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건선에서 생물학적 제제의 규칙적 및 불규칙적 투여에 따른 치료 결과 비교
최고운 ( Go Woon Choi ),임남주 ( Nam Ju Lim ),신정우 ( Jung U Shin ),이희정 ( Hee Jung Lee ),윤문수 ( Moon Soo Yoon ),김동현 ( Dong Hyun Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.6
Background: Patients with stable psoriasis showing clear/near-clear response can consider extending the dosing interval of biologics. However, few studies have reported the treatment outcomes following irregular dosing intervals of biologics in patients with psoriasis. Objective: We compared treatment outcomes after regular and irregular dosing intervals of biologics in patients with psoriasis. Methods: This single-center, retrospective observational study included patients who received biologics for treatment of plaque psoriasis between January 1, 2014 and December 31, 2019. We compared patient demographics, clinical characteristics, biologics administered, and treatment outcomes based on the regularity of the dosing interval. Results: Among 95 patients investigated, 63 (66.3%) received biologics at regular dosing intervals. We observed no significant intergroup differences in the final Psoriasis Area Severity Index (PASI) scores (1.2 vs. 1.8, p=0.16) and in the percentage improvement in PASI scores from baseline levels (-89.8% vs. -90.8%, p=0.68). The rate at which biologics were switched was higher in the irregular-dosing group than in the regular-dosing group; however, the difference was statistically nonsignificant (28.1% vs. 12.7%, p=0.06). We observed a significant intergroup difference in patients who were administered guselkumab at baseline (12 [21.8%] vs. 0 [0.0%], p=0.01). Conclusion: This study showed that compared with regular dosing intervals, irregular dosing intervals of biologics were associated with high rates of switching of these agents, although we observed no statistically significant differences with regard to PASI scores. Therefore, it is important to adhere to the standard dosing schedule prescribed for biologics, and guselkumab may improve patient compliance. (Korean J Dermatol 2021;59(6):440∼446)
Pembrolizumab에 의해 유발된 독성표피괴사용해 1예
최고운 ( Go Woon Choi ),이희정 ( Hee Jung Lee ),김동현 ( Dong Hyun Kim ),윤문수 ( Moon Soo Yoon ),신정우 ( Jung U Shin ) 대한피부과학회 2022 대한피부과학회지 Vol.60 No.2
Pembrolizumab is an immune checkpoint inhibitor that selectively blocks the programmed cell death (PD)-1 receptor. Although it has a dramatic effect on the treatment of advanced malignancies, instability of immune tolerance may cause immune-related adverse events in the skin. A 62-year-old male with a history of metastatic urothelial carcinoma was referred to the dermatology department and presented with a widespread mucocutaneous rash. Itching appeared 7 days after the first administration of pembrolizumab, and on the third day after the second administration, an erythematous maculopapular rash that coalesced into large flaccid bullae on the whole body with a positive Nikolsky’s sign developed. A biopsy revealed a subepidermal bulla with basal keratinocyte necrosis. Pembrolizumab was discontinued due to the diagnosis of toxic epidermal necrolysis (TEN), and intravenous methylprednisolone was started. Herein, we report a case of TEN induced by pembrolizumab to highlight immune-related cutaneous adverse events in patients receiving anti-PD-1 therapy. (Korean J Dermatol 2022;60(2): 120∼124)
레스베라트릴 트라이아세테이트(RTA)를 함유한 크림의 피부 노화 완화 효과
최고운 ( Go Woon Choi ),정현진 ( Hyun Jin Jeong ),석진경 ( Jin Kyung Seok ),백지훈 ( Ji Hwoon Baek ),김영미 ( Young Mi Kim ),부용출 ( Yong Chool Boo ) 대한화장품학회 2018 대한화장품학회지 Vol.44 No.2
피부 노화의 정도는 기기 분석을 통해 객관적으로 측정 할 수 있다. 본 연구의 목적은 인체 적용 시험을 통해 8000 PPM의 레스베라트릴 트라이아세테이트(RTA)를 함유한 크림의 피부 노화 완화 효과를 평가하는 것이다. 여성 피험자 20명에게 시험 제품을 얼굴에 매일 2회 8주 동안 바르고, 4주마다 기기 분석을 통해 주름, 처짐, 탄력, 진피치밀도, 수분 및 밝기 등을 측정하였다. 시험 제품을 4 주 및 8 주 동안 사용한 결과 총 주름 면적이 감소하고(5.12%, 4.86%), 총 주름 용적이 감소하고(10.53%, 8.41%), 탄력성이 증가하고(2.84%, 3.98%), 진피치밀도가 증가하고(15.65%, 20.80%), 수분이 증가하고(5.83%, 7.37%), 밝기(L<sup>*</sup> 값)가 증가하고(0.79%, 1.07%), 피부색(individual typology angle, ITA<sup>o</sup>)이 밝아졌으며(5.43%, 4.95%), 이들 변화는 통계적으로 유의하였다(p < 0.05). 시험 기간 동안 모든 참가자에게서 부정적인 피부 반응이 관찰되지 않았다. 본 연구는 시험 제품의 피부 노화 완화 효과를 뒷받침한다. Skin aging degree can be objectively measured using the instrumental analysis. The purpose of this study was to evaluate the anti-aging effects of a cream containing 8000 PPM of resveratryl triacetate (RTA) in the human skin test. Twenty female subjects were given test products twice a day for 8 weeks on the face, and wrinkles, sagging, elasticity, dermis denseness, moisture and brightness were measured every 4 weeks by instrument analysis. After 4 and 8 week-use of the test product, total wrinkle area decreased (5.12%, 4.86%), total wrinkle volume decreased (10.53%, 8.41%), sagging decreased (4.69%, 5.91%), elasticity increased (2.84%, 3.98%), dermis denseness increased (15.65%, 20.80%), water content increased (5.83%, 7.37%), lightness (L<sup>*</sup> value) increased (0.79%, 1.07%), and individual typology angle (ITA<sup>o</sup>) increased (5.43%, 4.95%)compared with the baseline values before treatments, and all these changes were statistically significant (p < 0.05). No adverse skin reactions were observed in all participants during the study period. This study supports the anti-aging effects of the test product.
