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최세림 ( Se Rim Choi ),김우중 ( Woo Joong Kim ),이희정 ( Hee Jung Lee ),김동현 ( Dong Hyun Kim ),윤문수 ( Moon Soo Yoon ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.1
Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare, localized variant of Sweet syndrome, and it was first described by Galaria et al. in 2000. It usually occurs in middle-aged women and it is characterized by erythematous papules, plaques, pustules and hemorrhagic bullae that are generally located on the dorsal hands. The histopathological findings show prominent papillary dermal edema and a dense dermal neutrophilic infiltration. A neutrophilic infiltrate can also cause a variable degree of vascular damage: endothelial cell swelling, RBC extravasation, leukocytoclasia and fibrin deposition within the walls of vessels. We report here on a case of NDDH in a 50-year-old man who was treated with oral corticosteroid and the NDDH recurred after 9 months. (Korean J Dermatol 2011;49(1):86~89)
최세림 ( Se Rim Choi ),김태윤 ( Tae Yoon Kim ),김동현 ( Dong Hyun Kim ),윤문수 ( Moon Soo Yoon ) 大韓皮膚科學會 2009 大韓皮膚科學會誌 Vol.47 No.7
Circumscribed palmar or plantar hypokeratosis is a rare disease that is characterized by a well-circumscribed, erythematous depressed macule or patch on the palm or sole. It usually presents as an asymptomatic, solitary lesion in middle-aged or elderly women. The characteristic histopathological finding is a sharp stair-like alteration between involved and uninvolved skin with a markedly thinner horny layer and slightly decreased granular layer compared with adjacent normal skin. Herein we report a case of circumscribed palmar hypokeratosis and review the literature. (Korean J Dermatol 2009;47(7):865~867)
1기, 2기 매독환자에서 Treponema pallidum 항체를 이용한 면역조직화학염색 연구
최세림 ( Se Rim Choi ),김동현 ( Dong Hyun Kim ),이희정 ( Hee Jung Lee ),김태헌 ( Tae Heon Kim ),윤문수 ( Moon Soo Yoon ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.10
Background: Syphilis is an infection caused by Treponema pallidum (T. pallidum), and this disease is increasing in incidence. However, making the diagnosis of syphilis is sometimes still challenging because of the variable clinical and histopathologic findings and there are cases with negative serologic findings, and especially in the setting of HIV infection and immunosuppressive therapy. Objective: In this study, we specifically evaluated the number and distribution patterns of T. pallidum in the skin lesions from patients with primary or secondary syphilis. Methods: Forty eight skin biopsy specimens with the clinical and/or serological diagnosis of syphilis were evaluated by immunohistochemistry (IHC) using primary polyclonal antibodies against T. pallidum. Results: Overall, T. pallidum was identified in 45 specimens (94%). The IHC of the 22 specimens from the patients with primary syphilis were all positive (100%). Twenty three (88%) out of 26 specimens from the patients with secondary syphilis showed positive results. T. pallidum was also identified in three patients with negative VDRL. Although the density of T. pallidum was higher in the specimens from the patients with primary syphilis than in those from the patients with secondary syphilis, the differences were not statistically significant (p=0.32). An epitheliotropic pattern was more frequently observed in the specimens from the patients with secondary syphilis (81%) than in those from the patients with primary syphilis (50%) (p=0.01). The density and distribution patterns of T. pallidum didn`t show any correlation with the duration of skin lesions or the VDRL titer. Conclusion: IHC using a polyclonal antibody against T. pallidum could be an effective method for making the diagnosis of primary and secondary syphilis. (Korean J Dermatol 2010;48(10):844~852)
전신홍반루푸스 환자에서 발생한 다발성 발진성 피부섬유종
김진기 ( Jin Ki Kim ),최세림 ( Se Rim Choi ),김동현 ( Dong Hyun Kim ),윤문수 ( Moon Soo Yoon ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.11
Dermatofibromas are common benign fibrohistiocytic tumors that occur primarily as a solitary lesion, while multiple eruptive dermatofibromas (MEDFs) are a rare presentation of dermatofibromas and MEDFs are frequently associated with altered immunity, such as autoimmune diseases and immunosuppression. It is still unclear why MEDFs occur in association with these conditions, but this relationship may suggest that MEDFs are the result of an abortive immunoreactive process. We herein report on a case of MEDF that developed in a patient who was diagnosed with systemic lupus erythematosus. (Korean J Dermatol 2009;47(11):1300~1303)
김태윤 ( Tae Yoon Kim ),최세림 ( Se Rim Choi ),김태헌 ( Tae Heon Kim ),김동현 ( Dong Hyun Kim ),윤문수 ( Moon Soo Yoon ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.5
Pachydermoperiostosis is a very rare genodermatosis that is characterized by pachydermia, digital clubbing and periostosis. It usually occurs during adolescence and the disease is inherited in an autosomal dominant manner. Although the pathogenesis of this disease is still a matter of debate, it is associated with abnormal proliferation of fibroblasts, osteoblasts and endothelial cells and altered proteoglycan synthesis. We report here on a case of pachydermoperiostosis in a 21-year-old man who was diagnosed by the clinical features, skin biopsy and radiological examinations. (Korean J Dermatol 2010;48(5):445~448)
동맥류성 변형과 비정형성 변형을 보인 낭종 형태의 혼합형 피부섬유종
김우중 ( Woo Joong Kim ),최세림 ( Se Rim Choi ),이희정 ( Hee Jung Lee ),윤문수 ( Moon Soo Yoon ),김동현 ( Dong Hyun Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.9
Dermatofibroma is a common benign fibrohistiocytic tumor that mainly presents as a brown papule or nodule. However, it can sometimes present with diverse clinical forms such as a cyst. Combined dermatofibroma is defined as a tumor that comprises two or more variants of dermatofibroma in a single lesion. We herein report on a case of combined dermatofibroma in a 40-year-old woman who presented with a cyst form on her lateral neck. The histological findings included the combined features of the aneurysmal and atypical variants of dermatofibroma such as cleft-like spaces with hemorrhage, some pleomorphic cells and multinucleated giant cells, as well as a feature of typical dermatofibroma. (Korean J Dermatol 2010;48(9):810~813)
김진기 ( Jin Ki Kim ),김우중 ( Woo Joong Kim ),최세림 ( Se Rim Choi ),이희정 ( Hee Jung Lee ),김동현 ( Dong Hyun Kim ),윤문수 ( Moon Soo Yoon ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.9
Lichen sclerosus et atrophicus (LSA) is a benign, chronic inflammatory mucocutaneous disease of unknown etiology with a predilection for the female genital area, which is highly bothersome. It may also involve other areas, mainly the upper trunk, axillae and buttocks and clinicians often make a misdiagnosis of these extragenital lesions due to their rarity and lack of symptoms. We herein report the case of a 69-year-old female patient with multiple extragenital LSA presenting with hemorrhagic change. Histopathologic evaluation showed follicular plugging, atrophy of stratum malpighii with hydropic degeneration of basal cells, prominent upper dermal edema and lichenoid lymphocytic infiltration in the mid dermis which was consistent with LSA. We remind clinicians of including LSA in the differential diagnoses of multiple cutaneous hemorrhagic lesions. (Korean J Dermatol 2011;49(9):826~829)