생부자(生附子) 및 삼부탕(蔘附湯)의 aconitine 함량 분석 및 삼부탕 단회투여 독성시험

정해룡,손변우,김경철,신순식,황원덕,Jeong, Hae-ryong,Son, Byun-woo,Kim, Gyeong-cheul,Shin, Soon-shik,Hwang, Won-deuk 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.3

Objectives: This study investigated the aconitine contents analysis of Buja extracts (raw material of Buja, hot water extract of Buja, and hot water extract of Sambu-tang) and the single oral dose toxicity of Sambu-tang-R in six-week-old Sprague-Dawley rats in order to compare the toxicity of Buja extracts.Methods: Aconitine content analysis is that Buja extracts were hold purity test. To detect single oral dose toxicity, six-week-old Sprague-Dawley rats were divided into two groups, a normal control group and a sambutang-R (2,000 mg/kg) group. For 14 days of treatment, clinical signs, body weight, clinical chemistry, necropsy, and histopathology were examined.Results: The aconitine contents of the Buja extracts were Buja-RH (0.1738%), Buja-RD (0.1746%), and Sambu-tang-R (0.0961%). There were no cases of death in either the control group or the experimental group. Nor was there any disorder to the clinical signs or any significant change in body weight in either group. There was no significant change of clinical chemistry or disorder of necropsy findings in either the control or the experimental group. And there was no difference in histopathological findings in comparing the control group with the experimental group.Conclusions: These results suggest that the aconitine content of the hot water extract of Buja was similar to the raw material of Buja, but the hot water extract of Sambu-tang had greatly decreased aconitine content. These results also suggest that a single oral lethal dose of Sambu-tang-R for Sprague-Dawley rats exceeds 2,000 mg/kg for both female and male rats.

MBO 총장이어야 한다

정해룡,Jeong, Hae-Ryong 한국대학교육협의회 2006 大學敎育 Vol.143 No.-

대학의 총장은 도덕적 덕망과 학자로서의 소양을 지닌 진정한 교육자야 하며 탁월한 행정 능력의 소유자여야 함과 동시에 대학의 자율성 확보를 위해‘할 말은 할 줄 아는’총장이어야 한다. 아울러 대학 조직의 구심점으로서의 역할을 수행할 수 있어야 하며 장기적인 대학발전을 위해 교육경영자로서의 역할을 잊지 않고 합리적인 목표를 세우며 효율적으로 추진해 나갈 수 있는 MBO 총장이어야 한다.

Purification, Structure Determination and Biological Activities of 20(29)-lupen-3-one from Daedaleopsis tricolor(Bull.ex Fr.)Bond.et Sing.

김은미,정해룡,민태진,Kim, Eun Mi,Jeong, Hae Ryong,Min, Tae Jin Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.1

The dried fruit-body of Daedaleopsis tricolor was extracted by the petroleum ether. The extracts were purified by liquid-liquid extraction, column chromatography, and recrystallization. The purified compound was a colorless orthorhombic crystal form. Its melting point, molecular weight and molar extinction coefficient $(\varepsilon)$ were estimated $168-170^{\circ}C$, 424 and 3,935 at 208 nm, respectively. Its structure was elucidated to be 20(29)-lupen-3-one by UV-Vis, FT-IR, NMR and X-ray crystallographic analysis. It showed antifungal activities against Saccharomyces cerevisiae and Microsporum gypseum, and antibacterial activities against Escherichia coli, Proteus vulgaris, Pseudomonas pyocyanea, Bacillus subtilis, and Staphylococcus aureus. In addition, this compound showed an antioxidative activity on lipid-peroxidation by 6.4%.

다발성 신경병증에 대한 한방 치험 1례

손변우,정해룡,황원덕,Son, Byun-woo,Jeong, Hae-ryong,Hwang, Won-deok 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.5

Objective: To describe the effects of Korean medical treatment on a 51-year-old male patient with polyneuropathy and chief complaints of lower limb paralysis and dysarthria. Methods: The Toronto Clinical Neuropathy Scoring System (TCNSS) was used to evaluate the function of the lower limb and the symptoms of the patient were observed daily. We applied herbal medication and acupuncture daily, depending on the patient’s symptoms. Results: After the treatment, the TCNSS score was improved. Conclusions: In this case, Korean medical therapy was effective in improving lower limb function.

