Epstein-Barr 바이러스 감염과 관련된 우두모양물집증 모양(HV-Like) 발진

조광현 ( Kwang Hyun Cho ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.9

Hydroa vacciniforme (HV) is a rare self-limiting disease characterized by vesicles and crust formation after sun exposure. However, cases with HV-like eruptions and severe systemic symptoms have also been described. It had been regarded as a different entity from typical HV. But latent Epstein-Barr Virus (EBV) infection has also been detected in typical HV patients and the possibility has been suggested that typical HV and atypical HV are variants within the same disease spectrum of EBV-associated lymphoproliferative disorders, which ranges from typical HV as a benign pole to severe HV progressing to hematologic malignancy as a malignant pole. Chronic active Epstein-Barr virus infection (CAEBV) is an atypical illness associated with serologic evidence of persistent EBV infection. The extremely high levels of EBV measured in affected tissue or peripheral blood are the most recently proposed diagnostic criteria. Recently, we found high levels of EBV in the peripheral blood of patients with EBV-associated HV-like eruptions. (Korean J Dermatol 2011;49(9):773~779)

새로운 항암제에 의한 피부부작용

조광현 ( Kwang Hyun Cho ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.4

Chemotherapeutic agents may induce cutaneous toxicity. Although the cutaneous side effects of chemotherapeutic agents are rarely life threatening, they can impact the physical, psychological, and social well-being of patients receiving these therapies. Recently, a number of new anti-cancer agents have been approved for the treatment of cancer. These new anti-cancer agents manifest a variety of cutaneous reactions. This article reviews the cutaneous toxicity of these agents, particularly those which dermatologists are likely to be consulted about. (Korean J Dermatol 2010;48(4):257~265)

유전 및 육종 : 홀스타인의 국제유전평가를 위한 모형개발에 관한 연구

조광현 ( Kwang Hyun Cho ),박병호 ( Byoung Ho Park ),최재관 ( Jac Kwan Choi ),최대과 ( Dae Kwa Choi ),최태정 ( Tae Jeong Choi ),최연호 ( Yun Ho Choy ),이승수 ( Seung Su Lee ),조총일 ( Chung Il Cho ) 한국동물자원과학회(구 한국축산학회) 2013 한국축산학회지 Vol.55 No.1

본 연구는 국내 국가단위 평가결과의 문제점을 해결하면서 유전능력평가시스템을 고도화하고 우리나라가 국제유전평가에 참여하기 위하여 국제평가기구에서 요구하는 검증작업을 통과하기 위하여 수행하였다. 본 연구에 이용된 자료는 농협중앙회 젖소개량부에서 수집한 분만일이 2001년부터 2009년까지의 검정성적으로 총 1,416,589개이며 산차는 5산으로 제한하였으며, 누적착유일은 75~305일로 제한하였고, 전체 혈통자료는 2,279,741개이며 부모를 갖는 개체는 535,409개이고 아비소는 2,467두로 구성되어 있는 기록들을 이용하였다. 유량, 유지방, 유단백에 대한 육종가는 신규로 개발한 다형질모형(Multiple traits model)을 이용하여 육종가를 구하였으며 기초작업은 SAS version 9.2와 R프로그램을 이용하였으며 유전모수를 추정하기 위하여 VCE 6.0을 이용하였다. 전반적으로 유전적 추세는 꾸준히 지속되어 오고 있으며 산차별 차이가 두드러지게 나타나지는 않았다. 유지방을 제외하고 유량과 유단백 형질의 추세가 잘 추정되었음을 알 수 있다. 유전평가분석결과 상위 1000두의 랭킹안에 최근의 생년을 갖는 딸소가 기존에 사용한 모수로 분석한 결과보다 딸소가 증가했음을 알 수 있다. 국제유전평가모형을 통해 새로 평가한 결과 씨수소상위 100두를 기존 평가모형에 의한 평가결과와 비교했을 때, 2006년생은 23두에서 28두로 2007년생은 12두에서 20두로 2008년생은 2두에서 8두로 증가하였다. 이는 최근의 딸소나 씨수소의 유전능력이 우수함에도 불구하고 상위에 랭크되지 못했던 결과가 새 모형의 적용으로 보완하여 새로운 평가분석에 적용할 수 있을 것으로 판단된다. 따라서 기존의 단형질 모형 대신 다형질 모형을 이용한 분석방법으로 평가를 실시하고 국제유전평가에도 다형질 모형을 이용한 육종가를 제시함으로써 다형질 선발의 정확도가 향상될 수 있을 것이다. This study was aimed to solve the problems of current national genetic evaluation systems in Korea and its development to pass the verification processes as required by International Bull Evaluation Service(Interbull). This will enable Korea to participate in international genetic evaluation program. A total of 1,416,589 test-day milk records with calving dates used in this study were collected by National Agricultural Cooperative Federation from 2001 to 2009. Parity was limited up to fifth calving and milk production records were adjusted to cumulative 305 day lactation. The pedigree consisted of 2,279,741 animals where 2,467 bulls had 535,409 parents. A newly developed multiple trait model was used in calculation of breeding values for milk yield, milk fat, and protein yield. Data were edited with SAS(version 9.2) and R programs, and genetic parameters were estimated using VCE 6.0. Results showed a continuous increase in genetic potentials, in general, and no remarkable differences were found between performances by parity. Except fat yield, potentials in milk yield and protein yield were well calculated. We found an increased number of daughters per each top ranked 1,000 bulls in recent years of calf births compared to the cases of previous evaluations. Of the bulls ranked top 100 by our new models(multiple-trait models) we found that increased numbers of bulls were included. Of twenty eight bulls born in 2006, twenty bulls born in 2007 and eight bulls born in 2008 that were listed by new models, only 23, 12, and 2 bulls born in respective years were represented on top 100 by old single-trait models. Re-ranking of the daughters or sires by multiple-trait models suggest that this new multiple trait approach should be used for dairy cattle genetic evaluation and seed-stock selection in the future to increase the accuracy of multiple trait selection. Breeding values for these traits should also be calculated by new method for international genetic evaluation.

