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이호진 ( Ho Jin Lee ),남승범 ( Seung Bum Nam ),정재욱 ( Jae Wook Jung ),나임일 ( Im Il Na ),김철현 ( Cheol Hyeon Kim ),류백렬 ( Baek Yeol Ryoo ),최두환 ( Du Whan Choe ),강진형 ( Jin Hyung Kang ),이재철 ( Jae Cheol Lee ) 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.2
Gefitinib is a novel drug used to treat advanced non-small cell lung cancer. However, drug-related interstitial pneumonia is a major life-threatening side effect, which has a worldwide prevalence of 0.3-0.4%. In Japan, the prevalence is high as 3-4% but the actual frequency in Korea has not been officially assessed. We report two cases of gefitinib-induced interstitial lung disease during the treatment of non-small cell lung cancer. High-resolution computerized tomography (HRCT) of one case showed nonspecific ground glass opacity and the chest x-ray of another case showed diffuse bilateral ground glass opacity. The former patient showed a rapid good response to corticosteroid treatment whereas the latter died despite receiving aggressive treatment with high dose corticosteroid and empirical antibiotics. (Tuberc Respir Dis 2007; 62: 134-139)