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유수식 연속노출장비를 이용한 과불화화합물(PFOS, PFOA)이 송사리(Oryzias latipes) 알의 초기발생과정에 미치는 영향 연구
조재구(Jae-Gu Cho),김경태(Kyung-Tae Kim),류태권(Tae-Kwon Ryu),박유리(Yuri Park),윤준헌(Junheon Yoon),이철우(Chul-woo Lee),김현미(Hyun-Mi Kim),최경희(Kyunghee Choi),정기은(Ki-Eun Jung) 환경독성보건학회 2010 환경독성보건학회지 Vol.25 No.2
Perfluorinated chemicals (PFCs) is a kinds of persistent organic pollutants, and have the potential toxicity of which is causing great concern. In this study, we employed Oryzias latipes embryos to investigate the developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)s compound using flow-throw system for 14 day. O. latipes embryos were exposed to solvent control, 20, 40 and 80 ㎎/L of PFOS and 62.5, 130,260 ㎎/L of PFOA respectively. After exposure, hatchability, mortality, total length and heart beats were examined. Hatching rates were reduced approximately 27% in the 80 ㎎/L PFOS-treated group and 17% in the 62.5, 130 ㎎/L PFOA-treated groups. Heart beats in the PFOS-treated groups were reduced at 7 day but, PFOA-treated groups were increased heart beats. 80 ㎎/L PFOS treated group showed significant reduction in growth (total length) level to 90% of control. But PFOA did not showed significant effect on growth. In the 14 days LC<SUB>50</SUB> of PFOS and PFOA was 22.74 ㎎/L and 173 ㎎/L, respectively. The overall results indicated that the early stage of O. latipes might be a reliable model for the testing of developmental toxicity to perfluorinated chemicals.
국내담수새우인 새뱅이(Neocaridina denticulata)를 이용한 다양한 물질에 대한 급성독성평가
이재현 ( Jae Hyun Lee ),김미선 ( Mi Seon Kim ),조재구 ( Jae Gu Cho ),김균 ( Kyun Kim ) 한국환경농학회 2013 한국환경농학회 학술대회집 Vol.2013 No.-
유해화학물질에 대한 환경 중 영향을 평가하기 위하여 생태독성시험이 필수적으로 요구되고 있다. 또한 국내 생태계에 보다 적합한 위해성평가를 수행하기 위해서는 국내에 서식하는 생물종을 이용한 독성평가 자료가 필요하다. 그러나 아직까지 국내에 서식하고 있는 생물종을 이용한 체계 적인 생태독성연구가 많이 진행되지 못하고 있는 실정이다. 따라서 본 연구에서는 국내에 서식하 고 있는 새뱅이(Neocaridina denticulata)를 이용하여 생태독성 시험종으로서의 가능성을 확인하고 자 하였다. 새뱅이는 절지동물문 갑각강 십각목 새뱅이과 얼룩생이속에 속하는 생물로써 국내에도 넓게 분포되어 서식하는 것으로 보고되어 있다. 시험에 사용한 새뱅이는 충청남도 청원군 초정리 내수읍 큰외골 저수지에서 채집하였으며, 채집한 새뱅이는 실험실내 사육장에서 순화 후 시험에 사용하였다. 시험물질은 Pentachlorphenol sodium salt, Potassium dichromate와 국내에 널리 쓰이 는 농약의 주성분에 따라서 Organophosphorus계(Phenthoate, Fenitrothion), Avermectin계(Emamection benzoate), Oxadiazine계(Indoxacarb), Pyrethroid계(Deltamethrin)로 나누어 96hr 동안 노출하였다. 그 결과, 96hr의 반수치사농도(LC50)는 Pentachlorphenol sodium salt는 0.35 mg/L이었고, Potassium dichromate는 1.35mg/L이었다. 그리고 Phenthoate는 1.037㎍/L, Fenitrothion 0.579㎍/L로 나타났으며, Emamection benzoate의 경우 22㎍/L, Indoxacarb 0.567㎍/L, Deltamethrin는 0.002㎍/L로 나타났다. 이와 같은 결과로 볼 때 새뱅이는 물벼룩, 어류와 다른 독성민감도를 보이는 것으로 판 단되었다. 따라서 새뱅이를 생태독성 시험종으로써 활용할 가능성이 있을 것으로 사료되었고, 향후 보다 더 다양한 물질들을 적용하여, 새뱅이의 독성민감도를 확인 할 예정이다.
