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위암에서 Cyclooxygenase-2 (COX-2)와 Peroxisome Proliferator-Activated Receptor (PPAR) 유전자의 역할
장영운 ( Young Woon Chang ),조황래 ( Hwoang Lae Cho ),장재영 ( Jae Young Jang ),동석호 ( Seok Ho Dong ),김효종 ( Hyo Jong Kim ),김병호 ( Byung Ho Kim ),이정일 ( Joung Il Lee ),장린 ( Rin Chang ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.5
Background/Aims: Gastric cancer is still the most frequently diagnosed malignancy in Korea. It has been reported that COX-2 and PPAR are involved in multi-step gastric carcinogenesis. The aim of the present study was to examine the expression of COX-2 and PPAR in gastric cancer. Methods: A total of 75 subjects including 45 patients with gastric cancer and 30 controls were enrolled. All subjects underwent upper gastrointestinal endoscopic examination with tissue collection. mRNA extraction from the tissues and real-time PCR for COX-2, PPAR-δ, and PPAR-?were performed. Gastric mucosal concentration of PGE2, which is a final product of COX-2, and 15d-PGJ2, which is a ligand of PPAR-γ were measured by the enzyme immunoassay method. Results: COX-2 mRNA expression was significantly higher in both early gastric cancer tissues (EGC, 8.32±4.84㎍/㎕, p<0.005) and advanced gastric cancer tissues (AGC, 8.16±2.67㎍/㎕, p<0.001) than in non-cancerous tissues of controls (3.46±1.72㎍/㎕). There was no significant difference of PPAR-δ and PPAR-γ mRNA expression between gastric cancer tissues and controls. Mucosal PGE2 concentration was significantly higher in both EGC tissues (5.31±0.49㎍/㎎ protein, p<0.001) and AGC tissues (5.46±0.54㎍/㎎ protein, p<0.001) than in non-cancerous tissues of controls (4.22±8㎍/㎎ protein). There was no significant difference of 15d-PGJ2 concentration between gastric cancer tissues and controls. Conclusions: COX-2 overexpression and increased PGE2 concentration in gastric tissues may play an important role in gastric carcinogenesis. However, the role of PPAR (δ and γ) and 15d-PGJ2 in gastric carcinogenesis is uncertain. Further studies are needed.(Korean J Gastroenterol 2004;43:291-298)
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약제 내성 폐렴구균의 비율이 높은 지역에서 발생한 하기도 감염 치료에 대한 Levofloxacin의 효능 및 안정성
조황래,오원섭,김춘관,김연숙,정숙인,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.3
목적 : Levofloxacin은 지역성 호흡기 감염의 흔한 원인인 폐렴구균과 같은 그람 양성균뿐만 아니라, 그람 음성균, atypical organisms에 대해서도 넓은 항균 스펙트럼을 갖는 항균제로 알려져 있다. MDRSP의 빈도가 증가하고 있는 국내에서의 지역성 호흡기 감염에 대한 levofloxacin의 유효성과 안전성을 평가하기 위해 계획하였다. 방법 : 본 임상시험은 전향적 방법으로 2000년 1월부터 2001년 4월까지 삼성서울병원에 내원한 지역사회 획득 폐렴, 만성 기관지염에 병발된 급성 세균성 감염 환자 60명을 대상으로 하였다. 투여량 및 투여방법은 Levofloxacin 500㎎을 하루에 한번씩 12.6일(±3.3일)간 투여 하여 임상적으로 호전된 경우, 경구제로 전환하였으며(500㎎ q 24hrs), 신기능 장애시(Ccr 20-50㎖/min) 주사 및 경구제 500㎎을 48시간 간격을 두고 투여하였다. 임상효과, 미생물학적 평가, 및 부작용을 관찰하였다. 결과 : 총 60명의 환자가 시험을 완료 하였고, 결핵환자로 판명된 3명과 NK/T cell lymphoma로 확인된 1명, 투약 후 피부발진 발생으로 2일만에 중단된 환자 1명을 제외하고 55명을 평가하였다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때 55예 중 49예(89%)에서 만족할 만한 결과를 얻었다. 미생물학적 평가에서 10예중 10예(100%) 모두에서 미생물학적 소실을 보였다. 부작용으로는 간염 4예, 피부 발진 1예로 모두 5예(9%)가 발생 하였다. 결론 : 약제 내성 폐렴구균의 빈도가 증가하고 있는 국내에서의 지역성 호흡기 감염에 대하여 levofloxacin은 비교적 효과적이고 안전한 치료 방법이라 할 수 있다. Background: To evaluate the efficacy and safety of levofloxacin in the treatment of lower respiratory infections in the area with high prevalence of multidrug-resistant Streptococcus pneumoniae(MDBSP) Methods: Outpatients of over 18 years old with a confirmed diagnosis of a community acquired pneumonia and an acute bacterial exacerbation of chronic bronchitis were enrolled. Patients were treated with parenteral levofloxacin(500㎎ once a day) followed by oral levofloxacin(500㎎ once a day) for about 2weeks and evaluated. Results: Total number of 60 patients received levofloxacin for a mean of 12.6days. Successful clinical response(cured and improved) was 89.1%(49/55) of patients. Microbiologic eradication rate was achieved in 100% of patients whose pathogens were isolated. Hepatitis was developed in 4 cases and drug eruption occurred in I case. Conclusion: A once a day of 500㎎ of levofloxacin for lower respiratory infections developed in the region of high prevalence of MDRSP was effective and safe.
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Aspergillus fumigatus에 의한 요추 척추염 1예
허상택,정숙인,김연숙,오원석,조황래,김성민,백경란,송재훈,이남용 대한감염학회 2001 감염 Vol.33 No.2
Aspergillus fumigatus is the most common pathogen causing invasive aspergillosis. Although invasive aspergillosis mainly involves lung, brain, and sinus, Aspergillus fumigatus osteomyelitis of the spine has been reported very rarely. We experienced a case of vertebral Aspergillus osteomyelitis and report it with a review. A 70-year-old women was admitted due to progressive lower back pain, which had begun 1 month before admission. Although she had diabetes and hypertension, no other underlying disease or immune dysfunction was fecund. MRI of spine showed severely destroyeded lumbar spines. Debridement and bone graft was done for correction of unstable spine, and Aspergillus fumigatus wsa grown from surgical specimen. Amphotericin B was given up to total 2 g, and was switched to oral itraconazole maintenance therapy. She is well until now, 120 days after operation. On the other hand, anthracofibrosis due to Mycobac-Terium tuberculosis was found through bronchoscopic study, which was done because of atelectasis in left lower lobe of lung. Therefore she was treated with anti-tuberculous agents also. (Korean J Infect Dis 33: 153∼156, 2001)
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