결절성 근막염 28예의 임상, 병리학적 고찰

최미라 ( Mi Ra Choi ),권인호 ( In Ho Kwon ),김동현 ( Dong Hyun Kim ),김규한 ( Kyu Han Kim ),조소연 ( So Yun Cho ),박귀영 ( Kui Young Park ),이갑석 ( Kap Sok Li ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),원종현 ( Chong Hy 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.6

Background: Nodular fasciitis presents as a solitary, slightly painful, rapidly growing nodule. It is associated with a reactive, proliferative process of unknown cellular origin and can be misdiagnosed as a sarcoma. Objective: Our study was designed to investigate the process and cellular origin of the disease. Methods: The clinical and histopathologic findings from 28 cases of nodular fasciitis were reviewed. Additional histochemical and immunohistochemical staining was done. Results: The mean age of onset was 29.8 years. A majority of patients with nodular fasciitis had a duration of symptoms of less than 6 months. The upper extremity and face were most frequently involved. Most of the lesions had diameters less than 2 cm. Total excisions were performed in 23 lesions; 3 lesions recurred thereafter. Histopathologically, a subcutaneous plane was most frequently involved. The nodule consisted of numerous large, pleomorphic fibroblasts growing haphazardly in a vascular stroma containing varying amounts of mucoid ground substance, which was confirmed by histochemical stains. In the immunohistochemical stain, most lesions had positive findings for smooth muscle actin (SMA), vimentin and negative findings for CD34 except in a few cases. The stains for desmin and S-100 were negative in all cases. Conclusion: It is suggested that nodular fasciitis is associated with a reactive proliferation of myofibroblasts rather than with a sarcomatous process. (Korean J Dermatol 2009;47(6):649∼657)

입원 중 피부과로 의뢰된 환자의 임상 분석

최미라 ( Mi Ra Choi ),박현선 ( Hyun Sun Park ),변희진 ( Hee Jin Byun ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3

Background: Dermatologic problems may represent a primary cutaneous disorder or an underlying systemic disease and are common but frequently overlooked in inpatients. Objective: We described and quantified dermatologic consultations in Seoul National University Hospital over 9 years for comparison with other reports. Methods: We retrospectively studied the records of 9,529 hospitalized patients for which a dermatologist consultation was requested. Results: Consult patients numbered 9,529 among 506,927 inpatients (1.88%). The total number of male and female patients were 5,428 (56.96%) and 4,101 (43.04%), respectively (M: F=1.32:1). The most frequent age group was the 6th decade (19.05%) and the lowest age group was the 1st decade (5.14%). In 2008, most of the consultations (72.24%) were made by internal medicine, followed by neurology (6.34%), and pediatrics (4.59%). Patients with cancer were most frequently consulted for underlying disease (24.58%), followed by hematologic malignancy (22.66%), and liver disease (10.69%). The most common skin disorders were drug eruption (24.5%), followed by eczema (15.7%), and viral infection (12.6%), and with more consults for drug eruption and viral infection than previous studies. The most common reasons for consultation were: dermatologic diseases or conditions (73.8%), diseases related to treatment (16.2%), and skin lesions of systemic disease (8.8%). Conclusion: Inpatient dermatology consultations not only improve the quality of patient care but also can provide opportunities for residency education and experience with clinical dermatology. (Korean J Dermatol 2010;48(3):163~170)

