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세침흡인 세포검사로 진단된 인두주위에 발생한 신경절 신경종 - 1예 보고 -
이지신,조향정,윤기중,문형배,Lee, Ji-Shin,Cho, Hyang-Jeong,Yun, Ki-Jung,Moon, Hyung-Bae 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2
Ganglioneuromas are a fully differentiated tumor that contains no immature elements. The majority of sanglioneuromas are diagnosed in patients older than 10 years and are most often located in the posterior mediastinum, followed by the retroperitoneum. The location of these tumors in the parapharyngeal region is extremely uncommon and there are only a few reports on the cytologic appearance of the tumor. We report a case of ganglioneuroma presenting in a parapharyngeal location in a 4 year-old boy, diagnosed by fine needle aspiration cytology. The smears revealed scattered large oval to polygonal cells with voluminous, granular cytoplasms. The nuclei were one to two in number and had a prominent nucleolus. Clusters of benign spindle-shaped cells were also present.
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최창수 ( Chang Soo Choi ),최석채 ( Suck Chei Choi ),서검석 ( Geom Seog Seo ),조은영 ( Eun Young Cho ),조향정 ( Hyang Jung Cho ),김용성 ( Yong Sung Kim ),김기훈 ( Ki Hoon Kim ),김태현 ( Tae Hyeon Kim ),나용호 ( Yong Ho Nah ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.6
목적: 대장게실과 대장종양은 발생의 병태 생리 기전은 유사한 것으로 알려져 있다. 이에 한국인에서의 대장게실과 대장종양의 빈도 사이의 연관성에 대해 알아보고자 하였다. 대상 및 방법: 2002년부터 2004년까지 대장내시경을 실시한 3,007명의 환자 중 선별된 2,377명을 대상으로 대상군의 특성 및 게실군과 나머지 대조군에서 종양, 진행 종양 빈도를 비교 분석하였다. 또한 다발 게실군과 나머지 대조군의 종양의 빈도 및 진행 종양 빈도를 비교하였다. 결과: 대상환자군 중 게실 환자는 9%, 종양의 빈도는 29%, 진행 종양의 빈도는 6%였다. 게실 환자 중 근위부에 게실은 92.5%였다. 대상 환자군에서 남자의 종양 빈도는 34.8%, 여성은 21.6%였다(p<0.01). 게실군과 대조군에서 종양 빈도는 각각 37.7%, 28.2%, 진행 종양 빈도는 각각 7.9%, 5.9%으로 게실군에서 종양의 빈도가 유의하게 높았으나(p=0.03), 진행 종양의 경우 유의한 차이는 없었다(p=0.23). 근위부 게실군과 대조군의 근위부 종양 빈도는 각각 24.6%, 14.3% (p<0.01), 근위부 진행 종양은 각각 4.5%, 2% (p=0.01)로 유의한 차이를 보였다. 다발 게실군과 대조군 간에 종양 및 진행 종양의 빈도는 차이가 없었다. 결론: 대장 게실이 있는 군이 게실이 없는 군보다 대장종양의 발생 빈도가 높았다. 그러나 한국의 게실 환자에서 추후 많은 대상군과 전향 연구 및 환자의 특성이 반영된 연구가 필요할 것이라 생각한다. Background/Aims: Although a few published studies have reported on the relationship between diverticulosis and neoplasia in the west, it is not yet examined in Korea. The aim of this study was to determine whether there is an association between diverticulosis and colonic neoplasia. Methods: We retrospectely analysed the medical records of 3,007 patients (M:F=1.3:1) who underwent colonoscopic examinations from year 2002 to year 2004. Patients who had a history of previous polypectomy, colon resection, or inflammatory bowel diseases were excluded. The size, extent (none, few, or many), and location of diverticuli and polyps were analyzed. Results: Of 2,377 patients, included 57% were male and the mean age was 50.8 year-old. Nine percent of the patient had diverticulosis, 29% had more than one neoplasm, and 6% had advanced neoplasia. Patients with diverticular diseases had higher risks of any neoplasia than those without diverticulum (p=0.03, 37.7% vs. 28.2%). There was no correlation between diverticular diseases and advanced neoplasia. Patients with proximal diverticular diseases had higher risk of any proximal neoplasia than other patients (p<0.01 24.6% vs. 14.3%). Moreover, they had higher risk of proximal advanced neoplasia than others (p=0.01, 4.5% vs. 2%). In addition, comparison of multiple diverticular disease with few or no diverticuli revealed no difference in the risk of any neoplasia. Conclusions: These data show that the patients with diverticular diseases have more neoplasms than controls without diverticula. (Korean J Gastroenterol 2007;49:364-368)
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비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구
한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2
The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.
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