피부과 자문

조광현 ( Kwang Hyun Cho ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.3

경북지방 돼지의 전염성 위장염에 대한 혈청학적 역학조사

조광현 ( Kwang Hyun Cho ),박최규 ( Choi Kyu Park ),김영환 ( Young Hoan Kim ),박인화 ( In Hwa Park ),김성국 ( Sung Kuk Kim ),박노찬 ( No Chan Park ),정종식 ( Jong Sik Jyeong ) 한국가축위생학회 2001 韓國家畜衛生學會誌 Vol.24 No.3

Swine sera collected from January to December 2000 were tested for the survey on transmissible gastroenteritis(TGE) infection in Gyeongbuk province. Serum neutralization(SN) test was performed in finishing pigs of 50 pigs industry without clinical signs of TGE and sows, gilts and growing pigs of four pigs industry with TGE. As the results of SN test in fifty industry, antibody titers of 90.6%(474/523 samples) showed below 4. Antibody titers of them showed highly in two pigs industry of western region and three pigs industry of southern region of Gyeongbuk province. The results indicated that TGE had been occurred before in five pigs industry. Most of antibody titers showed of highly in four pigs industry having had TGE. There were no significant differences of the antibody titers of TGE according to age when the survey was made. The above results indicated that the pigs of Gyeongbuk province were not almost exposed in porcine respiratory coronavirus(PRCV) by present.

불교사상 조형원리 재구현을 통한 도심사찰 건축유형 제안

조광현(Cho, Kwang-Hyun),김주원(Kim, Ju-Won) 대한건축학회 2013 대한건축학회 학술발표대회 논문집 Vol.33 No.2

선천성 멜라닌세포 모반의 병리조직학적 고찰

조광현(Kwang Hyun Cho),전호수(Ho Su Chun),김선훈(Seon Hoon Kim),박경찬(Kyung Chan Park),김규한(Kyu Han Kim),이승철(Seung Chul Lee),지제근(Je Geun Chil) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.4