연구논문 : 『시경(詩經)』에 나타난 행복구가와 인간성 회복

최미라 ( Mi Ra Choi ) 충남대학교 유학연구소 2014 儒學硏究 Vol.31 No.-

본고는 『詩經』의 詩들에서 행복구가의 내용을 살펴보고 이를 인간성 회복과 연결시킬수 있는지를 살펴보는 것이다. 사람은 행복하면 노래를 한다. 노래에 자신의 생각과 철학을 칭송이든 비판이든 솔직하게 담는다. 孔子는 이를 思無邪라고 했다. 하여튼 詩는 인간성을 회복한다. 최초의 시문집인 『詩經』에는 행복구가를 위한 詩들이 있다. 이것은 인간성 회복의 모습이다. 孔子 생애의 평범성과 현실성은 인간성 회복과 관계가 있다. 2500년 전 孔子에게 주어진 영감이나 계시는 자기 수양과 점점 더 분열되는 정체성에 도덕심을 회복시키겠다는 사명의식의 결과물이다. 『論語』에서 孔子는 인간성 회복으로서의 仁을 설명하고 있다. 孔子에게 仁은 행복구가의 전제였고 인간성 회복을 위한 修養이었기때문이다. 이러한 仁을 바탕으로 한 시들을 『詩經』에서 쉽게 찾을 수 있다. 『論語』에는『詩經』이 8번 인용된다. 孟子는 인간성 회복을 仁義에서 찾았다. 孟子에서도 『詩經』은37번이나 인용된다. 인용했다는 것은 인정한다는 전제이다. 결국 孔子와 孟子는 『詩經』을 인간성 회복의 전제로서 인정했다는 것이고 행복구가의 詩들은 仁과 仁義의 바탕이라고 설명된다. 『大學』에서 12번, 『中庸』에서 16번 『詩經』을 인용한다.『大學』에서 인간성 회복은 인격주체의 자기 수양, 그 자체로만 완결되지 않고, 더 정교화 된다. 몸을 닦아 공경하는 誠意와 正心, 몸을 닦아 사람을 편안하게 하는 修身과 齊家, 백성을 편안하게 만드는 治國과 平天下가 곧 ``행복구가``이며 ``인간성 회복``으로 확장된다. 현대인들은 이러한 ``인간성회복``의 구조를 인정하려면 『詩經』의 詩들을 통한 ``행복구가``의 의미를 생각하여야 한다. This study aims to examine the contents of singing happiness shown in poems of the Classic of Poetry(詩經) and the linkage thereof with the restoration of humanity. People sing songs when they are happy. They frankly express their thoughts and philosophies . whether they are praises or criticisms . through songs. Confucius referred to this expression as “having no depraved thoughts(思無邪).” Anyhow, poetry restores humanity. The first collection of poetry, the Classic of Poetry, contains poems that sing happiness. This is the effort to restore humanity. The commonality and reality of Confucius’s life are related to the restoration of humanity. Inspirations or revelations that Confucius received 2500 years ago are the results of his sense of mission to practice self discipline and to restore morality to his identity that was increasingly separated from his true self. In the Analects, Confucius explains about benevolence(仁) as the way of restoring humanity, because, for him, benevolence was the prerequisite to singing happiness and self discipline to restore humanity. Many poems based on such benevolence can be easily found in the Classic of Poetry. The Analects quoted the Classic of Poetry eight times. Mencius sought the restoration of humanity from benevolence and righteousness(仁義). Mencius also quoted the Classic of Poetry 37 times, which means that he acknowledged the latter. This suggests that both Confucius and Mencius acknowledged the Classic of Poetry as the prerequisite to the restoration of humanity, and that poems singing happiness are based on benevolence and benevolence and righteousness. Great Learning(大學) and Doctrine of the Mean(中庸) quoted the Classic of Poetry 12and 16 times, respectively. Great Learning argues that humanity cannot be restored by the person’s self discipline alone, but needs to be further refined. Sincerity(誠意) and right mind(正心) which are to discipline oneself and respect others, self-discipline(修身) and governing home(齊家) which are to practice self discipline and comfort others(治國), are ruling the state and pacifying the world(平天下) are the pursuit of singing happiness. Thisfurther expands into the restoration of humanity. Modern people should think of the meaning of singing happiness shown in poems of the Classic of Poetry in order to acknowledge the structure of restoring humanity.

당뇨 환자에서 인슐린 피하 주사 이후에 발생한 전신성 광택태선

최미라 ( Mi Ra Choi ),김민지 ( Min Ji Kim ),나세영 ( Se Young Na ),이종희 ( Jong Hee Lee ),조소연 ( So Yun Cho ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.8

Generalized lichen nitidus is a rare subtype of lichen nitidus, and the former condition is characterized by multiple, shiny flesh-colored pin-head sized papules that occur over the entire body. Generalized lichen nitidus is often associated with various degrees of pruritus and the clinical course tends to be chronic in contrast with the other forms of lichen nitidus. We report here on a case of a 39-year-old man who was diagnosed with generalized lichen nitidus that developed after a subcutaneous insulin injection. He was treated with topical corticosteroid. (Korean J Dermatol 2009;47(8):948~950)

