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최민철,Choi Min-chul 대한수의사회 1990 대한수의사회지 Vol.26 No.1
A dog which Showed dry muzzle, coughing, dyspnea, weight loss and exercise intolerance was clinically examined. Dirofilaria immitis infection was determined by hematological findings, radiographic evaluation and detection of microfilaria with modified Kno
Aloe vera가 Cobalt-60 gamma선 조사를 받은 쥐의 혈액성분에 미치는 영향
최민철,Choi Min-chul 대한수의사회 1990 대한수의사회지 Vol.26 No.1
The effect of Aloe vera administration(500mg/kg, P.O.) for 21 days on the total white blood cell, packed cell volume, hemoglobin, total protein, serum glutamic pyruvic transaminase and sorbitol dehydrogenase values in cobalt-60 gamma irradiated rats was s
자궁내막암에 있어 수술 후 보조 방사선치료법과 수술 후 복합항암화학치료법의 임상 비교 연구
최민철 ( Min Chul Choi ),박지현 ( Ji Hyeon Park ),김수현 ( Su Hyun Kim ),전경훈 ( Kyung Hun Jun ),정상근 ( Sang Geun Jung ),나영정 ( Young Jeong Na ),이선영 ( Sun Young Lee ),이찬 ( Chan Lee ),황윤영 ( Yeun Young Hwang ),김승조 ( 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.11
목적: 자궁내막암의 수술 후 보조 치료로서 기존의 방사선치료와 paclitaxel과 platinum으로 이루어진 복합화학요법을 비교해보고자 하였다. 방법: 2000년 1월부터 2006년 12월까지 포천중문 의과대학 분당차병원 산부인과에서 조직학적으로 자궁내막암 진단을 받고 병기적 수술을 시행받은 105명을 대상으로 하였다. 이 중 조직학적으로 자궁내막양 선암 이외의 조직 양상을 보인 15명은 제외하였다. 수술 후 수술-병리적 결과에 따라 중등도 위험도 이상을 보인 58명을 대상으로 후향적 분석하였다. 이 중 36명은 항암치료를 받았고, 방사선치료는 24명을 대상으로 시행하였다. 항암치료의 항암제는 paclitaxel 175 mg/m2과 carboplatin AUC5 (또는 cisplatin 50 mg/m2)을 3주 간격으로 총 3회에서 6회에 걸쳐 병용 투여하였고, 방사선치료는 4,500~5,040 cGy가 조사되었다. 결과: 총 58명 대상자의 평균 추적기간은 40.3개월 (7~64개월)이었다. 5년 생존율은 항암치료군이 91.3%였고, 방사선치료군은 91.4%로 나타났으며 (P=0.646), 5년 무병 생존율은 항암치료군이 91.0%, 방사선치료군은 82.8%의 결과를 보였으나 통계적으로 유의한 차이는 없었다 (P=0.129). 항암치료의 가장 흔한 부작용은 혈액학적인 독성이었으나, 대부분 grade가 낮았고 보존적 치료로 조절되었다. 방사선치료군에서는 심각한 위장관계 독성을 5명 (20.8%)에서 보였고, 이 중 3명은 ileo-cecal bypass와 같은 수술적 중재를 요했으나 복통, 설사와 같은 증상은 수술 후에도 지속되었다. 결론: 자궁내막암에 있어 수술 후 보조 치료로서의 paclitaxel과 platinum의 복합화학요법은 유사한 치료 효과와 적은 독성의 측면에서 기존의 방사선치료를 대체할 수 있을 것으로 기대된다. 앞으로 더욱 많은 전향적인 대규모 연구가 필요할 것으로 사료된다. Objective: This study was performed to compare postoperative adjuvant paclitaxel and platinum (TC) chemotherapy and radiation therapy in women with uterine endometrial carcinoma. Methods: Total one hundred five patients were entered into this trial. Non-endometrioid histologic subtypes such as serous, clear cell and small cell types were excluded from the study because they have different biological potentials. Of 58 assessable patients, who were needed adjuvant treatment according to surgico-pathologic reports, after surgery, 34 were received TC chemotherapy and 24 were received radiation therapy. Chemotherapy consisted of paclitaxel 175 mg/m2 and carboplatin AUC 5 (or cisplatin 50 mg/m2) every 3 weeks for 3 or 6 cycles. Irradiation dosage was 4,500~5,040 cGy in 28 fractions. Results: In 58 evaluated patients, median follow-up time was 40.3 months (range 7~64 months). The 5-year overall survival and 5-year disease-free survival were 91.3% and 91.0% in 34 patients treated with TC chemotherapy, and 91.4% and 82.8% in 24 cases who treated with radiation therapy, however, there were no significant difference (P=0.646, P=0.129). The most common adverse effect of TC chemotherapy was hematologic toxicity, which was manageable conservatively. The serious gastrointestinal complication of radiotherapy was noted in 5 patients (20.8%), three of these patients were received another bowel surgery, such as ileo-cecal bypass, however, symptoms were persisted after surgery. Conclusions: These data suggest that postoperative adjuvant TC chemotherapy is a promising treatment which could be substituted for radiation therapy, with major activity and a acceptable toxicity profile for the treatment of uterine endometrial carcinoma.