Background : since congenital nevi may not always be identified clirically, it remains a challange for histologists to separate an acquired from a congehital nevus. The camparative histologic feature of congenital and acquired lesions have been described by several authors. Objective : In an attempt to establish reliable microscopic recognition of congenital nevi, the histologic features of 52 congenital melanocytic nevi were studied. Material and methods By reviewing HMB slides, histologic paterns were observed depending on the extent of nevus cell infiltration. An immunohistochemical study wi h anti S-100 protein and HMB-45 antibody was also performed. Results : Diffuse infiltratien of upper and lower dermis with nevu. cells was observed in 21 cases (40.0%). Nevus cell infiltration of appendages and neurovascular structures was observed in 29 cases (55.8%). Indian filing of dermal nevus cells was observed in 33 casesl(64.7%). Epidermis showed elongation of rete ridges in 36 ca.es(69.2%). Immunohistochemical staining with HMB 45 showed a positive raction in 9 cases out of 51 having dermal nevus cells, and epidemal melanocytes showed positive reaction in 20 cases. Conclusion : Congenital melanocytie nevi can be classified by histolcgic appearance into several patterns. Nevus cells had a trend to infiltrate into the deeper dermis as the clinieal size increrased. Nevus cell infiltration of appendages and neurovascular structure was a common finding in congenital melanocytic nevi. (Kor J Dermatol 1993;31(4):523-531)

피부에 발생한 혈관 중심성 T - 세포 림프종

조광현 ( Kwang Hyun Cho ),양성규 ( Seong Gyu Yang ),김철우 ( Chul Woo Kim ),지두현 ( Doo Hyun Chi ),고재경 ( Jai Kyoung Koh ),김영근 ( Young Keun Kim ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.6

Background: Angiocentric T-cell lymphomas are rare T-cell malignancies which involve extranodal sites, such as the skin, nasal cavity, soft tissue and gastrointestinal tract. They have been reported with significant frequency in Asia. Objectives . The main objective of this study is to characterize t.he clinical, pathological, and immunohistochemical featnres of cutaneous angiocentric T-cell lymphoma. Another objective is to search for the Epstein-Barr virus (EBV) in the tissues of cutaneous angiocentiric T cell lymphoma. Methods : Clinical records, laboratory data, and histopathologic sections of 12 patients with cutaneous angiocentric T-cell lymphoma were reviewed. Paraffin tumor tissues were immunophenotyped. In situ hybridizaion studies were performed to detect the EBV genomes. Results : The ages of the 12 patients ranged from 34 to 64 years(mean 45.8 years). The cuta- neous lesions were nodules or plaqes, and were with ulcerated or had intact skin. Eight patients had evidence of extracutaneous involvement, usually involving lymph nodes, liver, and spleen. Eleven patients showed the abnormal laboratory findings including anemia, leukopenia, and elevated level of LDH. The dis ase pursued an aggressive course and was not uncommonly resistant to treatment. Hist,ologically, the lymphomatous infiltrate occurred predominantly in the subcutaneous layer with involvement f the dermis. The pattern was mainly perivascular and periadnexal. A prominent feature was invasion of small or medium vesselsby lymphoma cells. The infiltrating lymphrcytes expressed CD45RO in all cases ; variable expression of CD3 and CD56 was detected in piaffin sections. Among the 11 cases where in situ hybridization was performed, EBV genome could be detected in 9 cases. Conclusion . Angiocentvic T-cell lymphoma of the skin is an aggressive lymphoma distinct from classic cutaneous T-cell lymphoma. However, further studies are needed to regard them as a ho- mogeneous entity of T-cell lymphoma involving the skin. (Kor J Dermatol 1996;34(6): 953-960)

영남지방 도축돈에 대한 폐렴발생 조사

조광현 ( Kwang Hyun Cho ),박인화 ( In Hwa Park ),도재철 ( Jae Cheul Do ),장성준 ( Sung Jun Chang ),박노찬 ( No Chan Park ),권헌일 ( Huon Il Kwon ),박덕상 ( Duk Sang Park ) 한국가축위생학회 1996 韓國家畜衛生學會誌 Vol.19 No.2

