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주종호 ( Jong-ho Joo ),문영훈 ( Young-hoon Moon ),이아영 ( A-yeoung Lee ),권도형 ( Do-hyung Kwon ),김영희 ( Younghee Kim ),석광설 ( Kwang-seol Seok ),송금주 ( Geum-ju Song ) 한국환경분석학회 2016 환경분석과 독성보건 Vol.19 No.4
Anthropogenic emission of lead (Pb) and cadmium (Cd) were assessed at tow power plants fueled by bitu-minous coal, and at one power plant fueled by mixes (bituminous and anthracite) coal. Plant input and output materials were sampled in each process. The input materials were the coal and B-C oil as fuel in the combustor, and limestone as the remover of SOx in air-pollutant control device. The output materials were bottom ash, fly ash, gesso and sludge. The materials were sampled at least three times at each sampling point, then analyzed using ICP or ICP/MS. The coal fuel was the main input source of Pb and Cd, and the concentration of Pb and Cd was higher in the mixed coal than in the bituminous coal. Total Pb and Cd emission in fly ash was highest among the output materials, and very low in off gas and sludge. However, the concentration of Pb and Cd in the sludge was highest among the output materials. The fly ash is sold for reuse, and the sludge is dumped in a landfill site. Therefore, Pb and Cd in the fly ash and in the sludge should be managed before they are passed on in these ways.
타목시펜 내성 유방암세포(T47D:A18/4-OHT)에서 EGFR 및 HER2 억제 효과
원용성(Yong Sung Won),주종호(Jong Ho Joo),김정수(Jeong Soo Kim),오세정(Se Jung Oh),송병주(Byung Joo Song),전해명(Hae Myung Jeon),정상설(Sang Seol Jung),박우찬(Woo Chan Park) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.4
Purpose: Tamoxifen has been prescribed as a very effective hormonal agent not only for the treatment of breast cancer, but also for the prevention of the disease. The development of resistance to tamoxifen is one of the most important obstacles to hormonal therapy of breast cancer. HER2 or EGFR expression has been reported to be associated with the development of tamoxifen resistance. This study was performed to evaluate the effect of HER2 and EGFR inhibition on tamoxifen resistance using tamoxifen-resistant breast cancer cells (T47D:A18/4-OHT cells). Methods: Tamoxifen-resistant T47D:A18/4-OHT cells were established by long-term treatment of 1μM 4-hydroxytamoxifen on T47D:A18 human breast cancer cells. The effect of HER2 and EGFR inhibition was investigated by the use of a cell proliferation assay with treatment of trastuzumab, a monoclonal antibody to the extracellular domain of the human HER2 receptor, and ZD1839, an ERFR tyrosine kinase inhibitor. Results: In contrast to T47D:A18 cells, T47D:A18/4-OHT cells showed estrogen-independent proliferation and partial regulation by treatment with tamoxifen. With a single treatment of trastuzumab or ZD1839, T47D:A18/4-OHT cell growth was reduced to 77.8% (P=0.15) or 74.4% (P=0.034) respectively, as compared to untreated cells. Combinational treatment with 1 nM estradiol resulted in a further reduction of T47D:A17 cell proliferation by 83.6% (P=0.002) for trastuzumab and 77.7% (P=0.047) for ZD1839, as compared to the single treatments. Conclusion: Tamoxifen resistance could be partially regulated by inhibition of HER2 or EGFR in T47D:A18/4-OHT cells, especially in combination with a low dose of estradiol. This effect may provide an important clue to overcome tamoxifen resistance in the treatment of breast cancer.