피부과 영역에서의 저출력광치료

최미라 ( Mi Ra Choi ),도은진 ( Eun Jin Doh ),이동훈 ( Dong Hun Lee ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.4

Low-level laser or light therapy (LLLT) was used to accelerate wound healing without the use of thermal effects in the early days. Although the exact mechanism of LLLT is still unclear, it has been recognized as a photobiomodulation process. Today, LLLT is being credited as a non-invasive treatment modality, and in particular, being widely applied in the field of dermatology. In this review, we summarize the basic principles and clinical applications of LLLT to provide an up-to-date guidance on its practical and safe uses. Further studies are needed to elucidate the mechanism of action of LLLT in various indications, and to determine the wavelength and dose for optimal clinical use. (Korean J Dermatol 2016;54(4):241~248)

동시를 활용한 또래 함께읽기 전략이 초등학교 읽기학습부진아의 읽기유창성과 읽기태도에 미치는 영향

최미라 ( Mi Ra Choi ),강옥려 ( Ock Ryeo Kang ) 한국특수교육문제연구소 2012 특수교육저널 : 이론과 실천 Vol.13 No.4

본 연구는 동시를 활용한 또래 함께읽기 전략이 읽기학습부진아동의 읽기유창성과 읽기태도에 미치는 영향을 알아보았다. 이를 위해 초등학교 2학년 읽기학습부진아 20명을 선정하여 실험집단과 통제집단에 각각 10명씩 배치하였고 실험집단의 읽기학습부진아는 또래학습자 역할을 하였다. 또한 읽기학습부진이 없는 일반아동 10명을 선정하여 실험집단에서 또래 지도자 역할을 하도록 하였다. 실험집단에는 동시를 활용한 또래 함께읽기 전략을 매주 3회씩 총 5주 동안 실시하였다. 읽기유창성과 읽기태도에 대한 사전ㆍ사후검사 결과와 진전도 분석을 위한 읽기유창성에 대한 주 1회의 형성평가 결과를 분석한 결과, 동시를 활용하여 또래함께읽기 전략을 중재 받은 실험집단과 통제집단 간에는 진전도와 사후검사에서 모두 유의한 차이를 보였다. 즉, 동시를 활용한 또래 함께읽기 전략이 초등학교 읽기학습부진아의 읽기유창성과 읽기태도를 향상시키는데 효과적이었다. The purpose of this study was to investigate the effects of peer paired reading using children’s poem for enhancing reading skills, that is, oral reading fluency and attitude of low-achieving students in reading. For this purpose, 20 low-achieving students in second grade were selected. The students were divided into two groups of 10 persons each, an experimental group with peer paired reading and a control group. For tutors of the experimental group, 10 second graders were selected from the same elementary school. The experiment was conducted for 20 minutes each session, third times a week for 15 sessions. Tests of oral reading fluency and reading attitude were conducted. Oral reading fluency test was conducted pre-test and formative assessment once a week. Reading attitude test was conducted in pre- and post- test. The data of this study were also analyzed by t-test and HLM(Hierarchial Linear Model). The results obtained in this study are summarized as follows: First, peer paired reading had a positive effect on oral reading fluency and attitude of low-achieving students in reading. Second, peer paired reading showed significant faster growth rates on oral reading fluency. It showed the initial state and the linear slope depending on the individual child. In conclusion, peer paired reading using children’s poem is an effective method to enhance oral reading fluency and attitude of low-achieving students in reading.

이미퀴모드로 유발된 건선양 쥐 모델에서 건선 연관 유전자 발현에 대한 면역조직화학적 연구

김지영 ( Ji-young Kim ),최미라 ( Mi-ra Choi ),최종원 ( Chong-won Choi ),박경덕 ( Kyung-duck Park ),이영 ( Young Lee ),김창덕 ( Chang-deok Kim ),서영준 ( Young-joon Seo ),이증훈 ( Jeung-hoon Lee ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.10

