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과립구 감소증을 동반한 발열 환자에서의 MIPENEM/CILASTATIN(Tienam) 단일요법
박지훈,최환석,김정백,김시영,김정희,윤휘중,조경삼 대한감염학회 1994 감염 Vol.26 No.2
The need for prompt antibiotic therapy in the management of febrile neutropenic patients is well established. Imipenem is the first representitive of the new thienamycin class of antibiotics. It has the broadest antibacterial activity of all antibiotics available for systemic use in humans. We performed clinical studies to assess the efficacy and tolerability of Imipenem/Cilastatin as monotherapy in 20 febrile neutropenic patients. Clinical response rate was 80%(16/20). Microbiologically documented infections account for 55%(11/20). Microbiologic response rate was 86%(6/7) for G(+) and 75%(3/4) for G(-) infection. No serious side effects were noted in any patients. In conclusion, Imipenem/Cilastatin is a safe and effective antibiotics as monotherapy in febrile granulocytopenic patients.
중증 과립구 감소증을 동반한 환자에서 Fluconazole의 진균감염 예방 효과
윤휘중,김정백,어완규,김시영,조경삼 대한감염학회 1993 감염 Vol.25 No.1
Fungal infection is one of the major cause of mortality in neutropenic patients. We performed clinical studies to assess the effectiviveness and toxicity of fluconazole for prophylaxis of fungal infection in 20 neutropenic patients, who were admitted to Kyung Hee University Hospital from June 1991 to June 1992 and who had a high risk of fungal infection. The results were as follows. 1) In 18 case, there was no evidence of fungal infection during the hospital course. One patient had suspicious fungal infection on chest X-ray and clinical finding, and the other case had fungemia confirmed by blood culture. Two patients died of septicemia. 2) Elevation of AST, LAT (15%) G-I trouble (10%) were obserbed as toxicities of fluconazole, but renal dysfuntion, skin rash, or seizure was not obserbed.
림포킨활성살(LAK)세포와 산화미토겐활성살(OMAK)세포의 세포증식반응 및 세포독성의 비교 연구
조경삼,윤휘중 대한내과학회 1990 대한내과학회지 Vol.38 No.3
We compared the changes of proliferation responses and cytotoxicities of lymphokine activated killer(LAK) cells and oxydizing mitogen activated killer(OMAK) cells on the duration of culture. Proliferation responses were measured by ³H-thymidine uptake and cytotoxicities were measured by 4 hour ^(51)Cr release assay with K562 as NK sensitive target and RC29 or SNUC5 as NK resistant target. Effector cells were named as table 1. The results were as follows. The degree of proliferation response was highest in NAGO-AK followed by NAGO, IAK and LAK at 2nd day of culture. Proliferation response was peaked at 7th day in LAK, 4th day in IAK, and 3rd day in NAGO and NAGO-AK. Cytotoxicity against K562 was apparent at 1st day of culture of LAK and IAK. It was peaked at 4th day in LAK and 3rd day in IAK. Cytotoxicity against RC29 at 2nd day of culture was highest in NAGO-AK and lowest in LAK. It appeared at 2nd day in LAK and 1st day in IAK. LAK showed peak cytotoxicity from 3rd to 7th day, but IAK showed peak cytotoxicity at 3rd day and after then decreased. NAGO and NAGOAK showed peak cytotoxicities at 2nd day of culture and after then decreased. LAK and IAK cultured with 2% IL2 showed decreased cytotoxicity than those cultured with 10% IL2, and cytotoxicity of IAK cultured with 2% IL2 was lower than that of LAK cultured with 10% IL2. We thought OMAK cells may have more advantages than LAK cells because of its higher and earliergenerated cytotoxicity.