인배(In Bai Chung),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : To compare and analysis the result of second trimester maternal serum triple marker screening test for Down syndrome and open neural tube defects in singleton pregnancies conceived by conventional in vitro fertilization- embryo transfer (IVF-ET) with that of the naturally conceived pregnancies. Methods : Maternal serum screening tests during the second trimester in 49 singleton pregnancies conceived by IVF-ET and 813 singleton pregnancies conceived naturally of whom delivery outcome was normal in each other were analyzed from April 1997 to June 2000. Results : 4 (8.2%) out of 49 cases of IVF-ET singleton pregnancies compared with 62 (7.6%) out of 813 cases of naturally conceived pregnancies had a positive results for Down syndrome or open neural tube defects. The median level of the triple markers were 1.03 0.47 multiples of the median (MoM) in IVF-ET pregnancies vs 1.05±0.39 MoM in natural pregnancies for alpha-fetoprotein (AFP), 1.11±0.64 vs 1.19±1.13 MoM for unconjugated estriol (uE3) and 1.21±0.56 vs 1.11±0.59 MoM for human chorionic gonadotropin (hCG). Conclusion : The positive rate of triple test and the median values of triple markers for Down syndrome and open neural tube defect between two groups were not different in terms of statistical significance. To provide an objective assessment of an individual patient's risk of fetal abnormality, the impact of IVF-ET on triple marker biochemistry should be studied further in larger samples and adjustments made if appropriate.