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        갑상선 분화암 환자에서 갑상선 기능의 변화에 따른 심혈관계 지표의 변화

        김경원 ( Kyung Won Kim ),박영주 ( Young Joo Park ),장혁재 ( Hyuk-jae Chang ),이은정 ( Eun Jung Lee ),이은경 ( Eun Kyung Lee ),최성희 ( Md Sung Hee Choi ),임수 ( Soo Lim ),박도준 ( Do Joon Park ),장학철 ( Hak C. Jang ),조보연 ( Bo 대한갑상선학회 2009 International Journal of Thyroidology Vol.2 No.1

        Background and Objectives: Some patients with differentiated thyroid cancer experience short-term hypothyroidism in preparation for radioiodine (RAI) therapy. It is not clear whether short-term hypothyroidism induces clinically significant cardiac dysfunction. In this study, we evaluated the changes of cardiac function and B-type natriuretic peptide (BNP) during short-term hypothyroidism. Materials and Methods: The study was an 12-week controlled observational study. Nineteen female patients with differentiated thyroid cancer were recruited. Four patients had diabetes mellitus, and one of them had hypertension. All of them visited four times during the study period: on the 1st day after withdrawal of T4 (P1), on the 1st week after withdrawal of T4 (P2), on the 4th weeks after withdrawal of T4 (P3) and on the 8th weeks after RAI therapy (P4). The previous dose of T4 was given to each patient after RAI therapy. At the visiting, vital signs were checked and proBNP and echocardiography were performed. Results: During short-term hypothyroidism (P3), TSH was 136.5±48.8 mIU/L and heart rate decreased significantly during short-term hypothyroidism. Stroke volume and ejection fraction was significantly decreased at P3, but those were recovered after T4 administration. There was no diastolic dysfunction during the study. ProBNP was decreased at P3 (p=0.021), but all the values were in normal range. There were no signs and symptoms of heart failure and cardiac ischemia. Conclusion: Although short-term hypothyroidism induced systolic dysfunction, it didn’t induce the clinical problem. The withdrawal of thyroid hormone can safely be prescribed to patients with low cardiac risk.

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