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사례보고 : Alverine citrate에 의해 유발된 급성 간염 1예
한지영 ( Jee Young Han ),이진우 ( Jin Woo Lee ),김준미 ( Joon Mee Kim ),주고운 ( Kowoon Joo ),천웅 ( Ung Chon ),이정일 ( Jung Il Lee ),정석 ( Seok Jeong ),이돈행 ( Don Haeng Lee ),김영수 ( Young Soo Kim ),민경선 ( Kyung Sun Min 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.1
저자들은 75세 여자 환자에서 국내 처음으로 발생한 alverine citrate에 의한 약인성 간염 1예를 경험하였으며 이를 문헌고찰과 함께 보고하고자 한다. Alverine citrate is one of the most commonly used antispasmodic drugs for patients with irritable bowel syndrome. Alverine-citrate-induced hepatotoxicity is extremely rare, with only a few cases having been reported worldwide. We present a case of a 75-year-old female patient who experienced complicated jaundice and abdominal discomfort after taking alverine citrate. Other causes of hepatitis were ruled out and the results of the liver function test returned to normal after ceasing the drug. This is the first case report in Korea of alverine-citrate-induced hepatotoxicity. (Korean J Hepatol 2010;16:75-78)
SAPHO 증후군에서 경구 Alendronate로 치료한 1예
심현익 ( Hyun Ik Shim ),박원 ( Won Park ),김여주 ( Yeo Ju Kim ),정경희 ( Kyong Hee Jung ),백지현 ( Ji Hyeon Baek ),임미진 ( Mie Jin Lim ),주고운 ( Kowoon Joo ),권성렬 ( Seong Ryul Kwon ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.5
본 저자들은 손가락의 골절과 감염이 동반된 SAPHO 증후군에서 경구 bisphosphonate로 성공적으로 치료하였기에 이를 보고하는 바이다. SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis is rare compared to other spondyloarthropathies. It is also difficult to diagnose, and treatment methods have not yet been fully identified. Approximately 72% of patients are diagnosed with at least one other disease before a final diagnosis of SAPHO syndrome. In addition, SAPHO syndrome is subject to a delayed diagnosis period of 4.5 to 9.1 years. Medications such as non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and tumor necrosis factor inhibitors are used in treatment of SAPHO syndrome. Bisphosphonate is also used for refractory SAPHO syndrome; however, most reports on this relate to intravenous injection of medication. The authors experienced and subsequently reported on a case involving a patient with SAPHO syndrome accompanied by fracture and infection of the left second finger who was treated with the oral biphosphonate, alendronate. (J Rheum Dis 2015;22:313-316)