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글릭콜릭산 필링 후 rhEGF and Palmitoyl pentapeotide-4의 피부 재생 효과
주지현 ( Ji Hyun Ju ),김도현 ( Do Hyeon Kim ),박건 ( Kun Park ),김남산 ( Nam San Kim ),김정희 ( Jeonghee Kim ) 한국미용학회 2020 한국미용학회지 Vol.26 No.1
Glycolic acid peel is a popular superficial peeling technique associated with low morbidity and prompt recovery. These processes, as well as the final step of corneodesmolysis, which mediates exfoliation, are often disturbed by environmental conditions, resulting in dry, flaky skin conditions. Therefore, aftercare is required to avoid these side effects and achieve the maximum possible improvement in skin condition. To evaluate the skin regeneration effect of rhEGF and palmitoyl pentapeptide-4 after glycolic acid peeling. A base gel, a gel containing rhEGF, and a gel containing palmitoyl pentapeptide-4 were prepared, and their safety was evaluated by patch test. The 30 healthy female volunteers (age 25-39 years) underwent a glycolic acid (20%) face peel once per week and then the prepared gels were applied to the face for 4 weeks. Stratum corneum hydration, transepidermal water loss (TEWL), and erythema index were then evaluated. No specific skin reaction in prepared gels was detected by a patch test. In the application group of rhEGF and palmitoyl pentapeptide-4, stratum corneum hydration is increased, TEWL and erythema index are reduced. Therefore, the skin regeneration effect was confirmed. The skin regeneration effect of the palmitoyl pentapeptide-4 application group was shown to be the best result in particular. The gels containing rhEGF and palmitoyl pentapeptide-4 were safe and effective for skin recovery after glycolic acid peeling. The palmitoyl pentapeptide-4-containing gel was superior to the rhEGF-containing gel in terms of skin regeneration after peeling.
폐암환자에서 급성호흡부전과 장천공을 동반한 분선충 감염증
김현식 ( Hyeon Sik Kim ),김유은 ( Yu Eun Kim ),윤은영 ( Eun Young Yun ),주지현 ( Ji Hyun Ju ),마정은 ( Jeong Eun Ma ),이기동 ( Gi Dong Lee ),조유지 ( Yu Ji Cho ),김호철 ( Ho Cheol Kim ),이종덕 ( Jong Deok Lee ),황영실 ( Young Sil 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.1
Strongyloides stercoralis is an intestinal nematode that is a parasite to humans. The infecting filariform larvae of S. stercoralis enters the host body via the bloodstream, passes through the lungs, penetrates the alveoli, and then ascends the airway to transit down the esophagus into the small bowel. The infection can persist for decades without causing major symptoms and can elicit eosinophilia of varying magnitudes. Of note, this infection can also develop into a disseminated, often fatal, disease (hyperinfection) in patients receiving immunosuppressive corticosteroids. A 65-year-old man who was receiving corticosteroid therapy for the treatment of spinal stenosis was admitted to the emergency room with complaints of abdominal pain and severe dyspnea. We detected many S. stercoralis larvae in the sputum and in the bronchoalveolar-lavage sample collected by bronchoscopy. Here, we report a fatal case of strongyloidiasis with acute respiratory failure and intestinal perforation. In addition, we provide a brief review of the relevant medical literature.
PD-L1 발현 B세포를 통한 활성 T세포의 IL-17 분비 조절
우윤주 ( Yun Ju Woo ),조미라 ( Mi La Cho ),민준기 ( Jun Ki Min ),주지현 ( Ji Hyeon Ju ),주세영 ( Se Young Ju ),박성환 ( Sung Hwan Park ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2008 대한류마티스학회지 Vol.15 No.2
목적: 최근 들어 면역조절능을 가지는 B세포의 존재에 관한 연구가 보고되고 있다. B세포의 특성 중 면역조절기능을 세포상호작용을 통해 연구하고자 본 실험에서는 B세포를 B세포 수용체(anti IgM)와 CD40에 대한 단클론항체(agonist anti mouse CD40 monoclonal antibody)로 자극하여 관찰하였다. 방법: 마우스의 비장에서 분리한 B세포를 lipopolysaccharide (LPS), B세포 수용체 또는 CD40에 대한 단클론항체로 자극하여 24시간 동안 배양하여 B세포에서 발현하는 공동신호분자(CD40, CD80, CD86, MHC-II, PD-1, PD-L1)를 유세포 분석기로 조사하였다. 그리고 활성화된 B세포를 anti CD3로 자극한 T세포와 공조 배양하여 T세포에서 발현하는 사이토카인을 중합효소연쇄반응(PCR, polymerase chain reaction)과 효소결합 면역흡수 분석법(ELSIA, enzyme-linked immunosorbent assay)으로 조사하였다. 결과: B세포에서의 공동신호분자는 자극(LPS, B세포 수용체 또는 CD40에 대한 단클론항체)에 대해 반응하여 모두 증가하는 경향을 나타냈으며 특히 B세포 수용체와 CD40에 대한 단클론항체로 자극하였을 경우 음성신호분자로 알려져 있는 PD-L1의 발현이 가장 의미 있게 증가되었다. B세포를 T세포와 공조배양 하면, T세포에서 분비되는 IL-17이 의미 있게 감소(nil: 1932±386 pg/mL vs anti IgM+agonist CD40mAb: 1193±334 pg/mL, p<0.01)하였다. 그러나 IFN-γ (nil: 4658±752 pg/mL, anti IgM+agonist CD40mAb: 5525±315 pg/mL)와 TNF-α (nil: 1445±178 pg/mL, anti IgM+agonist CD40mAb: 1,469±281 pg/mL)의 형성에는 변화가 없었다. 또한 공조배양을 통한 IL-17 생성 억제는 PD-L1 중성화 항체 처리로 회복되는 경향을 보였다. 결론: 이와 같은 연구로 B세포는 B세포 수용체와 CD40에 대한 단클론항체로 자극하면 PD-L1의 발현이 증가되고, T세포와 공조배양 시 IL-17분비를 뚜렷이 감소시킨다는 결과를 얻을 수 있었다. 이는 면역조절능을 가진 B세포는 PD-L1발현을 통해 결과적으로 IL-17의 생성을 억제시킨다는 것을 시사한다.
