한국인의 반복자연유산 환자에서 Thymidylate Synthase Enhancer Region (TSER) 돌연변이형의 혈중 호모시스테인 양과의 관련성

최윤경,강명서,김남근,김선희,최동희,안명옥,이수만,Choi, Yoon-Kyung,Kang, Myung-Seo,Kim, Nam-Keun,Kim, Sun-Hee,Choi, Dong-Hee,An, Myung-Ok,Lee, Su-Man 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.3

Objectives: Methylenetetrahydrofolate reductase (MTHFR) mutation are commonly associated with hyperhomocysteinemia, and through their defects in homocysteine metabolism, they have been implicated as a risk factor for recurrent spontaneous abortion. Recent report describe that 28-bp tandem repeat polymorphism in thymidylate synthase enhancer region (TSER) that influence enzyme activity would affect plasma homocysteine level. We have investigated the relationship between TSER genotype and plasma homocysteine level in 54 patients with recurrent spontaneous abortion. Methods: Plasma homocysteine level was measured by fluorescent polarizing immunoassay. MTHFR mutation (C677T and A1298C) was identified by PCR-restriction fragment length polymorphism assay and TSER mutation was analyzed by PCR method. The data were analyzed using the program SAS 8.2 for Windows. Results: Total homocysteine level was significantly higher in MTHFR 677TT genotype ($9.80{\pm}3.87{\mu}mol/L$) than MTHFR 677CC genotype ($8.14{\pm}1.74{\mu}mol/L$) in Korean patients with unexplained recurrent spontaneous abortion (p=0.0143). However, the plasma homocysteine level was not significantly different in the MTHFR 1298AA ($8.42{\pm}2.65{\mu}mol/L$) and 1298CC ($6.09{\pm}0.32{\mu}mol/L$; p=0.2058) and, TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and 3R3R ($8.05{\pm}2.81{\mu}mol/L$; p=0.9319) mutant genotypes, respectively. In this study, we found the combination effects of TSER and MTHFR C677T genotypes. Plasma homocysteine levels were the highest ($11.47{\pm}4.66{\mu}mol/L$) in individuals with TSER 3R3R ($8.05{\pm}2.81{\mu}mol/L$) and MTHFR 677TT ($9.80{\pm}3.87{\mu}mol/L$) genotypes. Individuals with a combination of both TSER 2R2R/2R3R and MTHFR 677CC/CT genotypes ($7.69{\pm}1.77{\mu}mol/L$) had lower plasma homocysteine levels than TSER 2R2R ($8.61{\pm}1.68{\mu}mol/L$) and MTHR 677CC ($8.14{\pm}1.74{\mu}mol/L$) genotypes, respectively. The effect of MTHFR polymorphism in the homocysteine metabolism appears to be stronger than that of TSER polymorphism. Conclusion: Although statistically not significant, we found the elevated level of plasma homocysteine in combined genotypes with TSER and MTHFR (C677T and A1298C) in Korean patients with unexplained habitual abortion. In this study, we reported the possibility that TSER polymorphism is a genetic determinant of plasma homocysteine levels in the Korean patients as well as MTHFR C677T polymorphism. A large prospective study is needed to verify our findings.

디지털 강의자원 관리를 위한 메타데이터 요소에 관한 연구

최윤경,정연경,Choi, Yoon-Kyung,Chung, Yeon-Kyoung 한국과학기술정보연구원 과학기술정보센터 2008 Journal of Information Science Theory and Practice Vol.39 No.3

본 연구는 국가 교육 표준 메타데이터인 KEM을 기반으로 국내 대학에서 강의자원을 효과적으로 관리하고 재사용성을 높일 수 있는 강의자원 메타데이터 필수 요소 및 확장 요소를 제안하였다. 이를 위해 문헌 연구와 국내외 사례 분석, 그리고 국내 현황조사 방법을 이용하였다. 국내외 사례 조사 및 현황 분석을 통해 KEM의 요소를 기반으로 국내 대학의 현황을 반영하여 강의자원 메타데이터의 필수 요소와 확장 요소를 제안하였다. 필수 요소로는 69개 요소를 2개 수준으로 제안하였다. 제 1수준의 31개 요소들은 강의자원 관리를 위해 대학에서 공통적으로 사용해야하는 필수 항목이다. 제 2수준 필수 요소는 총 38개로, 강의자원 관리를 위한 핵심 요소는 아니지만, 개별 대학에서 이 요소를 필수 요소로 사용하도록 권고하였다. 확장 요소는 면담 조사 결과를 바탕으로 전체 6개 응답 기관 중 50% 이상에서 확장이 필요하다고 선택한 12개를 제안하였다. The purpose of this study is to propose the mandatory and extensible elements of Korea Education Metadata elements for digital course resources universities in Korea. For the study, literature research, case study and interview were performed. The mandatory elements of KEM consisted of sixty nine elements, and were proposed by two phases. Also, based on interview process twelve items were newly recommended to supplement KEM elements.