보문 : Potassium dichromate에 대한 새뱅이 유생, 물벼룩 및 송사리 치어 급성독성 민감도 비교
이재우 ( Jae Woo Lee ),김경태 ( Kyung Tae Kim ),조재구 ( Jae Gu Cho ),김지은 ( Ji Eun Kim ),이재안 ( Jae An Lee ),김필제 ( Pil Je Kim ),유지성 ( Ji Sung Ryu ) 한국환경생물학회 2012 환경생물 : 환경생물학회지 Vol.30 No.4
The aims of the present study were to estimate the possibility for toxicity test and compare acute toxicity of potassium dichromate in the larva stage of Neocaridina denticulata, Daphnia magna and the juvenile stage of Oryzias latipes. N. denticulate, a freshwater shrimp lives in Korea, is an indigenous species and considered to be useful for toxicity test. D. magna and O. latipes were recommended as a test species for the OECD test guideline. The 96 h-LC50 potassium dichromate value was 0.62 mg L^-1 for the larva stage of N. denticulata and 168.44 mg L^-1 for the juvenile stage of O. latipes. The 48 h-EC50 value was 1.27 mg L^-1 for the D. magna. The study was confirmed higher sensitivity of the larva stage of N. denticulata to potassium dichromate compared to the D. magna and the juvenile stage of O. latipes.
조천래(Chonrae Cho),조재구(Jae-Gu Cho),엄익춘(Ig-chun Eom),이병천(Byoung-cheun Lee),김수진(Sue-jin Kim),최경희(Kyunghee Choi),윤준헌(Junheon Yoon) 환경독성보건학회 2010 환경독성보건학회지 Vol.25 No.3
During the last decade, perfluorinated compounds (PFCs) have gained more attention due to their toxicity and global distribution. The aim of this study was to examine the distribution and bioaccumulation of perfluorinated compounds (PFCs) in aquatic wildlife effected from a sewage treatment plant. The concentrations of 12 PFCs were determined in water, sediment and fish samples. PFOS were predominantly detected in both ambient environment and fish. In fish, the concentration of PFCs in blood was the highest (i.e., 112.47 ng/㎖ wet-wt. PFOS) in comparison to other tissues. However, PFOA and PFHpS were highly detected in gonad as 3.87 and 4.58 ng/g wet-wt., respectively. The bioconcentration factor (BCF) of PFCs was greatest in the blood> liver?gonad > kidney> gill, and lowest in the muscle tissue. The BCFs of PFUnDA (39,000), PFDA(2.700) and PFOS (1,100) were rated as high values based on wet weight concentration. BCFs increased with increasing the length of the perfluoralkyl chain.
Prognostic Factor of Laryngeal Papillomatosis: 20 Years Experience
정은재,홍석진,조재구,백승국,우정수,권순영,정광윤,Chung, Eun-Jae,Hong, Seok-Jin,Cho, Jae-Gu,Baek, Seung-Kuk,Woo, Jeong-Soo,Kwon, Soon-Young,Jung, Kwang-Yoon The Korean Bronchoesophagological Society 2010 大韓氣管食道科學會誌 Vol.16 No.2
Background: Laryngeal papillomatosis, which is cased by human papillomavirus, is the most common benign neoplasm of the larynx. However, the prognosis of this disease remains really unpredictable. The aim of this paper is to determine whether any clinical features at the time of diagnosis could predict its course. Material and Method: Eighty-six patients treated at our institution during the last 20 years were analyzed retrospectively. All patients had microsurgery under general anesthesia. All patients' follow-up period was more than 1 year. We divided the patients into 1) Juvenile versus adult group based on their age 20, 2) single surgical method with laser versus dual surgical method with laser and microdebrider group, and 3) single subsite versus multiple subsites group. And we compared the therapeutic outcome. Results: The recurrence rate was 100% (15 patients) in the JP group and 56% (40 patients) in the AP group. Juvenile versus adult group was the only independent prognostic factor by univariate, and multivariate analysis. Microdebrider resection technique and multiple subsites were not associated with treatment result. Time period from the first surgery to recurrence detection was different statistically only for the age group. The number of surgery in the JP group ranged from 1 to 31 (mean 8.8). In the AP group the number of surgery ranged from 1 to 25 (mean 3.7). It was statistically different. Conclusion: Prognosis for the laryngeal papillomatosis remains unpredictable. Only patients' age was the only independent prognostic factor.