정승민 ( Seung Min Jung ),주지현 ( Ji Hyeon Ju ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.5
Since induced pluripotent stem cell (iPSC) was first introduced by Yamanaka in 2006, it took only six years to win a Nobel Prize for his pioneering work. It is unusual to win a Nobel Prize for such recent research with a short history. Many scientists and clinicians are interested in iPSC for its potential application. Significant progression in this field has been made, while there remain many hurdles to overcome for application of iPSC technique in real clinics. In this review, the concept of reprogramming and the basic techniques of iPSC generation will be discussed for the reader`s convenience, followed by discussion of recent progress, followed by the topics of “disease modeling” and “cell therapy” with iPSC in the second half of this article. Several examples of rheumatologic application of iPSC will be provided in the main text. If rheumatologists could understand the merits and potentials of iPSC, opportunities for innovative research and therapy can be expanded.
남유준 ( Yoojun Nam ),임예리 ( Yeri Alice Rim ),주지현 ( Ji Hyeon Ju ) 대한내과학회 2019 대한내과학회지 Vol.94 No.2
Osteoarthritis is a musculoskeletal disease representative of an aging society. As medical conditions are usually complicated in an aging population, osteoarthritis becomes more frequently encountered in the physician’s office. There is a growing need, therefore, for physicians to pay attention to this common orthopedic condition. Cartilage degeneration, arthritic pain, and joint dysfunction are major manifestations of osteoarthritis, and degenerated cartilage is difficult to repair with conventional treatment modalities. Scientists and physicians have developed various therapeutic strategies, including the use of stem cells. Here, we discuss previous and current progress in cartilage regenerative therapy against osteoarthritis. (Korean J Med 2019;94:145-151)
류마티스관절염 활막세포에서 NF-${\kappa}B$ 신호전달을 통한 MIF의 SDF-1 생성 유도
조미라,박미경,김경운,오혜좌,이선영,박진실,허유정,주지현,민준기,이상헌,박성환,김호연,Cho, Mi-La,Park, Mi-Kyung,Kim, Kyoung-Woon,Oh, Hye-Jwa,Lee, Seon-Yeong,Park, Jin-Sil,Heo, Yu-Jung,Ju, Ji-Hyeon,Min, Jun-Ki,Lee, Sang-Heon,Park, Sung-Hwa 대한면역학회 2007 Immune Network Vol.7 No.1
Background: Stromal cell-derived factor (SDF)-1 is a potent chemoattractant for activated T cells into the inflamed Rheumatoid arthritis (RA) synovium. To determine the effect of macrophage migration inhibitory factor (MIF) on the production of SDF-1 in the inflamed RA synovium. Methods: The expression of SDF-1 and MIF in RA and Osteoarthritis (OA) synovium was examined by immunohistochemical staining. The SDF-1 was quantified by RT-PCR and ELISA after RA fibroblast like synoviocyte (FLS) were treated with MIF in the presence and absence of inhibitors of intracellular signal molecules. The synovial fluid (SF) and serum levels of MIF and SDF-1 in RA, OA and healthy control were measured by ELISA. Results: Expression of SDF-1 and MIF in synovium was higher in RA patients than in OA patients. The production of SDF-1 was enhanced in RA FLS by MIF stimulation. Such effect of MIF was blocked by the inhibitors of NF-${\kappa}B$. Concentrations of SDF-1 in the serum and SF were higher in RA patients than in OA patients and healthy control. SDF-1 and MIF was overexpressed in RA FLS, and MIF could up-regulate the production of SDF-1 in RA FLS via NF-${\kappa}B$-mediated pathways. Conclusion: These results suggest that an inhibition of interaction between MIF from T cells and SDF-1 of FLS may provide a new therapeutic approach in the treatment of RA.
