젊은 성인에서 신체 불만족과 성격 특성 및 스트레스와의 관계

김재헌,김정란,왕성근,지익성,Kim, Jae-Heon,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aims of this study was to evaluate relationship between body dissatisfaction, personality characteristic, and stress in young adults. Methods : One hundred and ninety five young, healthy, and normal participants filled out all 3 types of self-reported questionnaire, the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR ; K-BDDE-SR), Neuroticism, Extraversion, Openness-Five Factor Inventory (NEO-FFI) and Stress Scale of Korean version of the Depression Anxiety Stress Scale (K-DASS-21). Results : Out of the 195 participants, 30% (n=59) was male and 70% (n=136) was female. There was no statistical difference between high K-BDDE-SR group (K-BDDE-SR score 75 percentile or higher, n=50) and low K-BDDE-SR group (K-BDDE-SR score below than 75 percentile, n=145) in terms of weight, height, and BMI. In high K-BDDE-SR group, neuroticism was significantly higher than low K-BDDE-SR group, and extraversion, agreeableness, conscientiousness were significantly lower than low K-BDDE-SR group. Also, level of stress in high K-BDDE-SR group was significantly higher than low K-BDDE-SR group. Conclusion : Our study revealed that individual's with more body dissatisfaction were more neurotic and stressful. Thus, body dissatisfaction and diverse psychiatric diseases should be considered in treating neurotic and stressful young adults.

정신과 외래 우울증 환자에서 분노 경험

안병훈(Byung-Hoon Ahn),지익성(Ik-Seung Chee),왕성근(Seong-Keun Wang),홍주봉(Joo-Bong Hong),박권수(Kwon-Soo Park),김영란(Young-Lan Kim),김정란(Jeong-Lan Kim) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: This study was conducted to evaluate the degree and type of anger experienced by patients with depressive disorders and to determine which type of anger is correlated with symptom severity. Methods: One hundred-six psychiatric outpatients with depressive disorders and ninety normal control subjects completed the Korean version of Aggression Questionnaire(AQ) and Korean version of Depression, Anxiety, and Stress Scale (DASS). Comparison between two groups was conducted to evaluate which type of anger are prominent in the depressed group. Therefore, correlation and partial correlation between the scores of 4 subscales(Anger, Hostility, Verbal aggression, and Physical aggression) of AQ and the scores of 3 subscales(Depression, Anxiety, and Stress) of DASS were assessed. A multiple regression analysis was performed to determine which type of anger predicted symptom severity. Results: Total AQ score, hostility, anger and physical aggression scores were significantly higher in patients with depressive disorders. After the score of Stress and Anxiety subscale of DASS were controlled; the depression score was significantly correlated with total AQ score, physical aggression and hostility score. The Hostility score was a major predictor of the depressive symptom severity. In addition, the Anger score was a major predictor of the anxiety and stress symptom severity. Conclusion: Anger is frequently found symptom in patients with depressive disorders. Therefore, it is important that clinicians routinely evaluate the degree and type of anger in patients with depressive disorders.

젊은 성인에서 대인관계문제 및 신체불만족이 자살사고에 미치는 영향

이재민,김정란,왕성근,지익성,Lee, Jae-Min,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aim of this study was to investigate the relationship between interpersonal problems, body dissatisfaction, and suicidal idea. Methods : Two hundred ninety-four participants filled out the self-reporting questionnaires : Body dissatisfaction was measured with Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) ; Interpersonal problems was measured with Korean Inventory of Interpersonal Problem (KIIP) ; Suicidal Ideation Questionnaire (SIQ) was used to assess suicidal idea. A path analysis was conducted to identify the impact of interpersonal problems and body dissatisfaction on the suicidal ideas. Results : 'Socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)', age, and gender had a direct effect on their body dissatisfaction, and those factors had a indirect effect on the suicidal ideas. Also, 'cold (KIIP_C3)' and body dissatisfaction had a direct effect on the suicidal ideas. Conclusions : These findings can help to identify how interpersonal problems and body dissatisfaction influence the suicidal ideas of people. It would be useful to consider and assess suicidal ideas in the patients with 'cold (KIIP_C3)', 'socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)'.

