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안성구,황상민,김선욱,최응호,안형진 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.3
Background:The umbilicus is a simple scar that obliterates the portal through which the omphalomesenteric duct connected the primitive gut to the yolk sac; through which the intestine was expelled prior to its rotation; through which passed the umbilical arteries and vein; at which the allantosis attached to the early urinary bladder; and at which the umbilical cord that carried these structures was fused to the body wall. The umbilicus is situated at the level of L3 to L4 in the midline of the abdomen. It's shape, size, and configuration vary greatly related to age and sex. Deramtoses of the umbilicus are umbilical hernia, congenital abnormalities, granulomas, omphalith, infections, eczema and tumors. Objective:The purpose of this study was to examine the umbilical shape and size related to age and sex and diseases of the umbilicus. Methods:During a 6-month-period from May to October, 1998, 420 person's umbilical shapes and size were examined with regard to age and sex. The diseases of the umbilicus were evaluated, too. Results & Conclusions: 1. The mean vertical diameter of the umbilicus is 1.89±0.65cm and the mean transverse diameter is 1.98±0.86cm. The mean diameter of umbilicus in women(vertical: 1.98±0.73cm, transverse: 2.07±0.99cm) is larger than the mean diameter of umbilicus in men(vertical: 1.80±0.53cm, transverse: 1.89±0.66cm)(p$lt;0.05). 2. The vertical diameter of umbilicus in both sexes showed increasing aspect until the 30-39 year old group, and the transverse diameter of umbilicus in both sexes showed increasing aspect until the 40-49 year old group. 3. The shapes of umbilicus were divided into the protruded type and the depressed type. Most of our cases showed the depressed type. The protruded types were more in the 0-9 year old group(23%) than other year old groups. The shapes of umbilicus were divided into the round type and the elliptical type, too. The elliptical type(transverse diameter$gt;vertical diameter) is more than the elliptical type(vertical diameter$gt;transverse diameter) in men, and the elliptical type(vertical diameter $gt;transverse diameter) is more than the elliptical type(transverse diameter$gt;vertical diameter) in women. 4. The diseases of the umbilicus are allergic contact dermatitis(6 cases), pityriasis rosea(5 cases), psoriasis(3 cases), scabies(3 cases), rhus dermatitis(2 cases), pemphigus(2 cases), drug eruption(1 case), and insect bite(1 case).
역 모낭성 각화증의 임상적 고찰 및 Human Papillomavirus의 검색에 관한 연구
안성구,이인욱,최응호,이원수,이승헌,이동원 ( In Wook Lee,Eung Ho Choi,Sung Ku Ahn,Won Soo Lee,Seung Hun Lee,Dong Won Lee ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.6
Background : Inverted follicular keratosis has distinctive histopathological features and is infre quently encountered by dermatologists. To date, the pathogenesis of inverted follicular keratosis has not, been concluded. Many authors have suggest,ed several theories for the nature of invert.ed follicular keratosis including vearuca vulgaris with squamous eddies, irritated seborrheic keratosis and dist,inctive follicular tumors. Objective : It is the purpose of this study to observe and compare the clinical features of in verted follicular keratosis with previous studies and evaluate the possible relationship between in verted follicular keratosis and human papillomavirus to clarify the nature of this condition. Methods : We studied 9 patients with inverted follicular keratosis for clinical features including the duratiori of the disease, the location and size of the lesions, the clinical impressions at the first visit and we made a record of the patients age and sex. To evaluate the relationship be tween inverted follicular kerato is and the human papillomavirus, we performed immunohistochvm ical staining using polyclonal antibodies to the human papillomavirus common antigen. We also used the polymerase chain relation to detect hurnan papillomavirus DNA in inverted follicular keratosis from paraffin embedded tissue preparation. Results : 1. Seven of the 9 patients,vere male and the ages ranged fiom 36 to 77 years(mean 53 years). The lesions were situat d on the face(4/9),abdomen(1/9), back(1/9), chest(1/9), scapular area(1/9) and leg(1/9). The average size of the lesions was 1.5 cm. Verruca vulgaris was the most common clinical diagnosis(3/9), followed by seborrheic keratosis(2/9), soft fibroma(2/9), pigmented nevi(1/9), and granioloma pyogenicum(1/9). 2. Immunohistochemical stainiiigs using polyclonal antibodies to the human papillomavirus common antigen were negative for all 9 cases. 3. Polymerase chain reaction; using primers for human papillomavirus DNA were negative for all 9 cases. Conclusipn : In general, our linical findings are similar to those of others in previous studies. Our results of immunohistocheriiical staining and the polymerase chain reactions suggest, that in vert,ed follicular keratosis is ncl, related to the human papillomavirus. Further investigat.ions inf'o the nature of invert,ed follicular keratosis, should be centered on initated seborrheic keratosis and distinct follicular tumor s. (Korean J Dermatol 1997;35(6): 1074-1081)
두피 건선에 대한 Calcipotriol 액의 치료 효과
안성구,한승경,최응호,이인욱 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.1
Background : Calcipotriol ointment has been reported to be a safe and effective treatment for patients with psoriasis vulgaris. Scalp involvement of psoriasis is extremely common and in some patients the scalp may be the only affected site. Objective: Our purpose was to assess the efficacy, safety and tolerability of calcipotrial solution(50 u g/ml) in the treatment of scalp psoriasis. Methods: Twenty five patients with mild to moderate scalp psoriasis were treated with calcipotriol solution(50 u g/ml) twice daily for 8 weeks. Efficacy as measured by erythema, thickness and scale of the lesions and safety were assessed every 2 weeks. Results: Reduction of scores of erythema, thickness and scale of the lesions was statistically significant through the treatment. The extent of psoriasis and itching also decreased. An analysis of the overall assessment by investigator and patients at the end of the treatment showed cleared or marked improvement in 80% and 68% individually. Some patients developed a mild and transient burning sensation(2%) or lesional irritation(2%). Laboratory tests including serum calcium levels did not show any significant changes. Conclusion: Calcipotriol solution can be used as an effective and safe treatment method for scalp psoriasis.