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RISS 인기검색어
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- 저자 : 채정훈(Chae Jung-Hun) (검색결과 2 건)
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노화와 일회 지구성 운동이 골격근 내 mTOR, 4E-BP1, p70S6K 및 AMPK 발현에 미치는 영향
어수주(Eo Su-Ju),권형태(Kwon Hyeong-Tae),선주상(Shan Zhou-Xiang),채정훈(Chae Jung-Hun),김효식(Kim Hyo-Sik),손희정(Son Hui-Jung),김효정(Kim Hyo-Iung),김창근(Kim Chang-Keun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.3
We determined acute endurance exercise on mTOR signaling responses in aging skeletal muscle(soleus; SOL, extensor digitorium longus; EDL). Total 32 Sprague-Dawley rats were divided into two groups by age; young group(YG; 20wk; n=16) or old group(OG; 72wk; n=16). Each experimental group was further allocated two subgroups; Exercise(EX; n=8), Control(CON; n=8) group. All animals in exercise group performed one bout of 3hr endurance swimming exercise (30min×6bouts). The phosphorylation of mammalian target of rapamycin(mTOR) and p70 ribosomal S6 kinase(p70S6K) were significantly increased in 20wk(YG) soleus (p<.05). However, the phosphorylation of mTOR and eukaryotic initiation of factor 4E binding protein 1(4EBP1) were significantly decreased in 72wk(OG) muscles(p<.05) after endurance acute swimming exercise. The phosphorylation state of AMPK was significantly increased in 20wk(YG) muscles(p<.05) and 72wk soleus(p<.01) after exercise. The results suggest that a bout endurance exercise was increased AMPK activity but inhibited mTOR and 4E-BP1 phosphorylation in aging slow-twitch muscle.
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산제 조제 업무의 효율성 및 산제의 안정성 확보를 위한 개선방안
권대선,김재희,채정훈,김윤경,이은주,박지수,최지홍,문보경 한국병원약사회 2009 병원약사회지 Vol.26 No.2
Abstract: A medication is designed to act effectively, and it is crucial to administrate a original dosage form so as to maintain the stability of compound and to bring adequate effects. However, it is happening to break into powder in terms of patient's age and difficulty in swallowing. Therefore, among the oral dosage medications, we should categorize into “The group of prohibit-ing crushing” and “The group of permitting crushing, with wary”. In addition, by providing these information to the prescribers and placing on records, we try to guarantee the efficacy, stability, as well as safety. From 16th of June in 2008 to 20th of June in 2008(5days), all prescriptions were compiled and analyzed. According to the data, we realized that “The group of prohibiting crush-ing” had been prescribed to crush although they could not crush. That it, useless and impractical system laid a burden on both prescribers and pharmacists. Moreover, by means of distinctive standard, the accuracy of double-checking system was also deteriorated. Therefore, new com-puterized program is made. Owing to this program which is restricted to prescribe “The group of prohibiting crushing” to crush, consistent checkup for compounding medication turn into possible Accordingly, through this program, a patient can not only be administrated appropriately, but the pharmacist also behave more coherently. However, in order to administrate more delicately and to establishing better compounding circumstance, further investigation will be required.
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