한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구

김태성,차승민,왕성근,김정란,이영호,최혜인,지익성,Kim, Tae-Sung,Cha, Seung-Min,Wang, Seong-Keun,Kim, Jeong-Lan,Lee, Young-Ho,Choi, Hye-In,Chee, Ik-Seung 대한생물정신의학회 2012 생물정신의학 Vol.19 No.1

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

뇌 Single Photon Emission Computer Tomography 영상을 이용한 정신분열병 환자의 초기 증상 차이에 대한 연구

이진구,김성민,서영덕,김기성,왕성근,지익성,김정란,Lee, Jin-Gu,Kim, Seong-Min,Seo, Young-Duk,Kim, Ki-Seong,Wang, Seong-Keun,Chee, Ik-Seung,Kim, Jeong-Lan 대한생물정신의학회 2010 생물정신의학 Vol.17 No.3

Objectives : This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain $^{99m}Tc$-ECD PECT. Methods : Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent $^{99m}Tc$-ECD PECT. Results : Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. Conclusion : The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

청소년 물질 남용, 의존 환자에서 세로토닌수송단백질 유전자의 다형성

이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),신윤오(Yun-O Shin),지익성(Ik-Seong Chee),이영호(Yoeng-Ho Lee),이현정(Hyun-Jung Lee),조정혜(Jung-Hye Jo),김준호(Jun-Ho Kim),서홍석(Hongseok Seo) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.1

