한국인에서 치주질환과 관상동맥질환의 관련성에 대한 염증표지자와 IL-1 유전자 다변성의 영향

정하나,정현주,김옥수,김영준,김주한,고정태,Jeong, Ha-Na,Chung, Hyun-Ju,Kim, Ok-Su,Kim, Young-Joon,Kim, Ju-Han,Koh, Jung-Tae 대한치주과학회 2004 Journal of Periodontal & Implant Science Vol.34 No.3

Recently epidemiologic studies have indicated that the patients with periodontitis may have increased risk of ischemic cardiovascular events, and have suggested the important roles of blood cytokines and acute reactant proteins in the systemic infection and inflammatory response. Periodontitis and coronary heart disease (CHD) may share the common risk factors and the genetic mechanism associated with interleukin(IL)-1A, B and RA genotype may be involved in the production of IL-1. This study was aimed to investigate the relationship between angiographically defined CHD and periodontitis as chronic Gram-negative bacterial infection and to determine whether the IL-1 gene polymorphism is associated in both diseases. Patients under the age of 60 who had undergone diagnostic coronary angiography were enrolled in this study. Subjects were classified as positive CHD (+CHD, n=37) with coronary artery stenosis more than 50% in at least one of major epicardial arteries, and negative CHD (-CHD, n=30) without significant stenosis. After recording the number of missing teeth, periodontal disease severity was measured by means of plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), and radiographic bone loss around all remaining teeth. Gingival crevicular fluid (GCF) was collected from the 4 deepest periodontal pockets and assessed for cytokine ($IL-1{\beta}$, IL-6, IL-1ra, tumor necrosis $factor-{\alpha}$, and prostaglandin $E_2$). Additionally, blood CHD markers, lipid profile, and blood cytokines were analyzed. IL-1 gene cluster genotyping was performed by polymerase chain reaction and enzyme restriction using genomic DNA from buccal swab, and allele 2 frequencies of IL-1A(+4845), IL-1B(+3954), IL-B(-511), and IL-1RA(intron 2) were compared between groups. Even though there was no significant difference in the periodontal parameters between 2 groups, GCF level of $PGE_2$ was significantly higher in the +CHD group(p<0.05). Correlation analysis showed the positive relationship among PD, CAL and coronary artery stenosis(%) and blood $PGE_2$. There was also significant positive relationship between the periodontal parameters (PI, PD, CAL) and the blood CHD markers (leukocyte count, C-reactive protein, and lactic dehyrogenase). IL-1 gene genotyping showed that IL-1A(+3954) allele 2 frequency was significantly higher in the +CHD group compared with the -CHD group (15% vs. 3.3%, OR 5.118,p=0.043). These results suggested that periodontal inflammation is related to systemic blood cytokine and CHD markers, and contributes to cardiovascular disease via systemic inflammatory reaction. IL-1 gene polymorphism might have an influence on periodontal and coronary heart diseases in Korean patients.

여대생의 HDL-콜레스테롤 수준에 따른 임상건강지표와 영양섭취 실태

정하나(Ha Na Jung),김정희(Jung Hee Kim) 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.1

Recently, a lot of epidemiological studies revealed that low HDL-cholesterol level was a better predictor of risk for coronary heart disease than total cholesterol. This study investigated the anthropometric parameters, clinical blood indices, and dietary factors influencing serum HDL-cholesterol level by using a cross-sectional study for Korean female college students. The subjects were 94 female college students. They were divided into three groups according to their serum HDL-cholesterol levels, low HDL-cholesterol (< 50 mg/dL, n = 20), medium HDL-cholesterol (50≤, < 60 mg/dL, n = 39) high serum HDL-cholesterol groups (60≤ mg/dL, n = 35). This study examined their demographic data and dietary intake throughout a questionnaire. Clinical blood indices were measured using an automatic blood chemistry analyzer (Selectra E), after 12 hours of fasting. BMI, body weight, fat mass, and waist circumferences were significantly increased according to low serum HDL-cholesterol levels. Serum lipid analysis showed a significantly higher level of TG, LDL-/ HDL-Ratio, atherogenic index in the low HDL-cholesterol group. Serum levels of GPT, uric acid and alkaline phosphatase in the low HDL-cholesterol group were significantly higher than in the other group. The average consumption of energy was 1627 kcal and 77.76% of estimated energy requirement (EER). The mean ratio of calories from carbohydrate : protein : fat was 57 : 15 : 28. The low HDL-cholesterol group was significantly higher than the other groups in eggs, fat and oils consumption. Interestingly, milk and diary products consumption of low HDL-cholesterol group was half (p < 0.05) of those of the other groups. In conclusion, serum HDL-cholesterol levels appeared to be decreased by increasing BMI, fat mass, waist circumference, and serum TG level. In addition, some dietary factors seemed to be related to serum HDL-cholesterol levels. However, further research is needed to elucidate the exact relationship between serum HDL-cholesterol level and dietary factors. (Korean J Community Nutrition 13(1) : 100~110, 2008)

