갑상선 수질암의 세침흡인 세포학적 소견 - 1 증례 보고 -

주영채,황태숙,Chu, Young-Chae,Hwang, Tae-Sook 대한세포병리학회 1991 대한세포병리학회지 Vol.2 No.2

A 33-year-old woman who was diagnosed as medullary carcinoma by fine needle aspiration of thyroid mass is presented. The smear revealed dispersed pattern and small clusters of cells without follicular or papillary structures. The nuclei were round, oval or spindle shaped and eccentrically located. The cytoplasm was abundant and showed red-stained cytoplasmic granulation and tail-like projection with indistinct border. Clumps of amorphous, light-green material were intermingled with tumor cells.

흉수의 혈관육종의 세포학적 소견 - 1예 보고 -

주영채,박인서,김윤주,한혜승,한지영,Chu, Young-Chae,Park, In-Seo,Kim, Yoon-Ju,Han, Hye-Seung,Han, Jee-Young 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.1

Angiosarcomas are rare tumors, seen most commonly in the skin and soft tissue of head and neck legion. But it has been described in numerous body sites including thyroid, breast, liver, spleen, bone, etc.. Their biological behaviors depend on the microscopic grade, site of origin, and multifocality. We report the unique cytological features of an angiosarcoma in pleural fluid. A 61-year-old woman presented with a 6 month history of dyspnea on exertion and chest pain. Chest computerized tomography(CT) revealed multiple subpleural small nodules in the right lung and widespread all space consolidation and pleural effusion in the left lung. CT of liver revealed multiple small low attenuated lesion. The smears obtained from pleural fluid showed hypocellularity with a hemorrhagic background. The tumor cells were highly pleomorphic oval or spindle in shape and presented singly, in loose groups, in knitted syncytial aggregates, and in acinar pattern. Their nuclei had vesicular chromatin with delineated, thick nuclear membranes and occasionally a large eosinophilic, prominent nucleolus. The cytoplasm was plump, thin or protected in spindly fashion. Almost ail tumor cells showed variable sized intracytoplasmic vacuoles and their nuclei were sometimes crescentic by a huge vacuole. Occasional binucleated tumor cells and mitotic figures were present. Cellular debris and streaky materials were identified. Needle biopsy specimen from the pleura revealed anastomosing slit-like spaces lined by pleomorphic tumor cells. The tumor cells showed a strong reactivity for CD31 and vimentin and focal weak reactivity for factor VIII-related antigen.

Peripheral Neuroblastoma of the Ulnar Nerve : Diagnosis by Fine Needle Aspiration Cytology

주영채,김준미,Chu, Young-Chae,Kim, Joon-Mee The Korean Society for Cytopathology 1993 대한세포병리학회지 Vol.4 No.1

A 30-year-old woman who was diagnosed as peripheral neuroblastoma by fine needle aspiration of a soft mass of the right upper arm is described. She presented a slowly growing, soft mass of the right upper arm for 1 month. The right humerus revealed no abnormal finding on X-ray. Ultrasonogram of the right upper arm revealed a well demarcated, smooth marginated solid mass without invasion of adjacent structures. Fine needle aspiration was done under the impression of soft tissue tumor with undetermined biologic behavior. The aspirates were highly cellular and the tumor cells were dispersed both singly and in clusters of varying size. The clusters occasionally showed a central capillary core and rosette-like structures. The tumor cells were small in size and had a small to medium amount of cytoplasm. Some of them revealed slender cytoplasmic processes. The nuclei showed distinct nuclear membranes, finely clumped chromatin and small conspicuous nucleoli. Cellular pleomorphism or mitotic figure was not definite. These cytologic findings were interpreted as a malignant, non-lymphomatous small round cell tumor, most likely representing peripheral neuroblastoma or Ewing's sarcoma. Final diagnosis was confirmed by simple excision as peripheral neuroblastoma. 말초성 신경아세포종은 예후가 나쁘고 희귀한 종양으로 이 종양의 세침흡인 세포학적 소견에 관한 보고는 세계 문헌상 1988년 Neuhold에 의해 처음 기술된 1례가 있을 따름이다. 최근 저자들은 30세 여자의 우측 상박의 연부조직 종괴로 부터 세침흡인 세포 검사를 시행하여 진단된 말초성 신경아세포종을 경험하여 그 세침흡인 세포학적 소견을 기술하는 바이다. 환자는 1개월전 부터 우측 상박에 서서히 자라는 종괴를 주소로 내원하였다. 우측 상박 X-선 및 초음파 촬영술에서 주위와 잘 경계지어진 방추형의 연부조직 종괴가 관찰되었고 주변조직으로 침윤하는 소견은 관찰할 수 없었으며 상완골은 정상이었다. 종괴의 세침흡인 도말은 세포밀도가 매우 높았고 작고 둥근 세포들이 뭉쳐있거나 산재되어 있었다. 세포간의 크기나 모양의 차이는 아주 미약하였고 유사분열은 거의 관찰되지 않았다. 종양세포들의 집단은 간혹 모세혈관을 중심으로 뭉치거나, 로제트 형태를 보이며 그 세포질은 가늘고 긴 돌기를 보였다. 핵은 뚜렷한 핵막과 미세하게 뭉친 염색질 및 작고 뚜렷한 핵 소체를 갖고 있었다. 이상의 소견은 작고 둥근 세포로 된 악성 종양 중 말초성 신경아세포종에 매우 합당하였으나 골외 Ewing 육종과의 감별은 불가능하였다. 단순 절제술이 시행되었고 종양은 조직학적으로 말초성 신경아세포종임이 확인되었다.