목적 : 최근 청소년에서 약물 남용 문제가 늘어나고 그 시작하는 연령이 어려지고 심각도에서 지속적으로 심해지는 실정이다. 특히 청소년의 경우에는 인격형성 및 신체적 성장 단계에 있기 때문에 이러한 예민한 시기에 막대한 악영향을 미치게 되는 것이다. 약물 남용으로 인하여 신체적 및 정신적 약물의존 상태 뿐만 아니라 약물 중독에 이르게 되어 이러한 정도가 심해지면 환각, 망상과 같은 정신병적 증상에서부터 각 약물의 금단 및 중독 증상을 일으켜 건강에 심각한 해를 끼칠 수 있으며, 건전한 가치관의 발달에도 영향을 미처 인성 발달에 지장을 초래하게 될 것이다. 이에, 연구자는 최근 우리사회에서 문제가 되는 청소년 약물환자에 초점을 맞추어 기존에 많이 연구되어진 사회심리학적 연구 및 실태 연구보다 근원적인 원인을 알아보기 위하여, 기존의 알코올리즘 및 니코틴 중독 환자에서 보고된 기능적 세로토닌 운반체 유전자의 연관성을 청소년 약물 남용 환자에서 알아보기 위하여 본 연구를 시행하였다. 방법 : 국립감호정신병원에 입원한 물질남용이나 물질의존으로 진단 받은 55명의 청소년 환자와 62명의 정상 대조군을 대상으로 하였다. 기능적 세로토닌 운반체 유전자형을 판별하기 위해 중합효소 연쇄반응과 제한효소 및 전기영동을 시행하여, 유전자형 및 대립유전자의 분포를 비교하였다. 또한 환자군은 가족력의 유무, 사용한 약물 횟수, 약물 사용의 빈도, 범죄 동반유무 등과 같이 다양한 임상 변수에 따라 두 군으로 나누어 비교하였다. 결과 : 환자군과 정상대조군 사이의 유전자형(χ²=3.915, df=2, p=0.041)에서는 차이는 없었으나, 대립유전자(χ²=3.966, df=1, p=0.046) 빈도에는 통계적으로 유의미한 연관성을 보이고 있었다. 환자군에서 흡연하는 아집단에서는 흡연하지 않은 아집단에 비해 SS 유전자형 분포가 통계적으로 의미 있게 높았으며(χ²=8.615, df=2, p=0.017), S 대립유전자 빈도가 통계적으로 의미 있게 높았다(χ²=9.92, df=1, p=0.002). 또한 물질에 대한 금단증상이 있었던 아집단이 금단 증상이 없었던 아집단보다 S 대립유전자가 통계적으로 의미 있게 높았다(χ²=3.929, df=1, p=0.047). 결론 : 본 연구의 결과 환자군과 정상대조군 사이에 기능적 세로토닌 운반체의 대립유전자 분포에서 유의한 차이를 발견하였다. 이는 기능적 세로토닌 운반체 유전자의 다형성이 한국인 청소년 물질 남용 발병에 유의한 영향을 끼칠 수 있음을 추정할 수 있다. 또한 S 대립 유전자와 흡연, 금단증상과의 연관성은 세로토닌 운반체 유전자의 다형성이 물질 남용의 아형 내지는 증상발현에도 부분적인 영향을 끼칠 수 있음을 예상케 한다. 따라서 추가 대상자 확보와 함께 향후 후속 연구가 필요할 것으로 사료된다. Objectives : This study was carried out to explore the relationship between adolescents diagnosed with either substance abuse or dependence and a polymorphism of the promoter region of the 5-HTT gene(5-HTTLPR). Methods : We compared the genotype distributions and allele frequencies of the serotonin transporter gene polymorphism in 55 adolescents diagnosed with either substance abuse or dependence and 62 normal subjects. In addition, further studies were conducted on the substance abuse or dependence group, in order to investigate the association between serotonin transporter gene polymorphisms and various clinical factors, including the age of onset, the number of criminal events, the use of alcohol, the history of smoking, the type of substance use disorder, level of education and family history of substance use. Results : We found significant differences in the allele frequency(χ²=3.966, df=1, p=0.046) between patients and controls. When the genotype distribution and allele frequency of the serotonin transporter gene were compared in the patients according to the clinical variance, the distribution of the SS genotype(χ²=8.615, df=2, p=0.017) and S allele(χ²=9.92, df=1, p=0.002) were significantly higher in those patients with smoking than without smoking. And the distribution of S allele(χ²=3.929, df=1, p=0.047) were also significantly higher in those patients with withdrawal symptom than without withdrawal symptom. Conclusion : These results suggest that the 5-HTTLPR polymorphism seems to have a potential role as the genetic factor of substance abuse or dependence in adolescent. Further systematic researches including varying variables of phenotype would be required.

정신분열병 환자에서 G-protein β3 Subunit Gene (GNB3)의 C1429T 유전자의 다형성

서홍석(Hong-Seok Seo),이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),지익성(Ik-Seong Chee),김정란(Jeong-Lan Kim),윤지영(Ji-Young Yoon),이태경(Tea-Keong Lee) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.1

