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김승용,정병수,최규철 ( Seung Yong Kim,Byoung Soo Chung,Kyu Cherl Choi ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.1
This mycological and cultural investigation was made in 86 cases of onychomycosis diagnosed on positive KOH wet mount at Chosun University Hospital from October, 1989 to February, 1990. The results were as follows : l. The ratio of male to female was 1.2:1. According to Zaiass classificat.ion, distal subungual onychomycosis (DSO) was the most predominant type(79 cases) and others, in decreasing frequency, were superficial white onychomycosis (SWO) (Fcases), total dyst,rophic onychomycosis (TDO) (1 cases, and proximal subungual onychomycosis (PSO) was not. found. 2. In DSO, isolat,ed fungi were T. mentagrophyte(31 cases), i'. rubrum(23 c<ses), saprophyt.es(7 cases) and C albicans (5 cases). In SWO, 2 species were isolated, which were T. mentagraphytes (5 cases) and saprophyte (1 case). C. albicans was cultured in one case of TDO. 3. Eight cases of iisolat,ed sapr ophytes were Aspergillus ( 5 cases), Scopulariopsis (1 case), Hormodendrum(1 case), and Cepalosporium(1 case). Saprophytes were tound only in toe nails. 4. Uo saprophytes were isolated from coexisting skin lesi.ons. Among 10 cases of coexisting tinea manus and/or tinea corporis, T. rubrum were cultured in 8 cases. 5. The positive rate of culture by two different sampling methods and media was as follows : On Sabouraud glucose agar media, it was 47.7% (41 cases) by clipping methodand 40.7% (35 Cases) by file-method. On dermatophyte test medium, it was 43.0 (3'7 eases) by cliipping method and 45.3% (39 cases) by file-method. It seem that the selection of sampling site is important in increasing the positive rate in culture of onychomyc.osis. (Kor J Dermatol 29(1): 50 55, 1991)
자외선에 노출된 멜라닌세포성 모반에서 랑게르한스 세포 수와 사이토카인 발현에 관한 연구
김도형 ( Do Hyeong Kim ),최규철 ( Kyu Cherl Choi ),정병수 ( Byoung Soo Chung ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.9
Background: It is well established that UV-induced DNA damage is involved in the mutation of oncogenes and tumor suppressor genes, and the subsequent development of skin cancers. Langerhans cells (LC) are thought to play an important role in the presentation of tumor antigens for the induction of anti-tumor immunity. Cytokines may have a key role in the UV-induced modulation of the skin`s immune system. Objective: To clarify the role of Langerhans cells, cytokines in UV-irradiated Melanocytic Nevi vs non-irradiated melanocytic nevi. Methods: Skin biopsies from 10 melanocytic nevi, taken from partially covered melanocytic navi and irradiated part with a defined UV dose, were examined. Immunohistochemical staining was used for the quantitative distribution of LC and the expression of cytokines which are related to LC migration and maturation (TNF-α and GM-CSF), Th1 response (IL-12), and Th2 response (IL-10). Results: LC number increased in non-irradiated neoplastic epithelium compared to control skin. In UV-exposed nevi, LC density decreased significantly but a constant number was still maintained. TNF-α and GM-CSF were predominently expressed in lesional epithelium and some nevus cells, 2 days after irradiation. GM-CSF expression in nevus cells was maintained up to 7 days after exposure. IL-10 was expressed in epidermis 2 days after exposure. While IL-12 was weakly positive and maintained up to 7 days in unexposed lesional epidermis, it was not detected after 2 days but reappeared in an exposed lesion after 7 days. Conclusion: Langerhans cells (LC) modulated by cytokines in UV-exposed skin may have a functional role in UV-induced carcinogenesis. (Korean J Dermatol 2007;45(9):915∼922)
최연홍(Youn Hong Choi),이광열(Kwang Youl Lee),최규철(Kyu Cherl Choi),김영표(Young Pio Kim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.5
We report an atypieal case of xanthoma without evidence of underlying disease, A 50-year-old asymptomatic, yellowish, flat plaques on the upper eyelids, trunk and thighs, and huge, deep-seated tumors on anterior aspect of the neck, back and ankle areas of 3 years duration. Biopsies were performed at the lesions of the neck and hack. Two biopsy specimens showed the same findings of xanthoma, respectively. The appearance of refrigerated serum was clear. Paper electrophoresis didn't show elevation of any lipoprotein, suggesting normolipoproteinemia.
최연홍(Youn Hong Choi),정병수(Byoung Soo Chung),최규철(Kyu Cherl Choi) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.6
We herein present two cases of angioleiomyoma with unusual location and number of cutaneous lesion. One was 58-year-old male who has two small peasized nodules on the left palm and volar aspect of the left fifth finger. The other was 63-year-old male with three small pea-sized nodules on the left palm, volar aspect of the left middle finger and the right sole. We confirmed these as angioleiomyoma by clinical and histopathological findings.