Background: Psoriasis is a chronic inflammatory skin disease with an incidence of 0.5∼3% of the worldwide population. The pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune reactions. Notably, genetic factors are considered important etiological contributors. Globally, several researchers have recently performed genome-wide association studies (GWAS) to identify the genes related with psoriasis. Objective: We aimed to investigate the expression pattern of 2 candidate genes that were identified by GWAS. These include interleukin 28 receptor alpha (IL28RA) and CUB and Sushi multiple domains 1 (CSMD1). Methods: We applied imiquimod cream to develop a psoriasis-like mouse model and obtained skin tissue. We performed immunohistochemistry to detect the expression of IL-28A and CSMD1. Results: IL28RA expression increased at an early time point such as 1 day after the topical application of 5% imiquimod cream. However, its expression returned to baseline levels 2 weeks after the topical application of imiquimod cream. CSMD1 expression also increased after the topical application of imiquimod, with increased expression particularly observed in the upper epidermal layer. Notably, CSMD1 expression decreased 7 days after imiquimod cream application. Conclusion: These results suggest that IL28RA and CSMD1 may play key roles in the pathogenesis of psoriasis. (Korean J Dermatol 2018;56(10):609∼613)

공동주택의 리모델링 전략을 위한 안전진단의 경제성분석 모델

서광준,최미라,신남수,Seo Kwang-Jun,Choi Mi-Ra,Shin Nam-Soo 한국건설관리학회 2005 건설관리 : 한국건설관리학회 학회지 Vol.6 No.4

최근 생애주기비용 분석의 중요성이 대두됨에 따라 공동주택 리모델링 사업에서의 생애주기비용 분석을 위한 이론적 모델, 표준지침 및 소프트웨어 등이 개발되어지고 있다. 그러나 현재까지도 실질적인 안전진단에 대한 과거 보수이력데이터의 부재로 인한 LCC분석 결과에 대한 신뢰수준이 여전히 미흡하다. 본 연구에서는 사례 공동주택의 신뢰성에 기초한 LCC분석을 통해 리모델링 전략을 평가하고, 장래 요구되는 리모델링 조치수준의 비교 $\cdot$ 분석을 통해 적정 경제성지수를 제시함과 동시에 최근 연구가 활발히 진행 중인 공동주택 리모델링에 대한 실적 LCC 기초자료를 얻고자 하였다. 본 연구에서 제안된 퍼지로직에 기초한 안전성평가와 LCC분석모델은 공동주택 리모델링사업에서의 가치 지향적 설계대안 선정, 경제성평가 및 합리적인 예산의 분배 등에 크게 기여할 것으로 기대된다. The importance of the life cycle cost analysis(LCCA) for apartment housing remodeling projects has been fully recognized over the last decade. Accordingly theoretical models, guidelines, and supporting software systems were developed for the life cycle cost analysis of apartment housing remodeling systems. However, the level of consensus on LCCA results is still low due to the lack of reliable data on remodeling activities for safety diagnosis. in order to predict the reliability based LCCA of the given case, suggested the remodeling strategies level after reviewing other related materials. Apply the real information of the economic index. And based on such analytical measures, remodeling and operation cost and LCC in remodeling strategies level have been predicted; suggests the basic information about remodeling interventions level for the apartment housing. The LCC analysis models and the fuzzy logic based safety assessment presented in this study can greatly contribute to the value-oriented design alternative selection, estimation of the economic analysis, and the allocation of budget for apartm.

공동주택의 시간의존적 설계VE 및 LCC분석 모델

서광준,최미라,신남수,Seo, Kwang-Jun,Choi, Mi-Ra,Shin, Nam-Soo 한국건설관리학회 2005 건설관리 : 한국건설관리학회 학회지 Vol.6 No.6

