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Lamotrigine에 의한 약물 과민반응과 동반된 무균성뇌막염
이소희 ( So Hee Lee ),양민석 ( Min Suk Yang ),김태완 ( Tae Wan Kim ),권재우 ( Jae Woo Kwon ),이상민 ( Sang Min Lee ),권혁수 ( Hyouk Soo Kwon ),박흥우 ( Heung Woo Park ),장윤석 ( Yoon Seok Chang ),김선신 ( Sun Sin Kim ),조상헌 ( Sa 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.2
Drug-induced aseptic meningitis (DIAM) is a rare manifestation of drug-induced hypersensitivity syndrome. Lamotrigine is a non-aromatic anticonvulsant drug with antidepressant activity and widely used nowadays. So far, several cases of lamotrigine-induced hypersensitivity syndrome have been reported. However, there has been only one case report of lamotrigine-induced DIAM worldwide. A 33-year-old woman with an 8-year history of bipolar disorder was hospitalized, complaining of fever, a generalized maculopapular rash, leucocytopenia, hepatic dysfunction, and lymphadenopathy which developed 10 days after initiation of lamotrigine treatment. In addition, she presented meningeal irritation signs, and cerebrospinal fluid examination showed pleocytosis, an increased protein concentration, and a normal glucose level. However, no evidence of an infectious condition was found. Based on clinical and laboratory findings, we diagnosed her as having lamotrigine-induced hypersensitivity syndrome with DIAM and administered methylprednisolone systemically. Her clinical symptoms quickly improved and abnormal laboratory findings were normalized. To the best of our knowledge, this is the first case of lamotrigine-induced DIAM in Korea. (Korean J Asthma Allergy Clin Immunol 2007;27:140-142)