Rowell 증후군

정하나 ( Ha Na Jung ),이단비 ( Dan Bi Lee ),채웅석 ( Woong Suk Chae ),성준영 ( Jun Young Seong ),서호석 ( Ho Seok Suh ),최유성 ( Yu Sung Choi ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.6

Rowell`s syndrome is a rare entity consisting of lupus erythematosus with associated erythema multiforme-like lesions and characteristic immunological findings, and it was first described by Rowell et al. in 1963. Because of the clinical similarities between subacute cutaneous lupus erythematosus and Rowell`s syndrome, it is difficult to clinically distinguish between the annular-polycyclic type of subacute cutaneous lupus erythematosus and Rowell`s syndrome. We report a case of 18-year-old woman with systemic lupus erythematosus who presented erythema multiforme-like eruptions on both thighs. Simultaneously, she developed urticarial-like rashes on her trunk consistent with atypical skin lesion of lupus erythematosus. She also developed a positive antinuclear antibody with speckled pattern and positive anti-Ro antibody.

아토피피부염과 혈청 비타민 D의 상관관계에 대한 연구

정하나 ( Ha Na Jung ),최유성 ( Yu Sung Choi ),이지호 ( Ji Ho Lee ),오인보 ( Inbo Oh ),이현진 ( Hyun Jin Lee ),서호석 ( Ho Seok Suh ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.7

Artificial infection of Honeybee larvae with Sacbrood virus for virus propagation

Ha-Na Jung(정하나),Mi-Sun Yoo(유미선),Young-Ha Kim(김영하),Nam-Hee Kim(김남희),Kondreddy Eswar Reddy,Lien Thi Kim Nguyen,Suk-Chan Jung(정석찬),Seung-Won Kang(강승원) 한국양봉학회 2014 한국양봉학회 학술대회 자료집 Vol.2014 No.9

우리나라와 싱가포르의 초등학교 과학 교과서에 제시된 물리 영역 탐구 활동의 특징 비교

정하나 ( Ha Na Jung ),전영석 ( Young Seok Jhun ) 경북대학교 과학교육연구소 2012 科學敎育硏究誌 Vol.36 No.1