최근에 공동주택 건설사업을 위한 가치공학 및 생애주기비용(LCC)분석의 중요성이 대두됨에 따라, 대형 건축물의 건설사업에서 가치공학 및 생애주기분석을 위한 이론적 모델, 표준지침 및 소프트웨어 등이 개발되어지고 있다. 그러나 현재까지도 실질적인 과거 보수이력데이터의 부재로 인한 VE 및 LCC분석 결과에 대한 신뢰수준이 미흡하다. 본 연구에서는 공동주택의 건설사업에 대한 합리적인 투자의사결정과 설계대안선정을 위한 시간의존적 LCC분석에 의한 가치분석 방법론을 제시하였다. 제안된 방법론은 과거이력데이터의 불확실성과 분석대안의 가치분석을 보다 합리적으로 고려하기 위한 시간의존적 생애주기비용 모델과 퍼지로직에 의한 성능평가기법과의 상관관계를 규명하였다. 또한, 제시된 시간의존적 생애주기비용 모델과 가치분석 절차의 타당성을 검토하기 위하여 실제대상사업에 적용하였다. 본 연구에서 제안된 방법론은 공동주택 건설사업에서의 설계대안 선정, 생애주기 비용 평가 및 합리적인 예산의 분배 등에 크게 기여할 것으로 기대된다. In the resent years, the importance of VE (value engineering) and LCC (life cycle cost) analysis for apartment building construction projects has been fully recognized. Accordingly theoretical models, guidelines, and supporting software systems were developed for the value engineering and life cycle cost analysis for construction management including large building systems. However, the level of consensus on VE and LCC analysis results is still low due to the lack of reliable data on maintenance. This paper presents time dependent LCC model based value analysis method for rational investment decision making and design alternative selection for construction of apartment building. The proposed method incorporates a time dependent LCC model and a performance evaluation technique by fuzzy logic theory to properly handle the uncertainties associated with statistics data and to analyze the value of alternatives more rationally. The presented time dependent VE and LCC analysis procedure were applied to a real world project, and this case study is discussed in the paper. The model and the procedure presented in this study can greatly contribute to design value engineering alternative selection, the estimation of the life cycle cost, and the allocation of budget for apartment building construction projects.

한국인의 피부 수분함유량, 유분 함유량 및 경표피수분손실량의 특성에 관한 연구

석장미 ( Jang Mi Suk ),박신영 ( Shin Young Park ),최미라 ( Mi Ra Choi ),안송이 ( Song Yi An ),김범준 ( Beom Joon Kim ),박진오 ( O Jin Park ),정상욱 ( Sang Wook Jung ) 대한화장품학회 2013 대한화장품학회지 Vol.39 No.3

본 연구에서는 연령별 수분함유량, 유분함유량 및 경표피수분함유량에 대한 데이터를 비교 분석함으로써 연령별 피부 특성 차이를 규명하여 향후 화장품 산업개발에 도움을 줄 수 있는 기초자료를 제공하고자 한다. 피험자 남녀 총 638명을 대상으로 볼 부위의 수분함유량, 코 끝 부위의 유분함유량, 볼과 전박부위의 경표피수분손실량을 측정하였으며, Statistical Package for the Social Sciences (version 19.00; SPSS Inc., Chicago, IL, USA) 프로그램을 사용하여 분석하였고 피험자에 대한 정보뿐 아니라 피부 수분함유량, 유분함유량, 경표피수분손실량의 피부 측정치 결과를 평균 ± 표준편차로 나타내었다. 그 결과 볼 부위의 수분함유량은 여성이 남성보다 높았으며, 연령이 높아질수록 수분함유량이 증가하였다. 또한 코 부위의 유분함유량은 남성이 여성보다 높았으며 연령이 낮아질수록 유분함유량이 증가하였다. 볼 부위의 경표피손실량은 여성이 남성보다 높은 반면, 전박 부위의 경표피손실량은 남성이 여성보다 높았다. 이상의 연구 결과로 추후 화장품 산업에서 연령별, 성별 기초화장품 개발 등에 도움을 줄 수 있는 기초자료로 활용될 수 있을 것이라 사료된다. In this study, water content, sebum content, and transepidermal water content were investigated to provide basic data for the future cosmetics industry as comparing the skin characteristics of different ages. Water content of cheek area, sebum content of nose area, and transepidermal water loss (TEWL) of cheek and forearm of trial subjects (total 638 people of both male and female) were measured. Data were analyzed using Statistical Package for the Social Sciences program (version 19.00; SPSS Inc., Chicago, IL, USA). Water content, sebum content, and TEWL of skin were measured as mean ± standard deviation. As a result, water content of cheek from female was higher than male and the water content increased with the older ages. However, sebum content of nose from male was higher than female and the sebum content increased with the younger ages. TEWL of cheek from female was higher than male, but TEWL of forearm from male was higher than female. Therefore, these results can be used as basic data in the development of future cosmetics for different ages and genders.