최연홍(Youn Hong Choi),정병수(Byong Soo Chung),최규철(Kyu Cherl Choi) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.1
Sixty-one cases in which the diagnosis of epithelial cysts had been made studied. The data were collected from our own clinical records and a review of all histopathologic slides of epithelial aysts that had been filed at Departrnent of Dermatology, Chosun University Hospita.l during the past g years from July, 1979 to June, 1984. The results were as follows: 1) Among the 61 cases of epithelial cysts, 41 cases were epidermal cysts, 10 cases of milia, 7 cases of steatocystoma. multiplex, 2 cases of pilar cysts and 1 case of eruptive vellus hair cyst. 2) The average age of these patients was third decade. 3) The commonest site of epidermal cyst and milium was face. Two cases of pilar cyst occurred only on the scalp. Fteatocystoma multiplex was developed on the several sites, but not on the scalp and scrotum, 4) The average diameter was 6. 5 mm for epidermal cyst, p 6 mm for milium, 3 1 mm for steatocystoma multiplex and 17 mm for pilar cyst.
김영균(Young Kyoon Kim),최연홍(Youn Hong Choi),최규철(Kyu Cherl Choi),김형균(Hyoung Kyun Kim) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.5
Subepidermal calcified nodules, consisting of solitary circumscribed deposits of insoluble calcium within the subepidermis, have generally been assumed to be idiopathic. As the disease is not associated with any systemic or cutaneous diseases, or any biochemical abnormalities, the pathogenesis is still unexplained, and it is thought to be a definite entity with only a characteristic histopathology. We report a 36-year-old female who has had subepidermal calcified nodules on both upper eyelids symmetrically for about 20 years. It is interesting that the lesions have xanthelasma-like appearance and are associated with syringomas. Excisional biopsy showed typical histopathologic and histochemical features of the sub epidermal calcified nodules.
피부 종양의 Keratin 분포에 대한 면역 조직화학적 연구
이광열(Kwang Youl Lee),최연홍(Youn Hong Choi),최규철(Kyu Cherl Cho) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1
Sixty cutaneous tumors of different types were investigated by means of immunoperoxidase technique(avidin-biotm-peroxidase complex method) with the use of antikeratin antibody. The results were as follows: 1. Squamous cell carcinomas, keratoacanthomas, and Bowen's disease exhibited strong reactivity with antikeratin antibody. 2. In squamous cell carcinomas and keratoacanthomas, the most heaviest staining patterns were detected in areas of keratinization and horn pearl formation. 3. Basal cell carcinomas and seborrheic keratosis were moderately stained, whereas Paget'a disease and metastatic carcinoma(oat cell carcinoma) did not contain keratin. 4. In some cases of basal cell carcinomas, the tumor cells were partially positive. 5. Malignant melanomas, nevi, malignant.lymphomas, neural tumors, hemangiomas, and dermatofibromas were uniformly negative.
일광 노출과 관련된 표피 종양에서 MAPK 발현에 관한 면역조직화학적 연구
고정훈 ( Jung Hun Ko ),김정수 ( Jung Su Kim ),최규철 ( Kyu Cherl Choi ),정병수 ( Byoung Soo Chung ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.5
N/A Background : Mitogen-activated protein kinase(MAPK) is an important molecule in transducing extracellular signal from cell surface to the nucleus. MAPK family includes ERK(extracellular signal-regulated protein kinase), JNK(stress-activated c-Jun N-terminal kinase), p38 kinases. Not only various growth factors and cytokines, but also other signals such as UV light are able to activate MAPK, resulting in various cellular responses including proliferation, differentiation and apoptosis. Objective : The purpose of our study was to determine patterns of MAPK expression in epidermal tumors including seborrheic keratosis(SK) on sun-exposed skin and unexposed area, actinic keratosis(AK), Bowen`s disease(BD), acantholytic squamous cell carcinoma(ASCC), and other squamous cell carcinoma(SCC). Methods : Using pan ERK, JNK-2 and p-JNK, we have examined MAPK expression immunohistochemically in epidermal tumors(total 30 cases) including SK on sun-exposed skin(5 cases) and unexposed areas(5 cases), AK(5 cases), BD(5 cases), ASCC(5 cases), and SCC(5 cases). Results : ERK was expressed in AK and ASCC positively but not in BD, and the staining pattern with ERK also showed positivity in microinvasive area and dysplastic cells of SCC. JNK was not expressed in all tumor cells of SK, AK, BD, and ASCC with the exception of dyskeratotic cells in BD and acantholytic cells in ASCC. Conclusions : We suggest that ERK expression may be related to sun exposure and responsible for proliferation of tumor and invasion into surrounding tissue. JNK may not be related with malignant progression of tumor and carcinogenesis cauesd by sun exposure, but with apoptosis of tumor cells. (Korean J Dermatol 2003;41(5) : 578~585)