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백서 좌골신경의 동종이식후 조직반응에 관한 실험적 연구
정형배,임창준,이동근,서재덕,Chung, Hyung-Bai,Yim, Chang-Joon,Lee, Dong-Keun,Se, Jae-Deok 대한악안면성형재건외과학회 1991 Maxillofacial Plastic Reconstructive Surgery Vol.13 No.2
Nerve allografts as a bridge of regeneration is useful in the repair of peripheral nerve defect resulting from trauma, and leprosy. But immunological rejection and complicated scar formation is an unavoidable problem in the application of allogeneic nerves. This article is intended to study of the regeneration of allogeneic nerve grafts in rats with histopathologically, scanning electron microscopically. 24 adult male Sprague-Dawley rats were used as the experimental animals. A 2cm skin incision was made on the lateral aspects of limb, parallel to femur. Segments of sciatic nerve trunk taken from rats, 10mm was resected at the middle of the thigh, nerve graft was inserted between the ends of gaps with perineural and epineural suture method with 10-0 prolene. Obsrevation was made simultaneously at 3 day, 1, 2, 3, 4, 5, 6, 8 weeks after surgery. The results were as follows. 1. In light and electronic microscopic studies, marked degenerative change of the graft nerves were observed at 2 weeks after surgery. 2. After surgery, blood clot fromation was observed at 3 day, granualtion tissue formation was observed at 2 week, and fibrous tissue proliferation was observed at 3 week. 3. In change of nerve fiber, there were Wallerian degeneration at early stage, decrease in degeneration at 4 week but degeneration of myeline was continuded at 8 week. 4. At 4 week, schwann cells proliferate at its cut ends to join with the distal and proximal stump of the damaged nerve. 5. Fibrous scar tissues are formed at 2 weeks and increased progressively in 8 weeks, which was interrupted the regeneration of grafted nerve.
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백서 좌골신경의 동종이식후 조직반응에 관한 실험적 연구
정형배,임창준,이동근,김수남 원광대학교 치의학연구소 1990 圓光齒醫學 Vol.1 No.1
Nerve allografts as a bridge through which lost nerve can regenerate is useful in the repair of peripheral nerve defect resulting from trauma, and leprosy. But immunological rejection and complicated scar formation is an unavoidable problem in the application of allogenic nerves. This article is intended to study of the regeneration of allogenic nerve grafts in rats with histopathologically, scanning electron microscopically. 24 adult male Sprage-Dawley rats were used as the experimental animals. A 2㎝ skin incision was made on the lateral aspects of limb, parallel to femur. Segemnts of sciatic nerve trunk taken from rats, 10㎜ was resected at the middle of the thigh, nerve graft was inserted between the ends of gaps with perineural and epineural suture method with 10-0 prolene. Obsrevation was made simultaneous at 3 day, 1, 2, 3, 4, 6, 8 weeks after surgery. The results were as follows. 1. In light and electronic microscopic studies, marked degenerative change of the graft nerves were observed at 2 weeks after surgery. 2. After surgery, blood clot fromation was observed at 3 day, granualtion tissue formation was observed at 2 week & fibrous tissue proliferation was observed at 3 week. 3. In change of nerve fiber, there were wallerian degeneration at early stage, decrease in degeneration at 4 week and degeneration of myeline was continuded at 8 week. 4. At 4 week, schwann cells proliferate at its cut ends to join with the distal and proximal stump of the damaged nerve. 5. Fibrous scar tissues are formated at 2 weeks and increased progressively in 8 weeks, which was interrupted the regeneration of grafted nerve.
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CASES REPORT OF CLEFT ALVEOLUS REPAIR WITH PMCB GRAFT
Lee, Dong-Keun,Chung, Hyung-Bai,Choi, Seong-Hoon 大韓顎顔面成形再建外科學會 1991 Maxillofacial Plastic Reconstructive Surgery Vol.13 No.1
치조골 파열은 전체 구개파열 환자의 약75% 정도 발생하며 발생원인은 유전적 요인이 강하며 환경적 요인으로 모체의 영양장애, 방사선조사, 스테로이드투여, 저산소증, 양수변화 바이러스에 의한 질환등을 들 수 있다. 치조골 파열시 상악골의 전후방관계의 전방골결손 및 수평관계의 후방골결손, 인접치아에 대한 골지지력 결여, 측절치의 조기결손, 그리고 안모의 외형에도 많은 변화를 줄 수 있다. 치조골 파열에 대한 골이식은 치조골을 안정시키고, 치조골의 연속성 도모 및 인접치아에 대한 골지지와 치아상실 예방 및 비익저부를 제공하는데 그 목적이 있다. 골이식은 시기에 따라 2세미만에 실시하는 일차 골이식술, 2세에서 5세사이에 시술하는 조기 이차 골 이식골, 5세에서 16세 사이에 실시하는 이차 골 이식술, 그리고 16세 이후에 실시하는 말기 이차골 이식술 등이 있으며 이중 혼합치열기인 5세에서 16세 사이에 실시하는 이차골 이식술이 가장 성공률이 높은 것으로 알려져 있다. 본 교실에서는 치조골 파열환자에 자가망상골을 이용한 골이식술을 시행하여 비교적 양호한 결과를 얻었기에 이에 보고하는 바이다. The cleft alveolus occurs about 75% of cleft lip and palate patients. The purpose of bone grafting is improve the maxillary growth, rehabilitation of continuty of maxillary arch and providing bone for periodontal support for unerupted teeth. The bone grafting for alveolar cleft defect repair are classsified; primary bone grafting, early secondary bone grafting secondary bone grafting and late secondary bone grafting. In this article, we reported the cases of PMCB grafts for repair of the alveolar clefts showed potential benifit to the patient to induce a normal maxillary growth and providing bone foor periodontal support of unerupted teeth.
ScienceON
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