최민철 ( Min Chul Choi ),이창진 ( Chang Jin Lee ),임영태 ( Young Tae Lim ) 한국운동역학회 2010 한국운동역학회지 Vol.20 No.4
This study was aimed at comparing selected joint angles at the golf address stance by categorizing three different body types. 43 elite male golfers were selected and 9 of them turned out to be the ectoderm while 24 of them to be the mesoderm. The remaining 10 subjects were the endoderm. The measurement was carried out at the address stance with the number 7 iron and the driver. The result showed that the angle of trunk flexion did not different among body types. The trunk tilting angle became more inclined to the right side, which confirmed the guidelines from most of golf lesson books, for bigger people since they tended to put more weight on the right foot. The angle of both knees showed similar but the right knee was bent more than the left knee. The target direction and body alignment faced more to the left side than the target spot because of the influence of open stance and natural aiming position. It seems that pelvis and knees turned a little bit more to the right side than the target direction in order to maintain the parallel. Overall, significant differences among body types were found at the trunk tilting angle and pelvis-target alignment and golf address configuration can be differentiate by these factors.
Xylazine과 pentobarbital로 마취한 개에서 yohimbine과 4-aminopyridine투여가 위십이지장 통과 시간에 미치는 영향
김동준,최민철,성재기,Kim, Dong-jun,Choi, Min-chul,Sung, Jai-ki 대한수의학회 1990 大韓獸醫學會誌 Vol.30 No.1
The present study was undertaken to determine the effect of xylazine-pentobarbital anesthesia on the gastroduodenal transit time of barium sulfate and whether this condition can be antagonized by yohimbine, 4-aminopyridine and yohimbine+4-aminopyridine in dogs. Xylazine-pentobarbital anesthesia prolonged the gastroduodenal transit time to $121.50{\pm}21.25$ minutes compared with $5.25{\pm}0.90$ minutes of control. Yohimbine and yohimbine+4-aminopyridine reversed $121.50{\pm}21.25$ minutes of transit time of anesthetized dog to $25.25{\pm}6.83$ and $63.25{\pm}15.69$ minutes, respectively. 4-aminopyridine alone, $115.75{\pm}$18.35 minutes, was not effective in reversing the xylazine-pentobarbital-induced prolongation of gastroduodenal transit time. Yohimbine was the most effective for reversal of xylazine-pentobarbital-induced prolongation of gastroduodenal transit time in dogs.
복강경보조질자궁절제술과 복강경전자궁절제술의 수술결과 비교
박현 ( Hyun Park ),최민철 ( Min Chul Choi ),윤보성 ( Bo Sung Yoon ),성석주 ( Seok Ju Seong ),조연경 ( Yeon Kyung Cho ),신중식 ( Joong Sik Shin ),전혜선 ( Hye Sun Jun ),심정연 ( Jeong Yun Shim ),김인현 ( In Hyun Kim ),박종택 ( Cho 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
목적: 복강경보조질자궁절제술 (LAVH)과 복강경전자궁절제술 (TLH)의 수술 결과를 비교하고자 하였다. 방법: 병원기록을 바탕으로 2006년 9월부터 2007년 8월까지 복강경자궁절제술을 받았고 병리소견이 자궁근종 혹은 샘근육증인 경우만을 대상으로 하여 LAVH를 받은 93명과 TLH를 받은 142명을 선정하였다. 수술방법에 따라서 환자의 인구학적 특징과 수술결과를 비교하였다. 여러 변수들 사이의 관계를 알아보고자 다중회귀분석을 실시하였다. 결과: 두 군 간에 나이 및 체질량지수, 수술력, 병리소견은 차이가 없었다. 단변량 분석에서 LAVH의 수술시간 (129.0±34.5분, 123.6±40.8분)과 실혈량 (385.5±296.1 mL, 294.7±285.4 mL)이 증가하였다 (P<0.050). 검체무게는 LAVH에서 무거운 경향이 있었으며 (378.7±211.7 g, 316.9±170.1 g, P=0.060), 입원기간 (5.63±1.61일, 5.71±1.61일)과 부작용 발생률 (10.8%, 14.0%)은 차이가 없었다 (LAVH, TLH, P>0.050). 다변량 분석에서 실혈량은 수술시간 및 검체무게과 관련이 있었으며 (P=0.000), 수술방법과는 관련이 적었다 (P=0.213). 결론: TLH에 비하여 LAVH가 시행된 경우에는 자궁이 무겁고 수술시간이 길며 실혈량이 많은 경향이 있었다. 다변량 분석을 통하여 복강경자궁절제술에서 실혈량은 수술방법과는 관련이 없으며 검체무게 및 수술시간과 비례함을 알 수 있었다. Objective: To compare the surgical outcomes between laparoscopy-assisted vaginal hysterectomy (LAVH) and total laparoscopic hysterectomy (TLH). Methods: The data were collected retrospectively from hospital records. Between September 2006 and August 2007, Patients undergone with LAVH (93 cases) and TLH (142 cases) with pathologic reports of leiomyoma or adenomyosis were enrolled. The characteristics and surgical results were compared according to the operation type. The correlations among the variables were analyzed with multiple linear regression. Results: Between two groups, the characteristics of patients were similar such as age, body mass index, surgical history, and pathologic findings. In the univariate analysis, the differences of operation duration and blood loss between LAVH (129.0±34.5 min, 385.5±296.1 mL) and TLH (123.6±40.8 min, 294.7±285.4 mL) were significant (P<0.050). Specimen weight was slightly heavier in LAVH (378.7±211.7 g vs. 316.9±170.1 g, P=0.060), Admission duration (5.63±1.61 day vs. 5.71±1.61 day) and the incidence of complications (10.8% vs. 14.0%) were indifferent to the groups (LAVH vs. TLH, P>0.050). In multivariate analysis, blood loss was correlated with operation duration and specimen weight (P=0.000) but not with operation type (P=0.213). Conclusions: LAVH tends to be selected in larger uteri and results in more blood loss and longer operation duration. Operation type (LAVH or TLH) does not affect blood loss which is related with operation duration and uterine weight.