김현숙 ( Hyun Sook Kim ),서수홍 ( Soo Hong Seo ),허지안 ( Ji An Hur ),곽승기 ( Seung Ki Kwok ),주지현 ( Ji Hyeon Ju ),윤종현 ( Chong Hyeon Yoon ),김완욱 ( Wan Uk Kim ),홍연식 ( Yeon Sik Hong ),조철수 ( Chul Soo Cho ),김호연 ( Ho Y 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.1
Objective: To investigate the clinical manifestation and prognostic factors of interstitial lung disease (ILD) in Korean patients with idiopathic inflammatory myopathies include with polymyositis (PM) and dermatomyositis (DM). Methods: Clinical and laboratory data of 110 patients with PM/DM in our rheumatology clinic were investigated. Clinical data including history, medication, pulmonary function tests (PFT) findings, radiologic findings, and labaratory findings were obtained from medical records at the first diagnosis of ILD with PM/DM. ILD was diagnosed on the basis of the imaging abnormalities defined above on definite findings of chest X-rays and high resolution computed tomography (HRCT), restrictive changes on PFT with respiratory symptoms. During the course of treatment, we assessed chest radiograph and HRCT findings. Results: Forty-two PM/DM patients (38.2%) developed ILD. Anti-extracellular nuclear antigen (ENA) antibody, anti-Jo-1 antibody and ground glass opacity in HRCT were significantly high in PM-ILD. However honeycoomb appearance (53%:22%) and fibrosis (41%:6%) in HRCT were significantly high in DM-ILD. Interest in aspects of prognosis including initial steroid treatment response in HRCT were favorable in PM-ILD. There were statistically significant association between normal level of CPK and usual interstitial pneumonia (UIP) pattern in HRCT in DM-ILD. Such cases had resistance to steroid therapy. Overall interval between steroid and immunosuppressant therapy was significantly shorter in those with DM-ILD. Conclusion: The clinical manifestations between PM-ILD and DM-ILD in Korean patients were not significant different from those of other populations. DM-ILD is more refractory to steroid treatment, expecting in poor prognosis compared with PM-ILD. So immediate intensive immunosuppressive therapy should be considered in DM-ILD.
항 TNF 제제로 치료한 류마티스관절염 환자에서 발생한 심각한 감염의 발생 빈도
김현옥 ( Hyun Ok Kim ),강귀영 ( Kwi Young Kang ),주지현 ( Ji Hyeon Ju ),김호연 ( Ho Youn Kim ),박성환 ( Sung Hwan Park ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.3
Objective: We wanted to investigate the incidence of serious infections among the rheumatoid arthritis (RA) patients who were treated with tumor necrosis factor α (TNF-α) antagonists Methods: We enrolled the 175 RA patients who were treated with TNF-α antagonists for at least 3 months during February 2003 to July 2008, and these patients were in the SMART-b cohort of Kangnam St. Mary`s hospital. Patients were prescribed infliximab, etanercept or adalimumab. The data was retrospectively collected. Results: The incidence of serious infections among the RA patients treated with TNF-α was significantly increased according to the survival analysis, as compared with that of those patient treated with conventional DMARDs (p<0.01). The most common serious infection was pneumonia. There was no significant difference in the incidence of serious infections among the three TNF-α antagonists used in this study (p=0.96). But the serious infections occurred more often in the patients who received more than 10 mg methotrexate (MTX) per week (p=0.02). Conclusion: RA patients treated with TNF-α antagonists had a higher incidence of serious infection. Therefore, close monitoring for serious infection is needed for RA patients who are receiving TNF-α antagonists.
전신홍반루푸스 환자에서 양측 가돌림 신경마비로 발현된 리스테리아 뇌수막염
황유미 ( You Mi Hwang ),곽승기 ( Seung Ki Kwok ),김지민 ( Ji Min Kim ),윤호성 ( Ho Sung Yoon ),주지현 ( Ji Hyeon Ju ),박경수 ( Kyung Su Park ),박성환 ( Sung Hwan Park ),김호연 ( Ho Youn Kim ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.4
Infection still remains a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Patients with SLE are well known to have an increased risk of various opportunistic infections, which can be fatal. Central nervous system (CNS) infections such as meningitis are rare complications to SLE. On occasion, nonspecific neurologic manifestations of infectious meningitis in SLE patients can be confused with neuropsychiatric lupus. Listeria monocytogenes is a less-commonly identified organism causing meningitis in SLE patients. Here, we describe a case of Listeria monocytogenes meningitis presenting with bilateral abducens nerve (sixth cranial nerve) palsy in a patient with SLE, who was successfully treated with systemic antibiotics.