송금주 ( Geum-ju Song ),문영훈 ( Young-hoon Moon ),주종호 ( Jong-ho Joo ),이아영 ( A-yeoung Lee ),권도형 ( Do-hyung Kwon ),김영희 ( Younghee Kim ),석광설 ( Kwang-seol Seok ) 한국환경분석학회 2016 환경분석과 독성보건 Vol.19 No.3
The lead (Pb) and cadmium (Cd) distribution characteristics was investigated in the zinc, lead and copper smelting plants for the assessment of anthropogenic Pb and Cd emitted from the non ferrous smelting plants. To assess the anthropogenic Pb and Cd emitted from a smelting plant, the input materials and output materials were collected from each process. The materials were sampled over the three times at each sampling point and analyzed with ICP or ICP-MS. According to the input materials used in the non-ferrous smelting plants, the ores were main input source of Pb and Cd. The Pb and Cd included in ores were produced the products throμgh the roasting process and casting process. In addition from the roasting process and casting process many byproduct or process waste were generated as the output materials emitted into the environment. Among the output materials emitted into the environment, the sludge was main source of Pb and Cd emitted into the environment. The emission amount of sludge was not so much, but the concentration of Pb and Cd in the sludge was very high. Therefore, the sludge dumped in landfill site should be controlled with Pb and Cd as content value, not as leaching value.
석탄화력발전시설에서의 TSP 및 PM<sub>10</sub>, PM<sub>2.5</sub> 배출특성
송금주 ( Geum-ju Song ),문영훈 ( Young-hoon Moon ),주종호 ( Jong-ho Joo ),이아영 ( A-yeoung Lee ),이재복 ( Jae-bok Lee ) 한국환경분석학회 2018 환경분석과 독성보건 Vol.21 No.1
To quantify TSP, PM<sub>10</sub> and PM<sub>2.5</sub> emission characteristics, these parameters were sampled during all processes in a coal-fired power plant. Concentrations of TSP, PM<sub>10</sub> and PM<sub>2.5</sub> emitted from boiler were high, and the ratios of PM<sub>10</sub>/TSP and PM<sub>2.5</sub> /TSP were very low; this result means that the boiler emitted more coarse particles than fine particles. The ESP removed most of the coarse particles. At the FGD inlet the concentrations of TSP, PM<sub>10</sub> and PM<sub>2.5</sub> were low, but the ratios of PM<sub>10</sub>/TSP and PM<sub>2.5</sub>/TSP were higher than at the SCR inlet. The ESP removed ~99.8%, of the particulates but only ~99.5% of fine particles (PM<sub>10</sub>) and ~97.3% of ultrafine particles (PM<sub>2.5</sub>). Among the TSPs emitted from the stack, the proportion of PM<sub>10</sub> was 80-85% and of this, the proportion of PM<sub>2.5</sub> was 47-56%. Therefore, this study demonstrates that the stack of the plant emitted mostly PM<sub>10</sub> and PM<sub>2.5</sub>, and that the ESP as the dust remover installed in the plant should be improved to remove the fine particles.
석탄화력발전시설에서 배출되는 TSP, PM10, PM2.5의 유해중금속 분포
송금주 ( Geum-ju Song ),문영훈 ( Young-hoon Moon ),주종호 ( Jong-ho Joo ),이아영 ( A-yeoung Lee ),이재복 ( Jae-bok Lee ) 한국환경분석학회 2018 환경분석과 독성보건 Vol.21 No.3
In this study, the distributions of hazardous heavy metals (HHMs) in TSP, PM10, PM2.5 were investigated. In the coal used in the tested plant, that Zn and Cu were most common HHMs, and Cd was rarest. In TSPs from the SCR inlet, FGD inlet and stack, the content of Zn in the coal was the highest, but the distributions of other HHMs were different. At the SCR inlet, the distributions of HHMs in PM10 and TSP differed, and concentration of HHMs in PM10 and TSP was increased. At the FGD inlet and stack the HHM distributions in PM10 and TSP were the same. At the SCR inlet, the HHM distribution in PM2.5 differed from those in TSP and PM10. At the SCR inlet, the HHM concentration was higher in PM2.5 than in TSP and PM10. At the FGD inlet and stack the distribution of HHMs in PM2.5 was very different from those in TSP and PM10 at FGD.