증례 : 심정지 후 발생한 일과성 중간 좌심실 풍선 확장 증후군의 1예

김정은 ( Jeong Eun Kim ),최경수 ( Kyung Soo Choi ),정해룡 ( Hae Ryong Jeong ),김석환 ( Seok Hwan Kim ),신정훈 ( Jeong Hun Shin ),신진호 ( Jin Ho Shin ),임영효 ( Young Hyo Lim ) 대한내과학회 2012 대한내과학회지 Vol.83 No.3

일과성 중간 좌심실 풍선 확장 증후군은 스트레스성 심근증의 한 변형으로 중간부 좌심실에 국한된 심근벽 운동장애와 확장을 보이는 질환이다. 임상양상이 급성 관상동맥 증후군과 유사하여 감별 진단이 필요하다는 점에서 중요하며, 정확한 병태생리의 확립을 위한 추가 연구가 요구된다. 본 저자들은 자가 지방 이식 수술 도중 발생한 심정지로 심폐 소생술 시행 후 내원하여 심전도와 심초음파에서 급성 심근경색이 의심되었으나 관상동맥 조영술 및 좌심실 조영술 시행 후 일과성 중간 좌심실 풍선 확장 증후군이 진단된 증례를 경험하여 이를 보고한다. Stress-induced cardiomyopathy is characterized by transient wall-motion abnormalities involving the left ventricular apex. Emotional or physical stress might play a key role in this reversible form of cardiomyopathy, but the etiology remains unclear. Clinical features of stress-induced cardiomyopathyare similar to those of acute coronary syndrome, but there is no significant stenosis in the coronary arteries. Recently, transient mid-ventricular ballooning syndrome, a variant form of stress-induced cardiomyopathy in which only the mid-ventricle is affected, has been reported. Here, we report a case of a 42-year-old female patient who developed transient mid-ventricular ballooning syndrome after cardiac arrest during autologous fat transplantation.

의인성 쿠싱증후군에 대한 한방 증례 보고

이보람,강유경,정해룡,김경민,조성우,김원일,Lee, Bo Ram,Kang, You Gyung,Jeong, Hae Ryong,Kim, Kyung Min,Cho, Sung Woo,Kim, Won-Ill 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : The purpose of this study is to report the improvement of a patient diagnosed as iatrogenic Cushing syndrome treated with herbal medicine. Methods : We treated a patient diagnosed as iatrogenic Cushing syndrome with s Wiryeong-tang gagam and Sinbeopbanha-tang for 10days. While being treated with herbal medicine, the patient got acupuncture treatment two times a day. Results : After treatment, weakness of lower limb and tremor got improved. Vomiting and disgusting also got better. Conclusion : Using herbal medicine may improve various symptoms of iatrogenic Cushing syndrome effectively.

증례 : 소화기; 십이지장 구부에 발생한 심재성 낭종성 장염에서 지방종을 동반한 1예

이대성 ( Dae Sung Lee ),정해룡 ( Hae Ryong Jeong ),김진옥 ( Jin Ok Kim ),태혜진 ( Hye Jin Tae ),최호순 ( Ho Soon Choi ),안혜인 ( Hye In Ahn ),백승삼 ( Seung Sam Paik ) 대한내과학회 2014 대한내과학회지 Vol.86 No.3

Enteritis cystica profunda (ECP) is a very rare hyperplastic benign lesion of the small intestine. Histologically, it is characterized by mucin-filled cystic spaces frequently lined by benign epithelium within the submucosa and muscularis propria. ECP occurs much less frequently than gastritis cystica profunda (GCP) or colitis cystica profunda (CCP). It is most often seen in adults with Crohn`s disease, Peutz-Jeghers syndrome, hamartomatous polyp, or congenital anomalies. We encountered a case of ECP (90 × 15 mm) accompanied by an elongated lipoma in the duodenal bulb, in the absence of any other disease. An endoscopic polypectomy proved sufficient for diagnosing and treating the ECP. To our knowledge, this is the first reported case of ECP accompanied by a lipoma in the duodenal bulb in the absence of any other intestinal disease.

논문 : 암반의 불균질성을 고려한 불포화대 지하수 유동 평가

하재철 ( Jae Chul Ha ),이정환 ( Jeong Hwan Lee ),정재열 ( Jae Yeol Cheong ),정해룡 ( Hae Ryong Jung ) 대한지질공학회 2016 지질공학 Vol.26 No.1