목적 : 본 연구는 정신 분열병과 관계있다고 알려진 GNB3 유전자 중, C1429T 유전자 다형성에 초점을 맞추어 정신분열병과 연관 관계를 알아보기 위하여 시행되었다. 방법 : DSM-IV 진단기준에 의해 진단된 정신분열병 환자군 100명과 정상 대조군 90명을 대상으로 하였다. C1429T 유전자형 판별을 위해 Restriction Fragment Length Enzyme(RFLP)을 이용한 Polymerase Chain Reaction(PCR)이 사용되었다. 결과 : 정신분열병 환자군에서 C1429T 유전자형의 분포는 CC 64(64.0%), CT 36(36.0%), TT 0(0.0%) 이었으며, 대립 유전자의 빈도는 C 164(82.0%), T 36(18.0%)이었다. 정상 대조군에서 C1429T 유전자형의 분포는 CC 60(66.7%), CT 24(26.7%), TT 6(6.7%) 이었으며 대립 유전자의 빈도는 C 144(80.0%), T 36(20.0%)이었다. 정신분열병 환자군과 대조군 간 C1429T 유전자형의 분포에서 통계적으로 의미 있는 차이를 보여주고 있었으나, 대립 유전자의 빈도에서는 차이는 유의미하지 않았다. 또한, 환자군을 성별, 정신과적 질병의 가족력, PANSS scale에 따른 증상 심각도 등의 변수에 따라 분류하였을 때도 유전자형의 분포와 대립 유전자의 빈도 차이는 유의미하지 않았다. 결론 : 이 연구의 결과는 한국인 정신분열병 환자들에서 GNB3/C1429T 유전자 다형성이 정신분열병의 병인과 관계가 있음을 보여준다. 가족-기초 비교 위험 연구와 정신분열병의 다른 임상적 변수들을 포함한 향후의 연구가 필요할 것이다. Objectives:This study aimed to investigate the association between polymorphisms of CNB3/C1429T and schizophrenia. Methods:100patients with schizophrenia and 90controls were enrolled in the study. A polymerase chain reaction( PCR) with restriction fragment length enzyme(RFLP) was used to genotype the C1429T polymorphisms. Results:1) In schizophrenic patients, genotype distributions of the GNB3/C1429T polymorphism were CC 64(64.0%), CT 36(36.0%) and TT 0(0.0%), and allele frequencies were C 164(82.0%), and T 36(18.0%). In normal control, genotype distributions of the GNB3/C1429T polymorphism were CC 60(66.7%), CT 24(26.7%) and TT 6(6.7%), and allele frequencies were C 144(80.0%), and T 36(20.0%). There were significant differences in the genotype frequencies of the GNB3/C1429T polymorphisms between the schizophrenia patients and the controls, while no significant differences in the alleic frequencies. 2) There were no difference in genotype distribution and allele frequencies of the GNB3/C1429T polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale. Conclusions:These results suggest a GNB3/C1429T polymorphism is causally related to the pathogenesis of schizophrenia in the Korean population. Further study of GNB3/C1429T polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.

후기 발생 조증 환자의 정신병리와 임상적 특징

김드레(Dre Kim),이미지(Miji Lee),안소현(Sohyun Ahn),왕성근(Seong Keun Wang),신윤오(Yun O Shin),지익성(Ik-Seung Chee),이선우(Sun Woo Lee),김정란(Jeong Lan Kim) 대한생물치료정신의학회 2015 생물치료정신의학 Vol.21 No.1

정신분열병 환자에서 Heat Shock Protein 70(HSP70) 유전자 다형성

이대호(Dae-Ho Lee),이선우(Sun-Woo Lee),왕성근(Seong-Keun Wang),신윤오(Yun-O Shin),지익성(Ik-Seoung Chee),김정란(Jeong-Ran Kim),이영호(Young-Ho Lee),김지욱(Ji-Wook Kim) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2