본 연구는 우리나라와 싱가포르의 초등학교 과학 교과서에 제시된 탐구 활동을 물리 영역 중심으로 비교하여 그 특징을 찾고, 교과서 및 교육과정 개선을 위한 시사점을 얻고자 한다. 탐구 활동의 특징 비교를 위해 탐구 활동 수, 탐구 과정 요소, 탐구 목적, 탐구 과제의 개방성 정도를 비교하였다. 연구 도구로는 이봉우(2005) 의 탐구 과정 요소 분석 틀과 Millar 등(1998)의 탐구활동 분석틀을 수정하여 사용하였다. 연구 결과, 우리나라의 탐구 활동 수가 싱가포르에 비해 1.5배 가량 많았으나 주당 과학 수업 시간은 같거나 싱가포르가 조금 더 많았다. 탐구 과정 요소를 비교해 본 결과 우리나라의 경우 기초 탐구 과정이 차지하는 비율이 높았고 싱가포르는 기초 탐구 과정과 통합 탐구 과정이 거의 균형을 이루고 있었다. 하지만 5~6학년의 경우 싱가포르는 통합 탐구 과정의 비율이 더 높았다. 탐구 활동 목적을 분석해 본 결과 우리나라는 내용 중심적인 활동이 많았고 싱가포르는 내용 학습과 과정 학습이 균형을 이루고 있는 것으로 나타났다. 하지만 내용 학습 중``변인이나 개념 사이의 관계를 학습하는 것``에서는 싱가포르가 높은 비율을 나타냈다. 우리나라도 과정 학습 중``의사소통 학습하기``에서 높은 비율을 차지했다. 하지만 교과서의 의사소통 활동이 실제 의사소통의 목적으로 사용되기 보다는 정리의 목적으로 사용되고 있는 것이아닌지 조심스레 의문을 던져 본다. 탐구 활동 과제 개방성을 비교한 결과``문제인식``은 우리나라와 싱가포르 모두 교사에 의해 이루어져 개방성이 낮은 것으로나타났다. ``실험 과정``, ``결과 해석``의 개방성은 싱가포르에서 높았고``사용할 실험장치``, ``데이터를 다루는방법``에서는 우리나라의 개방성이 높았다. 우리나라는재료나 데이터를 작성하는 방법은 자율성을 주지만 실험과정이나 결과 해석은 주로 교사 주도로 이루어지고있었다. 이 연구를 통해 시사하는 점은 첫 째, 탐구활동수를 줄여 핵심적인 내용으로 적정화 하는 것이다. 둘째, 기초 탐구와 통합 탐구의 균형을 추구하되 고학년은 통합 탐구 과정 요소를 늘리는 것이다. 셋째, 탐구활동의 목적을 내용 학습과 과정 학습의 균형을 이루되내용 학습에선 단순한 사실·개념 전달보다는 관계를 파악할 수 있는 내용을 마련하고 과정 학습에선 실제적의사소통이 이루어질 수 있도록 탐구 활동을 구성해야 할 것이다. 마지막으로``실험 과정``과``결과 해석``의 개방성을 높여 요리책 식의 과학책에서 탈피하도록 노력해야할 것이다. The purpose of this study is to provide some suggestions for future improvement of scientific inquiry activities in Korean elementary science textbook. The modified framework of Lee(2005) and Millar et al.(1998) was used to compare inquiry activities in the Korean and Singaporean science textbooks. The results of this study are as follows: Korean text books have more activities than Singapore`s, but both countries have similar time allotment for science classes. In the area of ``inquiry process skill``, Singapore is more balanced in ``Basic inquiry process skills`` and ``Integrated inquiry process skills`` than Korea. Singapore`s integrated inquiry rate is also higher than Korea`s. Next the results of comparing leaning objectives to scientific inquiry activities shows that Korean text books tend to focus on ``contents objectives``, while Singapore`s text books focus on balancing ``contents objectives`` and ``process objectives``. Korean science textbooks encourage students to communicate the results of experiments but in most case these communication activities are actually not performed. Lastly Korea and Singapore have low degree of openness in inquiry activities. Remarkably ``Suggest questions`` are totally conducted by teachers. This study implies that Korean science textbooks should have lower amounts of inquiry activities to accomodate enough time for communication about results. Next we need to make balance not only ``Basic inquiry process skills`` and ``Integrated inquiry process skills`` but also ``Content objectives`` and ``Process objectives``. Lastly we need to make student to be the leader in science classes through encouraging them to plan procedures for experiments and to discover results by themselves.

여자야구 동호인의 레크리에이션 전문화가 팀몰입에 미치는 영향

정하나(Ha Na Jung),황선환(Sun Hwan Hwang) 한국사회체육학회 2014 한국사회체육학회지 Vol.0 No.56

The purpose of this study was to examine the effect of women`s baseball club member`s recreation specialization on their team commitment. To achieve this purpose, 235 women baseball club members who have registered in WBAK (Women Baseball Association Korea) were selected using the purposive sampling method. Finally, 229 data were analyzed by SPSS 18.0 program for the statistical analyses. In order to analyze, EFA, Crobach`s α, cluster, t-test, correlation, simple and multiple regression analyses were conducted. Through the analyses, the main findings were as follows: First, recreation specialization had a positive effect on team commitment. Second, only the cognitive factor of recreation specialization sub-factors had a positive effect on team commitment. Third, levels of team commitment were different based on the levels of recreation specialization. Finally, levels of team commitment were different based on the levels of cognitive, behavioral, affective sub-factors but, it was not different on the level of physical investment.