본 연구에서는 단열을 포함하는 불포화 암반에서의 지하수 유동 흐름을 예측하기 위한 2차원 수치 모델링을 수행하였다. 특히, 불연속 단열망 모델링(Dscrete Fractured Network, DFN)을 통하여 도출된 투수계수의 분포를 나타내는 k-field를 모델링 입력변수로 적용하였다. 투수계수 차이는 불포화대에서 지하수의 이동속도 차이를 야기시키는 중요한 인자로 적용되었다. 연구지역의 지표 토양층으로부터 지하 대수층까지의 불포화대 깊이를 적용하여 지하수 유동 모델링의 초기조건을 실제와 유사하게 설정하였다. 강우의 지표 침투율은 인공구조물과 자연 토양층의 침투율 차이를 적용하여 실제 불포화 암반을 거쳐서 포화대까지 지하수의 이동흐름을 해석하고 시각화하였다. 특히, 오염물질의 이동 시작점이 될 수 있는 인공구조물의 하부에 모니터링 지점을 설정하여 실제 오염물질원이 지하수에 용해되어 불포화대를 이동할 때의 경로를 예측 하였으며 중력방향인 직하부로 이동하는 것을 확인되었다. We present the results of two-dimensional numerical simulations predicting the flow of groundwater in a fractured unsaturated zone. We applied the k-field distribution of permeability derived from discrete fracture network (DFN) modeling as the hydraulic properties of a model domain. To model an unsaturated zone, we set the depth from the ground surface to the underground aquifer. The rate of water infiltration into the unsaturated zone was divided into two parts, an artificial structure surface and unsaturated soil zone. The movement of groundwater through the unsaturated zone was simulated with particular emphasis on contaminant transport. It was clearly observed that the contaminants dissolved in groundwater transported vertically from the ground surface to the saturated zone.

중풍 예방 검진에서 중풍 표준화 변증과 가속도맥파의 상관성 연구

정소연(So Youn Jung),허희수(Hee Soo Hur),정해룡(Hae Ryong Jeong),김경민(Kyoung Min Kim),김영균(Young Kyun Kim) 한의병리학회 2015 동의생리병리학회지 Vol.22 No.2

This study was performed to find a relationship between each pattern identification and vascular status using the second derivative of photoplethysmogram waveform(SDPTG) indices. We analyzed 200 subjects who participated in stroke preventive examination. We classified the subjects into four groups of pattern identifications; Fire-Heat pattern (火熱證; FH), Yin Deficiency pattern(陰虛證; YD), Qi Deficiency pattern(氣虛證; QD) and Dampness-Phlegm pattern(濕痰證; DP) that based on Korean Standard Pattern Identifications for Stroke-Ⅲ. We studied a relationship between each pattern identification and the SDPTG. The total number of the subject group was 200, whereas the groups were divided into four groups; Fire-Heat pattern group(n=49), Yin Deficiency pattern(n=57), Qi Deficiency pattern(n=45), and Dampness-Phlegm pattern(n=49). b/a ratio was related with age and systolic blood pressure, c/a ratio was associated with age, systolic blood pressure, fasting blood sugar and Total cholesterol, d/a ratio was affected with age, diastolic blood pressure, and hypertension, e/a ratio was related with age and sex and SDPTG AI was associated with age. c/a ratio and d/a ratio were significantly higher in the Fire-Heat group than in the Qi Deficiency group. SDPTG AI was significantly higher in the Qi Deficiency group than in the Fire-Heat group. The Qi Deficiency group was significantly older than the Fire-Heat group and the number of hypertension patients was significantly more in the Fire-Heat group than in the Qi Deficiency group. Through this study, we found out some significant relationships between each pattern identification group and the SDPTG indices.

팥 신장기 과습처리에 의한 생육특성 및 단백질 발현

정해룡, 유장환, 윤성현, 권수정, 우선희 충북대학교 농업과학기술연구소 2022 農業科學硏究 Vol.38 No.2

Adzuki bean is sensitive to waterlogging stress. The overall study on the waterlogging stress is limited comparing to the study on the drought and any environmental stress. Therefore, the present study was conducted to investigate the changes in growth characteristics and the expression patterns of proteins at the 5-leaf stage periods of adzuki bean. The domestic cultivar, Arari (Miryang No. 8) was used to test the waterlogging stress. In the waterlogging treatment for 3 days, the plant height showed slightly decrease in the treatment at 3 days of waterlogging, but root fresh weight showed significantly changes at 3 days of the waterlogging treatment. Chlorophyll contents showed also significantly different at 3 days of waterlogging treatment compared to control the plants. The waterlogging stress gradually influenced the growth differences between the control and the treatment respectively. More than 350 pro- tein spots were identified on 2-D gels using an image analysis. Moreover, a total of 28 proteins were analyzed using LTQ-FT-ICR MS. Among these 28 proteins, a total of 18 proteins were up-regulated, and 10 proteins were down-regulated under waterlogging treatment. According to biological process, the most of the proteins were found to be involved in carbohydrate metabolism. Regarding the subcellular local- ization, most of the proteins were localized into chloroplasts in 5-leaf stage.