목적 : 본 연구는 정신 분열병과 관계 있다고 알려진 HSP70 유전자 중, HSP70-2(HSPA1B) 유전자 다형성에 초점을 맞추어 정신분열병과 관계가 있는지를 알아보기 위해 시행되었다. 방법 : DSM-Ⅳ 진단기준에 의해 진단된 정신분열병 환자군 104명과 정상 대조군 107명을 대상으로 하였다. HSPA1B 유전자형 판별을 위해 restriction fragment length enzyme(RFLP)을 이용한 polymerase chain reaction(PCR)이 사용되었다. 결과 : 정신분열병 환자군에서 HSPA1B 유전자형의 분포는 AA 32(30.8%), AG 57(54.8%), GG 15(14.4%)였으며, 대립 유전자의 빈도는 A 121(58.2%), G 87(41.8%)였다. 정상 대조군에서 HSPA1B 유전자형의 분포는 AA 35(32.7%), AG 63(58.9%), GG 9(8.4%)였으며 대립 유전자의 빈도는 A 133(62.1%), G 81(37.9%)였다. 정신분열병 환자군과 대조군 간 HSPA1B 유전자형의 분포와 대립 유전자의 빈도에 있어서의 차이는 유의하지 않았다. 또한, 환자군을 성별, 정신과적 질병의 가족력, PANSS scale에 따른 증상 심각도 등의 변수에 따라 분류하였을 때도 유전자형의 분포와 대립 유전자의 빈도 차이는 유의하지 않았다. 결론 : 이 연구의 결과는 한국인 정신분열병 환자들에서 HSPA1B 유전자 다형성이 정신분열병의 병인과 관계가 없음을 나타낸다. 가족-기초 비교 위험 연구와 정신분열병의 다른 임상적 변수들을 포함한 향후의 연구가 필요할 것이다. Objectives:The heat shock protein 70(HSP70) is believed to be involved in the pathogenesis of schizophrenia with regards to neurodevelopment. An aberration in the HSP70 has been proposed in schizophrenia patients, suggesting that it is a candidate gene for schizophrenia. This study aimed to investigate the association between polymorphsims of HSP70-2(HSPA1B) and schizophrenia. Methods:One hundred and four patients with schizophrenia and One hundred and seven normal controls were enrolled in the study. A polymerase chain reaction(PCR) with restriction fragment length enzyme(RFLP) was used to genotype the HSPA1B polymorphisms. Results:1) In schizophrenic patients, genotype distributions of the HSPA1B polymorphism were AA 32(30.8%), AG 57(54.8%) and GG 15(14.4%), and allele frequencies were A 121(58.2%), and G 87(41.8%). In normal control, genotype distributions of the HSPA1B polymorphism were AA 35(32.7%), AG 63(58.9%) and GG 9(8.4%), and allele frequencies were A 133(62.1%), and G 81(37.9%). There were no significant differences in the allelic or genotype frequencies of the HSPA1B polymorphisms between the schizophrenia patients and the controls. 2) There were no difference in genotype distribution and allele frequencies of the HSPA1B polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale. Conclusion:These results suggest a HSPA1B polymorphism is not causally related to the pathogenesis of schizophrenia in the Korean population. Further study of HSPA1B polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.

의과 대학생의 신체부위 불만족과 성격특성에 대한 연구

김현진(Hyun-Jin Kim),차승민(Seung-Min Cha),김정란(Jeong-Lan Kim),왕성근(Seong-Keun Wang),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.2

Objectives : This study investigated the relationship of the dissatisfied body parts, personality characteristics, depression, obsessive-compulsive disorder, social anxiety, and self-esteem in a Korean medical student sample. Methods : Three hundred and eighty six medical students completed the measures of Body Dysmorphic Disorder Examination-self report(BDDE-SR-Korean version), Eysenck Personality Questionnaire(EPQ-Korean version), Beck Depression Inventory(BDI-Korean version), Maudsley Obsessional-Compulsive Inventory(MOCI-Korean version), Liebowitz social anxiety scale(LSAS-Korean version), Rosenberg Self Esteem scale(SES-Korean version). Results : Out of the 386 students, 72.0%(N=278) were male and 28%(N=108) were female. The most dissatisfied body part of participants were waist-abdomen(10.0%), tooth(8.3%), head hair(7.8%), nose(6.8%) and thigh(5.3%). The gender difference in dissatisfied body parts, the body part in female student were breast, calves, thighs, nose and buttocks. Whereas, males were concerned about head hair, shoulder, genitals, chest, eyes, mouth. In Higher BDDE-SR score group, neuroticism, addiction, impulsivity, empathy and criminality personality traits were significantly higher than lower BDDE-SR score group. And, Higher BDDE-SR score were linked with high levels of MOCI, BDI, and LSAS score but with lower level of SES score. Conclusion : These findings indicate that the medical college students with higher level of body dissatisfied are highly associated with neuroticism, addiction, impulsivity empathy and criminality personality traits, and have higher score of depression, social anxiety, obsession and poor self-esteem.