세침흡인된 갑상선의 여포상 선종과 여포상 암종의 형태계측학적 연구

주영채,차희정,민수기,김준미,황태숙,Chu, Young-Chae,Cha, Hee-Jung,Min, Soo-Kee,Kim, Joon-Mee,Hwang, Tae-Sook 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.1

Fine needle aspiration cytology of "cold" nodules of the thyroid has proved to be of great value in their preoperative diagnosis. Most types of thyroid tumors are readily recognizable from characteristic cellular patterns in the smears of needle aspirates. But follicular neoplasms present some problems because the cytomorphology of the adenomas frequently is same as in carcinoma. For differentiation of benign from malignant follicular neoplasms of the thyroid we tested the usefulness of two objective parameters - nuclear area and perimeter - by morphometry. This study was made on fine needle aspirates from 30 cases with cytologic diagnosis of follicular neoplasm of thyroid. The histologic classification was follicular adenoma in 22 cases and follicular carcinoma in 8 cases. As a reference group we used seven caes with nodular hyperplasia. The smears of aspirates were stained by Papanicolaou method. On each slide 200 randomly selected cells with intact nuclei were measured. The mean value of nuclear area are $25.32{\pm}5.50{\mu}m^2,\;34.08{\pm}7.50{\mu}m^2\;and\;39.97{\pm}6.63{\mu}m^2$ in nodular hyperplasia, follicular adenoma, and follicular carcinoma, respectively. The mean value of perimeter are $19.48{\pm}2.26{\mu}m,\;22.95{\pm}2.65{\mu}m\;and\;24.78{\pm}2.23{\mu}m$ in nodular hyperplasia, follicular adenoma and follicular carcinoma, respectively. The mean nuclear areas and perimeters of cells from follicular adenoma were significantly larger than those from nodular hyperplasia (p<0.05). The mean nuclear areas and perimeters of cells from follicular carcinoma were larger than those from follicular adenoma but the differences are not significant statistically(p>0.05). Therefore, morphometric assessment alone is inadequate to predict malignancy in thyroid aspirates.

우측 경부에 발생한 제 1 새열낭종 ( Type 1 ) 의 치험례

주영채(Young Chae Chu),이성준(Seong Jun Lee),하수용(Soo Yong Ha),김일규(Il Kyu Kim) 대한악안면성형재건외과학회 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.1

This is a case report of first branchial cleft cyst in 56 year old male patient, which was tentatively diagnosed as acute right submandibular abscess resulted from the periapical lesion of the lower right second molar. The results are as follows, 1. The accompanying ipsilateral inflammatory swelling resulted from the periapical lesion of lower right second molar tooth makes the diagnosis difficult 2. The onset of this case was very late in comparison to the mean discovering age of branchial cleft cysts. 3 The plain radiography using contrast media is helpful for the diagnosis of cystic lesions within soft tissues. 4 This case is a first branchial cleft cyst (Type I) which occurs less than 1% of all branchial deft anomalies.

유방의 아포크린 선암의 임상병리학적 특성

최소영(So Young Choi),김세중(Sei Joong Kim),조영업(Young Up Cho),박재영(Jae Young Park),박정미(Jeong Mi Park),주영채(Young Chae Chu),최윤미(Yun Mee Choe),최선근(Sun Keun Choi),허윤석(Yoon Seok Heo),이건영(Keon Young Lee),안승익(Seung 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5

Purpose: Apocrine carcinoma of the breast is rare and there is confusion about the criteria of its histopathologic diagnosis. The purpose of this study is to investigate the clinical and pathologic characteristics of the disease. Methods: 9 patients diagnosed with apocrine carcinoma or apocrine carcinoma in situ and 1,009 patients diagnosed with non-apocrine carcinoma of the breast from April 1999 to March 2008 were retrospectively analyzed. Results: The mean age of the patients with apocrine carcinoma was 52.3 year. 5 patients (55.6%) among 9 patients with apocrine carcinoma were postmenopausal. There were 2,1 and 6 patients with stage 0, Ⅰ and Ⅱ disease, respectively according the TNM stage. These demographic and clinical differences between the patients with apocrine carcinoma and non-apocrine carcinoma were not significant. Only four patients (44.4%) were preoperatively diagnosed with apocrine carcinoma or apocrine carcinoma in situ. By surgical biopsy, additional 5 patients were diagnosed as apocrine carcinoma. In the immunohistochemical study, Bcl-2 was positive in one (12.5%) of 8 patients. p53 was positive in 4 (44.4%) of 9 patients. Expressions of estrogen and progesterone receptor were positive only in two patients (22.2%) with weakly positive staining. Androgen receptor was positively expressed in all cases (100%) of apocrine carcinoma. Overexpression of c-erb-B2 was detected in four patients. Conclusion: Treatment modality and prognosis of apocrine carcinoma are similar as non-apocrine carcinoma. But its preoperative diagnosis is more difficult than that of non-apocrine carcinoma and it shows different expression of hormone receptor. Further study is needed for the development of new hormonal therapy using androgen.