중국어 소리 내어 읽기과제가 기억전략 및 인지전략에 미치는 영향

최윤경 ( Yoon Kyung Choi ) 서강대학교 언어정보연구소 2015 언어와 정보 사회 Vol.26 No.-

This study investigates whether Chinese voice reading assignments have positive effects to memory strategies and cognitive strategies. If it has positive effects, statistical method using SPSS is used to evaluate what is more effective teaching method. In conclusion, Chinese voice reading assignments are effective learning methods that help the learners to improve their memory strategies and cognitive strategies. It is proved that the learners who have high academic achievements, used higher level of memory strategies and cognitive strategies than those who have low academic achievements. When the professor figures out the level of academic achievements of the learners as soon as possible and provides adequate feedback according to the level of the learners, the learner can improve the usage of memory strategies and cognitive strategies.

역병(疫病) ‘코로나19’ -그 의미, 감성, 그리고 인문치유-

최윤경(Choi, Yoon-kyung) 경북대학교 인문학술원 2020 동서인문 Vol.0 No.14

본 연구에서는 현 세기 ‘역병’이 함축하는 의미를 확정하고, 우리들의 감성을 살펴보며, 그 난제를 인문 치유의 관점으로 천착해 본다. 이것은 ‘코로나19’ 팬데믹의 한 가운데에서 인문학의 시대적 역할이며, 충분한 가치적 의미를 가진다. ‘코로나19’의 의미를 알아보기 위해서 트위터의 빅데이터 자료를 활용하여 구조적 등위성분석(CONCOR analysis)을 실시하였다. 크게 네가지 의미로 집약할 수 있었다. ‘초기방역 실패’, ‘의사파업 책임’, ‘신천지 동향’, 그리고 ‘코로나19 상황 · 대책’이다. 다음으로 ‘코로나19’에 대한 사람들의 인식과 감정을 알아보기 위해서 빅데이터 자료를 활용하여 감성분석을 실시하였다. 감성어휘 총 594건이 추출되었고, 긍정과 부정은 각각 182건 (31%)과 412건(69%)으로 나타났다. 긍정의 하위 감성은 순서대로 호감(112건·18.9%)>기쁨(52건·8.8%)>흥미(18건·3.0%)로 나타났고, 부정의 하위 감성은 분노(154건·25.9%)>거부감(106건·17.8%)> 슬픔(74건·12.5%)>두려움(60건·10.1%)>놀람(14건·2.4%)> 통증(4건·0.7%)으로 확인되었다. 마지막으로 ‘코로나19’로 인한 정신적 · 정서적 · 사회적 문제들을 해결하기 위해서 인문치유를 제안한다. 독서, 토론, 글쓰기를 포함하는 문학치료가 있다. 아울러 정부나 공공기관의 안내문이나 캠페인의 발표에 앞서 필요하다면 전문가의 검토를 거친 적절한 용어 사용을 제언한다. 인문치유는 반성적 성찰과 함께 그 상흔과 화해하고 치유하는 방법이 될 것이다. This study determines the meaning and implications of the plague of the 21st century, examines our emotional response, and explore related issues from the perspective of humanities therapy. In other words, this paper examines the role of humanities in the ‘COVID-19’ pandemic. First, the meaning of ‘COVID-19’ is determined based on Twitter"s big data and structural equivalence analysis (CONCOR analysis), and appears to be fourfold: ‘initial quarantine failure’, ‘responsibility of the doctors’ strike’, ‘Shincheonji trend’, and ‘COVID-19 situation and countermeasures’. Second, sentiment analysis is performed using big data in order to find out the general perceptions and feelings regarding ‘COVID-19’. A total of 594 emotion-related expressions have been extracted, consisting of 182 positive (31%) and 412 (69%) negative expressions. The positive emotions are favorable impression (112 cases, 16.64%) > joy (52 cases, 8.78%) > interest (18 cases, 2.47%); the negative emotions are anger (154 cases, 29.53%) > rejection (106 cases, 17.42%) > sadness (74 cases, 11.42%) > fear (60 cases, 9.99%) > surprise (14 cases, 2.77%) > pain (4 cases, 0.99%). Finally, the paper proposed to solve the mental, emotional, and social distress caused by ‘COVID-19’ with humanities therapy, which includes reading, discussion, and writing as literary therapy. In addition, it is suggested that experts review, if necessary, the appropriate use of terms, prior to the publication of notices or campaign. Humanities therapy are seen as a way to subdue and cure the current ills with reflective introspection.