아토피피부염과 혈청 비타민 D의 상관관계에 대한 연구

정하나 ( Ha Na Jung ),이현진 ( Hyun Jin Lee ),오인보 ( In Bo Oh ),이지호 ( Ji Ho Lee ),최유성 ( Yu Sung Choi ),서호석 ( Ho Seok Suh ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.2

Background: Vitamin D is known to play roles in immunity through the stimulation of Toll-like receptors, regulating pro-inflammatory cytokine production, and increasing antimicrobial peptide production. Recent studies have revealed the role of vitamin D deficiency in the immunopathogenesis of atopic dermatitis (AD). Objective: We aimed to assess the correlation between vitamin D concentrations and the severity of AD and also elucidate the relationship between the amount of sunlight exposure and serum 25-Hydroxy vitamin (25(OH)D) levels using the sunlight exposure questionnaire. Methods: Sixty-one Korean patients with AD and 120 healthy control patients were enrolled. We evaluated the disease severity using the SCORAD index and measured the serum levels of 25(OH)D, and total IgE levels and eosinophil counts. All patients completed a one-week recall sunlight exposure questionnaire. Results: There was no significant difference in the 25(OH)D levels between the two groups. Eosinophil counts (p <0.001) were significantly higher in patients with AD than in control patients. A significant inverse correlation (r=-0.309, p=0.015) was found between the SCORAD score and 25(OH)D levels. A significant positive correlation (r=0.236, p=0.001) was found between the weekly sunlight exposure score and the serum levels of 25(OH)D. Conclusion: Our study suggests that vitamin D deficiency is related to the severity of AD and the serum 25(OH)D concentration is positively correlated with the sunlight exposure score. (Korean J Dermatol 2016;54(2):105∼111)

Rapid diagnosis of viral honeybee diseases by Multiplex PCR

Ha-Na Jung(정하나),Mi-Sun Yoo(유미선),Young-Ha Kim(김영하),Nam-Hee Kim(김남희),Kondreddy Eswar Reddy,Lien Thi Kim Nguyen,Suk-Chan Jung(정석찬),Seung-Won Kang 한국양봉학회 2014 한국양봉학회 학술대회 자료집 Vol.2014 No.9

극화놀이를 통한 유아공감능력 증진 프로그램 개발 및 효과

정하나 ( Ha Na Jung ),지성애 ( Sung Ae Chi ) 한국유아교육학회 2015 유아교육연구 Vol.35 No.6

본 연구는 극화놀이를 통한 유아공감능력증진 프로그램을 개발하고, 개발한 프로그램의 유아교육현장 적용 타당성을 검증하는데 목적이 있다. 극화놀이를 통한 유아공감능력 증진 프로그램은 목적·목표 → 교육내용(인지적공감·정서적공감·소통적공감) → 교수학습방법 → 평가체계로 개발되었다. 개발한 극화놀이를 통한 유아공감능력 증진 프로그램의 효과를 분석하기 위해 실험집단과 비교집단을 선정하고, 실험집단에는 극화놀이를 통한 유아공감능력 증진 프로그램을 처치하였고 비교집단에는 스토리 만들기를 통한 유아공감능력 증진 프로그램을 제공하였다. 연구대상의 월령은 80.01개월이었으며 수집된 연구자료는 t-test와 ANCOVA를 통해 실험처치의 효과를 분석하였다. 연구결과 극화놀이를 통한 유아공감능력 증진 프로그램이 스토리 만들기를 통한 유아공감능력 증진 프로그램 보다 유아의 자아존중감, 마음이론 발달 그리고 공감능력을 유의미하게 증진시키는데 효과가 있는 것으로 밝혀졌다. The purpose of this study was to develop Empathy Program through Dramatic play for young children and to analyze the effects of the program. The subject used in this study were 5 year-old children. The mean age of the subjects was 8 months. experimental group carried out the Empathy Program through Dramatic Play for Young Children, developed in this study, whereas the comparative group carried out a story making-based young children`s empathy improvement program. "Young Children`s Self-Esteem Test" and "Content Exchange Task", "Location Shift Task", "First/Second Order False Belief Task" and "Test of Ability of Empathy" were used in collection of data. It also used t-test and ANCOVA to analyze the data. It was revealed that there were significant differences between the experimental group and comparative group in the post-test scores. The scores of the experimental group in the young children’s sense of self-esteem, theory of mind and ability of empathy were significantly higher than the scores of the comparative group. In conclusion, the results of this study suggest that Empathy Program through Dramatic play for young children are effective on promoting young children’ sense of self-esteem, theory of mind and ability of empathy.