패트리샤 폴라코(Patricia Polacco)의 그림책에 나타난 노인 인물의 이미지 분석
최고운(Choi, Go-Woon),신세니(Shin, Se-Ni),조희숙(Jo, Hea-Soog) 한국어린이미디어학회 2011 어린이미디어연구 Vol.10 No.2
본 연구는 패트리샤 폴라코의 그림책들 중, 노인들이 주인공과 중심인물로 등장한 국내 번역본 8권을 대상으로 하여 그림책 속 노인 이미지를 분석하였다. 연구결과, 패트리샤 폴라코의 작품들에 나타난 노인 인물의 이미지는 첫째, 자애로운 보호자, 둘째, 전통의 계승자, 셋째, 지혜의 전수자, 넷째, 사회로부터 소외ㆍ고립된 주변인으로 나타나 있었다. 본 연구를 통해 패트리샤 폴라코의 작품에 대한 이해는 물론, 이들 작품을 활용하여 유아들에게 긍정적인 노인 이미지 교육 기회를 제공할 뿐 아니라 관련 교육 프로그램에 유용한 참고자료로 활용할 수 있을 것으로 본다. In this paper, the image of the elderly in picture books is analyzed with eight picturebooks written by Patricia Polacco that describe well the life of the elderly by presenting the elderly as protagonists or supporting roles in her books. This can enlighten readers about Patricia Polacco’s books and can establish the basis that her works can be utilized as principal references that help children to build the positive image of the elderly. The image of the elderly in Patricia Polacco’s picture books is categorized into four groups: gracious guardians, inheritors of tradition, initiators of wisdom, and loners isolated from society. We expect that results presented in this paper propose the basis that Patricia Polacco"s works can be employed as principal media that furnish children with educational opportunities for the image of the elderly.
Confocal Scanning Laser Microscope (CSLM)을 이용한 피부 기저층 멜라닌 밀도의 정량화
김동현 ( Dong Hyun Kim ),이승호 ( Sung Ho Lee ),오명진 ( Myoung Jin Oh ),최고운 ( Go Woon Choi ),양우철 ( Woo Chul Yang ),박장서 ( Chang Seo Park ) 대한화장품학회 2014 대한화장품학회지 Vol.40 No.3
최근 여러 가지 비침습적인 방법으로 피부조직의 생검 또는 조직학적 처리과정 없이 피부의 실시간 이미지를 이용한 연구가 가능해졌다. Confocal scanning laser microscope (CSLM) 이미지는 830 nm의 근적외선 파장을 사용하는 비침습적 방법으로 피부의 내부 구조를 이미지화할 수 있으며, CSLM을 이용한 연구를 통해 비침습적인 피부 측정법으로 색소 침착 부위의 기저층과 진피 유두 사이에서 melanin cap, papillary ring 과 같은 지표가 뚜렷하게 관찰된다고 보고되었다. 본 연구에서는 scanning probe image processor (SPIP)소프트 웨어를 사용하여 CSLM 디지털 이미지 정량 분석을 처음 시도하였으며 본 연구결과는 정성적 피부조직 이미지 데이터를 정량화함으로써 향후 CSLM 활용범위를 높이게 될 것으로 기대하고 있다. Non-invasive technologies in skin research have enabled to use a live image of living skin without a biopsy or histologic processing of tissue. Confocal scanning laser microscope (CSLM) operated at a near-infrared wavelength of 830 nm allows visualization of inner structure of skin as a non-invasive manner. According to previous researches using CSLM, melanin cap and papillary ring were clearly observed in pigmented areas between stratum basale and papillary dermis. In this study, conversional analysis of CSLM digital images into numerical estimation using scanning probe image processor (SPIP) software was attempted for the first time. It is concluded that a quantification of CSLM images can pave way to expand the field of applications of CSLM.