다양한 시험생물종을 이용한 산업폐수 생태독성 평가 및 원인물질 탐색
류태권(Tae-Kwon Ryu),조재구(Jae-Gu Cho),김경태(Kyung-Tae Kim),양창용(Chang-Yong Yang),정기은(Ki-Eun Joung),윤준헌(Junheon Yoon),최경희(Kyunghee Choi) 환경독성보건학회 2010 환경독성보건학회지 Vol.25 No.3
Toxicity identification and quantification are important factors to evaluate the effect of industrial effluent on the aquatic environment. In order to measure the potential and real toxicity of mixed chemicals in the effluents. the biological method (i.e., WET test) should be used as well as chemical analysis method. In this study, we conducted WET test for various kinds of industrial effluents using aquatic organisms such as water flea (Daphnia magna), algae (Pseudokirchneriella subcapitatai, fish (Oryzias talipes, Danio rerio), and microorganism (Vibrio fisheri). In addition, we carried out chemical analysis and TIE (Toxicity Identification Evaluation) for effluents in order to identify the substances causing toxicity. Among the 30 kinds of wastewater, S13 showed the highest eco-toxicity and Ca²? and Cl? ion were suspected as major compounds causing toxicity for aquatic organisms. In order to confirm these suspected compounds, various confirmation procedures need to be carried out.
Predictors of Distant Metastasis in Adenoid Cystic Cancer of Salivary Gland
김강우,김연수,오경호,박민우,조재구,백승국,우정수,정광윤,권순영,Kim, Kang Woo,Kim, Yeon Soo,Oh, Kyoung Ho,Park, Min Woo,Cho, Jae-Gu,Baek, Seung-Kuk,Woo, Jeong-Soo,Jung, Kwang-Yoon,Kwon, Soon Young The Korean Society for Head and Neck Oncology 2014 대한두경부 종양학회지 Vol.30 No.1
배경 및 목적 타액선 선양낭성암종은 느린 성장 속도와 늦은 원격 전이를 특징으로 하는 드문 상피성종양이다. 본 연구는 다양한 임상 병리학적 변수를 통해 선양낭성암종의 원격 전이에 영향을 주는 인자를 조사하고자 하였다. 대상 및 방법 1999년 10월부터 2011년 12월까지 본원 이비인후과에서 타액선 선양낭성암종으로 진단되어 치료 받은 44명(남자 19명, 여자 25명)을 대상으로 원격전이를 유발하는 위험 인자를 조사하였다. 8명의 환자는 배제 기준에 따라 제외하였다. 환자의 평균 연령은 54세였다. 환자의 병리 보고서, 종양의 크기, T 병기, 수술 절제연의 종양 존재 유무, 신경 조직 침습, 림프절 전이가 조사되었다. 결 과 15명의 환자가 원격전이가 있었으며 21명은 원격 전이가 없었다. 원격 전이를 유발할 수 있는 여러 인자들을 비교하였을 때, 원격 전이는 수술 절제연의 종양 세포 잔존(p=0.014), 종양의 크기(p=0.038), 진행된 T 병기(p=0.024)가 통계적으로 유의하게 연관성이 있었다. 림프절 전이와 신경 조직 침습은 원격 전이와 연관이 없었다. 결 론 종양의 크기, 진행된 T 병기, 수술 후 절제연의 종양 세포 잔존은 원격 전이의 예측 인자로 생각된다. 따라서 이에 해당하는 환자의 경우 더욱 철저한 관리 및 경과 관찰을 요한다.
최환,홍석진,김연수,조재구,백승국,우정수,정광윤,권순영,Choe, Hwan,Hong, Seok-Jin,Kim, Yeon-Soo,Cho, Jae-Gu,Baek, Seung-Kuk,Woo, Jeong-Soo,Jung, Kwang-Yoon,Kwon, Soon-Young 대한기관식도과학회 2010 大韓氣管食道科學會誌 Vol.16 No.2
Background: Penetrating neck injuries are potentially dangerous and require emergency management because of the presence of vital structures in the neck. The risk of airway, vascular, neurological, and pharyngoesophageal injuries leads to many difficult diagnostic decisions. The purpose of this retrospective study is to evaluate our experience with management of penetrating neck injuries, and to assess treatment outcome. Material and Method: Forty-two consecutive patients were identified (26 patients from Korea university Ansan hospital, 16 patients from Guro hospital) as having penetrating neck injuries from 2003 to 2009. With review of medical records, variables were collected and evaluated including the location of injury, mechanism of injury, number of significant injuries, diagnostic modalities, duration of hospital stay and outcome. Results: The location of injury was zone I (lower neck) in 13 cases (31%), zone II (midportion of the neck) in 22 (52%), and zone III (upper neck) in 7 (17%). Injuries were caused by stab wounds in 23 patients, penetrating foreign bodies in 12. Among 35 patients who had deep injuries that violated the platysma, significant injuries, including major vascular (20), trachea (5) Pharyngoesophageal injuries (5) were identified in 24 patients. The mean hospital stay was 9.5 days. Conclusion: The penetrating trauma in the neck may show various degrees of severity. However, Cervical penetrating injury should not be underestimated in spite of the minimal width of the lesion.