난소에 발생한 원발성 이행세포상피암 3예

김소영 ( So Young Kim ),주영채 ( Young Chae Chu ),최석진 ( Suk Jin Choi ),이진교 ( Jin Gyo Lee ),이기은 ( Ki Eun Lee ),송은섭 ( Eun Seop Song ),황성욱 ( Sung Ook Hwang ),이문희 ( Moon Hee Lee ),김석모 ( Seok Mo Kim ),이우영 ( Woo 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.3

갑상선의 미만성 경화성 변종 유두상 암종의 세침흡인 세포학적 소견 - 1예 보고 -

김준미,민수기,주영채,김미림,김경래,Kim, Joon-Mee,Min, Soo-Kee,Chu, Young-Chae,Kim, Mi-Rim,Kim, Kyung-Rae 대한세포병리학회 2000 대한세포병리학회지 Vol.11 No.1

Diffuse sclerosing papillary carcinoma(DSPC), a variant of papillary carcinoma of the thyroid, is characterized by diffuse involvement of one or both thyroid lobes, and histologic features such as prominent sclerosis, intense lymphocytic infiltrate, numerous psammoma bodies, and squamous metaplasia together with the characteristic cytoarchitectural pattern of classical papillary carcinoma. We experienced a case of fine needle aspiration cytologic(FNAC) findings of DSPC, which was confirmed by histologic examination of the thyroidectomy specimens. The patient was 26 years old female who presented with diffuse firm enlargement of the thyroid gland with enlargement of many cervical lymph nodes. FNAC smears showed numerous psammoma bodies, many lymphocytes, metaplastic squamous cells, absence of stringy colloid, and epithelial cells showing classical features of papillary carcinoma, such as nuclear grooves, intranuclear unclusions, and ground glass chromatin pattern.

내시경 초음파 유도하에 세침흡인 세포검사로 진단한 위의 위장관 기질 종앙 1예 보고

김루시아,김형길,주영채,박인서,최석진,한지영,김선희,이돈행,김준미,Kim, Lucia,Kim, Hyung-Gil,Chu, Young-Chae,Park, In-Suh,Choi, Suk-Jin,Han, Jee-Young,Kim, Sun-Hee,Lee, Don-Haeng,Kim, Joon-Mee 대한세포병리학회 2008 대한세포병리학회지 Vol.19 No.2

We report here a case of a gastrointestinal stromal tumor (GIST) in the stomach that was diagnosed by endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNA). A 67 year old male patient underwent regular check-ups for five years due to the presence of a submucosal tumor that was found in the fundus of the stomach incidentally. EUS-FNA was performed to evaluate the tumor, which had increased in size from 1 cm to 2.8cm. A cytologic smear revealed cohesive sheets or clusters of spindle cells with elongated nuclei. Immunohistochemical staining revealed a strong positive reaction for c-kit and CD34, without any reaction for smooth muscle actin and Ki-67. Therefore, a diagnosis of GIST was made.

기관지암종 진단에 있어서 객담과 기관지 세척액 검사의 유용성 - 기관지경 검사를 통해 확진된 예를 대신으로 -

김준미,민수기,주영채,조철호,Kim, Joon-Mee,Min, Soo-Kee,Chu, Young-Chae,Cho, Chul-Ho 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

To evaluate the role of sputum and bronchial washing for the diagnosis of lung carcinoma, we studied the sensitivity of both cytologic techniques using the biopsy confirmed cases from 228 patients. Among them, 123 cases were squamous cell carcinomas, 42 cases were adenocarcinomas, 48 cases were small cell carcinomas, one case was large cell carcinoma, and 14 cases were other types of carcinoma including poorly differentiated carcinomas. Three hundreds and ninety two sputa and 173 sputa were obtained in the pre- and post-bronchoscopic periods. Bronchial washing had been taken once in each patient. The overall sensitivity of the sputum cytology was 0.52 and that of the bronchial washing 0.63, while it increased to 0.83 when a combination of both techniques. Squamous cell carcinomas were diagnosed to the great extent in which sensitivities were 0.59 and 0.74, in sputum and bronchial washing, respectively. The post-bronchoscopic sputa showed higher sensitivity (0.44) than pre-bronchoscopic sputa (0.30). The sensitivity on sputa increased from 0.34 to 0.49 when three samples were examined compared to the single examination. The accuracy of cell typing was 94.0% in sputa and 93.8% In bronchial washing. Repeated sputum examination including post-bronchoscopic sputa is warranted to Improve sensitivity and a complementary role of both cytologlc techniques can be postulated by these data.