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노화흰쥐의 시상하부에서 vasopressin-면역반응 신경세포의 형태학적 변화
박영란(Young-Lan Park),정윤영(Yoon-Young Chung),천관영(Kwan-Young Cheon),박근용(Keun-Yong Park),설경수(Kyeong-Soo Seol),김종중(Jong-Joong Kim),문정석(Jeong Seok Moon) 대한체질인류학회 2007 해부·생물인류학 (Anat Biol Anthropol) Vol.20 No.1
노화는 중추신경계의 구조를 변화시킬 뿐 아니라 여러 신경인자들의 분포에 영향을 미쳐 생체리듬에 많은 변화를 초래한다. vasopressin (VP)은 시상하부에서 분비되는 펩타이드의 일종으로서, 주로 혈압을 상승시키고 항이뇨호르몬 작용을 가진다. 본 연구는 여러 생체리듬조절에 관여하는 시상하부에 분포하는 VP-면역반응 신경세포의 형태학적 변화를 노화흰쥐에서 관찰함으로써 노화로 인한 신경세포 변화를 관찰하고자 하였다. Sprague-Dawley계의 약 12주령인 젊은 흰쥐와 약 18월령의 노화흰쥐에 통상의 조직처리를 한 후 VP 일차항체를 사용하여 면역조직화학염색을 시행한 후 광학현미경으로 비교 관찰하였다. VP의 염색결과, VP-면역반응 신경세포는 주로 시상하부의 뇌실곁핵과 시각로위핵에서 두드러지게 관찰되었으며 노화흰쥐의 VP-면역반응 신경세포에서 핵과 세포체 크기가 젊은흰쥐에 비해 매우 크게 관찰되었으나 노화흰쥐의 VP-면역반응 신경세포의 수는 감소하였다. 그리고 시각교차위핵에서 노화흰쥐에서 VP-면역반응 신경세포의 수는 젊은흰쥐보다 약 2배정도 많이 나타났다. 따라서 노화가 진행됨에 따라 시상하부에서 VP 분비의 변화를 초래하여 다양한 기본생활주기가 달라지고 하루주기행동의 주간리듬(diurnal rhythm)의 변화에 영향을 미칠 것으로 사료된다. The role of neuropeptides in the central nervous system (CNS) has received increasing attention. Numerous peptide molecules are found in the mammalian CNS and many of them are thought to act as either neurotransmitters or neuromodulators. The neuropeptides found in high concentration in the hypothalamus include vasopressin (VP), vasoactive intestinal polypeptide, somatostatin, and oxytocin. The main approches to assess the involvement of neuropeptides can be focused on functions affecting the aging of the brain. Morphological aging of the CNS has been characterized by degenerative changes of fiber connections and cell loss, although degeneration does not always occur to the same extent throughout various parts of the brain and, moreover, varies for different cell types. Despite of many studies in VP containing neurons , there exist discrepancies in results about the changes of aged rat brain. The aim of the present study is, therefore, to investigative possible changes in the number and morphology of VPimmunoreactive neurons with aging in each area of the hypothalmus of the aged rats. As a result, the number of VP-immunoreactive neurons was decreased in hypothalamus nucleus of aged group. Especially, in VP-immunoreactive neurons of hypothalamus, the size of neuronal cell body and nuclei in aged group is larger than in young group and the fiber density of immunoreactivity neurons of median eminance (ME) in aged group is stronger than in young group. But, the total number of VP-immunoreactive neurons in the suprachiasmatic nucleus (SCN) of the aged group is larger than in the young group. These studies indicate the involvement of VP-immunoreactive neurons in aging process of hypothalamus, and aging process may affect the synthesis of VP in the neurons of hypothalamic nuclei. Whereas, in VP expression, aging process induces an enlargement of the cell size of surviving neurons to compensate.
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모체 Thyroxine 투여가 태아알코올효과를 가진 흰쥐 대뇌겉질 및 해마에서 NPY함유 신경세포의 생후 발달에 미치는 영향
김복,박상기,박영란,김종중,문정석,김주수,문영민,현영식,천관영,정윤영 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2
Background and Objectives: Maternal alcohol abuse is considered to be one of the most prominent cause of neurobiological malformations in the postnatal and adult life of the offspring. In this study, we investigated the effects of maternal alcohol drinking on the postnatal development of NPY-containing neuron, and, the influence of thyroxine treatment on the cerebral cortex and hippocampus of pups of alcohol abused mother. Materials and Method: Time-pregnant rats were divided into three groups. Alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day 6; control pair-fed group B was fed a liquid diet in dextrin replaced alcohol isocalorically: alcohol + T4 group C received 35 calories liquid alcohol diet and exogenous thyroxine subcutaneously. Results: Group C showed prominent NPY immunoreactivity in the cerebral cortex compared to group A and B at P7. In group C, NPY-containing neurons were widely distributed in the all layers of cerebral cortex after P14. Besides, numerical decrease of NPY-containing neuron as age increases was not found in group C. However, the decrease of NPY-containing neuron was clearly observed in group A compared to group C after P14. In hippocampus, group Band C were appeared similar patterns after P7. Additionally, in group C, NPY immunoreactivity was prominently appeared in CA2 and CA3 at P14 as compared to group B. Conclusions: The present results showed the increase of intensity and number of NPY-containing neurons in cerebral cortex and hippocampus of pups of exogenous T₄ supplemented alcohol-exposed dams as compared to control pair-fed and alcohol-exposed pups at P7. It presumably suggest that NPY-containing neurons might be regulated by the early postnatal growth stimulatory effect of the exogenously supplemented T₄. Therefore, the increase of NPY synthesis caused by maternal administration of exogenous thyroxine may ameliorate fetal alcohol effect, one of the ill effects as a result of the dysthyroid state following maternal alcohol abuse.
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