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등줄쥐(Apodemus agrarius Pallas), KK 마우스 및 Chinese Hamster에 있어서 고지방사료 급여의 영향
채갑용(Kab-Ryong Chae),김용규(Yong-Kyu Kim),강태석(Tae-Surk Kang),김철규(Chuel-Kyu Kim),장인석(In-Surk Jang),황진희(Jin-Hee Hwang),황대연(Tae-Yeon Hwang),임철주(Chul-Joo Lim),이은(Euen Li),조정식(Jung-Sik Cho) 한국실험동물학회 1999 Laboratory Animal Research Vol.15 No.1
SHR 랫드에서 Streptozotocin 유발 당뇨가 소장 흡수세포의 형태학적 변화와 Na⁺-의존성 D-Glucose 수송에 미치는 영향
장인석(In-Surk Jang),채갑용(Kab-Ryong Chae),임철주(Chul-Joo Lim),강태석(Tae-Seok Kang),김용규(Yong-Kyu Kim),김철규(Chuel-Kyu Kim),황진희(Jin-Hee Hwang),황대연(Dae-Youn Hwang),안병우(Byeong-Woo Ahn),조정식(Jung-Sik Cho) 한국실험동물학회 1998 Laboratory Animal Research Vol.14 No.2
비만 Zucker(fa/fa) 랫드에서 주령에 따른 지방대사 관련 혈액 생화학성분, 호르몬 및 체지방 합성 유전자의 변화
장인석(InSurk Jang),황대연(Dae Youn Hwang),채갑용(Kab Ryong Chae),이주은(Ju Eun Lee),조정식(Jung Sik Cho) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
The aim of the present study was to investigate the age-related onset of obesity in obese Zucker(fa/fa) rats as indicated by adipogenic biomarkers and genes. The Zucker rats aged 6, 8, 10, 12, and 16 wk were used to determine age-related changes in biochemical components including triglyceride, glucose, cholesterol, insulin and leptin in serum, and the expression of adipogenic genes such as acetyl CoA carboxylase (ACC) and peroxisome proliferator activated receptor y (PPARγ) in the epididymal fat pads. As a result, the serum levels of glucose and cholesterol did not significantly affected by ages. However, the level of triglyceride in serum resulted in a significant (p<0.05) increase after 8 wk of age and stayed at this level till 16 wk of age we examined. The level of insulin at 6 wk of age was significantly (p<0.05) lower than any other ages examined. Also, the Zucker rats aged 16 wk showed a markedly (p<0.05) higher serum leptin level when compared with the rats aged 6 and 8 wk. Especially, leptin level at 16 wk of age increased by a two-fold as compared with that at 6 wk old. We also observed age-related differences in the expressions of ACC and PPARy in the epididymal fats. In particular, ACC mRNA expression did show much of an age-associated alteration in fat tissues. The PPARγ expression in rats aged 6 wk was to be much lower (p<0.05) compared with the rats aged 8, 10, 12 and 16 wk. From the evidences we observed here, it is suggested that preobese status at 6 wkold Zucker(fa/fa) rats rapidly developed obesity around at 8 wk of age as indicated by biomarkers and consequently showed pathophysiological symptom of obesity after 8 wk of age.