환경오염물질이 여성 불임에 미치는 영향에 대한 베이지안 잠재계층모형 분석

최윤경(Yoon Kyung Choi),황범석(Beom Seuk Hwang) 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.5

대표적인 환경오염물질인 PCB가 여성의 불임에 미치는 영향에 대해 조사한 LIFE 연구를 기반으로 해서 그 관계를 분석한 잠재계층모형을 제시하였다. 본 모형에서는 피험자의 잠재적인 위험군이 존재한다고 가정하고 잠재계층 변수를 도입하여 PCB와 여성의 불임에 대한 로짓 모형을 연결시켜주었다. 또한 반연속적인 형태를 띠는 PCB값을 다루기 위해 혼합 분포 모형을 적용시켰다. 구체적인 분석 방법으로 MCMC에 기반을 둔 베이지안 접근법을 사용하였고, 모형의 비교를 위해서 DIC를 계산하여 최적의 모형을 찾아내려고 하였다. 분석 결과 피험자들이 속한 잠재작인 위험군에 따라 불임에 대한 확률이 영향을 받고 있음을 확인할 수 있었다. We proposed a latent class model to examine the association between an environmental pollutant (PCB) and female infertility in the LIFE study. We assumed there exist latent risk groups of subjects and linked the PCB exposure and logit model for female infertility through the latent class variable. Also, semicontinuous PCB exposure was analyzed through a mixture of a degenerate distribution at zero and a continuous distribution for nonzero values. We took a Bayesian perspective to inference and used Markov chain Monte Carlo algorithms to obtain posterior estimates of model parameters. We calculated and compared DICs for all comparable models to find the most appropriate model for LIFE study data. As a result, we found that the risk of infertility was affected by latent risk groups of PCB exposure.

중국어-한국어 언어교환 과제의 적용과 평가

최윤경 ( Choi Yoon-kyung ) 서강대학교 언어정보연구소 2016 언어와 정보 사회 Vol.29 No.-

In this study, language exchange assignments was performed that Chinese students who study Korean in Korea and Korean students who study Chinese were matched and studied Chinese and Korean together. After performing a task having a conversation in Korean - Chinese with the background knowledge learned in class at least once a week, the potentials and challenges of language exchange assignments were investi-gated by analyzing through surveys and in-depth discussion about the assessment of students.

자하 하디드의 홍콩 폴리텍 디자인스쿨

최윤경(Choi, Yoon-Kyung) 대한건축학회 2016 建築 Vol.60 No.6

건축 공간구조의 시각적 특성에 관한 연구

최윤경(Choi, Yoon-Kyung) 한국실내디자인학회 2006 한국실내디자인학회논문집 Vol.15 No.5

입체복합시설의 해외사례와 특성

최윤경(Choi Yoon Kyung) 대한건축학회 2008 建築 Vol.52 No.7

국내 지자체 공공청사의 공간조직 변화과정에 관한 연구

최윤경(Choi, Yoon-Kyung),현창용(Hyun, Chang-Yong) 한국실내디자인학회 2011 한국실내디자인학회논문집 Vol.20 No.6

The study presupposes that, ever since its modernization, the Korean local government buildings have undergone an evolutionary process of their spatial organizations and the process can be analyzed in terms of increased publicness of architectural space. For the purpose, fifteen examples of local government buildings in Korea are selected and analyzed in terms of their plans converted into spatial diagrams measuring accessibility depth. Within these analytical diagrams, some quantitative measures such as permeability and visual connection, and the number of decision making points that visitors face on the way to their targets. The study analyzes these analytic measures of selected samples which are categorized into three chronological groups in order to search any evolutionary tendency of spatial transformation. The analysis shows that the accessibility of public functions and presumably the publicness of the spatial organization of local government buildings has been increased. The results of the study implies that, to acquire architectural publicness in government buildings, not only the insertion of public programs but also the organization of open spatial structure is significant.