Lungs from 109 slaughter pigs with gross lesions indicating enzootic Pneumonia of pigs(EPP) and 16 grossly normal lungs, all originating from seven different herds, were subjected to microbiological examinations. The microbiological studies were included both bacterial and mycoplasmal culture. From lungs of 125 slaughter pigs, 87.2% pigs were pneumonia lesions alone or complexly. Mycoplasma spp., pasteurella multocida (P. multocida), Streptococcus spp., and Actinobacillus pleuropneumoniae(A. pleuropneumoniae) were detected in 39.4%, 42.2%, 13.8%, and 3.7% of the pneumonic lungs, respectively. P. multocida was the most frequently isolated organism in pneumonic lungs. Mycoplasmas not isolated organism in 33.9% the pneumonic lungs even if there are gross lessions mycoplasmas. The amounts of pneumonia in lungs with Mycoplasma spp. alone, a concurrence of Mvcoplasma spp. and P. multocida, P. multocida alone, a concurrence of P. multocida and A. pleuropneumoniae, and a concurrence of Mycoplasma spp. and A. pleuropneumoniae were 10.1%, 22.7%, 18.7%, 25%, and 30%, respectively. These findings indicated that P. multocida might be involved in the pathogenesis of pneumonia in slaughter pigs. Mycoplasma spp. was also, in this study, associated with higher frequency of pneumonia. The frequency of pigs snout lesion grade 0~5 inclusive were 27.2%, 28%, 19.2%, 16%, 6.4%, and 3.2% from 125 slaughter pigs. 32(25.6%) pigs were positive and 13~30% in the pigs from seven herds were found to be infected with atrophic rhintis(AR). A total of 46 P. multocida strains in pneumonic lungs were further characterized by capsular serotyping and testing for production of dermonecrotic toxin. 42(91.3%) of strains were capsular A and 4(8.7%) were type D. Out of the type A and type D strains, 86% and 75% were toxigenic, respectively.

키워드 네트워크 분석을 활용한 국내 설교학 분야 연구동향 연구

조광현 ( Cho Kwang Hyun ),김현숙 ( Kim Hyunsook ) 한국복음주의신학회 2022 성경과신학 Vol.102 No.-

이 연구는 국내 설교학 연구동향을 가늠하고자 설교학 분야에서는 지금까지 한 번도 시도되지 않았던 키워드 네트워크 분석을 시행하였는데, RISS(학술연구정보서비스)를 통해 가려낸 2000년 이후에 생산된 설교학 연구 논문 533편에서 1,613개의 저자 키워드를 추출해 NetMiner4 프로그램을 활용하여 분석하였다. 빈도분석 결과, ‘강해설교’, ‘신설교학,’ ‘설교자’, ‘수사학’, ‘설교신학’, ‘청중’, ‘예배’가 20회 이상 높은 빈도로 출현하였다. 연결중심성 분석에서는 ‘강해설교’, ‘신설교학’, ‘설교신학’, ‘수사학’, ‘설교자’, ‘내러티브 설교’, ‘적용’, ‘한국교회’ ‘청중’, ‘하나님의 말씀’, ‘개혁주의 설교’이 높은 순위를 보였다. 매개중심성이 높은 키워드는 ‘강해설교’, ‘설교자’, ‘수사학’, ‘청중’, ‘목회’, ‘신설교학’, ‘하나님의 말씀’, ‘설교신학’, ‘한국교회’, ‘내러티브 설교’였다. 응집성 분석 결과, 6개의 하위 주제가 네트워크를 형성하고 있었다. 하위 그룹은 G1: 설교의 전달, G2: 설교의 신학, G3: 설교의 맥락, G4: 강해설교와 신설교학, G5: 설교의 구성 요소, G6: 수사학으로 나타났다. This study examines the domestic research trends on homiletics by keyword network analysis that has not been attempted before in the field of homiletics. To achieve the objective, 1613 author keywords were extracted from 533 articles on homiletics published after the year 2000s from RISS(Research Information Sharing Service) and the keywords were analyzed using the NetMiner4 program. As a result of the frequency analysis, ‘Expository Preaching’, ‘The New Homiletic’, ‘Preacher’, ‘Rhetoric’, ‘Theology of Preaching’, ‘Listeners’, and ‘Worship’ all appeared more than 20 times, which is a high frequency of appearance. In the centrality analysis, ‘Expository Preaching’, ‘The New Homiletic’, ‘Rhetoric’, ‘Preacher’, ‘Narrative Preaching’, ‘Application’, ‘Korean Churches’, ‘Listeners’, ‘the Word of God’, and “Reformed Preaching” ranked high. ‘Expository Preaching’, ‘Preacher’, ‘Rhetoric’, ‘Listeners’, ‘Pastoral Ministry’, ‘the New Homiletic’, ‘the Word of God’, ‘Theology of Preaching’, ‘Korean churches’, and ‘Narrative Preaching’ show high values of betweenness centrality. The cohesion analysis shows that the network is classified into six sub-groups-G1: Delivery of Preaching, G2: Theology of Preaching, G3: Context of Preaching, G4: Expository Preaching and the New Homiletic, G5: Components of Preaching, G6: Rhetoric.